Adaptive mutations in the nuclear export protein of human-derived H5N1 strains facilitate a polymerase activity-enhancing conformation

Journal of Virology

Volumn 88, Issue 1, 2014, Pages 263-271

  Reuther, Peter ^a,b   Giese, Sebastian ^a   Götz, Veronika ^a   Kilb, Normann ^a   Mänz, Benjamin ^a,c   Brunotte, Linda ^a   Schwemmle, Martin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; NONSTRUCTURAL PROTEIN 2; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG; VIRUS POLYMERASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; INFLUENZA VIRUS A H5N1; LOW TEMPERATURE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

CELL NUCLEUS; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; TEMPERATURE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84890924311     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01495-13     Document Type: Article

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