Frequency of the congenital transmission of Trypanosoma cruzi: A systematic review and meta-analysis

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 121, Issue 1, 2014, Pages 22-33

  Howard, E J ^a   Xiong, X ^a   Carlier, Y ^a,b   Sosa Estani, S ^c   Buekens, P ^a  

^a TULANE UNIVERSITY   (United States)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Dr M Fatala Chaben National Institute of Parasitology   (Argentina)

Author keywords

Chagas disease; congenital infection; meta analysis; systematic review; Trypanosoma cruzi

Indexed keywords

CASE STUDY; CHAGAS DISEASE; CINAHL; CONGENITAL INFECTION; CONGENITAL TRANSMISSION; DISEASE TRANSMISSION; EMBASE; HUMAN; INFECTION RISK; MEDLINE; META ANALYSIS (TOPIC); OBSERVATIONAL STUDY; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TRYPANOSOMA CRUZI;

CHAGAS DISEASE; CONGENITAL INFECTION; META-ANALYSIS; SYSTEMATIC REVIEW; TRYPANOSOMA CRUZI;

CHAGAS DISEASE; FEMALE; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; RISK FACTORS; TRYPANOSOMA CRUZI;

EID: 84891027815     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.12396     Document Type: Review

References (92)

1. Schofield CJ, Jannin J, Salvatella R,. The future of Chagas disease control. Trends Parasitol 2006; 22: 583-8.
2. Rassi A Jr, Rassi A, Marin-Neto JA,. Chagas disease. Lancet 2010; 375: 1388-402.
3. Carlier Y, Pinto DJC, Luquetti AO, Hontebeyrie M, Torrico F, Truyens C,. Trypanosomiase américaine ou maladie de Chagas. Editions Scientifiques et Médicales ed. Paris: Elsevier SAS; 2002. p. 505.
4. Dias JC,. Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectives. Mem Inst Oswaldo Cruz 2007; 102 (Suppl. 1): 11-18.
5. Coura JR, Vinas PA,. Chagas disease: a new worldwide challenge. Nature 2010; 465: S6-7.
6. Carlier Y, Truyens C,. Maternal-fetal transmission of Trypanosoma cruzi. In:, Telleria J, Tibayrenc M, editors. American Trypanosomiasis-Chagas Disease, One Hundred Years of Research. Amsterdam: Elsevier Inc.; 2010. pp 539-81.
7. Zhang L, Tarleton RL,. Parasite persistence correlates with disease severity and localization in chronic Chagas' disease. J Infect Dis 1999; 180: 480-6.
8. Carlier Y, Torrico F, Sosa-Estani S, Russomando G, Luquetti A, Freilij H, et al. Congenital Chagas disease: recommendations for diagnosis, treatment and control of newborns, siblings and pregnant women. PLoS Negl Trop Dis 2011; 5: e1250.
9. Freilij H, Altcheh J,. Congenital Chagas' disease: diagnostic and clinical aspects. Clin Infect Dis 1995; 21: 551-5.
10. Schijman AG, Altcheh J, Burgos JM, Biancardi M, Bisio M, Levin MJ, et al. Aetiological treatment of congenital Chagas' disease diagnosed and monitored by the polymerase chain reaction. J Antimicrob Chemother 2003; 52: 441-9.
11. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, Dramaix M, et al. Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia. Am J Trop Med Hyg 2004; 70: 201-9.
12. Altcheh J, Moscatelli G, Moroni S, Garcia-Bournissen F, Freilij H,. Adverse events after the use of benznidazole in infants and children with Chagas disease. Pediatrics 2011; 127: e212-18.
13. Carlier Y, Torrico F,. Congenital infection with Trypanosoma cruzi: from mechanisms of transmission to strategies for diagnosis and control. Rev Soc Bras Med Trop 2003; 36: 767-71.
14. Buekens P, Almendares O, Carlier Y, Dumonteil E, Eberhard M, Gamboa-Leon R, et al. Mother-to-child transmission of Chagas' disease in North America: why don't we do more? Matern Child Health J 2008; 12: 283-6.
15. Higgins JP, Thompson SG,. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-58.
16. Russomando G, Almiron M, Candia N, Franco L, Sanchez Z, de Guillen I,. Implementation and evaluation of a locally sustainable system of prenatal diagnosis to detect cases of congenital Chagas disease in endemic areas of Paraguay. Rev Soc Bras Med Trop 2005; 38 (Suppl. 2): 49-54.
17. Neyeloff JL, Fuchs SC, Moreira LB,. Meta-analyses and Forest plots using a microsoft excel spreadsheet: step-by-step guide focusing on descriptive data analysis. BMC Res Notes 2012; 5: 52 -0500-5-52.
18. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62: 1006-12.
19. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12.
20. United States Centers for Disease Control and Prevention. Congenital transmission of Chagas disease-Virginia, 2010. Morb Mortal Wkly Rep 2012; 61: 477-9.
21. Gilson GJ, Harner KA, Abrams J, Izquierdo LA, Curet LB,. Chagas disease in pregnancy. Obstet Gynecol 1995; 86: 646-7.
22. Guarro A, El-Kassab H, Jorba MJ, Lobato A, Castro M, Martin C, et al. A case of congenital transmission of the Chagas disease in Catalonia. Enferm Emerg 2007; 9 (Suppl. 1): 28-30.
23. Jackson Y, Myers C, Diana A, Marti HP, Wolff H, Chappuis F, et al. Congenital transmission of Chagas disease in Latin American immigrants in Switzerland. Emerg Infect Dis 2009; 15: 601-3.
24. Munoz J, Portus M, Corachan M, Fumado V, Gascon J,. Congenital Trypanosoma cruzi infection in a non-endemic area. Trans R Soc Trop Med Hyg 2007; 101: 1161-2.
25. Riera C, Guarro A, Kassab HE, Jorba JM, Castro M, Angrill R, et al. Congenital transmission of Trypanosoma cruzi in Europe (Spain): a case report. Am J Trop Med Hyg 2006; 75: 1078-81.
26. Burgos JM, Altcheh J, Petrucelli N, Bisio M, Levin MJ, Freilij H, et al. Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery. Diagn Microbiol Infect Dis 2009; 65: 58-61.
27. Okumura M, Aparecida dos Santos V, Camargo ME, Schultz R, Zugaib M,. Prenatal diagnosis of congenital Chagas' disease (American trypanosomiasis). Prenat Diagn 2004; 24: 179-81.
28. Da-Costa-Pinto EA, Almeida EA, Figueiredo D, Bucaretchi F, Hessel G,. Chagasic megaesophagus and megacolon diagnosed in childhood and probably caused by vertical transmission. Rev Inst Med Trop Sao Paulo 2001; 43: 227-30.
29. Fiss DVC, Katz B, Pegas K,. Congenital Chagas disease in a 1 year-old patient with Down Syndrome-case report. Histopathology 2010; 57: 175.
30. Araujo AB, Castagno VD, Gallina T, Berne ME,. Prevalence of Chagas disease among pregnant women in the southern region of Rio Grande do Sul. Rev Soc Bras Med Trop 2009; 42: 732-3.
31. Strohmeyer M, Gabrielli S, Bartalesi F, Mantella A, Aiello KH, Di Tommaso MR, et al. Screening of congenital Chagas disease in Florence, Italy. Trop Med Int Health 2009; 14: 239.
32. de Rissio AM, Riarte AR, Garcia MM, Esteva MI, Quaglino M, Ruiz AM,. Congenital Trypanosoma cruzi infection. Efficacy of its monitoring in an urban reference health center in a non-endemic area of Argentina. Am J Trop Med Hyg 2010; 82: 838-45.
33. Szarfman A, Urman J, Otalora A, Larguia A, Yanovsky JF,. Specific agglutinins and immunoglobulin levels in congenital Chagas infection. Medicina (B Aires) 1975; 35: 245-50.
34. Alegria I, Coll MT, Bachs MR, Botet F, Anquela I, Laya M, et al. Congenital Chagas disease: the importance of screening before the delivery. Our experience in a regional hospital in Catalonia. Trop Med Int Health 2011; 16: 370.
35. Bern C, Verastegui M, Gilman RH, Lafuente C, Galdos-Cardenas G, Calderon M, et al. Congenital Trypanosoma cruzi transmission in Santa Cruz, Bolivia. Clin Infect Dis 2009; 49: 1667-74.
36. Mora MC, Sanchez Negrette O, Marco D, Barrio A, Ciaccio M, Segura MA, et al. Early diagnosis of congenital Trypanosoma cruzi infection using PCR, hemoculture, and capillary concentration, as compared with delayed serology. J Parasitol 2005; 91: 1468-73.
37. Bern C, Martin DL, Gilman RH,. Acute and congenital Chagas disease. Adv Parasitol 2011; 75: 19-47.
38. Moretti E, Basso B, Castro I, Carrizo Paez M, Chaul M, Barbieri G, et al. Chagas' disease: study of congenital transmission in cases of acute maternal infection. Rev Soc Bras Med Trop 2005; 38: 53-5.
39. Hermann E, Truyens C, Alonso-Vega C, Rodriguez P, Berthe A, Torrico F, et al. Congenital transmission of Trypanosoma cruzi is associated with maternal enhanced parasitemia and decreased production of interferon-γ in response to parasite antigens. J Infect Dis 2004; 189: 1274-81.
40. Bua J, Volta BJ, Velazquez EB, Ruiz AM, Rissio AM, Cardoni RL,. Vertical transmission of Trypanosoma cruzi infection: quantification of parasite burden in mothers and their children by parasite DNA amplification. Trans R Soc Trop Med Hyg 2012; 106: 623-8.
41. Saito S, Nakashima A, Shima T, Ito M,. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63: 601-10.
42. Scapellato PG, Bottaro EG, Rodriguez-Brieschke MT,. Mother-child transmission of Chagas disease: could coinfection with human immunodeficiency virus increase the risk? Rev Soc Bras Med Trop 2009; 42: 107-9.
43. Sosa-Estani S, Cura E, Velazquez E, Yampotis C, Segura EL,. Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission. Rev Soc Bras Med Trop 2009; 42: 484-7.
44. Brutus L, Schneider D, Postigo J, Romero M, Santalla J, Chippaux JP,. Congenital Chagas disease: diagnostic and clinical aspects in an area without vectorial transmission, Bermejo, Bolivia. Acta Trop 2008; 106: 195-9.
45. Torrico F, Vega CA, Suarez E, Tellez T, Brutus L, Rodriguez P, et al. Are maternal re-infections with Trypanosoma cruzi associated with higher morbidity and mortality of congenital Chagas disease? Trop Med Int Health 2006; 11: 628-35.
46. Salas NA, Cot M, Schneider D, Mendoza B, Santalla JA, Postigo J, et al. Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia. Trop Med Int Health 2007; 12: 1498-505.
47. Leiby DA, Fucci MH, Stumpf RJ,. Trypanosoma cruzi in a low- to moderate-risk blood donor population: seroprevalence and possible congenital transmission. Transfusion 1999; 39: 310-15.
48. Streiger M, Fabbro D, del Barco M, Beltramino R, Bovero N,. Congenital Chagas disease in the city of Santa Fe. Diagnosis and treatment. Medicina (B Aires) 1995; 55: 125-32.
49. Bisio M, Seidenstein ME, Burgos JM, Ballering G, Risso M, Pontoriero R, et al. Urbanization of congenital transmission of Trypanosoma cruzi: prospective polymerase chain reaction study in pregnancy. Trans R Soc Trop Med Hyg 2011; 105: 543-9.
50. Sanchez NO, Mora MC, Basombrio MA,. High prevalence of congenital Trypanosoma cruzi infection and family clustering in Salta, Argentina. Pediatrics 2005; 115: e668-72.
51. Mansilla M, Rocha MC, Sarubbi MA,. Congenital Chagas: report of a clinical case and bibliographic review. Rev Hosp Matern Infant Ramon Sarda 1999; 18: 29-35.
52. Pavia PX, Montilla M, Florez C, Herrera G, Ospina JM, Manrique F, et al. The first case of congenital Chagas' disease analyzed by AP-PCR in Colombia. Biomedica 2009; 29: 513-22.
53. Voelker R,. Congenital Chagas disease reported in United States. JAMA 2012; 308: 443.
54. Angheben A, Anselmi M, Gobbi F, Marocco S, Monteiro G, Buonfrate D, et al. Chagas disease in Italy: breaking an epidemiological silence. Euro surveillance 2011; 16: 2-9.
55. Apt W, Zulantay I, Solari A, Ortiz S, Oddo D, Corral G, et al. Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: preliminary report (2005-2008). Biol Res 2010; 43: 269-74.
56. Arcavi M, Orfus G, Griemberg G,. Incidence of Chagas infection in pregnant women and newborn infants in a non-endemic area. Medicina (B Aires) 1993; 53: 217-22.
57. Avila AO, Liendo AP, Martinez IL, Martinez AT, Pocheville GM, Egurbide AM,. Prevalence of Trypanosoma cruzi infection and vertical transmission in Latin-American pregnant women in a health area of Biscay. Enferm Infecc Microbiol Clin 2012; 31: 210-6.
58. Barona-Vilar C, Gimenez-Marti MJ, Fraile T, Gonzalez-Steinbauer C, Parada C, Gil-Brusola A, et al. Prevalence of Trypanosoma cruzi infection in pregnant Latin American women and congenital transmission rate in a non-endemic area: the experience of the Valencian Health Programme (Spain). Epidemiol Infect 2012; 140: 1896-903.
59. Bassa N, Soldevila F, Soriano P, Gassiot P, Mora C,. Prevalence of Chagas infection in pregnant women native of South America in an area of northeast Spain. Clin Chem Lab Med 2011; 49: S516.
60. Blanco SB, Segura EL, Cura EN, Chuit R, TuliÃn L, Flores I, et al. LCongenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north-western Argentina. Trop Med Int Health 2000; 5: 293-301.
61. Blasco GL, Nuñez MV, Cruceyra BM, Magdaleno DF, García BS,. Enfermedad de Chagas y embarazo; Chagas disease and pregnancy. Rev Chil Obstet Ginecol 2011; 76: 162-8.
62. Brutus L, Schneider D, Postigo J, Delgado W, Mollinedo S, Chippaux JP,. Evidence of congenital transmission of Trypanosoma cruzi in a vector-free area of Bolivia. Trans R Soc Trop Med Hyg 2007; 101: 1159-60.
63. Cruz CC, Piris BS, Caman o Gutierrez I,. Screening for Chagas disease: a priority in our health system. J Matern Fetal Neonatal Med 2010; 23: 391.
64. Cucunuba Z, Valencia C, Florez C, Leon C, Castellanos Y, Cardenas A, et al. Pilot program for surveillance of congenital Chagas disease in Colombia 2010-2011. Int J Infect Dis 2012; 16: e343.
65. de Rissio AM, Scollo K, Cardoni RL,. Maternal-fetal transmission of Trypanosoma cruzi in Argentina. Medicina (B Aires) 2009; 69: 529-35.
66. Diez CN, Manattini S, Zanuttini JC, Bottasso O, Marcipar I,. The value of molecular studies for the diagnosis of congenital Chagas disease in northeastern Argentina. Am J Trop Med Hyg 2008; 78: 624-7.
67. Flores-Chavez M, Merino F, Garcia-Bujalance S, Martin-Rabadan P, Merino P, Garcia-Bermejo I, et al. Surveillance of Chagas disease in pregnant women in Madrid (Spain), 2008-2010. Trop Med Int Health 2011; 16: 368.
68. Gamboa-Leon R, Gonzalez-Ramirez C, Padilla-Raygoza N, Sosa-Estani S, Caamal-Kantun A, Buekens P, et al. Do commercial serologic tests for Trypanosoma cruzi infection detect Mexican strains in women and newborns? J Parasitol 2011; 97: 338-43.
69. Hoff R, Mott KE, Milanesi ML, Bittencourt AL, Barbosa HS,. Congenital Chagas's disease in an urban population: investigation of infected twins. Trans R Soc Trop Med Hyg 1978; 72: 247-50.
70. Jackson Y, Delieutraz-Marchand J, Reis C, Benchouk M, Mauris A, Sizonenko S, et al. Prevalence of Chagas disease among pregnant Latin American women and their newborns in Geneva, Switzerland. Trop Med Int Health 2009; 14: 238.
71. Lucas RM, Barba MC,. Prevalence of American trypanosomiasis in pregnant women from a health area of Valencia, Spain: 2005-2007. Rev Esp Salud Publica 2009; 83: 543-55.
72. Lucero RH, Bruses BL, Merino DE, Fernandez GJ, Crenna EC, Alonso JM,. Congenital Chagas' Disease in hospitals of Corrientes city-Argentina. Enferm Emerg 2007; 9: 121-4.
73. Mallimaci MC, Sosa-Estani S, Russomando G, Sanchez Z, Sijvarger C, Alvarez IM, et al. Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina. Am J Trop Med Hyg 2010; 82: 55-9.
74. Merino P, Gonzalez F, Amor E, Gastanaga T, Urbon J, Picazo J,. Seroprevalence of Chagas' Disease in pregnant woman from Latin America. Screening and follow up of their children in a non-endemic country. Trop Med Int Health 2009; 14: 238.
75. Moya P, Moretti E, Paolasso R, Basso B, Blanco S, Sanmartino C,. Enfermedad de Chagas neonatal. Diagnostico de Laboratorio durante el primer ano de vida. Medicina (B.Aires) 1989; 49: 595-9.
76. Munoz J, Coll O, Juncosa T, Verges M, del Pino M, Fumado V, et al. Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona, Spain. Clin Infect Dis 2009; 48: 1736-40.
77. Munoz-Vilches MJ, Salas J, Cabezas T, Metz D, Vazquez J, Soriano MJ,. Chagas screening in pregnant Latin-American women. Experience in Poniente Almeriense (Almeria, Spain). Enferm Infecc Microbiol Clin 2012; 30: 380-2.
78. Murcia L, Carrilero B, Munoz-Davila MJ, Thomas MC, Lopez MC, Segovia M,. Risk factors and primary prevention of congenital Chagas disease in a non-endemic country. Clin Infect Dis 2013; 56: 496-502.
79. Olivera MA, Guillen OF, Cruz VS, Hernandez-Becerril N, Perez GE, Cordova CG, et al. Serological and parasitological screening of Trypanosoma cruzi infection in mothers and newborns living in two Chagasic areas of Mexico. Arch Med Res 2006; 37: 774-7.
80. Otero S, Sulleiro E, Molina I, Espiau M, Suy A, Martin-Nalda A, et al. Congenital transmission of Trypanosoma cruzi in non-endemic areas: evaluation of a screening program in a tertiary care hospital in Barcelona, Spain. Am J Trop Med Hyg 2012; 87: 832-6.
81. Paricio-Talayero JM, Benlloch-Muncharaz MJ, Collar-del-Castillo JI, Rubio-Soriano A, Serrat-Perez C, Magraner-Egea J, et al. Epidemiological surveillance of vertically-transmitted Chagas disease at three maternity hospitals in the Valencian Community. Enferm Infecc Microbiol Clin 2008; 26: 609-13.
82. Polo Vigas I, Martin Salas C, Tordoya Titichoca I, Lopez Sanchez Y, Martinez De Artola V, Ezpeleta Baquedano C,. Diagnosis of Chaga's disease in Navarra, Spain. Clin Microbiol Infect 2012; 18: 705.
83. Ramos JM, Milla A, Rodriguez JC, Lopez-Chejade P, Flores M, Rodriguez JM, et al. Chagas disease in Latin American pregnant immigrants: experience in a non-endemic country. Arch Gynecol Obstet 2012; 285: 919-23.
84. Romero M, Postigo J, Schneider D, Chippaux JP, Santalla JA, Brutus L,. Door-to-door screening as a strategy for the detection of congenital Chagas disease in rural Bolivia. Trop Med Int Health 2011; 16: 562-9.
85. Ruiz BH,. Chagas' disease in the population assisted in Perinatal Hospital of the Buenos Aires city. Rev Hosp Matern Infant Ramon Sarda 1999; 18: 57-60.
86. Russomando G, de Tomassone MM, de Guillen I, Acosta N, Vera N, Almiron M, et al. Treatment of congenital Chagas' disease diagnosed and followed up by the polymerase chain reaction. Am J Trop Med Hyg 1998; 59: 487-91.
87. Russomando G, Almiron M, Candia N, Franco L, Sanchez Z, de Guillen I,. Implementation and evaluation of a locally sustainable system of prenatal diagnosis to detect cases of congenital Chagas disease in endemic areas of Paraguay. Rev Soc Bras Med Trop 2005; 38 (Suppl 2): 49-54.
88. Salas CN, Postigo JR, Schneider D, Santalla JA, Brutus L, Chippaux JP,. Prevalence of Chagas disease in pregnant women and incidence of congenital transmission in Santa Cruz de la Sierra, Bolivia, Acta Trop 2012; 124: 87-91.
89. Salas J, Cabezas T, Munoz MJ, Vazquez J, Martin R, Benitez C, et al. Chagas screening in pregnant women from Latin America: experience in western Almeria. Trop Med Int Health 2011; 16: 288.
90. Sombrero HR, Arnal IO, Carrasco EG,. DO we need the screening of congenital Chagas disease in our country. J Matern Fetal Neonatal Med 2010; 23: 160-1.
91. Sosa-Estani S, Dri L, Touris C, Abalde S,. Dell'arciprete A, Braunstein J. Vectorial and congenital transmission of Trypanosoma cruzi in Las Lomitas, Formosa. Medicina (B Aires) 2009; 69: 424-30.
92. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, Dramaix M, et al. Endemic level of congenital Trypanosoma cruzi infection in the areas of maternal residence and the development of congenital Chagas disease in Bolivia. Rev Soc Bras Med Trop 2005; 38 (Suppl 2): 17-20.