Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 374-380

  Ling, Yong ^a,b   Wang, Zhiqiang ^a,b   Zhu, Hongyan ^b   Wang, Xuemin ^b   Zhang, Wei ^b   Wang, Xinyang ^b   Chen, Li ^a   Huang, Zhangjian ^a   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

Anti cancer agents; Cell apoptosis; Diamines; Farnesylthiosalicylic acid; Ras related signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; N (2 AMINOETHYL) 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N (3 AMINOPROPYL) 2 [(3,7,11TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N (4 AMINOBUTYL) 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N (5 AMINOPENTYL) 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N (6 AMINOHEXYL) 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N [2 (2 AMINOETHOXY)ETHYL] 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE; N,N' (BUTANE 1,4 DIYL)BIS[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE]; N,N' (ETHANE 1,2 DIYL)BIS[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE]; N,N' (HEXANE 1,6 DIYL)BIS[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE]; N,N' (PENTANE 1,5 DIYL)BIS[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE]; N,N' (PROPANE 1,3 DIY)BIS[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]BENZAMIDE]; PIPERAZIN 1 YL[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PHENYL]METHANONE; PIPERAZINE 1,4 DIYLBIS[[2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PHENYL]METHANONE]; PROTEIN BAX; PROTEIN BCL 2; SALIRASIB; SORAFENIB; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANTI-CANCER AGENTS; CELL APOPTOSIS; DIAMINES; FARNESYLTHIOSALICYLIC ACID; RAS-RELATED SIGNALING PATHWAY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; FARNESOL; HUMANS; NEOPLASMS; SALICYLATES; SIGNAL TRANSDUCTION;

EID: 84891485975     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.013     Document Type: Article

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