Identification of H ferritin-dependent and independent genes in K562 differentiating cells by targeted gene silencing and expression profiling

Gene

Volumn 535, Issue 2, 2014, Pages 327-335

  Misaggi, Roberta ^a   Di Sanzo, Maddalena ^a   Cosentino, Carlo ^a   Bond, Heather M ^a   Scumaci, Domenica ^a   Romeo, Francesco ^a   Stellato, Claudia ^b   Giurato, Giorgio ^b   Weisz, Alessandro ^b   Quaresima, Barbara ^a   Barni, Tullio ^a   Amato, Francesco ^a   Viglietto, Giuseppe ^a   Morrone, Giovanni ^a   Cuda, Giovanni ^a   Faniello, Maria Concetta ^a   Costanzo, Francesco ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Differentiation; Gene expression; Microarray

Indexed keywords

FERRITIN; H FERRITIN; HEMIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; ERYTHROID CELL; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE SILENCING; HEAVY CHAIN; HUMAN; HUMAN CELL; IRON METABOLISM; PRIORITY JOURNAL; WESTERN BLOTTING;

DIFFERENTIATION; FERRITIN HEAVY CHAIN; FERRITIN LIGHT CHAIN; FHC; FLC; GENE EXPRESSION; MICROARRAY; QPCR; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; SHORT HAIRPIN RNA; SHRNA;

CELL DIFFERENTIATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; FERRITINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; GENE REGULATORY NETWORKS; GENE SILENCING; HEMIN; HUMANS; K562 CELLS; PROTEIN SUBUNITS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84891142930     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.10.067     Document Type: Article

References (45)

1. Addya S., et al. Erythroid-induced commitment of K562 cells results in clusters of differentially expressed genes enriched for specific transcription regulatory elements. Physiol. Genomics 2004, 19:117-130.
2. Alkhateeb A.A., Connor J.R. Nuclear ferritin: a new role for ferritin in cell biology. Biochim. Biophys. Acta 2010, 1800:793-797.
3. Beard J.L., Connor J.R., Jones B.C. Iron in the brain. Nutr. Rev. 1993, 51:157-170.
4. Bevilacqua M.A., Giordano M., D'Agostino P., Santoro C., Cimino F., Costanzo F. Promoter for the human ferritin heavy chain-encoding gene (FERH): structural and functional characterization. Gene 1992, 111:255-260.
5. Bevilacqua M.A., et al. Transcriptional activation of the H-ferritin gene in differentiated Caco-2 cells parallels a change in the activity of the nuclear factor Bbf. Biochem. J. 1995, 311:769-773.
6. Bevilacqua M.A., Faniello M.C., Cimino F., Costanzo F. Okadaic acid stimulates H ferritin transcription in HeLa cells by increasing the interaction between the p300 CO-activator molecule and the transcription factor Bbf. Biochem. Biophys. Res. Commun. 1997, 240:179-182.
7. Bevilacqua M.A., et al. A common mechanism underlying the E1A repression and the cAMP stimulation of the H ferritin transcription. J. Biol. Chem. 1997, 272:20736-20741.
8. Bevilacqua M.A., Faniello M.C., Russo T., Cimino F., Costanzo F. P/CAF/p300 complex binds the promoter for the heavy subunit of ferritin and contributes to its tissue-specific expression. Biochem. J. 1998, 335:521-525.
9. Bevilacqua M.A., Faniello M.C., Iovine B., Russo T., Cimino F., Costanzo F. Transcription factor NF-Y regulates differentiation of CaCo-2 cells. Arch. Biochem. Biophys. 2002, 407:39-44.
10. Bomford A., Conlon-Hollingshead C., Munro H.N. Adaptive responses of rat tissue isoferritins to iron administration. Changes in subunit synthesis, isoferritin abundance, and capacity for iron storage. J. Biol. Chem. 1981, 256:948-955.
11. Brahma P.K., et al. The mRNA-binding protein Zfp36 is upregulated by β-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes. Obesity 2012, 20:40-47.
12. Brazma A., et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 2001, 29:365-371.
13. Bubici C., Papa S., Pham C.G., Zazzeroni F., Franzoso G. NF-kappaB and JNK: an intricate affair. Cell Cycle 2004, 3:1524-1529.
14. Chazenbalk G.D., Wadsworth H.L., Rapoport B. Transcriptional regulation of ferritin H messenger RNA levels in FRTL5 rat thyroid cells by thyrotropin. J. Biol. Chem. 1990, 265:666-670.
15. Chlenski A., Cohn S.L. Modulation of matrix remodeling by SPARC in neoplastic progression. Semin. Cell Dev. Biol. 2010, 21:55-65.
16. Cicatiello L., et al. Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am. J. Pathol. 2010, 176:2113-2130.
17. Coffman L.G., Parsonage D., D'Agostino R., Torti F.M., Torti S.V. Regulatory effects of ferritin on angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:570-575.
18. Costanzo F., et al. Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res. 1986, 14:721-736.
19. D'Agostino P., et al. Negative and positive elements in the promoter region of the human apoferritin L gene. Biochem. Biophys. Res. Commun. 1995, 215:329-337.
20. Di Sanzo M., et al. H ferritin gene silencing in a human metastatic melanoma cell line: a proteomic analysis. J. Proteome Res. 2011, 10:5444-5453.
21. Downes M., Koopman P. SOX18 and the transcriptional regulation of blood vessel development. Trends Cardiovasc Med 2001, 11:318-324.
22. Dubey R., Chhabra R., Saini N. Small interfering RNA against transcription factor STAT6 leads to increased cholesterol synthesis in lung cancer cell lines. PLoS One 2011, 6(12):e28509.
23. Erkmann J.A., Kutay U. Nuclear export of mRNA: from the site of transcription to the cytoplasm. Exp. Cell Res. 2004, 296:12-20.
24. Faniello M.C., et al. The B subunit of the CAAT-binding factor NFY binds the central segment of the co-activator p300. J. Biol. Chem. 1999, 274:7623-7626.
25. Faniello M.C., et al. An alternative model of H ferritin promoter transactivation by c-Jun. Biochem. J. 2002, 363:53-58.
26. Faniello M.C., et al. Detection and functional analysis of an SNP in the promoter of the human ferritin H gene that modulates the gene expression. Gene 2006, 377:1-5.
27. Faniello M.C., et al. p53-Mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y. Int. J. Biochem. Cell Biol. 2008, 10:2110-2119.
28. Goodyear O., et al. Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010, 116:1908-1918.
29. Greene L.A., Lee H.Y., Angelastro J.M. The transcription factor ATF5: role in neurodevelopment and neural tumors. J. Neurochem. 2009, 108:11-22.
30. Iwasaki K., Mackenzie E.L., Hailemariam K., Sakamoto K., Tsuji Y. Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells. Mol. Cell. Biol. 2006, 26:2845-2856.
31. Jacquel A., et al. A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis. Oncogene 2006, 25:781-794.
32. Ji M., Li H., Suh H.C., Klarmann K.D., Yokota Y., Keller J.R. Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins. Blood 2008, 112:1068-1077.
33. Levi S., et al. Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants. J. Biol. Chem. 1988, 263:18086-18092.
34. Li R., Luo C., Mines M., Zhang J., Fan G.H. Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain. J. Biol. Chem. 2006, 281:37616-37627.
35. Liau G., Chan L.M., Feng P. Increased ferritin gene expression is both promoted by cAMP and a marker of growth arrest in rabbit vascular smooth muscle cells. J. Biol. Chem. 1991, 266:18819-18826.
36. Mattia E., den Blaauwen J., Ashwell G., van Renswoude J. Multiple post-transcriptional regulatory mechanisms in ferritin gene expression. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:1801-1805.
37. Mega T., et al. Zinc finger protein 521 antagonizes early B-cell factor 1 and modulates the B-lymphoid differentiation of primary hematopoietic progenitors. Cell Cycle 2011, 10:2129-2139.
38. Mutarelli M., et al. Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells. BMC Bioinforma. 2008, 26(9 Suppl. 2):S12.
39. Pierantoni G.M., et al. High-mobility group A1 proteins are overexpressed in human leukaemias. Biochem. J. 2003, 372:145-150.
40. Pountney D., Trugnan G., Bourgeois M., Beaumont C. The identification of ferritin in the nucleus of K562 cells, and investigation of a possible role in the transcriptional regulation of adult β-globin gene expression. J. Cell Sci. 1999, 112:825-831.
41. Quaresima B., et al. BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo. Clin. Cancer Res. 2008, 14:6797-6803.
42. Ray P.D., Huang B.W., Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell. Signal. 2012, 24:981-990.
43. Tsolmon S., Nakazaki E., Han J., Isoda H. Apigetrin induces erythroid differentiation of human leukemia cells K562: proteomics approach. Mol. Nutr. Food Res. 2011, 55(Suppl. 1):S93-S102.
44. Wandzik K., Zahn C., Dassler K., Fuchs H. Substantial changes of cellular iron homeostasis during megakaryocytic differentiation of K562 cells. Dev Growth Differ 2009, 51:555-565.
45. Yan C., Wang X., Cao J., Wu M., Gao H. CCAAT/enhancer-binding protein γ is a critical regulator of IL-1β-induced IL-6 production in alveolar epithelial cells. PLoS One 2012, 7(4):e35492.