Amelioration of radiation-induced skin injury by HIV-TAT-mediated protein transduction of RP-1 from Rana pleurade

International Journal of Medical Sciences

Volumn 11, Issue 1, 2013, Pages 44-51

  Zhang, Shuyu ^a   Wang, Wenjie ^b   Peng, Ying ^c   Gu, Qing ^a   Luo, Judong ^a   Zhou, Jundong ^d   Wu, Jinchang ^d   Hou, Yinglong ^e   Cao, Jianping ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

^e SHANDONG UNIVERSITY   (China)

Author keywords

HaCat cells; HIV TAT; Protein transduction domain (PTD); Radiation induced skin injury; RP 1

Indexed keywords

CELL MEMBRANE PROTEIN; HYBRID PROTEIN; PROTEIN RP 1; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MEMBRANE TRANSPORT; DERMIS; DRUG CYTOTOXICITY; DRUG PENETRATION; EPIDERMIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; IONIZING RADIATION; KERATINOCYTE; MALE; MEDICINAL PLANT; NONHUMAN; PROTEIN DOMAIN; PROTEIN TRANSPORT; RADIATION INDUCED SKIN INJURY; RADIATION INJURY; RADIOSENSITIVITY; RANA PLEURADE; RAT; SKIN INJURY; SKIN PROTECTION; SUBCUTANEOUS TISSUE; VIRAL GENE DELIVERY SYSTEM;

HACAT CELLS; HIV-TAT; PROTEIN TRANSDUCTION DOMAIN (PTD); RADIATION-INDUCED SKIN INJURY; RP-1;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS REGULATORY PROTEINS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KERATINOCYTES; MALE; RADIATION INJURIES; RANIDAE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; SKIN; SUPEROXIDES; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSDUCTION, GENETIC;

EID: 84891126409     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.7463     Document Type: Article

References (35)

1. Thompson IM, Jr., Tangen CM, Paradelo J et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. Jama 2006;296:2329-2335.
2. Sprung CN, Chao M, Leong T et al. Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res 2005;11:6352-6358.
3. Miller DL, Balter S, Noonan PT et al. Minimizing radiation-induced skin injury in interventional radiology procedures. Radiology 2002;225:329-336.
4. Simonen P, Hamilton C, Ferguson S et al. Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans? Radiother Oncol 1998, 46:73-82.
5. Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol 2006, 54:28-46.
6. Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol 2012;132:985-993.
7. Palmer DM, Kitchin JS. Oxidative damage, skin aging, antioxidants and a novel antioxidant rating system. J Drugs Dermatol 2010;9:11-15.
8. Shindo Y, Witt E, Packer L. Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 1993;100:260-265.
9. Chevion S, Berry EM, Kitrossky N et al. Evaluation of plasma low molecular weight antioxidant capacity by cyclic voltammetry. Free Radic Biol Med 1997;22:411-421.
10. Schallreuter KU, Wood JM: Free radical reduction in the human epidermis. Free Radic Biol Med 1989, 6(5):519-532.
11. Duda TF, Jr., Vanhoye D, Nicolas P. Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides. Mol Biol Evol 2002;19:858-864.
12. Clarke BT. The natural history of amphibian skin secretions, their normal functioning and potential medical applications. Biol Rev Camb Philos Soc 1997;72:365-379.
13. Liu C, Hong J, Yang H et al. Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability. Free Radic Biol Med 2010;48:1173-1181.
14. Yang H, Wang X, Liu X et al. Antioxidant peptidomics reveals novel skin antioxidant system. Mol Cell Proteomics 2009;8:571-583.
15. Schwarze SR, Dowdy SF. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci 2000;21:45-48.
16. Embury J, Klein D, Pileggi A et al. Proteins linked to a protein transduction domain efficiently transduce pancreatic islets. Diabetes 2001;50:1706-1713.
17. Schwarze SR, Ho A, Vocero-Akbani A et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999;285:1569-1572.
18. Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 1988;55:1179-1188.
19. Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988;55:1189-1193.
20. Joliot A, Prochiantz A. Transduction peptides: from technology to physiology. Nat Cell Biol 2004;6:189-196.
21. Zhang S, Song C, Zhou J et al. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats. Radiat Oncol 2012;7:4.
22. Kohl RR, Kolozsvary A, Brown SL et al. Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor. Radiat Res 2007, 168:440-445.
23. Anand AJ, Dzik WH, Imam A et al. Radiation-induced red cell damage: role of reactive oxygen species. Transfusion 1997;37:160-165.
24. Yan S, Brown SL, Kolozsvary A et al. Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy. J Gene Med 2008;10:1012-1018.
25. Doctrow SR, Lopez A, Schock AM et al. A synthetic superoxide dismutase/ catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin. J Invest Dermatol 2012;133:1088-1096.
26. Murriel CL, Dowdy SF. Influence of protein transduction domains on intracellular delivery of macromolecules. Expert opinion on drug delivery 2006, 3(6):739-746.
27. van den Berg A, Dowdy SF. Protein transduction domain delivery of therapeutic macromolecules. Current opinion in biotechnology 2011, 22(6):888-893.
28. Ho A, Schwarze SR, Mermelstein SJ et al. Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res 2001;61:474-477.
29. Leifert JA, Harkins S, Whitton JL. Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity. Gene Ther 2002;9:1422-1428.
30. Jin LH, Bahn JH, Eum WS et al. Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells. Free Radic Biol Med 2001;31:1509-1519.
31. Lopes LB, Brophy CM, Furnish E et al. Comparative study of the skin penetration of protein transduction domains and a conjugated peptide. Pharm Res 2005;22:750-757.
32. Gniadecka M, Faurskov Nielsen O, Christensen DH et al. Structure of water, proteins, and lipids in intact human skin, hair, and nail. J Invest Dermatol 1998;110:393-398.
33. Taylor SC: Skin of color. biology, structure, function, and implications for dermatologic disease. J Am Acad Dermatol 2002, 46:S41-62.
34. Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol 2000;9:165-169.
35. Norlen L. Skin barrier structure and function: the single gel phase model. J Invest Dermatol 2001;117:830-836.