The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

Blood

Volumn 122, Issue 15, 2013, Pages 2609-2617

  Cohen, Shmuel J ^a   Gurevich, Irina ^a   Feigelson, Sara W ^a   Petrovich, Ekaterina ^a   Moser, Markus ^b   Shakhar, Guy ^a   Fassler, Reinhard ^b   Alon, Ronen ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; KINDLIN 3; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; KINDLIN-3 PROTEIN, MOUSE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD VESSEL WALL; CELL ADHESION; CONTROLLED STUDY; DIAPEDESIS; EFFECTOR CELL; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; C57BL MOUSE; CELL MOTION; CYTOLOGY; DEFICIENCY; DERMATITIS; HUMAN; IMMUNOLOGY; LYMPHADENITIS; PATHOLOGY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VASCULITIS;

ADOPTIVE TRANSFER; ANIMALS; CELL ADHESION; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DERMATITIS; HUMANS; INTEGRIN ALPHA4BETA1; LYMPHADENITIS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VASCULITIS;

EID: 84891521852     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-04-495036     Document Type: Article

References (51)

1. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7(9):678-689.
2. Ding ZM, Babensee JE, Simon SI, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999;163(9): 5029-5038.
3. Phillipson M, Heit B, Colarusso P, Liu L, Ballantyne CM, Kubes P. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med. 2006;203(12):2569-2575.
4. Auffray C, Fogg D, Garfa M, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007;317(5838):666-670.
5. Phillipson M, Heit B, Parsons SA, et al. Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature. J Immunol. 2009;182(11): 6870-6878.
6. Shulman Z, Shinder V, Klein E, et al. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009;30(3):384-396.
7. Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol. 2010;185(11): 7057-7066.
8. Moser M, Legate KR, Zent R, Fässler R. The tail of integrins, talin, and kindlins. Science. 2009; 324(5929):895-899.
9. Mory A, Feigelson SW, Yarali N, et al. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. Blood. 2008;112(6):2591.
10. Malinin NL, Zhang L, Choi J, et al. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med. 2009; 15(3):313-318.
11. Svensson L, Howarth K, McDowall A, et al. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med. 2009;15(3):306-312.
12. Moser M, Bauer M, Schmid S, et al. Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med. 2009; 15(3):300-305.
13. Manevich-Mendelson E, Feigelson SW, Pasvolsky R, et al. Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. Blood. 2009;114(11):2344-2353.
14. Feigelson SW, Grabovsky V, Manevich-Mendelson E, et al. Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells. Blood. 2011;117(26): 7042-7052.
15. Lefort CT, Rossaint J, Moser M, et al. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012;119(18): 4275-4282.
16. Guarda G, Hons M, Soriano SF, et al. L-selectinnegative CCR7-effector and memory CD81 T cells enter reactive lymph nodes and kill dendritic cells. Nat Immunol. 2007;8(7):743-752.
17. Martín-Fontecha A, Baumjohann D, Guarda G, et al. CD40L1 CD41 memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med. 2008;205(11):2561-2574.
18. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fässler R. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 2008;14(3):325-330.
19. Shulman Z, Cohen SJ, Roediger B, et al. Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots. Nat Immunol. 2011;13(1):67-76.
20. Zhang J, Dong Z, Zhou R, Luo D, Wei H, Tian Z. Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus. Cell Mol Immunol. 2005;2(4):271-280.
21. Reinhardt RL, Bullard DC, Weaver CT, Jenkins MK. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J Exp Med. 2003;197(6): 751-762.
22. Janatpour MJ, Hudak S, Sathe M, Sedgwick JD, McEvoy LM. Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J Exp Med. 2001;194(9):1375-1384.
23. Martín-Fontecha A, Thomsen LL, Brett S, et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol. 2004;5(12):1260-1265.
24. Lo CG, Lu TT, Cyster JG. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 2003;197(3):353-361.
25. Sasaki K, Okouchi Y, Rothkötter HJ, Pabst R. Ultrastructural localization of the intercellular adhesion molecule (ICAM-1) on the cell surface of high endothelial venules in lymph nodes. Anat Rec. 1996;244(1):105-111.
26. Park S, Murray D, John B, Crispe IN. Biology and significance of T-cell apoptosis in the liver. Immunol Cell Biol. 2002;80(1):74-83.
27. John B, Crispe IN. Passive and active mechanisms trap activated CD81 T cells in the liver. J Immunol. 2004;172(9):5222-5229.
28. Galkina E, Thatte J, Dabak V, Williams MB, Ley K, Braciale TJ. Preferential migration of effector CD81 T cells into the interstitium of the normal lung. J Clin Invest. 2005;115(12):3473-3483.
29. Sumagin R, Lomakina E, Sarelius IH. Leukocyteendothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling. Am J Physiol Heart Circ Physiol. 2008;295(3): H969-H977.
30. Carlin LM, Auffray C, Geissmann F. Measuring Intravascular migration of mouse Ly6C(low) monocytes in vivo using intravital microscopy. Curr Protoc Immunol. 2013;Chapter 14:Unit 14.33.1-16.
31. Kuebler WM, Kuhnle GE, Goetz AE. Leukocyte margination in alveolar capillaries: interrelationship with functional capillary geometry and microhemodynamics. J Vasc Res. 1999;36(4): 282-288.
32. Thatte J, Dabak V, Williams MB, Braciale TJ, Ley K. LFA-1 is required for retention of effector CD8 T cells in mouse lungs. Blood. 2003;101(12): 4916-4922.
33. Anderson KG, Sung H, Skon CN, et al. Cutting edge: intravascular staining redefines lung CD8 T cell responses. J Immunol. 2012;189(6): 2702-2706.
34. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med. 2004;200(6): 783-795.
35. Bajénoff M, Egen JG, Koo LY, et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 2006; 25(6):989-1001.
36. Woolf E, Grigorova I, Sagiv A, et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol. 2007;8(10):1076-1085.
37. Ebisuno Y, Katagiri K, Katakai T, et al. Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPLdependent and -independent manners. Blood. 2010;115(4):804-814.
38. Malhotra D, Fletcher AL, Astarita J, et al; Immunological Genome Project Consortium. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012;13(5):499-510.
39. Alon R, Feigelson SW. Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts. Curr Opin Cell Biol. 2012;24(5):670-676.
40. Schenkel AR, Mamdouh Z, Muller WA. Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol. 2004;5(4):393-400.
41. Alon R, Shulman Z. Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers. Exp Cell Res. 2011;317(5):632-641.
42. Park EJ, Peixoto A, Imai Y, et al. Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood. 2010;115(8):1572-1581.
43. Lämmermann T, Bader BL, Monkley SJ, et al. Rapid leukocyte migration by integrinindependent flowing and squeezing. Nature. 2008;453(7191):51-55.
44. Tietz W, Hamann A. The migratory behavior of murine CD41 cells of memory phenotype. Eur J Immunol. 1997;27(9):2225-2232.
45. Hamann A, Klugewitz K, Austrup F, Jablonski-Westrich D. Activation induces rapid and profound alterations in the trafficking of T cells. Eur J Immunol. 2000;30(11):3207-3218.
46. Lehmann JC, Jablonski-Westrich D, Haubold U, Gutierrez-Ramos JC, Springer T, Hamann A. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. J Immunol. 2003;171(5):2588-2593.
47. Masopust D, Vezys V, Usherwood EJ, et al. Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J Immunol. 2004; 172(8):4875-4882.
48. Agace WW. Tissue-tropic effector T cells: generation and targeting opportunities. Nat Rev Immunol. 2006;6(9):682-692.
49. Deane JA, Hickey MJ. Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging. Expert Rev Mol Med. 2009;11:e25.
50. Berlin-Rufenach C, Otto F, Mathies M, et al. Lymphocyte migration in lymphocyte functionassociated antigen (LFA)-1-deficient mice. J Exp Med. 1999;189(9):1467-1478.
51. Boscacci RT, Pfeiffer F, Gollmer K, et al. Comprehensive analysis of lymph node stromaexpressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood. 2010;116(6):915-925.