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Volumn 3 SEP, Issue , 2013, Pages

Autotaxin inhibition with PF-8380 enhances the radiosensitivity of human and murine glioblastoma cell lines

Author keywords

Autotaxin; Glioblastoma; Lysophosphatidic acid; PF 8380; Radiosensitizer

Indexed keywords

ACTIN; ANTINEOPLASTIC AGENT; AUTOTAXIN; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; PF8380; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84891106027     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00236     Document Type: Article
Times cited : (45)

References (51)
  • 1
    • 32944469010 scopus 로고    scopus 로고
    • Changing paradigms-an update on the multidisciplinary management of malignant glioma
    • doi:10.1634/theoncologist.11-2-165
    • Stupp R, Hegi ME, Van Den Bent MJ, Mason WP, Weller M, Mirimanoff RO, et al. Changing paradigms-an update on the multidisciplinary management of malignant glioma. Oncologist (2006) 11:165-245. doi:10.1634/theoncologist.11-2-165
    • (2006) Oncologist , vol.11 , pp. 165-245
    • Stupp, R.1    Hegi, M.E.2    Van Den Bent, M.J.3    Mason, W.P.4    Weller, M.5    Mirimanoff, R.O.6
  • 2
    • 36048994736 scopus 로고    scopus 로고
    • Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    • doi:10.1093/jnci/djm187
    • Hoelzinger D, Demuth T, Berens M. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst (2007) 99:1583-676. doi:10.1093/jnci/djm187
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1583-1676
    • Hoelzinger, D.1    Demuth, T.2    Berens, M.3
  • 3
    • 0034612289 scopus 로고    scopus 로고
    • Glioblastoma multiforme: the terminator
    • doi:10.1073/pnas.97.12.6242
    • Holland E. Glioblastoma multiforme: the terminator. Proc Natl Acad Sci U S A (2000) 97:6242-6. doi:10.1073/pnas.97.12.6242
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6242-6246
    • Holland, E.1
  • 4
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • doi:10.1016/S1470-2045(09)70025-7
    • Stupp R, Hegi ME, Mason WP, Van Den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol (2009) 10:459-66. doi:10.1016/S1470-2045(09)70025-7
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 5
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • doi:10.1038/359845a0
    • Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature (1992) 359:845-8. doi:10.1038/359845a0
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 6
    • 26944487557 scopus 로고    scopus 로고
    • Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines-a clue to radioresistance?
    • doi:10.1007/s11060-004-4204-7
    • Hovinga KE, Stalpers LJ, van Bree C, Donker M, Verhoeff JJ, Rodermond HM, et al. Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines-a clue to radioresistance? J Neurooncol (2005) 74:99-103. doi:10.1007/s11060-004-4204-7
    • (2005) J Neurooncol , vol.74 , pp. 99-103
    • Hovinga, K.E.1    Stalpers, L.J.2    van Bree, C.3    Donker, M.4    Verhoeff, J.J.5    Rodermond, H.M.6
  • 7
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res (1999) 59:3374-8.
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3    Calvin, D.P.4    Mauceri, H.J.5    Salloum, R.M.6
  • 8
    • 33947531672 scopus 로고    scopus 로고
    • VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
    • doi:10.1016/j.ijrobp.2006.11.011
    • Wachsberger PR, Burd R, Cardi C, Thakur M, Daskalakis C, Holash J, et al. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys (2007) 67:1526-37. doi:10.1016/j.ijrobp.2006.11.011
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1526-1537
    • Wachsberger, P.R.1    Burd, R.2    Cardi, C.3    Thakur, M.4    Daskalakis, C.5    Holash, J.6
  • 9
    • 70350602717 scopus 로고    scopus 로고
    • Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma
    • doi:10.1016/j.ejca.2009.08.004
    • Verhoeff JJ, Stalpers LJ, Claes A, Hovinga KE, Musters GD, Peter Vandertop W, et al. Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma. Eur J Cancer (2009) 45:3074-80. doi:10.1016/j.ejca.2009.08.004
    • (2009) Eur J Cancer , vol.45 , pp. 3074-3080
    • Verhoeff, J.J.1    Stalpers, L.J.2    Claes, A.3    Hovinga, K.E.4    Musters, G.D.5    Peter Vandertop, W.6
  • 10
    • 0024210839 scopus 로고
    • A rapid purification procedure for pyruvate kinase from the hyphal fungus Aspergillus nidulans
    • doi:10.1139/m88-203
    • Kester HC, Uitzetter JH, de Graaff LH, Visser J. A rapid purification procedure for pyruvate kinase from the hyphal fungus Aspergillus nidulans. Can J Microbiol (1988) 34:1154-8. doi:10.1139/m88-203
    • (1988) Can J Microbiol , vol.34 , pp. 1154-1158
    • Kester, H.C.1    Uitzetter, J.H.2    de Graaff, L.H.3    Visser, J.4
  • 11
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • doi:10.1200/JCO.2008.19.8721
    • Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol (2009) 27:4733-40. doi:10.1200/JCO.2008.19.8721
    • (2009) J Clin Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3    Mikkelsen, T.4    Schiff, D.5    Abrey, L.E.6
  • 12
    • 68649103010 scopus 로고    scopus 로고
    • Effects of concurrent topotecan and radiation on 6-month progression-free survival in the primary treatment of glioblastoma multiforme
    • doi:10.1016/j.ijrobp.2009.04.015
    • Grabenbauer GG, Gerber KD, Ganslandt O, Richter A, Klautke G, Birkmann J, et al. Effects of concurrent topotecan and radiation on 6-month progression-free survival in the primary treatment of glioblastoma multiforme. Int J Radiat Oncol Biol Phys (2009) 75:164-9. doi:10.1016/j.ijrobp.2009.04.015
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 164-169
    • Grabenbauer, G.G.1    Gerber, K.D.2    Ganslandt, O.3    Richter, A.4    Klautke, G.5    Birkmann, J.6
  • 13
    • 84879481249 scopus 로고    scopus 로고
    • ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation
    • doi:10.1158/1078-0432.CCR-12-3408
    • Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, et al. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clin Cancer Res (2013) 19:3189-200. doi:10.1158/1078-0432.CCR-12-3408
    • (2013) Clin Cancer Res , vol.19 , pp. 3189-3200
    • Biddlestone-Thorpe, L.1    Sajjad, M.2    Rosenberg, E.3    Beckta, J.M.4    Valerie, N.C.5    Tokarz, M.6
  • 14
    • 0035555907 scopus 로고    scopus 로고
    • Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth
    • doi:10.1054/bjoc.2001.2166
    • Hess C, Vuong V, Hegyi I, Riesterer O, Wood J, Fabbro D, et al. Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth. Br J Cancer (2001) 85:2010-6. doi:10.1054/bjoc.2001.2166
    • (2001) Br J Cancer , vol.85 , pp. 2010-2016
    • Hess, C.1    Vuong, V.2    Hegyi, I.3    Riesterer, O.4    Wood, J.5    Fabbro, D.6
  • 15
    • 79959841782 scopus 로고    scopus 로고
    • Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide
    • doi:10.1007/s11060-010-0390-7
    • Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, et al. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol (2011) 103:325-32. doi:10.1007/s11060-010-0390-7
    • (2011) J Neurooncol , vol.103 , pp. 325-332
    • Gerstner, E.R.1    Eichler, A.F.2    Plotkin, S.R.3    Drappatz, J.4    Doyle, C.L.5    Xu, L.6
  • 16
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • doi:10.1158/0008-5472.CAN-05-0071
    • Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res (2005) 65:7462-9. doi:10.1158/0008-5472.CAN-05-0071
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3    Konicek, B.W.4    Lynch, R.L.5    Bailey, S.N.6
  • 17
    • 84863011588 scopus 로고    scopus 로고
    • Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma
    • doi:10.1093/neuonc/nor130
    • Butowski N, Chang SM, Lamborn KR, Polley MY, Pieper R, Costello JF, et al. Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol (2011) 13:1331-8. doi:10.1093/neuonc/nor130
    • (2011) Neuro Oncol , vol.13 , pp. 1331-1338
    • Butowski, N.1    Chang, S.M.2    Lamborn, K.R.3    Polley, M.Y.4    Pieper, R.5    Costello, J.F.6
  • 18
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • doi:10.1038/nature07385
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 455:1061-8. doi:10.1038/nature07385
    • (2008) Nature , vol.455 , pp. 1061-1068
    • Cancer Genome Atlas Research, N.1
  • 19
    • 84875239034 scopus 로고    scopus 로고
    • RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
    • doi:10.1016/j.ijrobp.2012.10.008
    • Chakravarti A, Wang M, Robins HI, Lautenschlaeger T, Curran WJ, Brachman DG, et al. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys (2013) 85:1206-11. doi:10.1016/j.ijrobp.2012.10.008
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1206-1211
    • Chakravarti, A.1    Wang, M.2    Robins, H.I.3    Lautenschlaeger, T.4    Curran, W.J.5    Brachman, D.G.6
  • 20
    • 79955582712 scopus 로고    scopus 로고
    • Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074
    • doi:10.1016/j.ijrobp.2010.01.070
    • Uhm JH, Ballman KV, Wu W, Giannini C, Krauss JC, Buckner JC, et al. Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074. Int J Radiat Oncol Biol Phys (2011) 80:347-53. doi:10.1016/j.ijrobp.2010.01.070
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 347-353
    • Uhm, J.H.1    Ballman, K.V.2    Wu, W.3    Giannini, C.4    Krauss, J.C.5    Buckner, J.C.6
  • 21
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • doi:10.1016/j.cell.2007.06.009
    • Manning B, Cantley L. AKT/PKB signaling: navigating downstream. Cell (2007) 129:1261-335. doi:10.1016/j.cell.2007.06.009
    • (2007) Cell , vol.129 , pp. 1261-1335
    • Manning, B.1    Cantley, L.2
  • 22
    • 80053519192 scopus 로고    scopus 로고
    • Targeting the AKT pathway in glioblastoma
    • doi:10.2174/138161211797249224
    • McDowell K, Riggins G, Gallia G. Targeting the AKT pathway in glioblastoma. Curr Pharm Des (2011) 17:2411-31. doi:10.2174/138161211797249224
    • (2011) Curr Pharm Des , vol.17 , pp. 2411-2431
    • McDowell, K.1    Riggins, G.2    Gallia, G.3
  • 23
    • 67650458524 scopus 로고    scopus 로고
    • Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
    • doi:10.1158/0008-5472.CAN-09-0302
    • Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, et al. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res (2009) 69:5441-9. doi:10.1158/0008-5472.CAN-09-0302
    • (2009) Cancer Res , vol.69 , pp. 5441-5449
    • Zhang, H.1    Xu, X.2    Gajewiak, J.3    Tsukahara, R.4    Fujiwara, Y.5    Liu, J.6
  • 24
    • 14944366978 scopus 로고    scopus 로고
    • PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
    • doi:10.1007/s11060-004-1718-y
    • Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, et al. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol (2005) 71:215-37. doi:10.1007/s11060-004-1718-y
    • (2005) J Neurooncol , vol.71 , pp. 215-237
    • Nakamura, J.L.1    Karlsson, A.2    Arvold, N.D.3    Gottschalk, A.R.4    Pieper, R.O.5    Stokoe, D.6
  • 25
    • 63449125050 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2: targeting cancer through the tumor vasculature
    • doi:10.1158/1078-0432.CCR-08-1905
    • Linkous A, Geng L, Lyshchik A, Hallahan D, Yazlovitskaya E. Cytosolic phospholipase A2: targeting cancer through the tumor vasculature. Clin Cancer Res (2009) 15:1635-79. doi:10.1158/1078-0432.CCR-08-1905
    • (2009) Clin Cancer Res , vol.15 , pp. 1635-1679
    • Linkous, A.1    Geng, L.2    Lyshchik, A.3    Hallahan, D.4    Yazlovitskaya, E.5
  • 26
    • 52149094787 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium
    • doi:10.1038/cdd.2008.93
    • Yazlovitskaya E, Linkous A, Thotala D, Cuneo K, Hallahan D. Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium. Cell Death Differ (2008) 15:1641-94. doi:10.1038/cdd.2008.93
    • (2008) Cell Death Differ , vol.15 , pp. 1641-1694
    • Yazlovitskaya, E.1    Linkous, A.2    Thotala, D.3    Cuneo, K.4    Hallahan, D.5
  • 27
    • 84855669275 scopus 로고    scopus 로고
    • Novel therapeutic approaches for targeting tumor angiogenesis
    • Linkous A, Yazlovitskaya E. Novel therapeutic approaches for targeting tumor angiogenesis. Anticancer Res (2012) 32:1-13.
    • (2012) Anticancer Res , vol.32 , pp. 1-13
    • Linkous, A.1    Yazlovitskaya, E.2
  • 28
    • 79958719984 scopus 로고    scopus 로고
    • Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature
    • doi:10.1371/journal.pone.0022182
    • Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, et al. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS ONE (2011) 6(7):e22182. doi:10.1371/journal.pone.0022182
    • (2011) PLoS ONE , vol.6 , Issue.7
    • Schleicher, S.M.1    Thotala, D.K.2    Linkous, A.G.3    Hu, R.4    Leahy, K.M.5    Yazlovitskaya, E.M.6
  • 29
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • doi:10.1083/jcb.200204026
    • Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol (2002) 158:227-60. doi:10.1083/jcb.200204026
    • (2002) J Cell Biol , vol.158 , pp. 227-260
    • Umezu-Goto, M.1    Kishi, Y.2    Taira, A.3    Hama, K.4    Dohmae, N.5    Takio, K.6
  • 30
    • 0037131366 scopus 로고    scopus 로고
    • Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
    • doi:10.1074/jbc.M205623200
    • Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem (2002) 277:39436-78. doi:10.1074/jbc.M205623200
    • (2002) J Biol Chem , vol.277 , pp. 39436-39478
    • Tokumura, A.1    Majima, E.2    Kariya, Y.3    Tominaga, K.4    Kogure, K.5    Yasuda, K.6
  • 31
    • 34247534260 scopus 로고    scopus 로고
    • Regulation and biological activities of the autotaxin-LPA axis
    • doi:10.1016/j.plipres.2007.02.001
    • van Meeteren L, Moolenaar W. Regulation and biological activities of the autotaxin-LPA axis. Prog Lipid Res (2007) 46:145-205. doi:10.1016/j.plipres.2007.02.001
    • (2007) Prog Lipid Res , vol.46 , pp. 145-205
    • van Meeteren, L.1    Moolenaar, W.2
  • 32
    • 79551646019 scopus 로고    scopus 로고
    • Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
    • doi:10.1038/nsmb.1998
    • Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, et al. Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol (2011) 18:205-12. doi:10.1038/nsmb.1998
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 205-212
    • Nishimasu, H.1    Okudaira, S.2    Hama, K.3    Mihara, E.4    Dohmae, N.5    Inoue, A.6
  • 33
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • doi:10.1038/nrc1143
    • Mills G, Moolenaar W. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer (2003) 3:582-673. doi:10.1038/nrc1143
    • (2003) Nat Rev Cancer , vol.3 , pp. 582-673
    • Mills, G.1    Moolenaar, W.2
  • 34
    • 77952945271 scopus 로고    scopus 로고
    • Autotaxin and lipid signaling pathways as anticancer targets
    • Braddock D. Autotaxin and lipid signaling pathways as anticancer targets. Curr Opin Investig Drugs (2010) 11:629-66.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 629-666
    • Braddock, D.1
  • 35
    • 0033173080 scopus 로고    scopus 로고
    • Autotaxin expression in non-small-cell lung cancer
    • doi:10.1165/ajrcmb.21.2.3667
    • Yang Y, Mou L, Liu N, Tsao M. Autotaxin expression in non-small-cell lung cancer. Am J Respir Cell Mol Biol (1999) 21:216-38. doi:10.1165/ajrcmb.21.2.3667
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 216-238
    • Yang, Y.1    Mou, L.2    Liu, N.3    Tsao, M.4
  • 36
    • 0028871499 scopus 로고
    • Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients
    • Xu Y, Gaudette DC, Boynton JD, Frankel A, Fang XJ, Sharma A, et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res (1995) 1:1223-55.
    • (1995) Clin Cancer Res , vol.1 , pp. 1223-1255
    • Xu, Y.1    Gaudette, D.C.2    Boynton, J.D.3    Frankel, A.4    Fang, X.J.5    Sharma, A.6
  • 37
    • 0036456916 scopus 로고    scopus 로고
    • Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
    • Yang SY, Lee J, Park CG, Kim S, Hong S, Chung HC, et al. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis (2002) 19:603-11.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 603-611
    • Yang, S.Y.1    Lee, J.2    Park, C.G.3    Kim, S.4    Hong, S.5    Chung, H.C.6
  • 38
    • 33745221886 scopus 로고    scopus 로고
    • Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid
    • doi:10.1074/jbc.M601803200
    • Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, Kitayama J, et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem (2006) 281:17492-500. doi:10.1074/jbc.M601803200
    • (2006) J Biol Chem , vol.281 , pp. 17492-17500
    • Kishi, Y.1    Okudaira, S.2    Tanaka, M.3    Hama, K.4    Shida, D.5    Kitayama, J.6
  • 39
    • 13444294190 scopus 로고    scopus 로고
    • Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets
    • doi:10.1593/neo.04535
    • Hoelzinger DB, Mariani L, Weis J, Woyke T, Berens TJ, McDonough WS, et al. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia (2005) 7:7-23. doi:10.1593/neo.04535
    • (2005) Neoplasia , vol.7 , pp. 7-23
    • Hoelzinger, D.B.1    Mariani, L.2    Weis, J.3    Woyke, T.4    Berens, T.J.5    McDonough, W.S.6
  • 40
    • 77953778656 scopus 로고    scopus 로고
    • A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation
    • doi:10.1124/jpet.110.165845
    • Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther (2010) 334:310-7. doi:10.1124/jpet.110.165845
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 310-317
    • Gierse, J.1    Thorarensen, A.2    Beltey, K.3    Bradshaw-Pierce, E.4    Cortes-Burgos, L.5    Hall, T.6
  • 42
    • 84874426410 scopus 로고    scopus 로고
    • NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas
    • Kotipatruni RP, Ferraro DJ, Ren X, Vanderwaal RP, Thotala DK, Hallahan DE, et al. NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas. Integr Biol (Camb) (2012) 4:1185-97.
    • (2012) Integr Biol (Camb) , vol.4 , pp. 1185-1197
    • Kotipatruni, R.P.1    Ferraro, D.J.2    Ren, X.3    Vanderwaal, R.P.4    Thotala, D.K.5    Hallahan, D.E.6
  • 43
    • 0026459493 scopus 로고
    • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice
    • Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, et al. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res (1992) 52:6553-60.
    • (1992) Cancer Res , vol.52 , pp. 6553-6560
    • Leunig, M.1    Yuan, F.2    Menger, M.D.3    Boucher, Y.4    Goetz, A.E.5    Messmer, K.6
  • 44
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • doi:10.1056/NEJMoa043330
    • Stupp R, Mason WP, Van DenBent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 352:987-96. doi:10.1056/NEJMoa043330
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van DenBent, M.J.3    Weller, M.4    Fisher, B.5    Taphoorn, M.J.6
  • 45
    • 77949703248 scopus 로고    scopus 로고
    • Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration
    • doi:10.1158/1541-7786.MCR-09-0288
    • Ptaszynska M, Pendrak M, Stracke M, Roberts D. Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration. Mol Cancer Res (2010) 8:309-30. doi:10.1158/1541-7786.MCR-09-0288
    • (2010) Mol Cancer Res , vol.8 , pp. 309-330
    • Ptaszynska, M.1    Pendrak, M.2    Stracke, M.3    Roberts, D.4
  • 47
    • 77950828060 scopus 로고    scopus 로고
    • Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells
    • doi:10.1158/1535-7163.MCT-09-0904
    • Ho JN, Lee SB, Lee SS, Yoon SH, Kang GY, Hwang SG, et al. Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells. Mol Cancer Ther (2010) 9:825-32. doi:10.1158/1535-7163.MCT-09-0904
    • (2010) Mol Cancer Ther , vol.9 , pp. 825-832
    • Ho, J.N.1    Lee, S.B.2    Lee, S.S.3    Yoon, S.H.4    Kang, G.Y.5    Hwang, S.G.6
  • 48
    • 0030965154 scopus 로고    scopus 로고
    • Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer
    • doi:10.1074/jbc.272.23.14501
    • Heasley LE, Thaler S, Nicks M, Price B, Skorecki K, Nemenoff RA. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. J Biol Chem (1997) 272:14501-4. doi:10.1074/jbc.272.23.14501
    • (1997) J Biol Chem , vol.272 , pp. 14501-14504
    • Heasley, L.E.1    Thaler, S.2    Nicks, M.3    Price, B.4    Skorecki, K.5    Nemenoff, R.A.6
  • 49
    • 65649132676 scopus 로고    scopus 로고
    • Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    • doi:10.1016/j.ccr.2009.03.027
    • Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, et al. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell (2009) 15:539-50. doi:10.1016/j.ccr.2009.03.027
    • (2009) Cancer Cell , vol.15 , pp. 539-550
    • Liu, S.1    Umezu-Goto, M.2    Murph, M.3    Lu, Y.4    Liu, W.5    Zhang, F.6
  • 50
    • 84876736382 scopus 로고    scopus 로고
    • Targeting the Akt-pathway to improve radiosensitivity in glioblastoma
    • doi:10.2174/138161213804547286
    • Narayan RS, Fedrigo CA, Stalpers LJ, Baumert BG, Sminia P. Targeting the Akt-pathway to improve radiosensitivity in glioblastoma. Curr Pharm Des (2013) 19:951-7. doi:10.2174/138161213804547286
    • (2013) Curr Pharm Des , vol.19 , pp. 951-957
    • Narayan, R.S.1    Fedrigo, C.A.2    Stalpers, L.J.3    Baumert, B.G.4    Sminia, P.5
  • 51
    • 33745466418 scopus 로고    scopus 로고
    • Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    • doi:10.1128/MCB.02419-05
    • van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradère JP, et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol (2006) 26:5015-37. doi:10.1128/MCB.02419-05
    • (2006) Mol Cell Biol , vol.26 , pp. 5015-5037
    • van Meeteren, L.A.1    Ruurs, P.2    Stortelers, C.3    Bouwman, P.4    van Rooijen, M.A.5    Pradère, J.P.6


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