Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability

Journal of Applied Physiology

Volumn 115, Issue 12, 2013, Pages 1767-1776

  De Beer, Vincent J ^a   Merkus, Daphne ^a   Bender, Shawn B ^b,c   Tharp, Darla L ^b   Bowles, Douglas K ^b   Duncker, Dirk J ^a   Laughlin, M Harold ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MISSOURI   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Arginine; Endothelium; Exercise; PDE inhibitors

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; DRUG EFFECT; ENDOTHELIUM; EXERCISE; FAMILIAL HYPERCHOLESTEROLEMIA; HYPEREMIA; LUNG CIRCULATION; METABOLISM; PATHOPHYSIOLOGY; PDE INHIBITORS; PHYSIOLOGY; SWINE; VASODILATATION;

ARGININE; ENDOTHELIUM; EXERCISE; PDE INHIBITORS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL AVAILABILITY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENDOTHELIUM; HYPEREMIA; HYPERLIPOPROTEINEMIA TYPE II; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; PHOSPHODIESTERASE 5 INHIBITORS; PHYSICAL CONDITIONING, ANIMAL; PULMONARY CIRCULATION; SWINE; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 84891277715     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00619.2013     Document Type: Article

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