Reduced neointima formation after arterial injury in CD4-/-mice is mediated by cd8+cd28hi T cells

Journal of the American Heart Association

Volumn 2, Issue 3, 2013, Pages

  Dimayuga, Paul C ^a   Chyu, Kuang Yuh ^a   Lio, Wai Man ^a   Zhao, Xiaoning ^a   Yano, Juliana ^a   Zhou, Jianchang ^a   Honjo, Tomoyuki ^a   Shah, Prediman K ^a   Cercek, Bojan ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

CD8+ T cells; Cytolytic activity; Neointima; Vascular smooth muscle cells

Indexed keywords

CD28 ANTIGEN; INTERLEUKIN 2; RAG1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; BLOOD VESSEL WALL; CD28+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL TRANSFER; CONTROLLED STUDY; CYTOLYSIS; IMMUNOREGULATION; MALE; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; SPLEEN CELL; T CELL DEPLETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; ARTERY; BLOOD VESSEL INJURY; COMPLICATION; IMMUNOLOGY; PHYSIOLOGY; CYTOLYTIC ACTIVITY; INJURY; VASCULAR SMOOTH MUSCLE CELLS;

ANIMALS; ARTERIES; CD8-POSITIVE T-LYMPHOCYTES; MALE; MICE; NEOINTIMA; VASCULAR SYSTEM INJURIES;

CD8+ T CELLS; CYTOLYTIC ACTIVITY; NEOINTIMA; VASCULAR SMOOTH MUSCLE CELLS;

EID: 84891415213     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000155     Document Type: Article

References (28)

1. Dimayuga PC, Chyu KY, Cercek B. Immune responses regulating the response to vascular injury. Curr Opin Lipidol. 2010;21:416-421.
2. Zernecke A, Liehn EA, Gao JL, Kuziel WA, Murphy PM, Weber C. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosisprone mice: involvement of IL-10. Blood. 2006;107:4240-4243.
3. Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St HC, Boehm M. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest. 2010;120:303-314.
4. Kurobe H, Urata M, Ueno M, Ueki M, Ono S, Izawa-Ishizawa Y, Fukuhara Y, Lei Y, Ripen AM, Kanbara T, Aihara K, Ishizawa K, Akaike M, Gonzalez FJ, Tamaki T, Takahama Y, Yoshizumi M, Kitagawa T, Tomita S. Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling. Arterioscler Thromb Vasc Biol. 2010;30:210-217.
5. Hansson GK, Holm J, Holm S, Fotev Z, Hedrich HJ, Fingerle J. T lymphocytes inhibit the vascular response to injury. Proc Natl Acad Sci USA. 1991;88: 10530-10534.
6. Zhu B, Reardon CA, Getz GS, Hui DY. Both apolipoprotein E and immune deficiency exacerbate neointimal hyperplasia after vascular injury in mice. Arterioscler Thromb Vasc Biol. 2002;22:450-455.
7. Dimayuga PC, Li H, Chyu KY, Fredrikson GN, Nilsson J, Fishbein MC, Shah PK, Cercek B. T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency. Arterioscler Thromb Vasc Biol. 2005;25:2528-2534.
8. Dimayuga PC, Chyu KY, Kirzner J, Yano J, Zhao X, Zhou J, Shah PK, Cercek B. Enhanced neointima formation following arterial injury in immune Deficient rag-1-/-mice is attenuated by adoptive transfer of CD8 T cells. PLoS ONE. 2011;6:e20214.
9. Turka LA, Ledbetter JA, Lee K, June CH, Thompson CB. CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol. 1990;144:1646-1653.
10. Makrigiannis AP, Musgrave BL, Hoskin DW. Differential effects of B7-1 and B7-2 on the costimulation of mouse nonspecific cytotoxic T lymphocyte development in response to anti-CD3 antibody. J Leukoc Biol. 1999;66:792-802.
11. Butler JJ, Mader JS, Watson CL, Zhang H, Blay J, Hoskin DW. Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem. 2003;89:975-991.
12. Ortiz-Suarez A, Miller RA. A subset of CD8 memory T cells from old mice have high levels of CD28 and produce IFN-gamma. Clin Immunol. 2002;104:282-292.
13. Chyu KY, Dimayuga P, Zhu J, Nilsson J, Kaul S, Shah PK, Cercek B. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res. 1999;85:1192-1198.
14. Dimayuga P, Zhu J, Oguchi S, Chyu KY, Xu XO, Yano J, Shah PK, Nilsson J, Cercek B. Reconstituted HDL containing human apolipoprotein A-1 reduces VCAM-1 expression and neointima formation following periadventitial cuffinduced carotid injury in apoE null mice. Biochem Biophys Res Commun. 1999;264:465-468.
15. Dimayuga PC, Cesena FH, Chyu KY, Yano J, Amorn A, Fishbein MC, Shah PK, Cercek B. Natural antibodies and complement modulate intimal thickening after arterial injury. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1593-R1600.
16. Dimayuga P, Cercek B, Oguchi S, Fredrikson GN, Yano J, Shah PK, Jovinge S, Nilsson J. Inhibitory effect on arterial injury-induced neointimal formation by adoptive B-cell transfer in Rag-1 knockout mice. Arterioscler Thromb Vasc Biol. 2002;22:644-649.
17. Lecoeur H, Fevrier M, Garcia S, Riviere Y, Gougeon ML. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J Immunol Methods. 2001;253:177-187.
18. Peterson KE, Sharp GC, Tang H, Braley-Mullen H. B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis. J Immunol. 1999;162:1859-1867.
19. Lee TS, Yen HC, Pan CC, Chau LY. The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 1999;19:734-742.
20. Hidalgo LG, Urmson J, Halloran PF. IFN-gamma decreases CTL generation by limiting IL-2 production: a feedback loop controlling effector cell production. Am J Transplant. 2005;5:651-661.
21. Janas ML, Groves P, Kienzle N, Kelso A. IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation. J Immunol. 2005;175:8003-8010.
22. Nishio M, Spielman J, Lee RK, Nelson DL, Podack ER. CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. J Immunol. 1996;157:4347-4353.
23. Menager-Marcq I, Pomie C, Romagnoli P, van Meerwijk JP. CD8+CD28-regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology. 2006;131:1775-1785.
24. Kocher O, Gabbiani F, Gabbiani G, Reidy MA, Cokay MS, Peters H, Huttner I. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab Invest. 1991;65:459-470.
25. Oguchi S, Dimayuga P, Zhu J, Chyu KY, Yano J, Shah PK, Nilsson J, Cercek B. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler Thromb Vasc Biol. 2000;20:1729-1736.
26. Kolbus D, Ramos OH, Berg KE, Persson J, Wigren M, Bjorkbacka H, Fredrikson GN, Nilsson J. CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe(-/-) mice. BMC Immunol. 2010;11:58.
27. Chyu KY, Zhao X, Dimayuga PC, Zhou J, Li X, Yano J, Lio WM, Chan LF, Kirzner J, Trinidad P, Cercek B, Shah PK. CD8 T cells mediate the athero-protective effect of immunization with an ApoB-100 peptide. PLoS ONE. 2012;7:e30780.
28. Tyznik AJ, Sun JC, Bevan MJ. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med. 2004; 199:559-565.