Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis

Journal of Peptide Science

Volumn 20, Issue 1, 2014, Pages 30-35

  Hibino, Hajime ^a   Miki, Yasuyoshi ^b   Nishiuchi, Yuji ^a,c  

^a Peptide Institute Inc   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

4,4 dimethoxydiphenylmethyl (Ddm); 4 methoxybenzyloxymethyl (MBom); cysteine; microwave (MW) assisted solid phase peptide synthesis (SPPS); phosphonium reagent; protecting group; racemization; uronium reagent

Indexed keywords

4 METHOXYBENZYLOXYMETHYL; 4,4' DIMETHOXYDIPHENYLMETHYL; 9 FLUORENYLMETHYOXYCARBONYL; AMINE; AMINO ACID DERIVATIVE; CYSTEINE; ETHYLDIISOPROPYLAMINE; METHYL GROUP; N,N DIMETHYLFORMAMIDE; PHOSPHONIUM DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HIGH TEMPERATURE; MICROWAVE RADIATION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RACEMIZATION; SOLID PHASE SYNTHESIS;

4,4′-DIMETHOXYDIPHENYLMETHYL (DDM); 4-METHOXYBENZYLOXYMETHYL (MBOM); CYSTEINE; MICROWAVE (MW)-ASSISTED SOLID PHASE PEPTIDE SYNTHESIS (SPPS); PHOSPHONIUM REAGENT; PROTECTING GROUP; RACEMIZATION; URONIUM REAGENT;

AMINO ACID SEQUENCE; AMINO ACIDS; DIMETHYLFORMAMIDE; FLUORENES; MICROWAVES; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDES; PIPERIDINES; SOLID-PHASE SYNTHESIS TECHNIQUES; SOLVENTS; STEREOISOMERISM; TRIAZOLES;

EID: 84890995823     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2585     Document Type: Article

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