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Volumn 21, Issue 1, 2014, Pages 74-79

Epidermal growth factor receptor inhibitors: Coming of age

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CETUXIMAB; CISPLATIN; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; TUMOR MARKER;

EID: 84890956894     PISSN: 10732748     EISSN: 15262359     Source Type: Journal    
DOI: 10.1177/107327481402100111     Document Type: Article
Times cited : (56)

References (68)
  • 1
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer. 2001;37 (suppl 4):S3-S8.
    • (2001) Eur J Cancer. , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 2
    • 36048985044 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From development to tumorigenesis
    • Sibilia M, Kroismayr R, Lichtenberger BM, et al. The epidermal growth factor receptor: from development to tumorigenesis. Differentiation. 2007;75(9):770-787.
    • (2007) Differentiation. , vol.75 , Issue.9 , pp. 770-787
    • Sibilia, M.1    Kroismayr, R.2    Lichtenberger, B.M.3
  • 3
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol. 2003;21(14):2787-2799.
    • (2003) J Clin Oncol. , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 4
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An openlabel randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an openlabel randomised phase III trial. Lancet. 2009;373(9674):1525-1531.
    • (2009) Lancet. , vol.373 , Issue.9674 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 5
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
    • Pirker R, Pereira JR, von Pawel J, et al. EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol. 2012;13(1):33-42.
    • (2012) Lancet Oncol. , vol.13 , Issue.1 , pp. 33-42
    • Pirker, R.1    Pereira, J.R.2    von Pawel, J.3
  • 6
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial)
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial). J Clin Oncol. 2003;21(12):2237-2246.
    • (2003) J Clin Oncol. , vol.21 , Issue.12 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 7
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003;290(16):2149-2158.
    • (2003) JAMA. , vol.290 , Issue.16 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 8
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced nonsmall-cell lung cancer
    • Miller VA, Kris MG, Shah N, et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced nonsmall-cell lung cancer. J Clin Oncol. 2004;22(6):1103-1109.
    • (2004) J Clin Oncol. , vol.22 , Issue.6 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 9
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101(36):13306-13311.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 10
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304 (5676):1497-1500.
    • (2004) Science. , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 11
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366(9496):1527-1537.
    • (2005) Lancet. , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 12
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10):947-957.
    • (2009) N Engl J Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 13
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • West Japan Oncology Group
    • Mitsudomi T, Morita S, Yatabe Y, et al; West Japan Oncology Group. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11(2):121-128.
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 14
    • 34250694236 scopus 로고    scopus 로고
    • Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
    • Li J, Zhao M, He P, et al. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007;13(12):3731-3737.
    • (2007) Clin Cancer Res. , vol.13 , Issue.12 , pp. 3731-3737
    • Li, J.1    Zhao, M.2    He, P.3
  • 15
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated nonsmall-cell lung cancer
    • National Cancer Institute of Canada Clinical Trials Group
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated nonsmall-cell lung cancer. N Engl J Med. 2005;353(2):123-132.
    • (2005) N Engl J Med. , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 16
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer: Molecular and clinical predictors of outcome
    • Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer: molecular and clinical predictors of outcome. N Engl J Med. 2005;353(2):133-144.
    • (2005) N Engl J Med. , vol.353 , Issue.2 , pp. 133-144
    • Tsao, M.S.1    Sakurada, A.2    Cutz, J.C.3
  • 17
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutationpositive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica
    • Rosell R, Carcereny E, Gervais R, et al; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutationpositive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13(3):239-246.
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 18
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12(8):735-742.
    • (2011) Lancet Oncol. , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 19
    • 84878471164 scopus 로고    scopus 로고
    • Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC)
    • Chen G, Feng J, Zhou C, et al. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol. 2013; 24(6):1615-1622.
    • (2013) Ann Oncol. , vol.24 , Issue.6 , pp. 1615-1622
    • Chen, G.1    Feng, J.2    Zhou, C.3
  • 20
    • 80755181069 scopus 로고    scopus 로고
    • Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebocontrolled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
    • Brugger W, Triller N, Blasinska-Morawiec M, et al. Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebocontrolled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol. 2011;29(31):4113-4120.
    • (2011) J Clin Oncol. , vol.29 , Issue.31 , pp. 4113-4120
    • Brugger, W.1    Triller, N.2    Blasinska-Morawiec, M.3
  • 21
    • 70349477817 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • Miller VA, O'Connor P, Soh C, et al. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(18 suppl):LBA8002.
    • (2009) J Clin Oncol. , vol.27 , Issue.18 SUPPL.
    • Miller, V.A.1    O'Connor, P.2    Soh, C.3
  • 22
    • 2942511506 scopus 로고    scopus 로고
    • Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models
    • Higgins B, Kolinsky K, Smith M, et al. Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models. Anticancer Drugs. 2004;15(5):503-512.
    • (2004) Anticancer Drugs. , vol.15 , Issue.5 , pp. 503-512
    • Higgins, B.1    Kolinsky, K.2    Smith, M.3
  • 23
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial--INTACT 1
    • Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1. J Clin Oncol. 2004;22(5):777-784.
    • (2004) J Clin Oncol. , vol.22 , Issue.5 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 24
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial--INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2. J Clin Oncol. 2004;22(5):785-794.
    • (2004) J Clin Oncol. , vol.22 , Issue.5 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 25
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • TRIBUTE Investigator Group
    • Herbst RS, Prager D, Hermann R, et al; TRIBUTE Investigator Group. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol. 2005;23(25):5892-5899.
    • (2005) J Clin Oncol. , vol.23 , Issue.25 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 26
    • 34248140107 scopus 로고    scopus 로고
    • Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-smallcell lung cancer: The Tarceva Lung Cancer Investigation Trial
    • Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-smallcell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007;25(12):1545-1552.
    • (2007) J Clin Oncol. , vol.25 , Issue.12 , pp. 1545-1552
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 27
    • 24944578615 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: Case closed or is the jury still out?
    • Gandara DR, Gumerlock PH. Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: case closed or is the jury still out? J Clin Oncol. 2005;23(25):5856-5858.
    • (2005) J Clin Oncol. , vol.23 , Issue.25 , pp. 5856-5858
    • Gandara, D.R.1    Gumerlock, P.H.2
  • 28
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27(34):4702-4711.
    • (2008) Oncogene. , vol.27 , Issue.34 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 29
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012;13(5):528-538.
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 30
    • 84866655838 scopus 로고    scopus 로고
    • LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
    • Yang JC-H, Schuler MH, Yamamoto N, et al. LUX-Lung 3: a randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol. 2012;39(18 suppl):LBA7500.
    • (2012) J Clin Oncol. , vol.39 , Issue.18 SUPPL.
    • Yang, J.C.-H.1    Schuler, M.H.2    Yamamoto, N.3
  • 31
    • 84879290901 scopus 로고    scopus 로고
    • Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • Lindeman NI, Cagle PT, Beasley MB, et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Molec Diagnostics. 2013;15(4):415-453.
    • (2013) J Molec Diagnostics. , vol.15 , Issue.4 , pp. 415-453
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3
  • 33
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall-cell lung cancer
    • Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall-cell lung cancer. J Clin Oncol. 2010;28(2):357-360.
    • (2010) J Clin Oncol. , vol.28 , Issue.2 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 34
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005; 352(8):786-792.
    • (2005) N Engl J Med. , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 35
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su KY, Chen HY, Li KC, et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol. 2012;30(4):433-440.
    • (2012) J Clin Oncol. , vol.30 , Issue.4 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3
  • 36
    • 84861203302 scopus 로고    scopus 로고
    • EGFR-mutated oncogene-addicted non-small cell lung cancer: Current trends and future prospects
    • Soria JC, Mok TS, Cappuzzo F, et al. EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects. Cancer Treat Rev. 2012;38(5):416-430.
    • (2012) Cancer Treat Rev. , vol.38 , Issue.5 , pp. 416-430
    • Soria, J.C.1    Mok, T.S.2    Cappuzzo, F.3
  • 37
    • 79959732370 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer
    • Yarom N, Jonker DJ. The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov Med. 2011; 11(57):95-105.
    • (2011) Discov Med. , vol.11 , Issue.57 , pp. 95-105
    • Yarom, N.1    Jonker, D.J.2
  • 38
    • 33646143020 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • Townsley CA, Major P, Siu LL, et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Br J Cancer. 2006;94(8): 1136-1143.
    • (2006) Br J Cancer. , vol.94 , Issue.8 , pp. 1136-1143
    • Townsley, C.A.1    Major, P.2    Siu, L.L.3
  • 39
    • 33644822287 scopus 로고    scopus 로고
    • Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
    • Rothenberg ML, LaFleur B, Levy DE, et al. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol. 2005;23(36):9265-9274.
    • (2005) J Clin Oncol. , vol.23 , Issue.36 , pp. 9265-9274
    • Rothenberg, M.L.1    LaFleur, B.2    Levy, D.E.3
  • 40
    • 33646361363 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer
    • Meyerhardt JA, Zhu AX, Enzinger PC, et al. Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer. J Clin Oncol. 2006;24(12):1892-1897.
    • (2006) J Clin Oncol. , vol.24 , Issue.12 , pp. 1892-1897
    • Meyerhardt, J.A.1    Zhu, A.X.2    Enzinger, P.C.3
  • 41
    • 58149242890 scopus 로고    scopus 로고
    • A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer
    • Fisher GA, Kuo T, Ramsey M, et al. A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer. Clin Cancer Res. 2008;14(21):7074-7079.
    • (2008) Clin Cancer Res. , vol.14 , Issue.21 , pp. 7074-7079
    • Fisher, G.A.1    Kuo, T.2    Ramsey, M.3
  • 42
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, O'Callaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med. 2007;357(20):2040-2048.
    • (2007) N Engl J Med. , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 43
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351(4):337-345.
    • (2004) N Engl J Med. , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 44
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Köhne CH, Láng I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29(15):2011-2019.
    • (2011) J Clin Oncol. , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Köhne, C.H.2    Láng, I.3
  • 45
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
    • B okemeyer C, Bondarenko I, Hartmann JT, et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol. 2011;22(7): 1535-1546.
    • (2011) Ann Oncol. , vol.22 , Issue.7 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3
  • 46
    • 84861432557 scopus 로고    scopus 로고
    • Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: The NORDIC-VII study
    • T veit KM, Guren T, Glimelius B, et al. Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol. 2012;30(15):1755-1762.
    • (2012) J Clin Oncol. , vol.30 , Issue.15 , pp. 1755-1762
    • Tveit, K.M.1    Guren, T.2    Glimelius, B.3
  • 47
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • MRC COIN Trial Investigators
    • M aughan TS, Adams RA, Smith CG, et al; MRC COIN Trial Investigators. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet. 2011;377(9783):2103-2114.
    • (2011) Lancet. , vol.377 , Issue.9783 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 48
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • V an Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25(13):1658-1664.
    • (2007) J Clin Oncol. , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 49
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • D ouillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010;28(31):4697-4705.
    • (2010) J Clin Oncol. , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 50
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
    • P eeters M, Price TJ, Cervantes A, et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol. 2010;28(31):4706-4713.
    • (2010) J Clin Oncol. , vol.28 , Issue.31 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 51
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • S altz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol. 2007;25(29):4557-4561.
    • (2007) J Clin Oncol. , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3
  • 52
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • T ol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360(6): 563-572.
    • (2009) N Engl J Med. , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 53
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • H echt JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672-680.
    • (2009) J Clin Oncol. , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 54
    • 84860785653 scopus 로고    scopus 로고
    • Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer
    • S altz L, Badarinath S, Dakhil S, et al. Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer. Clin Colorectal Cancer. 2012;11(2):101-111.
    • (2012) Clin Colorectal Cancer. , vol.11 , Issue.2 , pp. 101-111
    • Saltz, L.1    Badarinath, S.2    Dakhil, S.3
  • 55
    • 84859403854 scopus 로고    scopus 로고
    • Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: A randomized trial
    • A lberts SR, Sargent DJ, Nair S, et al. Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: a randomized trial. JAMA. 2012;307(13): 1383-1393.
    • (2012) JAMA. , vol.307 , Issue.13 , pp. 1383-1393
    • Alberts, S.R.1    Sargent, D.J.2    Nair, S.3
  • 56
    • 84863993927 scopus 로고    scopus 로고
    • Explaining the unexplainable: EGFR antibodies in colorectal cancer
    • G rothey A, Lenz HJ. Explaining the unexplainable: EGFR antibodies in colorectal cancer. J Clin Oncol. 2012;30(15):1735-1737.
    • (2012) J Clin Oncol. , vol.30 , Issue.15 , pp. 1735-1737
    • Grothey, A.1    Lenz, H.J.2
  • 57
    • 84874641687 scopus 로고    scopus 로고
    • Metastatic colon cancer, version 3.2013: Featured updates to the NCCN Guidelines
    • Benson AB 3rd, Bekaii-Saab T, Chan E, et al. Metastatic colon cancer, version 3.2013: featured updates to the NCCN Guidelines. J Natl Compr Canc Netw. 2013;11(2):141-152.
    • (2013) J Natl Compr Canc Netw. , vol.11 , Issue.2 , pp. 141-152
    • Benson III, A.B.1    Bekaii-Saab, T.2    Chan, E.3
  • 58
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • B onner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006; 354(6):567-578.
    • (2006) N Engl J Med. , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 59
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Eastern Cooperative Oncology Group, Erratum in J Clin Oncol. 2006;24(4):724
    • B urtness B, Goldwasser MA, Flood W, et al; Eastern Cooperative Oncology Group. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study [Erratum in J Clin Oncol. 2006;24(4):724]. J Clin Oncol. 2005;23(34):8646-8654.
    • (2005) J Clin Oncol. , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3
  • 60
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • V ermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359(11): 1116-1127.
    • (2008) N Engl J Med. , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 61
    • 34347395051 scopus 로고    scopus 로고
    • A phase III randomized parallelgroup study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck
    • Presented at the, Los Angeles, CA, April 14-18
    • S tewart JS, Cohen E, Licitra L et al. A phase III randomized parallelgroup study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck. Presented at the 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, April 14-18, 2007.
    • (2007) 98th Annual Meeting of the American Association for Cancer Research
    • Stewart, J.S.1    Cohen, E.2    Licitra, L.3
  • 62
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • S oulieres D, Senzer NN, Vokes EE, et al. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol. 2004;22(1):77-85.
    • (2004) J Clin Oncol. , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3
  • 63
    • 84862788906 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor expression on patient survival in pancreatic cancer: A meta-analysis
    • L uo G, Long J, Qiu L, et al. Role of epidermal growth factor receptor expression on patient survival in pancreatic cancer: a meta-analysis. Pancreatology. 2011;11(6):595-600.
    • (2011) Pancreatology. , vol.11 , Issue.6 , pp. 595-600
    • Luo, G.1    Long, J.2    Qiu, L.3
  • 64
    • 84864052249 scopus 로고    scopus 로고
    • Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma
    • M ahipal A, Mcdonald MJ, Witkiewicz A, et al. Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma. Med Oncol. 2012;29(1):134-139.
    • (2012) Med Oncol. , vol.29 , Issue.1 , pp. 134-139
    • Mahipal, A.1    McDonald, M.J.2    Witkiewicz, A.3
  • 65
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • P hilip PA, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol. 2010;28(22):3605-3610.
    • (2010) J Clin Oncol. , vol.28 , Issue.22 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 66
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • National Cancer Institute of Canada Clinical Trials Group
    • M oore MJ, Goldstein D, Hamm J, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25(15):1960-1966.
    • (2007) J Clin Oncol. , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 67
    • 77950495095 scopus 로고    scopus 로고
    • Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer
    • L acouture ME, Mitchell EP, Piperdi B, et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol. 2010;28(8):1351-1357.
    • (2010) J Clin Oncol. , vol.28 , Issue.8 , pp. 1351-1357
    • Lacouture, M.E.1    Mitchell, E.P.2    Piperdi, B.3
  • 68
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Erratum appears in N Engl J Med. 2009;360(15):1579
    • C iardiello F, Tortora G. EGFR antagonists in cancer treatment [Erratum appears in N Engl J Med. 2009;360(15):1579]. N Engl J Med. 2008;358(11):1160-1174.
    • (2008) N Engl J Med. , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2


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