Low glutamine levels during critical illness - Adaptive or maladaptive?

New England Journal of Medicine

Volumn 368, Issue 16, 2013, Pages 1549-1550

  Van Den Berghe, Greet ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; GLUTAMINE; HEAT SHOCK PROTEIN; PLACEBO;

AMINO ACID SYNTHESIS; CRITICAL ILLNESS; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DRUG EFFECT; EDITORIAL; HUMAN; MORTALITY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC);

EID: 84876339123     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1302301     Document Type: Editorial

References (10)

1. Bongers T, Griffiths RD, McArdle A. Exogenous glutamine: the clinical evidence. Crit Care Med 2007;35:Suppl:S545-S552. (Pubitemid 47312193)
2. Parry-Billings M, Evans J, Calder PC, Newsholme EA. Does glutamine contribute to immunosuppression after major burns? Lancet 1990;336:523-5. (Pubitemid 20278097)
3. Rodas PC, Rooyackers O, Hebert C, Norberg Å, Wernerman J. Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) 2012;122:591-7.
4. Jackson NC, Carroll PV, Russell-Jones DL, Sönksen PH, Treacher DF, Umpleby AM. The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism. Am J Physiol 1999;276:E163-E170. (Pubitemid 29065606)
5. Wernerman J. Clinical use of glutamine supplementation. J Nutr 2008;138:2040S-2044S.
6. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med 2002;30:2022-9.
7. Heyland D, Muscedere J, Wischmeyer PE, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013;368:1489-97.
8. Andrews PJ, Avenell A, Noble DW, et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ 2011;342:d1542.
9. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011; 365:506-17.
10. Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med 2013;187:247-55.