The missing 'P' in pain management: How the current opioid epidemic highlights the need for psychiatric services in chronic pain care

General Hospital Psychiatry

Volumn 36, Issue 1, 2014, Pages 99-104

  Howe, Catherine Q ^a   Sullivan, Mark D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic pain; Opioid therapy

Indexed keywords

BUPRENORPHINE; CODEINE; LORAZEPAM; METHADONE; MORPHINE; OPIATE; PLACEBO; TRICYCLIC ANTIDEPRESSANT AGENT;

ANALGESIA; ANXIETY DISORDER; ARTICLE; CHRONIC PAIN; COMORBIDITY; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; DRUG MISUSE; DYSPHORIA; HEROIN DEPENDENCE; HUMAN; LONG TERM CARE; MALAISE; MANIA; MENTAL HEALTH; NAUSEA; OBSESSIVE COMPULSIVE DISORDER; OPIATE ADDICTION; POSTTRAUMATIC STRESS DISORDER; PSYCHOPHARMACOTHERAPY; SUBSTANCE ABUSE; TREATMENT OUTCOME;

CHRONIC PAIN; OPIOID THERAPY;

ANALGESICS, OPIOID; CHRONIC PAIN; COMORBIDITY; HUMANS; MENTAL DISORDERS; MENTAL HEALTH SERVICES; OPIOID-RELATED DISORDERS; PAIN MANAGEMENT;

EID: 84891276884     PISSN: 01638343     EISSN: 18737714     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2013.10.003     Document Type: Article

References (108)

1. National Center for Health Statistics: Health, United States, 2006 With Chartbook on Trends in the Health of Americans 2006, Hyattsville, MD.
2. Caudill-Slosberg M.A., Schwartz L.M., Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain 2004, 109(3):514-519.
3. Edlund M.J., Martin B.C., Devries A., Fan M.Y., Braden J.B., Sullivan M.D. Trends in use of opioids for chronic noncancer pain among individuals with mental health and substance use disorders: the TROUP study. Clin J Pain 2009, 26(1):1-8.
4. Gilson A.M., Ryan K.M., Joranson D.E., Dahl J.L. A reassessment of trends in the medical use and abuse of opioid analgesics and implications for diversion control: 1997-2002. J Pain Symptom Manage 2004, 28(2):176-188.
5. Centers for Disease Control and Prevention: Prescription painkiller overdoses in the US. CDC Vital Signs 2011.
6. Jones C.M., Mack K.A., Paulozzi L.J. Pharmaceutical overdose deaths, United States, 2010. JAMA 2013, 309(7):657-659.
7. Ballantyne J.C., Shin N.S. Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain 2008, 24(6):469-478.
8. Kalso E., Allan L., Dellemijn P.L., Faura C.C., Ilias W.K., Jensen T.S., et al. Recommendations for using opioids in chronic non-cancer pain. Eur J Pain 2003, 7(5):381-386.
9. Carroll L.J., Cassidy J.D., Cote P. The Saskatchewan Health and Back Pain Survey: the prevalence and factors associated with depressive symptomatology in Saskatchewan adults. Can J Public Health 2000, 91(6):459-464.
10. Dworkin R.H., Gitlin M.J. Clinical aspects of depression in chronic pain patients. Clin J Pain 1991, 7(2):79-94.
11. Lepine J.P., Briley M. The epidemiology of pain in depression. Hum Psychopharmacol 2004, 19(Suppl 1):S3-S7.
12. Sullivan M.D., Braden J.B. Assessment of psychiatric disorders. Handbook of Pain Assessment 2010, The Guilford Press, New York, NY. D.C. Turk, R. Melzack (Eds.).
13. Currie S.R., Wang J. Chronic back pain and major depression in the general Canadian population. Pain 2004, 107(1-2):54-60.
14. Gerber P.D., Barrett J.E., Barrett J.A., Oxman T.E., Manheimer E., Smith R., et al. The relationship of presenting physical complaints to depressive symptoms in primary care patients. J Gen Intern Med 1992, 7(2):170-173.
15. Kirmayer L.J., Robbins J.M., Dworkind M., Yaffe M.J. Somatization and the recognition of depression and anxiety in primary care. Am J Psychiatry 1993, 150(5):734-741.
16. Lepine J.P., Gastpar M., Mendlewicz J., Tylee A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol 1997, 12(1):19-29.
17. Moldin S.O., Scheftner W.A., Rice J.P., Nelson E., Knesevich M.A., Akiskal H. Association between major depressive disorder and physical illness. Psychol Med 1993, 23(3):755-761.
18. Ohayon M.M., Schatzberg A.F. Using chronic pain to predict depressive morbidity in the general population. Arch Gen Psychiatry 2003, 60(1):39-47.
19. Rethelyi J.M., Berghammer R., Ittzes A., Szumska I., Purebl G., Csoboth C. Comorbidity of pain problems and depressive symptoms in young women: results from a cross-sectional survey among women aged 15-24 in Hungary. Eur J Pain 2004, 8(1):63-69.
20. Tylee A., Gastpar M., Lepine J.P., Mendlewicz J. DEPRES II (Depression Research in European Society II): a patient survey of the symptoms, disability and current management of depression in the community. DEPRES Steering Committee. Int Clin Psychopharmacol 1999, 14(3):139-151.
21. Betrus P.A., Elmore S.K., Hamilton P.A. Women and somatization: unrecognized depression. Health Care Women Int 1995, 16(4):287-297.
22. Lamb S.E., Guralnik J.M., Buchner D.M., Ferrucci L.M., Hochberg M.C., Simonsick E.M., et al. Factors that modify the association between knee pain and mobility limitation in older women: the Women's Health and Aging Study. Ann Rheum Dis 2000, 59(5):331-337.
23. Gureje O., Simon G.E., Von Korff M. A cross-national study of the course of persistent pain in primary care. Pain 2001, 92(1-2):195-200.
24. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62(6):617-627.
25. Braden J.B., Zhang L., Fan M.Y., Unutzer J., Edlund M.J., Sullivan M.D. Mental health service use by older adults: the role of chronic pain. Am J Geriatr Psychiatry 2008, 16(2):156-167.
26. McWilliams L.A., Cox B.J., Enns M.W. Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample. Pain 2003, 106(1-2):127-133.
27. Stang P.E., Brandenburg N.A., Lane M.C., Merikangas K.R., Von Korff M.R., Kessler R.C. Mental and physical comorbid conditions and days in role among persons with arthritis. Psychosom Med 2006, 68(1):152-158.
28. Von Korff M., Crane P., Lane M., Miglioretti D.L., Simon G., Saunders K., et al. Chronic spinal pain and physical-mental comorbidity in the United States: results from the national comorbidity survey replication. Pain 2005, 113(3):331-339.
29. Gureje O., Simon G.E. The natural history of somatization in primary care. Psychol Med 1999, 29(3):669-676.
30. Kroenke K., Price R.K. Symptoms in the community. Prevalence, classification, and psychiatric comorbidity. Arch Intern Med 1993, 153(21):2474-2480.
31. Patten S.B. Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2. J Affect Disord 2001, 63(1-3):35-41.
32. Von Korff M., Dworkin S.F., Le Resche L., Kruger A. An epidemiologic comparison of pain complaints. Pain 1988, 32(2):173-183.
33. Kroenke K., Wu J., Bair M.J., Krebs E.E., Damush T.M., Tu W. Reciprocal relationship between pain and depression: a 12-month longitudinal analysis in primary care. J Pain 2011, 12(9):964-973.
34. Von Korff M., Simon G. The relationship between pain and depression. Br J Psychiatry Suppl 1996, 30:101-108.
35. Walker E.A., Gelfand A.N., Gelfand M.D., Katon W.J. Psychiatric diagnoses, sexual and physical victimization, and disability in patients with irritable bowel syndrome or inflammatory bowel disease. Psychol Med 1995, 25(6):1259-1267.
36. Stewart W., Breslau N., Keck P.E. Comorbidity of migraine and panic disorder. Neurology 1994, 44(10 Suppl 7):S23-S27.
37. Beck J.G., Clapp J.D. A different kind of co-morbidity: understanding posttraumatic stress disorder and chronic pain. Psychol Trauma 2011, 3(2):101-108.
38. Buchwald D., Goldberg J., Noonan C., Beals J., Manson S. Relationship between post-traumatic stress disorder and pain in two American Indian tribes. Pain Med 2005, 6(1):72-79.
39. Sareen J., Cox B.J., Stein M.B., Afifi T.O., Fleet C., Asmundson G.J. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom Med 2007, 69(3):242-248.
40. Blanchard E.B., Hickling E.J. After the crash: psychological assessment and treatment of survivors of motor vehicle accidents 2003, American Psychological Association, Washington, DC.
41. Aghabeigi B., Feinmann C., Harris M. Prevalence of post-traumatic stress disorder in patients with chronic idiopathic facial pain. Br J Oral Maxillofac Surg 1992, 30(6):360-364.
42. Amir M., Kaplan Z., Neumann L., Sharabani R., Shani N., Buskila D. Posttraumatic stress disorder, tenderness and fibromyalgia. J Psychosom Res 1997, 42(6):607-613.
43. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62(6):593-602.
44. Bailey J.A., Hurley R.W., Gold M.S. Crossroads of pain and addiction. Pain Med 2010, 11(12):1803-1818.
45. Larson M.J., Paasche-Orlow M., Cheng D.M., Lloyd-Travaglini C., Saitz R., Samet J.H. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction 2007, 102(5):752-760.
46. Martell B.A., O'Connor P.G., Kerns R.D., Becker W.C., Morales K.H., Kosten T.R., et al. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Ann Intern Med 2007, 146(2):116-127.
47. Atkinson J.H., Slater M.A., Patterson T.L., Grant I., Garfin S.R. Prevalence, onset, and risk of psychiatric disorders in men with chronic low back pain: a controlled study. Pain 1991, 45(2):111-121.
48. Nicassio P.M., Wallston K.A. Longitudinal relationships among pain, sleep problems, and depression in rheumatoid arthritis. J Abnorm Psychol 1992, 101(3):514-520.
49. Magni G., Moreschi C., Rigatti-Luchini S., Merskey H. Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain. Pain 1994, 56(3):289-297.
50. Leserman J., Drossman D.A., Li Z., Toomey T.C., Nachman G., Glogau L. Sexual and physical abuse history in gastroenterology practice: how types of abuse impact health status. Psychosom Med 1996, 58(1):4-15.
51. Nurco D.N., Kinlock T.W., O'Grady K.E., Hanlon T.E. Early family adversity as a precursor to narcotic addiction. Drug Alcohol Depend 1996, 43(1-2):103-113.
52. Spertus I.L., Burns J., Glenn B., Lofland K., McCracken L. Gender differences in associations between trauma history and adjustment among chronic pain patients. Pain 1999, 82(1):97-102.
53. Walker E.A., Keegan D., Gardner G., Sullivan M., Bernstein D., Katon W.J. Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect. Psychosom Med 1997, 59(6):572-577.
54. Breckenridge J., Clark J.D. Patient characteristics associated with opioid versus nonsteroidal anti-inflammatory drug management of chronic low back pain. J Pain 2003, 4(6):344-350.
55. Sullivan M.D., Edlund M.J., Steffick D., Unutzer J. Regular use of prescribed opioids: association with common psychiatric disorders. Pain 2005, 119(1-3):95-103.
56. Sullivan M.D., Edlund M.J., Zhang L., Unutzer J., Wells K.B. Association between mental health disorders, problem drug use, and regular prescription opioid use. Arch Intern Med 2006, 166(19):2087-2093.
57. Richardson L.P., Russo J.E., Katon W., McCarty C.A., DeVries A., Edlund M.J., et al. Mental health disorders and long-term opioid use among adolescents and young adults with chronic pain. J Adolesc Health 2012, 50(6):553-558.
58. Braden J.B., Sullivan M.D., Ray G.T., Saunders K., Merrill J., Silverberg M.J., et al. Trends in long-term opioid therapy for noncancer pain among persons with a history of depression. Gen Hosp Psychiatry 2009, 31(6):564-570.
59. Weisner C.M., Campbell C.I., Ray G.T., Saunders K., Merrill J.O., Banta-Green C., et al. Trends in prescribed opioid therapy for non-cancer pain for individuals with prior substance use disorders. Pain 2009, 145(3):287-293.
60. Seal K.H., Shi Y., Cohen G., Cohen B.E., Maguen S., Krebs E.E., et al. Association of mental health disorders with prescription opioids and high-risk opioid use in US veterans of Iraq and Afghanistan. JAMA 2012, 307(9):940-947.
61. Phifer J., Skelton K., Weiss T., Schwartz A.C., Wingo A., Gillespie C.F., et al. Pain symptomatology and pain medication use in civilian PTSD. Pain 2011, 152(10):2233-2240.
62. Noble M., Treadwell J.R., Tregear S.J., Coates V.H., Wiffen P.J., Akafomo C., et al. Long-term opioid management for chronic noncancer pain. Cochrane Database Syst Rev 2010, 1. CD006605.
63. Banta-Green C.J., Von Korff M., Sullivan M.D., Merrill J.O., Doyle S.R., Saunders K. The prescribed opioids difficulties scale: a patient-centered assessment of problems and concerns. Clin J Pain 2010, 26(6):489-497.
64. Portenoy R.K. Opioid therapy for chronic nonmalignant pain: a review of the critical issues. J Pain Symptom Manage 1996, 11(4):203-217.
65. Schofferman J. Long-term use of opioid analgesics for the treatment of chronic pain of nonmalignant origin. J Pain Symptom Manage 1993, 8(5):279-288.
66. Wasan A.D., Davar G., Jamison R. The association between negative affect and opioid analgesia in patients with discogenic low back pain. Pain 2005, 117(3):450-461.
67. Michna E., Ross E.L., Hynes W.L., Nedeljkovic S.S., Soumekh S., Janfaza D., et al. Predicting aberrant drug behavior in patients treated for chronic pain: importance of abuse history. J Pain Symptom Manage 2004, 28(3):250-258.
68. Reid M.C., Engles-Horton L.L., Weber M.B., Kerns R.D., Rogers E.L., O'Connor P.G. Use of opioid medications for chronic noncancer pain syndromes in primary care. J Gen Intern Med 2002, 17(3):173-179.
69. Ives T.J., Chelminski P.R., Hammett-Stabler C.A., Malone R.M., Perhac J.S., Potisek N.M., et al. Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res 2006, 6:46.
70. Morasco B.J., Dobscha S.K. Prescription medication misuse and substance use disorder in VA primary care patients with chronic pain. Gen Hosp Psychiatry 2008, 30(2):93-99.
71. Turk D.C., Swanson K.S., Gatchel R.J. Predicting opioid misuse by chronic pain patients: a systematic review and literature synthesis. Clin J Pain 2008, 24(6):497-508.
72. Tetrault J.M., Desai R.A., Becker W.C., Fiellin D.A., Concato J., Sullivan L.E. Gender and non-medical use of prescription opioids: results from a national US survey. Addiction 2008, 103(2):258-268.
73. Edlund M.J., Martin B.C., Fan M.Y., Devries A., Braden J.B., Sullivan M.D. Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. Drug Alcohol Depend 2010, 112(1-2):90-98.
74. Grattan A, Sullivan MD, Saunders K, Von Korff M: The association of depression with self-reported prescription opioid misuse among recipients of chronic opioid therapy without a history of substance abuse. Ann Fam Med In press.
75. Park J., Lavin R. Risk factors associated with opioid medication misuse in community-dwelling older adults with chronic pain. Clin J Pain 2010, 26(8):647-655.
76. Schieffer B.M., Pham Q., Labus J., Baria A., Van Vort W., Davis P., et al. Pain medication beliefs and medication misuse in chronic pain. J Pain 2005, 6(9):620-629.
77. Becker W.C., Sullivan L.E., Tetrault J.M., Desai R.A., Fiellin D.A. Non-medical use, abuse and dependence on prescription opioids among U.S. adults: psychiatric, medical and substance use correlates. Drug Alcohol Depend 2008, 94(1-3):38-47.
78. Boscarino J.A., Rukstalis M., Hoffman S.N., Han J.J., Erlich P.M., Gerhard G.S., et al. Risk factors for drug dependence among out-patients on opioid therapy in a large US health-care system. Addiction 2010, 105(10):1776-1782.
79. Wasan A.D., Butler S.F., Budman S.H., Benoit C., Fernandez K., Jamison R.N. Psychiatric history and psychologic adjustment as risk factors for aberrant drug-related behavior among patients with chronic pain. Clin J Pain 2007, 23(4):307-315.
80. Braden J.B., Russo J., Fan M.Y., Edlund M.J., Martin B.C., DeVries A., et al. Emergency department visits among recipients of chronic opioid therapy. Arch Intern Med 2010, 170(16):1425-1432.
81. Boudreau D., Von Korff M., Rutter C.M., Saunders K., Ray G.T., Sullivan M.D., et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf 2009, 18(12):1166-1175.
82. Tenore P.L. Psychotherapeutic benefits of opioid agonist therapy. J Addict Dis 2008, 27(3):49-65.
83. Lieberman J.A.I. History of the use of antidepressants in primary care. J Clin Psychiatry 2003, 5(Suppl 7):6-10.
84. Varga E., Sugerman A.A., Apter J. The effect of codeine on involutional and senile depression. Ann N Y Acad Sci 1982, 398:103-105.
85. Emrich H.M., Vogt P., Herz A., Kissling W. Antidepressant effects of buprenorphine. Lancet 1982, 2(8300):709.
86. Bodkin J.A., Zornberg G.L., Lukas S.E., Cole J.O. Buprenorphine treatment of refractory depression. J Clin Psychopharmacol 1995, 15(1):49-57.
87. Kosten T.R., Morgan C., Kosten T.A. Depressive symptoms during buprenorphine treatment of opioid abusers. J Subst Abuse Treat 1990, 7(1):51-54.
88. Dean A.J., Bell J., Christie M.J., Mattick R.P. Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence. Eur Psychiatry 2004, 19(8):510-513.
89. Judd L.L., Parker D.C., Janowsky D.S., Segal D.S., Risch S.C., Huey L.Y. The effect of methadone on the behavioral and neuroendocrine responses of manic patients. Psychiatry Res 1982, 7(2):163-170.
90. Pacini M., Maremmani I. Methadone reduces the need for antipsychotic and antimanic agents in heroin addicts hospitalized for manic and/or acute psychotic episodes. Heroin Add Rel Clin Probl 2005, 7(4):43-48.
91. Insel T.R., Pickar D. Naloxone administration in obsessive-compulsive disorder: report of two cases. Am J Psychiatry 1983, 140(9):1219-1220.
92. Shapira N.A., Keck P.E., Goldsmith T.D., McConville B.J., Eis M., McElroy S.L. Open-label pilot study of tramadol hydrochloride in treatment-refractory obsessive-compulsive disorder. Depress Anxiety 1997, 6(4):170-173.
93. Koran L.M., Aboujaoude E., Bullock K.D., Franz B., Gamel N., Elliott M. Double-blind treatment with oral morphine in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 2005, 66(3):353-359.
94. Gross-Isseroff R., Dillon K.A., Israeli M., Biegon A. Regionally selective increases in mu opioid receptor density in the brains of suicide victims. Brain Res 1990, 530(2):312-316.
95. Naber D., Pickar D., Post R.M., Van Kammen D.P., Waters R.N., Ballenger J.C., et al. Endogenous opioid activity and beta-endorphin immunoreactivity in CSF of psychiatric patients and normal volunteers. Am J Psychiatry 1981, 138(11):1457-1462.
96. Kennedy S.E., Koeppe R.A., Young E.A., Zubieta J.K. Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women. Arch Gen Psychiatry 2006, 63(11):1199-1208.
97. Elman I., Zubieta J.K., Borsook D. The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry 2011, 68(1):12-20.
98. Eisenberger N.I. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nat Rev Neurosci 2012, 13(6):421-434.
99. Baumgartner U., Buchholz H.G., Bellosevich A., Magerl W., Siessmeier T., Rolke R., et al. High opiate receptor binding potential in the human lateral pain system. Neuroimage 2006, 30(3):692-699.
100. Moles A., Kieffer B.L., D'Amato F.R. Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science 2004, 304(5679):1983-1986.
101. Michaels C.C., Holtzman S.G. Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists. J Pharmacol Exp Ther 2008, 325(1):313-318.
102. Herman B.H., Panksepp J. Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect. Pharmacol Biochem Behav 1978, 9(2):213-220.
103. Panksepp J., Najam N., Soares F. Morphine reduces social cohesion in rats. Pharmacol Biochem Behav 1979, 11(2):131-134.
104. Fabre-Nys C., Meller R.E., Keverne E.B. Opiate antagonists stimulate affiliative behaviour in monkeys. Pharmacol Biochem Behav 1982, 16(4):653-659.
105. Eisenberger N.I., Master S.L., Inagaki T.K., Taylor S.E., Shirinyan D., Lieberman M.D., et al. Attachment figures activate a safety signal-related neural region and reduce pain experience. Proc Natl Acad Sci U S A 2011, 108(28):11721-11726.
106. Dewall C.N., Macdonald G., Webster G.D., Masten C.L., Baumeister R.F., Powell C., et al. Acetaminophen reduces social pain: behavioral and neural evidence. Psychol Sci 2010, 21(7):931-937.
107. Merlo L.J., Gold M.S. Prescription opioid abuse and dependence among physicians: hypotheses and treatment. Harv Rev Psychiatry 2008, 16(3):181-194.
108. Wasan A.D., Ross E.L., Michna E., Chibnik L., Greenfield S.F., Weiss R.D., et al. Craving of prescription opioids in patients with chronic pain: a longitudinal outcomes trial. J Pain 2012, 13(2):146-154.