Cytomorphologic and molecular features of hobnail variant of papillary thyroid carcinoma: Case series and literature review

Diagnostic Cytopathology

Volumn 42, Issue 1, 2014, Pages 78-84

  Asioli, Sofia ^a   Maletta, Francesca ^a   Pagni, Fabio ^b   Pacchioni, Donatella ^a   Vanzati, Alice ^b   Mariani, Sara ^a   Palestini, Nicola ^c   Lloyd, Ricardo V ^d   Sapino, Anna ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

BRAF mutation; fine needle aspiration; hobnail papillary thyroid carcinoma; thyroid

Indexed keywords

B RAF KINASE; PROTEIN P53; THYROGLOBULIN; UVOMORULIN;

ARTICLE; CANCER CELL; CELL NUCLEUS; CELL POPULATION; CELL STRUCTURE; CYTOPLASM; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROSEQUENCING; STAINING; THYROID CARCINOMA; THYROID SURGERY; TISSUE SECTION; TUMOR VOLUME;

BRAF MUTATION; FINE-NEEDLE ASPIRATION; HOBNAIL PAPILLARY THYROID CARCINOMA; THYROID;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY, FINE-NEEDLE; CARCINOMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; THYROID NEOPLASMS;

EID: 84891435311     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.23028     Document Type: Article

References (32)

1. Asioli S, Erickson LA, Sebo TJ, et al. Papillary thyroid carcinoma with prominent hobnail features: A new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases. Am J Surg Pathol 2010; 34: 44-52.
2. Lloyd RV, Erickson LA, Asioli S,. Papillary Thyroid carcinoma with prominent hobnail features: A new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of 8 cases. Am J Surg Pathol 2010; 34: 914.
3. Asioli S, Erickson LA, Righi A, Lloyd RV,. Papillary thyroid carcinoma with hobnail features: Histopathologic criteria to predict aggressive behavior. Hum Pathol, 2013; 44: 320-328.
4. Bellevicine C, Cozzolino I, Malapelle U, Zeppa P, Troncone G,. Cytological and molecular features of papillary thyroid carcinoma with prominent hobnail features: A case report. Acta Cytol 2012; 56: 560-564.
5. Yang GC, Fried K, Scognamiglio T,. Cytological features of clear cell thyroid tumors, including a papillary thyroid carcinoma with prominent hobnail features. Diagn Cytopathol, 2012 Nov 16. doi: 10.1002/dc.22935. [Epub ahead of print].
6. British Thyroid Association, Royal College of Physicians. Fine needle aspiration cytology. In:, Perros P, editor. Guidelines for the management of thyroid cancer. Report of the Thyroid Cancer Guidelines Update Group. 2nd ed. London: Royal College of Physicians; 2007. p 9-10.
7. Cibas ES, Ali SZ,. NCI Thyroid FNA State of the Science Conference. The Bethesda System for reporting thyroid cytopathology. Am J Clin Pathol 2009; 132: 658-665.
8. Asioli S, Bussolati G,. Emerin immunohistochemistry reveals diagnostic features of nuclear membrane arrangement in thyroid lesions. Histopathology 2009; 54: 571-579.
9. Asioli S, Maletta F, Pacchioni D, Lupo R, Bussolati G,. Cytological detection of papillary thyroid carcinomas by nuclear membrane decoration with emerin staining. Virchows Arch 2010; 457: 43-51.
10. Peterse JL,. Breast carcinoma with an unexpected inside out pattern. Rotation of polarization associated with angioinvasion. Pathol Res Pract 1993; 189: 780.
11. Lee AH, Paish EC, Marchio C, et al. The expression of Wilms' tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology 2007; 51: 824-828.
12. Jin L, Sebo TJ, Nakamura N, et al. BRAF mutation analysis in fine needle aspiration (FNA) cytology of the thyroid. Diagn Mol Pathol 2006; 15: 136-143.
13. American Joint Committee on Cancer. AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
14. Asioli S, Erickson LA, Righi A, et al. Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression. Mod Pathol 2010; 23: 1269-1278.
15. Volante M, Rapa I, Gandhi M, et al. RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact. J Clin Endocrinol Metab 2009; 94: 4735-4741.
16. Nikiforov Nikiforova MN, Nikiforov YE,. Molecular genetics of thyroid cancer: Implications for diagnosis, treatment and prognosis. Expert Rev Mol Diagn 2008; 8: 83-95.
17. Rosai J, Carcangiu ML, DeLellis RA,. Tumors of the thyroid gland. Atlas of tumor pathology. Third Series. Fascicle 5. Washington, DC: Armed Forces Institute of Pathology; 1992.
18. Kini SR,. Guides to clinical aspiration biopsy thyroid. 2nd ed. New York: Igaku-Shoin; 1996.
19. Solomon A, Gupta PK, LiVolsi VA, Baloch ZW,. Distinguishing tall cell variant of papillary thyroid carcinoma from usual variant of papillary thyroid carcinoma in cytologic specimens. Diagn Cytopathol 2002; 27: 143-148.
20. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M,. Metastases to the thyroid: Review of the literature from the last decade. Thyroid 2012; 22: 258-268.
21. Lee KR, Tavassoli FA, Prat J, et al. Surface epithelial-stromal tumours. In:, Tavassoli FA, Devillee P, editors. World Health Organization classification of tumours. Pathology and genetics. Tumours of the breast and female genital organs. Lyon, France: IARC Press; 2003.p 117-145.
22. Foyle A, Al-Jabi M, McCaughey WT,. Papillary peritoneal tumors in women. Am J Surg Pathol 1981; 5: 241-249.
23. Ninomiya H, Hiramatsu M, Inamura K, et al. Correlation between morphology and EGFR mutations in lung adenocarcinomas: Significance of the micropapillary pattern and the hobnail cell type. Lung Cancer 2009; 63: 235-240.
24. Nassar H,. Carcinomas with micropapillary morphology: Clinical significance and current concepts. Adv Anat Pathol 2004; 11: 297-303.
25. Lennard TW, Wadehra V, Farndon JR,. Fine needle aspiration biopsy in diagnosis of metastases to thyroid gland. J R Soc Med 1984; 77: 196-197.
26. Gorla S, Di Bella C, Leone B, Pagni F,. Cytological and histological findings of thyroid florid papillary hyperplasia. Cytopathology 2012; 23: 417-419.
27. Ueng SH, Mezzetti T, Tavassoli FA,. Papillary neoplasms of the breast: A review. Arch Pathol Lab Med 2009; 133: 893-907.
28. Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6: 244-285.
29. Ushiku T, Matsusaka K, Iwasaki Y, et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology 2011; 59: 1081-1089.
30. Verdú M, Román R, Calvo M, et al. Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol 2011; 24: 729-738.
31. Nikiforova MN, Nikiforov YE,. Molecular diagnostics and predictors in thyroid cancer. Thyroid 2009; 19: 1351-1361.
32. Moses W, Weng J, Sansano I, Peng M, Khanafshar E, Ljung BM, et al. Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy. World J Surg 2010; 34: 2589-2594.