Attachment figures activate a safety signal-related neural region and reduce pain experience

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 28, 2011, Pages 11721-11726

  Eisenberger, Naomi I ^a   Master, Sarah L ^a   Inagaki, Tristen K ^a   Taylor, Shelley E ^a   Shirinyan, David ^b   Lieberman, Matthew D ^a,b   Naliboff, Bruce D ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Close relationship; Distress; Functional MRI; Neuroimaging

Indexed keywords

ADULT; ANTERIOR CINGULATE; ARTICLE; CONTROLLED STUDY; EMOTIONAL ATTACHMENT; FEMALE; GUSTATORY CORTEX; HUMAN; HUMAN EXPERIMENT; HUMAN RELATION; IMAGE DISPLAY; NERVE CONDUCTION; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; SAFETY; SENSORY STIMULATION; SIGNAL TRANSDUCTION; SOCIAL SUPPORT; VENTROMEDIAL PREFRONTAL CORTEX;

ADULT; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MODELS, NEUROLOGICAL; MODELS, PSYCHOLOGICAL; PAIN; PAIN THRESHOLD; PREFRONTAL CORTEX; SOCIAL BEHAVIOR; SPOUSES; YOUNG ADULT;

ARANEAE; SERPENTES;

EID: 79960976966     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108239108     Document Type: Article

References (51)

1. Bowlby J (1988) A Secure Base: Parent-Child Attachment and Healthy Human Development (Basic Books, USA), p 27.
2. Bowlby J (1969) Attachment (Basic Books, USA).
3. Hazan C, Shaver P (1987) Romantic love conceptualized as an attachment process. J Pers Soc Psychol 52:511-524.
4. Kulik JA, Mahler HIM (1989) Social support and recovery from surgery. Health Psychol 8:221-238.
5. Kennell J, Klaus M, McGrath S, Robertson S, Hinkley C (1991) Continuous emotional support during labor in a US hospital. A randomized controlled trial. JAMA 265:2197-2201.
6. Master SL, et al. (2009) A picture's worth: Partner photographs reduce experimentally induced pain. Psychol Sci 20:1316-1318.
7. Montoya P, Larbig W, Braun C, Preissl H, Birbaumer N (2004) Influence of social support and emotional context on pain processing and magnetic brain responses in fibromyalgia. Arthritis Rheum 50:4035-4044. (Pubitemid 39643953)
8. Younger J, Aron A, Parke S, Chatterjee N, Mackey S (2010) Viewing pictures of a romantic partner reduces experimental pain: Involvement of neural reward systems. PLoS ONE 5:e13309.
9. Coan JA, Schaefer HS, Davidson RJ (2006) Lending a hand: Social regulation of the neural response to threat. Psychol Sci 17:1032-1039. (Pubitemid 44952676)
10. Delgado MR, Olsson A, Phelps EA (2006) Extending animal models of fear conditioning to humans. Biol Psychol 73:39-48.
11. Kalisch R, et al. (2006) Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J Neurosci 26:9503-9511. (Pubitemid 44396863)
12. Milad MR, et al. (2007) Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry 62:446-454. (Pubitemid 47284021)
13. Mobbs D, et al. (2010) Neural activity associated with monitoring the oscillating threat value of a tarantula. Proc Natl Acad Sci USA 107:20582-20586.
14. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: Role of the amygdala and vmPFC. Neuron 43:897-905. (Pubitemid 39215019)
15. Quirk GJ, Garcia R, González-Lima F (2006) Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry 60:337-343. (Pubitemid 44215848)
16. Schiller D, Levy I, Niv Y, LeDoux JE, Phelps EA (2008) From fear to safety and back: Reversal of fear in the human brain. J Neurosci 28:11517-11525.
17. Gottfried JA, Dolan RJ (2004) Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat Neurosci 7:1144-1152. (Pubitemid 41184456)
18. Milad MR, Quirk GJ (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420:70-74. (Pubitemid 35291441)
19. Pruessner JC, et al. (2008) Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance imaging studies. Biol Psychiatry 63:234-240.
20. Wager TD, et al. (2009) Brain mediators of cardiovascular responses to social threat: Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. Neuroimage 47:821-835.
21. Critchley HD, Corfield DR, Chandler MP, Mathias CJ, Dolan RJ (2000) Cerebral correlates of autonomic cardiovascular arousal: A functional neuroimaging investigation in humans. J Physiol 523:259-270. (Pubitemid 30135837)
22. Wager TD, et al. (2009) Brain mediators of cardiovascular responses to social threat, part II: Prefrontal-subcortical pathways and relationship with anxiety. Neuroimage 47:836-851.
23. Critchley HD, et al. (2003) Human cingulate cortex and autonomic control: Converging neuroimaging and clinical evidence. Brain 126:2139-2152. (Pubitemid 37432360)
24. Atlas LY, Bolger N, Lindquist MA, Wager TD (2010) Brain mediators of predictive cue effects on perceived pain. J Neurosci 30:12964-12977.
25. Apkarian AV, Bushnell MC, Treede R-D, Zubieta J-K (2005) Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9:463-484. (Pubitemid 40836040)
26. Price DD (2000) Psychological and neural mechanisms of the affective dimension of pain. Science 288:1769-1772.
27. Rainville P (2002) Brain mechanisms of pain affect and pain modulation. Curr Opin Neurobiol 12:195-204.
28. Berridge KC, Kringelbach ML (2008) Affective neuroscience of pleasure: Reward in humans and animals. Psychopharmacology (Berl) 199:457-480.
29. Haber S, Knutson B (2010) The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacology Reviews 35:4-26.
30. Kringelbach ML (2005) The human orbitofrontal cortex: Linking reward to hedonic experience. Nat Rev Neurosci 6:691-702.
31. O'Doherty JP (2004) Reward representations and reward-related learning in the human brain: Insights from neuroimaging. Curr Opin Neurobiol 14:769-776.
32. Rogan MT, Leon KS, Perez DL, Kandel ER (2005) Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron 46:309-320. (Pubitemid 40545785)
33. Josselyn SA, Falls WA, Gewirtz JC, Pistell P, Davis M (2005) The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior. Neuropsychopharmacology 30:17-26. (Pubitemid 40024395)
34. Acevedo BP, Aron A, Fisher HE, Brown LL (2011) Neural correlates of long-term intense romantic love. Soc Cogn Affect Neurosci, 10.1093/scan/nsq092.
35. Aron A, et al. (2005) Reward, motivation, and emotion systems associated with early-stage intense romantic love. J Neurophysiol 94:327-337. (Pubitemid 40923250)
36. Bartels A, Zeki S (2004) The neural correlates of maternal and romantic love. Neuroimage 21:1155-1166. (Pubitemid 38314977)
37. Ortigue S, Bianchi-Demicheli F, Patel N, Frum C, Lewis JW (2010) Neuroimaging of love: fMRI meta-analysis evidence toward new perspectives in sexual medicine. J Sex Med 7:3541-3552.
38. Xu X, et al. (2011) Reward and motivation systems: A brain mapping study of early-stage intense romantic love in Chinese participants. Hum Brain Mapp 32:249-257.
39. Öhman A, Mineka S (2001) Fears, phobias, and preparedness: Toward an evolved module of fear and fear learning. Psychol Rev 108:483-522. (Pubitemid 33604135)
40. Seligman MEP (1971) Phobias and preparedness. Behav Ther 2:307-320.
41. Beckes L, Simpson JA, Erickson A (2010) Of snakes and succor: Learning secure attachment associations with novel faces via negative stimulus pairings. Psychol Sci 21:721-728.
42. Panksepp J (1998) Affective Neuroscience (Oxford Univ Press, New York).
43. Eippert F, Bingel U, Schoell E, Yacubian J, Büchel C (2008) Blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans. J Neurosci 28:5465-5472.
44. McNally GP, Pigg M, Weidemann G (2004) Opioid receptors in the midbrain periaqueductal gray regulate extinction of Pavlovian fear conditioning. J Neurosci 24:6912-6919. (Pubitemid 39045448)
45. McNally GP, Westbrook RF (2003) Opioid receptors regulate the extinction of Pavlovian fear conditioning. Behav Neurosci 117:1292-1301. (Pubitemid 37549430)
46. Kim JH, Richardson R (2009) The effect of the μ-opioid receptor antagonist naloxone on extinction of conditioned fear in the developing rat. Learn Mem 16:161-166.
47. Price DD, Von der Gruen A, Miller J, Rafii A, Price C (1985) A psychophysical analysis of morphine analgesia. Pain 22:261-269. (Pubitemid 15043125)
48. Gracely RH, Lota L, Walter DJ, Dubner R (1988) A multiple random staircase method of psychophysical pain assessment. Pain 32:55-63.
49. Gracely RH, McGrath F, Dubner R (1978) Ratio scales of sensory and affective verbal pain descriptors. Pain 5:5-18. (Pubitemid 8358130)
50. Lieberman MD, Cunningham WA (2009) Type I and Type II error concerns in fMRI research: Re-balancing the scale. Soc Cogn Affect Neurosci 4:423-428.
51. Friston KJ, et al. (1997) Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6:218-229. (Pubitemid 27488453)