Investigations of homologous recombination pathways and their regulation

Yale Journal of Biology and Medicine

Volumn 86, Issue 4, 2013, Pages 453-461

  Daley, James M ^a   Kwon, Young Ho ^a   Niu, Hengyao ^a   Sung, Patrick ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; Double Holliday junction; Double strand breaks; Homologous recombination; Presynaptic filament; Recombinase; Resection; Synaptic complex

Indexed keywords

DOUBLE STRANDED DNA; HELICASE; PROTEIN MPH1; PROTEIN RECQ5; PROTEIN SRS2; RAD51 PROTEIN; RAD54 PROTEIN; RECQ HELICASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME ARM; DNA END JOINING REPAIR; DNA RECOMBINATION; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; EUKARYOTIC CELL; HOMOLOGOUS RECOMBINATION; HUMAN; MEIOSIS; NONHUMAN; PRESYNAPTIC NERVE; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECOMBINATION REPAIR; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

DNA REPAIR; DOUBLE HOLLIDAY JUNCTION; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; PRESYNAPTIC FILAMENT; RECOMBINASE; RESECTION; SYNAPTIC COMPLEX;

DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, CRUCIFORM; DNA-BINDING PROTEINS; HOMOLOGOUS RECOMBINATION; HUMANS; MODELS, GENETIC; RAD51 RECOMBINASE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 84891122354     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Trujillo KM, Sung P. DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem. 2001;276(38):35458-35464. [PubMed]
2. Robertson RB, Moses DM, Kwon Y, Chan P, Chi P, Klein H. et al. Structural transitions within human Rad51 nucleoprotein filaments. Proc Natl Acad Sci USA. 2009;106(31):12688-12693.[PMC free article] [PubMed]
3. Robertson RB, Moses DM, Kwon Y, Chan P, Zhao W, Chi P. et al. Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments. J Mol Biol. 2009;388(4):703-720.[PMC free article] [PubMed]
4. Sigurdsson S, Trujillo K, Song B, Stratton S, Sung P. Basis for avid homologous DNA strand exchange by human Rad51 and RPA. J Biol Chem. 2001;276(12):8798-8806. [PubMed]
5. Sung P. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science. 1994;265(5176):1241-1243. [PubMed]
6. Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N. et al. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci USA. 1997;94(13):6927-6932.[PMC free article] [PubMed]
7. Petukhova G, Stratton S, Sung P. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins. Nature. 1998;393(6680):91-94. [PubMed]
8. Kwon Y, Chi P, Roh DH, Klein H, Sung P. Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling. DNA Repair (Amst) 2007;6(10):1496-1506.[PMC free article] [PubMed]
9. Nimonkar AV, Amitani I, Baskin RJ, Kowalczykowski SC. Single molecule imaging of Tid1/Rdh54, a Rad54 homolog that translocates on duplex DNA and can disrupt joint molecules. J Biol Chem. 2007;282(42):30776-30784. [PubMed]
10. Chi P, Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X. et al. Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors. Nucleic Acids Res. 2011;39(15):6511-6522.[PMC free article] [PubMed]
11. Holzen TM, Shah PP, Olivares HA, Bishop DK. Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin. Genes Dev. 2006;20(18):2593-2604.[PMC free article] [PubMed]
12. Santa Maria SR, Kwon Y, Sung P, Klein HL. Characterization of the Interaction between the Saccharomyces cerevisiae Rad51 Recombinase and the DNA Translocase Rdh54. J Biol Chem. 2013;288(30):21999-22005.[PMC free article] [PubMed]
13. Shah PP, Zheng X, Epshtein A, Carey JN, Bishop DK, Klein HL. Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth. Mol Cell. 2010;39(6):862-872.[PMC free article] [PubMed]
14. Bussen W, Raynard S, Busygina V, Singh AK, Sung P. Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. J Biol Chem. 2007;282(43):31484-31492. [PubMed]
15. Chang M, Bellaoui M, Zhang C, Desai R, Morozov P, Delgado-Cruzata L. et al. RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J. 2005;24(11):2024-2033.[PMC free article] [PubMed]
16. Raynard S, Bussen W, Sung P. A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J Biol Chem. 2006;281(20):13861-13864. [PubMed]
17. Raynard S, Niu H, Sung P. DNA double-strand break processing: the beginning of the end. Genes Dev. 2008;22(21):2903-2907.[PMC free article] [PubMed]
18. Singh TR, Ali AM, Busygina V, Raynard S, Fan Q, Du CH. et al. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev. 2008;22(20):2856-2868.[PMC free article] [PubMed]
19. Xu D, Guo R, Sobeck A, Bachrati CZ, Yang J, Enomoto T. et al. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev. 2008;22(20):2843-2855.[PMC free article] [PubMed]
20. Cejka P, Kowalczykowski SC. The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions. J Biol Chem. 2010;285(11):8290-8301.[PMC free article] [PubMed]