Physiological changes to the swallowing mechanism following (chemo)radiotherapy for head and neck cancer: A systematic review

Dysphagia

Volumn 28, Issue 4, 2013, Pages 481-493

  Wall, Laurelie R ^a,b   Ward, Elizabeth C ^a,b   Cartmill, Bena ^b,c   Hill, Anne J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QUEENSLAND HEALTH   (Australia)

^c PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Deglutition; Deglutition disorders; Head and neck neoplasms; Swallow pathophysiology

Indexed keywords

CARBOPLATIN; DOCETAXEL; FLUOROURACIL; GEMCITABINE; HYDROXYUREA; PACLITAXEL;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLINICAL EVALUATION; COHORT ANALYSIS; COMORBIDITY; DYSPHAGIA; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HYPOPHARYNX; LARYNX; MOUTH CAVITY; OROPHARYNX; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; REVIEW; SWALLOWING; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; CHEMORADIOTHERAPY; DEGLUTITION; DEGLUTITION DISORDERS; HEAD AND NECK NEOPLASMS; HUMANS; LARYNX; PHARYNX; PREVALENCE; RADIOTHERAPY; TONGUE;

EID: 84890959481     PISSN: 0179051X     EISSN: 14320460     Source Type: Journal    
DOI: 10.1007/s00455-013-9491-8     Document Type: Review

References (62)

1. Logemann JA, Smith CH, Pauloski BR, Rademaker AW, Lazarus CL, Colangelo LA, Mittal B, MacCracken E, Gaziano J, Stachowiak L, Newman LA. Effects of xerostomia on perception and performance of swallow function. Head Neck. 2001;23(4):317-21.
2. Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Mittal B, Gaziano J, Stachowiak L, MacCracken E, Newman LA. Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation. Head Neck. 2003;25(6):432-7. doi: 10.1002/hed.10255.
3. Murphy BA, Gilbert J. Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation. Semin Radiat Oncol. 2009;19(1):35-42. doi: 10.1016/j.semradonc.2008.09.007.
4. Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L, Zilberberg MD. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol. 2003;66:253-62. doi: 10.1016/S0167-8140(02)00404-8.
5. Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S. Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Otol. 2004;15(3):383-8. doi: 10.1093/annonc/mdh101.
6. Rosenthal DI, Lewin JS, Eisbruch A. Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol. 2006;24(17):2636-43. doi: 10.1200/JCO.2006.06.0079.
7. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214(2):199-210.
8. Semple CJ, Dunwoody L, George Kernohan W, McCaughan E, Sullivan K. Changes and challenges to patients' lifestyle patterns following treatment for head and neck cancer. J Adv Nurs. 2008;63(1):85-93.
9. Langendijk JA, Doornaert P, Verdonck-de Leeuw LM, Leemans CR, Aaronson NK, Slotman BJ. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol. 2008;26(22):3770-6.
10. McQuestion M, Fitch M, Howell D. The changed meaning of food: physical, social and emotional loss for patients having received radiation treatment for head and neck cancer. Eur J Oncol Nurs. 2011;15(2):145-51.
11. Alfano CM, Rowland JH. Recovery issues in cancer survivorship: a new challenge for supportive care. Cancer J. 2006;12(5):432-43.
12. Roe JWG, Carding PN, Dwivedi RC, Kazi RA, Rhys-Evans PH, Harrington KJ, Nutting CM. Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head & neck cancer: a systematic review. Oral Oncol. 2010;46:727-33. doi: 10.1016/j.oraloncology.2010.07.012.
13. Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S. Impact of dysphagia on quality of life after treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2005;61:772-8.
14. Oates JE, Clark JR, Reed J, Reeves N, Gao K, Jackson M, Boyer M, O'Brien CJ. Prospective evaluation of quality of life and nutrition before and after treatment for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2007;133(6):533-40. doi: 10.1001/archotol.133.6.533.
15. Carroll WR, Locher JL, Canon CL, Bohannon IA, McColloch NL, Magnuson JS. Pretreatment swallowing exercises improve swallow function after chemoradiation. Laryngoscope. 2008;118:39-43. doi: 10.1097/MLG.0b013e31815659b0.
16. Carnaby-Mann G, Crary MA, Schmalfuss I, Amdur R. "Pharyngocise" : randomized controlled trial of preventative exercises to maintain muscle structure and swallowing function during head-and-neck chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2011;83(1):210-9. doi: 10.1016/j.ijrobp.2011.06.1954.
17. Kotz T, Federman AD, Kao J, Milman L, Packer S, Lopez-Prieto C, Forsythe K, Genden EM. Prophylactic swallowing exercises in patients with head and neck cancer undergoing chemoradiation: a randomized trial. Arch Otolaryngol Head Neck Surg. 2012;138(4):376-82.
18. Kulbersh BD, Rosenthal EL, McGrew BM, Duncan RD, McColloch NL, Carroll WR, Magnuson JS. Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life. Laryngoscope. 2006;116:883-6. doi: 10.1097/01.mlg.0000217278.96901.fc.
19. van der Molen L, van Rossman MA, Burkhead LM, Smeele LE, Rasch CRN, Hilgers FJ. A randomised preventive rehabilitation trial in advanced head and neck cancer patients treated with chemoradiotherapy: feasibility, compliance and short-term effects. Dysphagia. 2011;26(2):155-70. doi: 10.1007/s00455-010-9288- y.
20. Roe JWG, Ashforth KM. Prophylactic swallowing exercises for patients receiving radiotherapy for head and neck cancer. Curr Opin Otolaryngol Head Neck Surg. 2011;19(3):144-9.
21. Krisciunas GP, Sokoloff W, Stepas K, Langmore SE. Survey of usual practice: dysphagia therapy in head and neck cancer patients. Dysphagia. 2012;27(4):538-49. doi: 10.1007/s00455-012-9404-2.
22. Roe JWG, Carding PN, Rhys-Evans PH, Newbold KL, Harrington KJ, Nutting CM. Assessment and management of dysphagia in patients with head and neck cancer who receive radiotherapy in the United Kingdom - a web-based survey. Oral Oncol. 2012;48(4):343-8. doi: 10.1016/j.oraloncology.2011.11.003.
23. Frowen J, Perry AR. Swallowing outcomes after radiotherapy for head and neck cancer: a systematic review. Head Neck. 2006;28(10):932-44. doi: 10.1002/hed.20438.
24. Lazarus CL. Effects of chemoradiotherapy on voice and swallowing. Curr Opin Otolaryngol Head Neck Surg. 2009;17:172-8. doi: 10.1097/MOO. 0b013e32832af12f.
25. Platteaux N, Dirix P, Dejaeger E, Nuyts S. Dysphagia in head and neck cancer patients treated with chemoradiotherapy. Dysphagia. 2010;25:139-52. doi: 10.1007/s00455-009-9247-7.
26. Russi EG, Corvo R, Merlotti A, Alterio D, Franco P, Pergolizzi S, De Sanctis V, Redda MGR, Ricardi U, Paiar F, Bonomo P, Merlano MC, Zurlo V, Chiesa F, Sanguineti G, Bernier J. Swallowing dysfunction in head and neck cancer patients treated by radiotherapy: review and recommendations of the supportive task group of the Italian Association of Radiation Oncology. Cancer Treat Rev. 2012;38:1033-49.
27. van der Molen L, van Rossman MA, Burkhead LM, Smeele LE, Hilgers FJ. Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otolaryngol. 2009;266:889-900. doi: 10.1007/s00405-008-0817-3.
28. Bleier BS, Levine MS, Mick R, Rubesin SE, Sack SZ, McKinney K, Mirza N. Dysphagia after chemoradiation: analysis by modified barium swallow. Ann Otol Rhinol Laryngol. 2007;116(11):837-41.
29. Cartmill B, Cornwell P, Ward E, Davidson W, Porceddu S. A prospective investigation of swallowing, nutrition, and patient-related functional impact following altered fractionation radiotherapy with concomitant boost for oropharyngeal cancer. Dysphagia. 2012;27(1):32-45. doi: 10.1007/s00455-011-9333- 5.
30. Cartmill B, Cornwell P, Ward E, Davidson W, Porceddu S. Swallowing, nutrition and patient-rated functional outcomes at 6 months following two non-surgical treatments for T1-T3 oropharyngeal cancer. Support Cancer Care. 2012;20:2073-81. doi: 10.1007/s00520-011-1316-4.
31. Eisbruch A, Lyden T, Bradford CR, Dawson LA, Haxer MJ, Miller AE, Teknos TN, Chepeha DB, Hogikyan ND, Terrell JE, Wolf GT. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53(1):23-8. doi: S0360-3016(02)02712-8.
32. Eisbruch A, Schwartz M, Rasch C, Vineberg K, Damen E, Van As CJ, Marsh R, Pameuer FA, Balm AJM. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol Biol Phys. 2004;60(5):1425-39. doi: 10.1016/j.ijrobp.2004.05.050.
33. Feng FY, Kim HM, Lyden TH, Haxer MJ, Feng M, Worden FP, Chepeha DB, Eisbruch A. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2007;68(5):1289-98. doi: 10.1016/j.ijrobp.2007. 02.049.
34. Goguen LA, Posner MR, Norris CM, Tishler RB, Wirth LJ, Annino DJ, Gagne A, Sullivan CA, Sammartino DE, Haddad RI. Dysphagia after sequential chemoradiation therapy for advanced head and neck cancer. Otolaryngol Head Neck Surg. 2006;134(6):916-22. doi: 10.1016/j.otohns.2006.02.001.
35. Graner DE, Foote RL, Kasperbauer JL, Stoeckel RE, Okuno SH, Olsen KD, Sabri AN, Maragos NE, Cha SS, Sargent DJ, Strone SE. Swallow function in patients before and after intra-arterial chemoradiation. Laryngoscope. 2003;113:573-9.
36. Hutcheson KA, Barringer DA, Rosenthal DI, May AH, Roberts DB, Lewin JS. Swallowing outcomes after radiotherapy for laryngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2008;134(2):178-83.
37. Hutcheson KA, Lewin JS, Barringer DA, Lisec A, Gunn GB, Moore MW, Holsinger FC. Late dysphagia after radiotherapy-based treatment of head and neck cancer. Cancer. 2012;118(23):5793-9. doi: 10.1002/cncr.27631.
38. Kendall KA, McKenzie SW, Leonard RJ, Jones C. Structural mobility in deglutition after single modality treatment of head and neck carcinomas with radiotherapy. Head Neck. 1998;20:720-5.
39. Kendall KA, McKenzie SW, Leonard RJ, Jones C. Timing of swallowing events after single-modality treatment of head and neck carcinomas with radiotherapy. Ann Otol Rhinol Laryngol. 2000;109:767-75.
40. Kotz T, Abraham S, Beitler JJ, Wadler S, Smith RV. Pharyngeal transport dysfunction consequent to an organ-sparing protocol. Arch Otolaryngol Head Neck Surg. 1999;125:410-3.
41. Kotz T, Costello R, Li Y, Posner MR. Swallowing dysfunction after chemoradiation for advanced squamous cell carcinoma of the head and neck. Head Neck. 2004;26(4):365-72.
42. Lal P, Tiwari A, Verma A, Maria Das KJ, Baijal SS, Bajpai R, Jumar P, Srivastava A, Kumar S. Role of videofluorography in assessing functional abnormalities in patients of head and neck cancer treated with chemoradiotherapy. Asia Pac J Clin Oncol. 2009;5(4):264-9. doi: 10.1111/j.1743-7563.2009.01241.x.
43. Logemann JA, Rademaker AW, Pauloski BR, Lazarus CL, Mittal B, Brockstein B, MacCracken E, Haraf DJ, Vokes EE, Newman LA, Liu D. Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck. 2006;28(1):64-73. doi: 10.1002/hed.20299.
44. Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Gaziano J, Stachowiak L, Newman L, MacCracken E, Santa D, Mittal B. Swallowing disorders in the first year after radiation and chemoradiation. Head Neck. 2007;30(9):148-58. doi: 10.1002/hed.20672.
45. Newman LA, Robbins KT, Logemann JA, Rademaker AW, Lazarus CL, Hamner A, Tusant S, Huang CF. Swallowing and speech ability after treatment for head and neck cancer with targeted intra-arterial versus intravenous chemoradiation. Head Neck. 2002;24(1):68-77. doi: 10.1002/hed.10000.
46. Pauloski BR, Rademaker AW, Logemann JA, Newman L, MacCracken E, Gaziano J, Stachowiak L. Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck. 2006;28(12):1069-76. doi: 10.1002/hed.20459.
47. Smith RV, Kotz T, Beitler JJ, Wadler S. Long-term swallowing problems after organ preservation therapy with concomitant radiation therapy and intravenous hydroxyurea. Arch Otolaryngol Head Neck Surg. 2000;126(3):384-9.
48. Des Jarlais DC, Lyles C, Crepaz N. Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement. Am J Public Health. 2004;94:361-6.
49. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.
50. Ogilvie D, Fayter D, Petticrew M, Sowden A, Thomas S, Whitehead M, Worthy G. The harvest plot: a method for synthesising evidence about the differential effects of interventions. BMC Med Res Methodol. 2008;8(2):8-14. doi: 10.1186/1471-2288-8-8.
51. Crowther M, Avenell A, MacLennan G, Mowatt G. A further use for the harvest plot: a novel method for the presentation of data synthesis. Res Synth Methods. 2011;2:79-83. doi: 10.1002/jrsm.37.
52. Leopold NA, Kagel MC. Pharyngo-esophageal dysphagia in Parkinson's disease. Dysphagia. 1997;12:11-8.
53. Cartmill B, Cornwell P, Ward E, Davidson W, Nund R, Bettington C, Rahbari RM, Poulsen M, Porceddu S. Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer. Head Neck. 2013;35(8):1211-9. doi: 10.1002/hed.23040.
54. Duprez F, Madani I, De Potter B, Boterberg T, De Neve W. Systematic review of dose-volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer. Dysphagia. 2013;28(3):337-49. doi: 10.1007/s00455-013-9452-2.
55. Fajardo LF, Berthrong M, Anderson RE. Alimentary tract. In: Fajardo LF, editor. Radiation pathology. Oxford: Oxford University Press; 2001. p. 209-17.
56. Popovtzer A, Cao Y, Feng FY, Eisbruch A. Anatomical changes in the pharyngeal constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study. Radiother Oncol. 2009;93(3):510-5. doi: 10.1016/j.radonc.2009.05.013.
57. Chang Y, Chen S, Lui LT, Wang T, Wang T, Hsiao T, Li Y, Lien I. Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study. Dysphagia. 2003;18(2):135-43. doi: 10.1007/s00455-002-0096-x.
58. Dworkin JP, Hill SL, Stachler RJ, Meleca RJ, Kewson D. Swallowing function outcomes following nonsurgical therapy for advanced-stage laryngeal carcinoma. Dysphagia. 2006;21(1):66-74. doi: 10.1007/s00455-005-9001-8.
59. Martin M, Lefaix J, Delanian S. TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys. 2000;47:277-90.
60. Eisele DW, Koch DG, Tarazi AE, Jones B. Aspiration from delayed radiation fibrosis of the neck. Dysphagia. 1991;6:120-2.
61. Denham JW, Peters LJ, Johansen J, Poulsen M, Lamb DS, Hindley A, O'Brien PC, Spry NA, Penniment M, Krawitz H, Williamson S, Bear J, Tripcony L. Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer? Radiother Oncol. 1999;52(2):157-64. doi: 10.1016/S0167-8140(99) 00107-3.
62. Dörr W, Hendry JH. Consequential late effects in normal tissues. Radiother Oncol. 2001;61(3):223-31. doi: 10.1016/S0167-8140(01)00429-7.