메뉴 건너뛰기




Volumn 3, Issue , 2013, Pages

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; MESSENGER RNA; MYC PROTEIN; MYCN PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

EID: 84890949034     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03450     Document Type: Article
Times cited : (63)

References (44)
  • 1
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • DOI 10.1038/nrc1014
    • Brodeur, G. M. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev. Cancer 3, 203-216 (2003). (Pubitemid 37328872)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.3 , pp. 203-216
    • Brodeur, G.M.1
  • 3
    • 79952098597 scopus 로고    scopus 로고
    • Oncogenic mutations of ALK in neuroblastoma
    • Ogawa, S., Takita, J., Sanada, M. & Hayashi, Y. Oncogenic mutations of ALK in neuroblastoma. Cancer Sci. 102, 302-308 (2011).
    • (2011) Cancer Sci. , vol.102 , pp. 302-308
    • Ogawa, S.1    Takita, J.2    Sanada, M.3    Hayashi, Y.4
  • 4
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
    • Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E. & Bishop, J. M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224, 1121-4 (1984). (Pubitemid 14106392)
    • (1984) Science , vol.224 , Issue.4653 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3
  • 5
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger, R. C. et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 13, 1111-6 (1985). (Pubitemid 16216827)
    • (1985) New England Journal of Medicine , vol.313 , Issue.18 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3
  • 6
    • 0021705664 scopus 로고
    • Activated expression of the N-myc gene in human neuroblastomas and related tumors
    • Kohl, N. E., Gee, C. E. & Alt, F. W. Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science 226, 1335-7 (1984). (Pubitemid 15215589)
    • (1984) Science , vol.226 , Issue.4680 , pp. 1335-1337
    • Kohl, N.E.1    Gee, C.E.2    Alt, F.W.3
  • 8
    • 0029743372 scopus 로고    scopus 로고
    • Conditional expression of N-myc in human neuroblastoma cells increases expression of α-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells
    • Lutz, W. et al. Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells. Oncogene 13, 803-12 (1996). (Pubitemid 26312908)
    • (1996) Oncogene , vol.13 , Issue.4 , pp. 803-812
    • Lutz, W.1    Stohr, M.2    Schurmann, J.3    Wenzel, A.4    Lohr, A.5    Schwab, M.6
  • 9
    • 0022908929 scopus 로고
    • N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma
    • Bernards, R., Dessain, S. K. &Weinberg, R. A. N-myc amplification causes downmodulation of MHC class I antigen expression in neuroblastoma. Cell 47, 667-74 (1986). (Pubitemid 17011410)
    • (1986) Cell , vol.47 , Issue.5 , pp. 667-674
    • Bernards, R.1    Dessain, S.K.2    Weinberg, R.A.3
  • 11
    • 54049121408 scopus 로고    scopus 로고
    • MYCN downregulates integrin alpha1 to promote invasion of human neuroblastoma cells
    • Tanaka, N. & Fukuzawa, M. MYCN downregulates integrin alpha1 to promote invasion of human neuroblastoma cells. Int. J. Oncol. 33, 815-2 (2008).
    • (2008) Int. J. Oncol. , vol.33 , pp. 815-822
    • Tanaka, N.1    Fukuzawa, M.2
  • 12
    • 0030999641 scopus 로고    scopus 로고
    • Targeted expression of MYCN causes neuroblastoma in transgenic mice
    • DOI 10.1093/emboj/16.11.2985
    • Weiss, W. A., Aldape, K., Mohapatra, G., Feuerstein, B. G. & Bishop, J. M. Targeted expression ofMYCNcauses neuroblastoma in transgenic mice. EMBO J. 16, 2985-95 (1997). (Pubitemid 27234938)
    • (1997) EMBO Journal , vol.16 , Issue.11 , pp. 2985-2995
    • Weiss, W.A.1    Aldape, K.2    Mohapatra, G.3    Feuerstein, B.G.4    Bishop, J.M.5
  • 13
    • 0026519022 scopus 로고
    • Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein
    • Alex, R., Sozeri, O., Meyer, S. & Dildrop, R. Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res. 20, 2257-63 (1992).
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2257-2263
    • Alex, R.1    Sozeri, O.2    Meyer, S.3    Dildrop, R.4
  • 14
    • 0026936825 scopus 로고
    • Regulation of Myc: Max complex formation and its potential role in cell proliferation
    • Blackwood, E. M. & Eisenman, R. N. Regulation of Myc: Max complex formation and its potential role in cell proliferation. Tohoku J. Exp. Med. 168, 195-202 (1992).
    • (1992) Tohoku J. Exp. Med. , vol.168 , pp. 195-202
    • Blackwood, E.M.1    Eisenman, R.N.2
  • 16
    • 33750475218 scopus 로고    scopus 로고
    • Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
    • De Preter, K. et al. Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biol. 7, R84 (2006).
    • (2006) Genome Biol. , vol.7
    • De Preter, K.1
  • 18
    • 54049118823 scopus 로고    scopus 로고
    • Oncogenic mutations of ALK kinase in neuroblastoma
    • Chen, Y. et al.Oncogenic mutations of ALK kinase in neuroblastoma. Nature 455, 971-974 (2008).
    • (2008) Nature , vol.455 , pp. 971-974
    • Chen, Y.1
  • 19
    • 54049120220 scopus 로고    scopus 로고
    • Activating mutations in ALK provide a therapeutic target in neuroblastoma
    • George, R. E. et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 455, 975-978 (2008).
    • (2008) Nature , vol.455 , pp. 975-978
    • George, R.E.1
  • 20
    • 54049149961 scopus 로고    scopus 로고
    • Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    • Janoueix-Lerosey, I. et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 455, 967-970 (2008).
    • (2008) Nature , vol.455 , pp. 967-970
    • Janoueix-Lerosey, I.1
  • 21
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as a major familial neuroblastoma predisposition gene
    • Mosse, Y. P. et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455, 930-5 (2008).
    • (2008) Nature , vol.455 , pp. 930-935
    • Mosse, Y.P.1
  • 22
    • 58149289668 scopus 로고    scopus 로고
    • High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours
    • Caren, H., Abel, F., Kogner, P. & Martinsson, T. High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours. Biochem. J. 416, 153-159 (2008).
    • (2008) Biochem. J. , vol.416 , pp. 153-159
    • Caren, H.1    Abel, F.2    Kogner, P.3    Martinsson, T.4
  • 23
    • 70349733112 scopus 로고    scopus 로고
    • Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients
    • Passoni, L. et al. Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients. Cancer Res. 69, 7338-7346 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 7338-7346
    • Passoni, L.1
  • 24
    • 84857202050 scopus 로고    scopus 로고
    • High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome
    • Duijkers, F. A. et al. High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. Am. J. Pathol. 180, 1223-3 (2012).
    • (2012) Am. J. Pathol. , vol.180 , pp. 1223-1233
    • Duijkers, F.A.1
  • 25
    • 77956244494 scopus 로고    scopus 로고
    • Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
    • De Brouwer, S. et al. Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification. Clin. Cancer Res. 16, 4353-62 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4353-4362
    • De Brouwer, S.1
  • 26
    • 79961002472 scopus 로고    scopus 로고
    • High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma
    • Schulte, J. H. et al. High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma. Clin. Cancer Res. 17, 5082-92 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5082-5092
    • Schulte, J.H.1
  • 27
    • 82955187719 scopus 로고    scopus 로고
    • Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma
    • Di Paolo, D. et al. Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma. Mol. Ther. 19, 2201-12 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 2201-2212
    • Di Paolo, D.1
  • 28
    • 0026541828 scopus 로고
    • 59 Flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and trans synaptic expression in transgenic mice
    • Banerjee, S. A.,Hoppe, P., Brilliant, M.&Chikaraishi, D. M. 59 Flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and trans synaptic expression in transgenic mice. J. Neurosci. 12, 4460-4467 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 4460-4467
    • Banerjee, S.A.1    Hoppe, P.2    Brilliant, M.3    Chikaraishi, D.M.4
  • 29
    • 80455162361 scopus 로고    scopus 로고
    • Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma
    • Akter, J. et al. Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma. Clin. Cancer Res. 17, 6681-92 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6681-6692
    • Akter, J.1
  • 31
    • 0021947043 scopus 로고
    • Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
    • DOI 10.1038/313404a0
    • Thiele, C. J., Reynolds, C. P. & Israel, M. A. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature 313, 404-406 (1985). (Pubitemid 15198727)
    • (1985) Nature , vol.313 , Issue.6001 , pp. 404-406
    • Thiele, C.J.1    Reynolds, C.P.2    Israel, M.A.3
  • 32
    • 0035161671 scopus 로고    scopus 로고
    • Downregulation of hASH1 is associated with the retinoic acidinduced differentiation of human neuroblastoma cell lines
    • Ichimiya, S. et al. Downregulation of hASH1 is associated with the retinoic acidinduced differentiation of human neuroblastoma cell lines. Med. Pediatr. Oncol. 36, 132-4 (2001).
    • (2001) Med. Pediatr. Oncol. , vol.36 , pp. 132-134
    • Ichimiya, S.1
  • 33
    • 77956415439 scopus 로고    scopus 로고
    • All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK
    • Futami, H. & Sakai, R. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer Let. 297, 220-225 (2010).
    • (2010) Cancer Let. , vol.297 , pp. 220-225
    • Futami, H.1    Sakai, R.2
  • 34
    • 0030908377 scopus 로고    scopus 로고
    • Myc target genes
    • DOI 10.1016/S0968-0004(97)01025-6, PII S0968000497010256
    • Grandori, C. & Eisenman, R. N. Myc target genes. Trends Biochem. Sci. 22, 177-181 (1997). (Pubitemid 27199319)
    • (1997) Trends in Biochemical Sciences , vol.22 , Issue.5 , pp. 177-181
    • Grandori, C.1    Eisenman, R.N.2
  • 35
    • 78049298226 scopus 로고    scopus 로고
    • PHOX2B-mediated regulation of ALK expression: In vitro identification of a functional relationship between two genes involved in neuroblastoma
    • Bachetti, T. et al. PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma. PLoS One 5, e13108 (2010).
    • (2010) PLoS One , vol.5
    • Bachetti, T.1
  • 36
    • 84871212519 scopus 로고    scopus 로고
    • Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells
    • Schonheer, C. et al. Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene 31, 5193-5200 (2012).
    • (2012) Oncogene , vol.31 , pp. 5193-5200
    • Schonheer, C.1
  • 37
    • 84863753157 scopus 로고    scopus 로고
    • The ALKF1174L mutation potentiates the oncogenic activity ofMYCN in neuroblastoma
    • Berry, T. et al. The ALKF1174L mutation potentiates the oncogenic activity ofMYCN in neuroblastoma. Cancer Cell 22, 117-130 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 117-130
    • Berry, T.1
  • 39
    • 79954591415 scopus 로고    scopus 로고
    • The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma
    • Huang, P. et al. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 71, 2938-48 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 2938-2948
    • Huang, P.1
  • 40
    • 84865712154 scopus 로고    scopus 로고
    • NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo
    • Hossain, S. et al. NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo. Cancer Res. 72, 4587-96 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 4587-4596
    • Hossain, S.1
  • 42
    • 84863569496 scopus 로고    scopus 로고
    • Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
    • Heukamp, L.C. et al. Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Sci. Trans. Med. 4, 141ra91 (2012).
    • (2012) Sci. Trans. Med. , vol.4 , pp. 141-191
    • Heukamp, L.C.1
  • 43
    • 79955964568 scopus 로고    scopus 로고
    • CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
    • Sakamoto, H. et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell 19, 679-690 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 679-690
    • Sakamoto, H.1
  • 44
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen, J. G. et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol. Cancer Ther. 6, 3314-22 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 3314-3322
    • Christensen, J.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.