-
1
-
-
0037014584
-
Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II
-
Jul 3
-
Grady D, Herrington D, Bittner V, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). Jama. Jul 3 2002;288(1):49-57
-
(2002)
JAMA
, vol.288
, Issue.1
, pp. 49-57
-
-
Grady, D.1
Herrington, D.2
Bittner, V.3
-
3
-
-
0037125379
-
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial
-
Jul 17
-
Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. Jama. Jul 17 2002;288(3):321-333
-
(2002)
JAMA
, vol.288
, Issue.3
, pp. 321-333
-
-
Rossouw, J.E.1
Anderson, G.L.2
Prentice, R.L.3
-
4
-
-
0026458371
-
Hormone therapy to prevent disease and prolong life in postmenopausal women
-
Dec 15
-
Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. Dec 15 1992;117(12):1016-1037
-
(1992)
Ann Intern Med
, vol.117
, Issue.12
, pp. 1016-1037
-
-
Grady, D.1
Rubin, S.M.2
Petitti, D.B.3
-
5
-
-
0025981467
-
Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence
-
Jan
-
Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence. Prev Med. Jan 1991;20(1):47-63
-
(1991)
Prev Med
, vol.20
, Issue.1
, pp. 47-63
-
-
Stampfer, M.J.1
Colditz, G.A.2
-
7
-
-
33748646566
-
Clinical trial design issues: At least 10 things you should look for in clinical trials
-
Oct
-
Glasser SP, Howard G. Clinical trial design issues: At least 10 things you should look for in clinical trials. J Clin Pharmacol. Oct 2006;46(10):1106-1115
-
(2006)
J Clin Pharmacol
, vol.46
, Issue.10
, pp. 1106-1115
-
-
Glasser, S.P.1
Howard, G.2
-
8
-
-
0037022021
-
An overview of clinical research: The lay of the land
-
Jan 5
-
Grimes DA, Schulz KF. An overview of clinical research: The lay of the land. Lancet. Jan 5 2002;359(9300):57-61
-
(2002)
Lancet
, vol.359
, Issue.9300
, pp. 57-61
-
-
Grimes, D.A.1
Schulz, K.F.2
-
9
-
-
30944452360
-
Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole
-
Nov 15
-
Loscalzo J. Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole. Circulation. Nov 15 2005;112(20):3026- 3029
-
(2005)
Circulation
, vol.112
, Issue.20
, pp. 3026-3029
-
-
Loscalzo, J.1
-
10
-
-
0030463385
-
The placebo effect in cardiovascular disease
-
Dec
-
Bienenfeld L, Frishman W, Glasser SP. The placebo effect in cardiovascular disease. Am Heart J. Dec 1996;132(6):1207-1221
-
(1996)
Am Heart J.
, vol.132
, Issue.6
, pp. 1207-1221
-
-
Bienenfeld, L.1
Frishman, W.2
Glasser, S.P.3
-
11
-
-
0028245747
-
Scientific and ethical issues in the use of placebo controls in clinical trials
-
Clark PI, Leaverton PE. Scientific and ethical issues in the use of placebo controls in clinical trials. Annu Rev Public Health. 1994;15:19-38
-
(1994)
Annu Rev Public Health
, vol.15
, pp. 19-38
-
-
Clark, P.I.1
Leaverton, P.E.2
-
12
-
-
0028070548
-
The continuing unethical use of placebo controls
-
Aug 11
-
Rothman KJ, Michels KB. The continuing unethical use of placebo controls. N Engl J Med. Aug 11 1994;331(6):394-398
-
(1994)
N Engl J Med
, vol.331
, Issue.6
, pp. 394-398
-
-
Rothman, K.J.1
Michels, K.B.2
-
13
-
-
27644487803
-
Randomized trials stopped early for benefit: A systematic review
-
Nov 2
-
Montori VM, Devereaux PJ, Adhikari NK, et al. Randomized trials stopped early for benefit: A systematic review. Jama. Nov 2 2005;294(17):2203-2209
-
(2005)
JAMA
, vol.294
, Issue.17
, pp. 2203-2209
-
-
Montori, V.M.1
Devereaux, P.J.2
Adhikari, N.K.3
-
14
-
-
77951529251
-
Streptomycin treatment of pulmonary tuberculosis
-
Medical Research Council
-
Medical Research Council. Streptomycin treatment of pulmonary tuberculosis. BMJ. 1948;ii:769-782
-
(1948)
BMJ
, vol.2
, pp. 769-782
-
-
-
19
-
-
0024995464
-
The use of a run-in to enhance compliance
-
Jan-Feb 87-93 discussion
-
Lang JM. The use of a run-in to enhance compliance. Stat Med. Jan-Feb 1990;9(1-2):87-93; discussion 93-85
-
(1990)
Stat Med
, vol.9
, Issue.1-2
, pp. 93-85
-
-
Lang, J.M.1
-
21
-
-
0043095587
-
Prospective, randomized, openlabel, blinded-endpoint (PROBE) designed trials yield the same results as double-blind, placebocontrolled trials with respect to ABPM measurements
-
Jul
-
Smith DH, Neutel JM, Lacourciere Y, Kempthorne-Rawson J. Prospective, randomized, openlabel, blinded-endpoint (PROBE) designed trials yield the same results as double-blind, placebocontrolled trials with respect to ABPM measurements. J Hypertens. Jul 2003;21(7):1291-1298
-
(2003)
J Hypertens
, vol.21
, Issue.7
, pp. 1291-1298
-
-
Smith, D.H.1
Neutel, J.M.2
Lacourciere, Y.3
Kempthorne-Rawson, J.4
-
22
-
-
0019976346
-
-
Multiple risk factor intervention trial Multiple Risk Factor Intervention Trial Research Group. Jama Sep 24
-
Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. Jama. Sep 24 1982;248(12):1465-1477
-
(1982)
Risk Factor Changes And Mortality Results
, vol.248
, Issue.12
, pp. 1465-1477
-
-
-
23
-
-
0010607277
-
-
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group Apr 14
-
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. Apr 14 1994;330(15):1029-1035
-
(1994)
N Engl J Med
, vol.330
, Issue.15
, pp. 1029-1035
-
-
-
24
-
-
0033546995
-
What is meant by intention to treat analysis? Survey of published randomised controlled trials
-
Sep 11
-
Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. Bmj. Sep 11 1999;319(7211):670-674
-
(1999)
Bmj
, vol.319
, Issue.7211
, pp. 670-674
-
-
Hollis, S.1
Campbell, F.2
-
25
-
-
0018962999
-
-
Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project Oct 30
-
Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project. N Engl J Med. Oct 30 1980;303(18):1038-1041
-
(1980)
N Engl J Med
, vol.303
, Issue.18
, pp. 1038-1041
-
-
-
26
-
-
0018903268
-
-
Sulfinpyrazone in the prevention of sudden death after myocardial infarction. The Anturane Reinfarction Trial Research Group Jan 31
-
Sulfinpyrazone in the prevention of sudden death after myocardial infarction. The Anturane Reinfarction Trial Research Group. N Engl J Med. Jan 31 1980;302(5):250-256
-
(1980)
N Engl J Med
, vol.302
, Issue.5
, pp. 250-256
-
-
-
27
-
-
0018640322
-
Controversy in counting and attributing events in clinical trials
-
Dec 27
-
Sackett DL, Gent M. Controversy in counting and attributing events in clinical trials. N Engl J Med. Dec 27 1979;301(26):1410-1412
-
(1979)
N Engl J Med
, vol.301
, Issue.26
, pp. 1410-1412
-
-
Sackett, D.L.1
Gent, M.2
-
28
-
-
0030712416
-
Assessing differences in clinical trials comparing surgical vs nonsurgical therapy: Using common (statistical) sense
-
Nov 5
-
Howard G, Chambless LE, Kronmal RA. Assessing differences in clinical trials comparing surgical vs nonsurgical therapy: Using common (statistical) sense. Jama. Nov 5 1997;278(17):1432-1436
-
(1997)
JAMA
, vol.278
, Issue.17
, pp. 1432-1436
-
-
Howard, G.1
Chambless, L.E.2
Kronmal, R.A.3
-
29
-
-
0034712491
-
Subgroup analysis and other (mis)uses of baseline data in clinical trials
-
Mar 25
-
Assmann SF, Pocock SJ, Enos LE, Kasten LE. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet. Mar 25 2000;355(9209):1064-1069
-
(2000)
Lancet
, vol.355
, Issue.9209
, pp. 1064-1069
-
-
Assmann, S.F.1
Pocock, S.J.2
Enos, L.E.3
Kasten, L.E.4
-
30
-
-
0034466679
-
Debate: Subgroup analyses in clinical trials: Fun to look at -but don't believe them
-
Sleight P. Debate: Subgroup analyses in clinical trials: Fun to look at -but don't believe them! Curr Control Trials Cardiovasc med. 2000;1(1):25-27
-
(2000)
Curr Control Trials Cardiovasc med
, vol.1
, Issue.1
, pp. 25-27
-
-
Sleight, P.1
-
31
-
-
36448964544
-
Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: The stroke prevention by aggressive reduction in cholesterol levels (sparcl) trial
-
Dec
-
Amarenco P, Goldstein LB, Szarek M, et al. Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke. Dec 2007;38(12): 3198-3204
-
(2007)
Stroke
, vol.38
, Issue.12
, pp. 3198-3204
-
-
Amarenco, P.1
Goldstein, L.B.2
Szarek, M.3
-
32
-
-
0037851836
-
Principal results of the controlled onset verapamil investigation of cardiovascular end points (convince) trial
-
Apr 23-30
-
Black HR, Elliott WJ, Grandits G, et al. Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial. Jama. Apr 23-30 2003;289(16):2073-2082
-
(2003)
JAMA
, vol.289
, Issue.16
, pp. 2073-2082
-
-
Black, H.R.1
Elliott, W.J.2
Grandits, G.3
-
33
-
-
25444447999
-
A noninferiority comparison of valsartan/hydrochlorothiazide combination versus amlodipine in black hypertensives
-
Sep
-
Weir MR, Ferdinand KC, Flack JM, Jamerson KA, Daley W, Zelenkofske S. A noninferiority comparison of valsartan/hydrochlorothiazide combination versus amlodipine in black hypertensives. Hypertension. Sep 2005;46(3):508-513
-
(2005)
Hypertension
, vol.46
, Issue.3
, pp. 508-513
-
-
Weir, M.R.1
Ferdinand, K.C.2
Flack, J.M.3
Jamerson, K.A.4
Daley, W.5
Zelenkofske, S.6
-
34
-
-
28244432534
-
Trials and tribulations of non-inferiority: The ximelagatran experience
-
Dec 6
-
Kaul S, Diamond GA, Weintraub WS. Trials and tribulations of non-inferiority: The ximelagatran experience. J Am Coll Cardiol. Dec 6 2005;46(11):1986-1995
-
(2005)
J Am Coll Cardiol
, vol.46
, Issue.11
, pp. 1986-1995
-
-
Kaul, S.1
Diamond, G.A.2
Weintraub, W.S.3
-
35
-
-
33644789375
-
Quality of reporting of noninferiority and equivalence randomized trials
-
Mar 8
-
Le Henanff A, Giraudeau B, Baron G, Ravaud P. Quality of reporting of noninferiority and equivalence randomized trials. Jama. Mar 8 2006;295(10):1147-1151
-
(2006)
JAMA
, vol.295
, Issue.10
, pp. 1147-1151
-
-
Le Henanff, A.1
Giraudeau, B.2
Baron, G.3
Ravaud, P.4
-
36
-
-
0030268577
-
Surrogate end points in clinical trials: Are we being misled
-
Oct 1
-
Fleming TR, DeMets DL. Surrogate end points in clinical trials: Are we being misled? Ann Intern Med. Oct 1 1996;125(7):605-613
-
(1996)
Ann Intern Med
, vol.125
, Issue.7
, pp. 605-613
-
-
Fleming, T.R.1
DeMets, D.L.2
-
37
-
-
0024520844
-
Surrogate endpoints in clinical trials: Definition and operational criteria
-
Apr
-
Prentice RL. Surrogate endpoints in clinical trials: Definition and operational criteria. Stat Med. Apr 1989;8(4):431-440
-
(1989)
Stat Med
, vol.8
, Issue.4
, pp. 431-440
-
-
Prentice, R.L.1
-
38
-
-
0036569112
-
Surrogate end points in heart failure
-
May 1
-
Anand IS, Florea VG, Fisher L. Surrogate end points in heart failure. J Am Coll Cardiol. May 1 2002;39(9):1414-1421
-
(2002)
J Am Coll Cardiol
, vol.39
, Issue.9
, pp. 1414-1421
-
-
Anand, I.S.1
Florea, V.G.2
Fisher, L.3
-
39
-
-
0034729997
-
Surrogate endpoints in assessment of new drugs in colorectal cancer
-
Jul 29
-
Kelsen DP. Surrogate endpoints in assessment of new drugs in colorectal cancer. Lancet. Jul 29 2000;356(9227):353-354
-
(2000)
Lancet
, vol.356
, Issue.9227
, pp. 353-354
-
-
Kelsen, D.P.1
-
40
-
-
0034729931
-
Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: A metaanalysis
-
Meta-Analysis Group in Cancer Jul 29
-
Buyse M, Thirion P, Carlson RW, Burzykowski T, Molenberghs G, Piedbois P. Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: A metaanalysis. Meta-Analysis Group in Cancer. Lancet. Jul 29 2000;356(9227):373-378
-
(2000)
Lancet
, vol.356
, Issue.9227
, pp. 373-378
-
-
Buyse, M.1
Thirion, P.2
Carlson, R.W.3
Burzykowski, T.4
Molenberghs, G.5
Piedbois, P.6
-
41
-
-
0026507736
-
The cardiac arrhythmia suppression trial: First cast then cast-ii
-
Apr
-
Greene HL, Roden DM, Katz RJ, Woosley RL, Salerno DM, Henthorn RW. The Cardiac Arrhythmia Suppression Trial: First CAST . then CAST-II. J Am Coll Cardiol. Apr 1992;19(5):894-898
-
(1992)
J Am Coll Cardiol
, vol.19
, Issue.5
, pp. 894-898
-
-
Greene, H.L.1
Roden, D.M.2
Katz, R.J.3
Woosley, R.L.4
Salerno, D.M.5
Henthorn, R.W.6
-
42
-
-
84875386757
-
-
FDA Adviser Questions Surrogate Endpoints For Diabetes Drug Approvals
-
FDA Adviser Questions Surrogate Endpoints for Diabetes Drug Approvals. Medpage Today; 2007
-
(2007)
Medpage Today
-
-
-
43
-
-
0026739680
-
Surrogate endpoints: A basis for a rational approach
-
Boissel JP, Collet JP, Moleur P, Haugh M. Surrogate endpoints: A basis for a rational approach. Eur J Clin Pharmacol. 1992;43(3):235-244
-
(1992)
Eur J Clin Pharmacol
, vol.43
, Issue.3
, pp. 235-244
-
-
Boissel, J.P.1
Collet, J.P.2
Moleur, P.3
Haugh, M.4
-
44
-
-
32944459943
-
How should clinicians interpret results reflecting the effect of an intervention on composite endpoints: Should I dump this lump?
-
Nov-Dec
-
Montori VM, Busse JW, Permanyer-Miralda G, Ferreira I, Guyatt GH. How should clinicians interpret results reflecting the effect of an intervention on composite endpoints: Should I dump this lump? ACP J Club. Nov-Dec 2005;143(3): A8
-
(2005)
ACP J Club
, vol.143
, Issue.3
-
-
Montori, V.M.1
Busse, J.W.2
Permanyer-Miralda, G.3
Ferreira, I.4
Guyatt, G.H.5
-
45
-
-
0037872688
-
Composite outcomes in randomized trials: Greater precision but with greater uncertainty
-
May 21
-
Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials: Greater precision but with greater uncertainty? Jama. May 21 2003;289(19):2554-2559
-
(2003)
Jama
, vol.289
, Issue.19
, pp. 2554-2559
-
-
Freemantle, N.1
Calvert, M.2
Wood, J.3
Eastaugh, J.4
Griffin, C.5
-
46
-
-
0037636758
-
Clinical trials-multiple treatments, multiple end points, and multiple lessons
-
May 21
-
Lauer MS, Topol EJ. Clinical trials-multiple treatments, multiple end points, and multiple lessons. Jama. May 21 2003;289(19):2575-2577
-
(2003)
JAMA
, vol.289
, Issue.19
, pp. 2575-2577
-
-
Lauer, M.S.1
Topol, E.J.2
-
48
-
-
0034696531
-
Canadian implantable defibrillator study (CIDS) : A randomized trial of the implantable cardioverter defibrillator against amiodarone
-
Mar 21
-
Connolly SJ, Gent M, Roberts RS, et al. Canadian implantable defibrillator study (CIDS) : A randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation. Mar 21 2000;101(11):1297-1302
-
(2000)
Circulation
, vol.101
, Issue.11
, pp. 1297-1302
-
-
Connolly, S.J.1
Gent, M.2
Roberts, R.S.3
-
49
-
-
3142667620
-
Long-Term comparison of the implantable cardioverter defibrillator versus amiodarone: Eleven-year follow-up of a subset of patients in the canadian implantable defibrillator study (cids
-
Jul 13
-
Bokhari F, Newman D, Greene M, Korley V, Mangat I, Dorian P. Long-Term comparison of the implantable cardioverter defibrillator versus amiodarone: Eleven-year follow-up of a subset of patients in the Canadian Implantable Defibrillator Study (CIDS). Circulation. Jul 13 2004;110(2):112-116
-
(2004)
Circulation
, vol.110
, Issue.2
, pp. 112-116
-
-
Bokhari, F.1
Newman, D.2
Greene, M.3
Korley, V.4
Mangat, I.5
Dorian, P.6
-
50
-
-
0035804846
-
Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The miracl study: A randomized controlled trial
-
Apr 4
-
Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial. Jama. Apr 4 2001;285(13):1711-1718
-
(2001)
JAMA
, vol.285
, Issue.13
, pp. 1711-1718
-
-
Schwartz, G.G.1
Olsson, A.G.2
Ezekowitz, M.D.3
-
51
-
-
0344373794
-
-
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT Dec 18
-
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Jama. Dec 18 2002;288(23):2981-2997
-
(2002)
JAMA
, vol.288
, Issue.23
, pp. 2981-2997
-
-
-
52
-
-
0028810729
-
Randomised trialomania? The multicentre liver transplant trials of tacrolimus
-
Nov 18
-
Starzl TE, Donner A, Eliasziw M, et al. Randomised trialomania? The multicentre liver transplant trials of tacrolimus. Lancet. Nov 18 1995;346(8986):1346-1350
-
(1995)
Lancet
, vol.346
, Issue.8986
, pp. 1346-1350
-
-
Starzl, T.E.1
Donner, A.2
Eliasziw, M.3
-
53
-
-
33846563409
-
Why most published research findings are false
-
Ioannidis JPA. Why most published research findings are false. PLoS. 2005;2:0696-0701
-
(2005)
PLoS
, vol.2
, pp. 0696-0701
-
-
Ioannidis, J.P.A.1
-
54
-
-
33644978229
-
Transition from meeting abstract to full-length journal article for randomized controlled trials
-
Mar 15
-
Toma M, McAlister FA, Bialy L, Adams D, Vandermeer B, Armstrong PW. Transition from meeting abstract to full-length journal article for randomized controlled trials. Jama. Mar 15 2006;295(11):1281-1287
-
(2006)
Jama
, vol.295
, Issue.11
, pp. 1281-1287
-
-
Toma, M.1
McAlister, F.A.2
Bialy, L.3
Adams, D.4
Vandermeer, B.5
Armstrong, P.W.6
|