Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies

Pediatric Blood and Cancer

Volumn 61, Issue 2, 2014, Pages 360-362

  Sandlund, J T ^a   Hudson, M M ^a   Kennedy, W ^a   Onciu, M ^a   Kastan, M B ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Ataxia telangiectasia; Children; Hodgkin lymphoma; Non Hodgkin lymphoma

Indexed keywords

BLEOMYCIN; DAUNORUBICIN; ETOPOSIDE; MESNA; METHOTREXATE; VINBLASTINE; VINCA ALKALOID;

ADULT; ARTICLE; ATAXIA TELANGIECTASIA; BURKITT LYMPHOMA; CANCER MORTALITY; CANCER STAGING; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; LARGE CELL LYMPHOMA; LUNG DISEASE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; YOUNG ADULT;

EID: 84890888147     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24696     Document Type: Article

References (20)

1. McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep 2004; 5:772-776.
2. Kastan MB. DNA damage responses: Mechanisms and roles in human disease: 2007 G. H. A. Clowes Memorial Award Lecture. Mol Cancer Res 2008; 6:517-524.
3. Olsen JH, Hahnemann JM, Borresen-Dale AL, et al. Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries. J Natl Cancer Inst 2001; 93:121-127.
4. Seidemann K, Henze G, Beck JD, et al. Non-Hodgkin's lymphoma in pediatric patients with chromosomal breakage syndromes (AT and NBS): Experience from the BFM trials. Ann Oncol 2000; 11:141-145.
5. Bienemann K, Burkhardt B, Modlich S, et al. Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): A retrospective survey. Br J Haematol 2011; 155:468-476.
6. Sandoval C, Swift M. Treatment of lymphoid malignancies in patients with ataxia-telangiectasia. Med Pediatr Oncol 1998; 31:491-497.
7. Murphy SB. Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: Dissimilarities from lymphomas in adults. Semin Oncol 1980; 7:332-339.
8. Patte C, Auperin A, Michon J, et al. The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: Highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood 2001; 97:3370-3379.
9. Cohen JM, Cuckow P, Davies EG. Bladder wall telangiectasis causing life-threatening haematuria in ataxia-telangiectasia: A new observation. Acta Paediatr 2008; 97:667-669.
10. Kaymaz NE, Kupeli S, Yalcin B, et al. Hemorrhagic cystitis in a child with Hodgkin lymphoma and ataxia-telangiectasia after cyclophosphamide. Pediatr Blood Cancer 2009; 53:516.
11. Nowak-Wegrzyn A, Crawford TO, Winkelstein JA, et al. Immunodeficiency and infections in ataxia-telangiectasia. J Pediatr 2004; 144:505-511.
12. Chen RL, Wang PJ, Hsu YH, et al. Severe lung fibrosis after chemotherapy in a child with ataxia-telangiectasia. J Pediatr Hematol Oncol 2002; 24:77-79.
13. Schroeder SA, Swift M, Sandoval C, et al. Interstitial lung disease in patients with ataxia-telangiectasia. Pediatr Pulmonol 2005; 39:537-543.
14. Maclean KH, Kastan MB, Cleveland JL. Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res 2007; 5:705-711.
15. Sandlund JT, Kastan MB, Kennedy W, et al. A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet 2006; 168:69-72.
16. Sillos EM, Shenep JL, Burghen GA, et al. Lactic acidosis: A metabolic complication of hematologic malignancies: Case report and review of the literature. Cancer 2001; 92:2237-2246.
17. Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346:235-242.
18. Kropshofer G, Wehl G, Klein-Franke A, et al. B-cell lymphoma in a girl with ataxia teleangiectasia (A-T) treated with rituximab monotherapy. Pediatr Blood Cancer 2006; 46:528-529.
19. Rossi G, Zecca M, Marchi A, et al. Modified chop-chemotherapy plus rituximab for diffuse large b-cell lymphoma complicating ataxia-telangiectasia. Br J Haematol 2003; 120:369-371.
20. Shabbat S, Aharoni J, Sarid L, et al. Rituximab as monotherapy and in addition to reduced CHOP in children with primary immunodeficiency and non-Hodgkin lymphoma. Pediatr Blood Cancer 2009; 52:664-666.