Valproic acid attenuates disease symptoms and increases endogenous myelin repair by recruiting neural stem cells and oligodendrocyte progenitors in experimental autoimmune encephalomyelitis

Neurodegenerative Diseases

Volumn 13, Issue 1, 2013, Pages 45-52

  Pazhoohan, Saeed ^a   Satarian, Leila ^a   Asghari, Ali Akbar ^a   Salimi, Mehdi ^a   Kiani, Sahar ^b   Mani, Ali Reza ^a   Javan, Mohammad ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

Author keywords

Experimental autoimmune encephalomyelitis; Myelin repair; Neural stem cells; Oligodendrocyte progenitors; Valproic acid

Indexed keywords

FREUND ADJUVANT; MYELIN; PERTUSSIS TOXIN; VALPROIC ACID; NESTIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL REGENERATION; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFICACY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GUINEA PIG; HISTOPATHOLOGY; HOMOGENATE; IMMUNIZATION; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOFLUORESCENCE ASSAY; NERVE FIBER; NEURAL STEM CELL; NEUROPHYSIOLOGICAL RECRUITMENT; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; SPINAL CORD; SPINAL CORD HOMOGENATE; SYMPTOM; VERTEBRA; ANIMAL MODEL; DEMYELINATION; DRUG WITHDRAWAL; HISTOLOGY; LOCOMOTION; MOTOR PERFORMANCE; MYELIN SHEATH; OLIGODENDROCYTE PRECURSOR CELL; TREATMENT DURATION;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIGS; NERVE FIBERS, MYELINATED; NEURAL STEM CELLS; OLIGODENDROGLIA; RATS; RATS, WISTAR; SEVERITY OF ILLNESS INDEX; SPINAL CORD; STEM CELLS; VALPROIC ACID;

EID: 84891047375     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000352021     Document Type: Article

References (28)

1. Blakemore WF, Franklin RJ: Remyelination in experimental models of toxin-induced demyelination. Curr Top Microbiol Immunol 2008; 318: 193-212.
2. Stüve O: Knowns and unknowns in the future of multiple sclerosis treatment. J Neurol Sci 2009; 287(suppl 1):S30-S36.
3. Trapp BD, Nave KA: Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008; 31: 247-269.
4. Franklin RJ, Ffrench-Constant C: Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839-855.
5. Bieber AJ, Ure DR, Rodriguez M: Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis. J Neuropathol Exp Neurol 2005; 64: 46-57. (Pubitemid 40189478)
6. Franklin RJ: Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci 2002; 3: 705-714. (Pubitemid 135706676)
7. Chari DM, Blakemore WF: Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia 2002; 37: 307-313.
8. Mason JL, Toews A, Hostettler JD, Morell P, Suzuki K, Goldman JE, Matsushima GK: Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions. Am J Pathol 2004; 164: 1673-1682. (Pubitemid 38529770)
9. Blaheta RA, Cinatl J Jr: Anti-tumor mechanisms of valproate: a novel role for an old drug. Med Res Rev 2002; 22: 492-511.
10. Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, Giavara S, Sleeman JP, Lo Coco F, Nervi C, Pelicci PG, Heinzel T: Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001; 20: 6969-6978. (Pubitemid 34062289)
11. Kondo T, Raff M: Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev 2004; 18: 2963-2972. (Pubitemid 39602314)
12. Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, Wu X: Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells. Proc Natl Acad Sci USA 2007; 104: 14982-14987. (Pubitemid 47619579)
13. Shen S, Sandoval J, Swiss VA, Li J, Dupree J, Franklin RJ, Casaccia-Bonnefil P: Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci 2008; 11: 1024-1034.
14. Wang XS, Chen YY, Shang XF, Zhu ZG, Chen GQ, Han Z, Shao B, Yang HM, Xu HQ, Chen JF, Zheng RY: Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis. Brain Res 2009; 1253: 198-209.
15. Kerschensteiner M, Stadelmann C, Buddeberg BS, Merkler D, Bareyre FM, Anthony DC, Linington C, Bruck W, Schwab ME: Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis. Am J Pathol 2004; 164: 1455-1469. (Pubitemid 38387811)
16. Siegenthaler MM, Tu MK, Keirstead HS: The extent of myelin pathology differs following contusion and transection spinal cord injury. J Neurotrauma 2007; 24: 1631-1646. (Pubitemid 350035840)
17. Snyder DH, Valsamis MP, Stone SH, Raine CS: Progressive demyelination and reparative phenomena in chronic experimental allergic encephalomyelitis. J Neuropathol Exp Neurol 1975; 34: 209-221.
18. Totoiu MO, Keirstead HS: Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol 2005; 486: 373-383. (Pubitemid 40605041)
19. Chen GQ, Chen YY, Wang XS, Wu SZ, Yang HM, Xu HQ, He JC, Wang XT, Chen JF, Zheng RY: Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats. Brain Res 2010; 1309: 116-125.
20. Zhao CB, Coons SW, Cui M, Shi FD, Vollmer TL, Ma CY, Kuniyoshi SM, Shi J: A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin. Biochem Biophys Res Commun 2008; 370: 16-21.
21. Johns TG, Kerlero de Rosbo N, Menon KK, Abo S, Gonzales MF, Bernard CC: Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. J Immunol 1995; 154: 5536-5541.
22. Wekerle H, Kojima K, Lannes-Vieira J, Lassmann H, Linington C: Animal models. Ann Neurol 1994; 36(suppl):S47-S53. (Pubitemid 24220843)
23. Marin-Husstege M, Muggironi M, Liu A, Casaccia-Bonnefil P: Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J Neurosci 2002; 22: 10333-10345. (Pubitemid 35416871)
24. Matsushima GK, Morell P: The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 2001; 11: 107-116.
25. Miron VE, Kuhlmann T, Antel JP: Cells of the oligodendroglial lineage, myelination, and remyelination. Biochim Biophys Acta 2011; 1812: 184-193.
26. Chari DM: Remyelination in multiple sclerosis. Int Rev Neurobiol 2007; 79: 589-620.
27. Levine JM, Reynolds R: Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 1999; 160: 333-347.
28. Zhang Z, Zhang ZY, Wu Y, Schluesener HJ: Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats. Neuroscience 2012; 221: 140-150.