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Volumn 34, Issue SUPPL1, 2014, Pages 18-23

Treatment of hepatitis C virus genotype 3-infection

Author keywords

Cirrhosis; Combination therapy; Direct acting antiviral; Hepatitis C virus; Polymerase inhibitor; Protease inhibitor; Replication complex inhibitor

Indexed keywords

ABT 072; ABT 267; ABT 333; ABT 450; ALISPORIVIR; ANTIVIRUS AGENT; ASUNAPREVIR; BI 207127; BMS 791325; BOCEPREVIR; CYCLOPHILIN; DACLATASVIR; DANOPREVIR; FILIBUVIR; IDX 184; LEDIPASVIR; LOMIBUVIR; MERICITABINE; MK 5172; PEGINTERFERON ALPHA; PPI 668; RIBAVIRIN; RITONAVIR; SCY 635; SETROBUVIR; SIMEPREVIR; SOFOSBUVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84890868782     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12405     Document Type: Review
Times cited : (22)

References (39)
  • 1
    • 22644438481 scopus 로고    scopus 로고
    • HCV genotype 2 as a risk factor for reactivation of chronic HCV infection
    • Coppola N, Vatiero LM, Sagnelli E. HCV genotype 2 as a risk factor for reactivation of chronic HCV infection. Gut 2005; 54: 1207.
    • (2005) Gut , vol.54 , pp. 1207
    • Coppola, N.1    Vatiero, L.M.2    Sagnelli, E.3
  • 2
    • 80052825683 scopus 로고    scopus 로고
    • HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis
    • Nkontchou G, Ziol M, Aout M, et al. HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis. J Viral Hepatol 2011; 18: e516-22.
    • (2011) J Viral Hepatol , vol.18
    • Nkontchou, G.1    Ziol, M.2    Aout, M.3
  • 3
    • 77956581747 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 3 and the risk of severe liver disease in a large population of drug users in France
    • Larsen C, Bousquet V, Delarocque-Astagneau E, et al. Hepatitis C virus genotype 3 and the risk of severe liver disease in a large population of drug users in France. J Med Virol 2010; 82: 1647-54.
    • (2010) J Med Virol , vol.82 , pp. 1647-1654
    • Larsen, C.1    Bousquet, V.2    Delarocque-Astagneau, E.3
  • 4
    • 69949182408 scopus 로고    scopus 로고
    • Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C
    • Bochud PY, Cai T, Overbeck K, et al. Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol 2009; 51: 655-66.
    • (2009) J Hepatol , vol.51 , pp. 655-666
    • Bochud, P.Y.1    Cai, T.2    Overbeck, K.3
  • 5
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-65.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 6
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 7
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H Jr, Morgan TR, et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346-55.
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette Jr, H.2    Morgan, T.R.3
  • 8
    • 2442683905 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3
    • Zeuzem S, Hultcrantz R, Bourliere M, et al. Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3. J Hepatol 2004; 40: 993-9.
    • (2004) J Hepatol , vol.40 , pp. 993-999
    • Zeuzem, S.1    Hultcrantz, R.2    Bourliere, M.3
  • 9
    • 79960453276 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: management of chronic hepatitis C virus infection
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of chronic hepatitis C virus infection. J Hepatol 2011; 55: 245-64.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 10
    • 47749115740 scopus 로고    scopus 로고
    • Meta-analysis: the outcome of anti-viral therapy in HCV genotype 2 and genotype 3 infected patients with chronic hepatitis
    • Andriulli A, Mangia A, Iacobellis A, et al. Meta-analysis: the outcome of anti-viral therapy in HCV genotype 2 and genotype 3 infected patients with chronic hepatitis. Aliment Pharmacol Ther 2008; 28: 397-404.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 397-404
    • Andriulli, A.1    Mangia, A.2    Iacobellis, A.3
  • 12
    • 84855212109 scopus 로고    scopus 로고
    • New targets for antiviral therapy of chronic hepatitis C
    • Buhler S, Bartenschlager R. New targets for antiviral therapy of chronic hepatitis C. Liver Int 2012; 32(Suppl.): 9-16.
    • (2012) Liver Int , vol.32 , Issue.SUPPL. , pp. 9-16
    • Buhler, S.1    Bartenschlager, R.2
  • 13
    • 77955880854 scopus 로고    scopus 로고
    • Interferon-lambda: a new addition to an old family
    • Donnelly RP, Kotenko SV. Interferon-lambda: a new addition to an old family. J Interferon Cytokine Res 2010; 30: 555-64.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 555-564
    • Donnelly, R.P.1    Kotenko, S.V.2
  • 15
    • 36348981708 scopus 로고    scopus 로고
    • Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial
    • Jacobson IM, Brown RS, Freilich B, et al. Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial. Hepatology 2007; 46: 971-81.
    • (2007) Hepatology , vol.46 , pp. 971-981
    • Jacobson, I.M.1    Brown, R.S.2    Freilich, B.3
  • 16
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 17
    • 34447318385 scopus 로고    scopus 로고
    • Peg-interferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3
    • Shiffman ML, Suter F, Bacon BR, et al. Peg-interferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3. N Engl J Med 2007; 357: 124-34.
    • (2007) N Engl J Med , vol.357 , pp. 124-134
    • Shiffman, M.L.1    Suter, F.2    Bacon, B.R.3
  • 18
    • 80052024078 scopus 로고    scopus 로고
    • Response-guided peg-interferon plus ribavirin treatment duration in chronic hepatitis C: meta-analyses of randomized, controlled, trials and implications for the future
    • Di Martino V, Richou C, Cervoni JP, et al. Response-guided peg-interferon plus ribavirin treatment duration in chronic hepatitis C: meta-analyses of randomized, controlled, trials and implications for the future. Hepatology 2011; 54: 789-800.
    • (2011) Hepatology , vol.54 , pp. 789-800
    • Di Martino, V.1    Richou, C.2    Cervoni, J.P.3
  • 19
    • 84890883966 scopus 로고    scopus 로고
    • The outcome of 24 vs 48 weeks of peginterferon alfa-2a (40KD) plus ribavirin on sustained virologic response rates in patients infected with genotype 2 or 3 hepatitis C virus who do not achieve a rapid viral response: the N-CORE study
    • Cheinquer H, Shiffman ML, Zeuzem S, et al. The outcome of 24 vs 48 weeks of peginterferon alfa-2a (40KD) plus ribavirin on sustained virologic response rates in patients infected with genotype 2 or 3 hepatitis C virus who do not achieve a rapid viral response: the N-CORE study. Hepatology 2013; 56(Suppl. 1): 271A.
    • (2013) Hepatology , vol.56 , Issue.SUPPL. 1
    • Cheinquer, H.1    Shiffman, M.L.2    Zeuzem, S.3
  • 20
    • 80052116134 scopus 로고    scopus 로고
    • Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
    • Foster GR, Hezode C, Bronowicki JP, et al. Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology 2011; 141: 881-9.
    • (2011) Gastroenterology , vol.141 , pp. 881-889
    • Foster, G.R.1    Hezode, C.2    Bronowicki, J.P.3
  • 21
    • 84874105854 scopus 로고    scopus 로고
    • Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202)
    • Lenz O, Vijgen L, Berke JM, et al. Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202). J Hepatol 2013; 58: 445-51.
    • (2013) J Hepatol , vol.58 , pp. 445-451
    • Lenz, O.1    Vijgen, L.2    Berke, J.M.3
  • 22
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010; 465: 96-100.
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.E.2    Belema, M.3
  • 23
    • 84865285928 scopus 로고    scopus 로고
    • Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial
    • Pol S, Ghalib RH, Rustgi VK, et al. Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial. Lancet Infect Dis 2012; 12: 671-7.
    • (2012) Lancet Infect Dis , vol.12 , pp. 671-677
    • Pol, S.1    Ghalib, R.H.2    Rustgi, V.K.3
  • 24
    • 84884223989 scopus 로고    scopus 로고
    • Daclatasvir combined with peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study
    • Dore GJ, Lawitz E, Hezode C, et al. Daclatasvir combined with peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study. J Hepatol 2012; 58(Suppl. 1): S570-1.
    • (2012) J Hepatol , vol.58 , Issue.SUPPL. 1
    • Dore, G.J.1    Lawitz, E.2    Hezode, C.3
  • 25
    • 84863650706 scopus 로고    scopus 로고
    • SVR-12 among G1/4 treatment-naive patients receiving Mericitabine in combination with PEG-IFN a-2A/RBV: interim analysis from the JUMP-C study
    • Pockros P, Jensen D, Tsai N, et al. SVR-12 among G1/4 treatment-naive patients receiving Mericitabine in combination with PEG-IFN a-2A/RBV: interim analysis from the JUMP-C study. J Hepatol 2012; 56(Suppl. 2): S477-8.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • Pockros, P.1    Jensen, D.2    Tsai, N.3
  • 26
    • 84871814966 scopus 로고    scopus 로고
    • Nucleotide polymerase inhibitor Sofosbuvir plus ribavirin for hepatitis C
    • Gane EJ, Stedman CA, Hyland RH, et al. Nucleotide polymerase inhibitor Sofosbuvir plus ribavirin for hepatitis C. N Engl J Med 2013; 368: 34-44.
    • (2013) N Engl J Med , vol.368 , pp. 34-44
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 27
    • 84876740954 scopus 로고    scopus 로고
    • Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naïve patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial
    • Lawitz E, Lalezari JP, Hassanein T, et al. Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naïve patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis 2013; 13: 401-08.
    • (2013) Lancet Infect Dis , vol.13 , pp. 401-408
    • Lawitz, E.1    Lalezari, J.P.2    Hassanein, T.3
  • 28
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012; 366: 216-24.
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 29
    • 84877730954 scopus 로고    scopus 로고
    • Sofosbuvir for previously untreated chronic hepatitis C infection
    • Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Eng J Med 2013; 368: 1878-87.
    • (2013) N Eng J Med , vol.368 , pp. 1878-1887
    • Lawitz, E.1    Mangia, A.2    Wyles, D.3
  • 30
    • 84877739274 scopus 로고    scopus 로고
    • Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options
    • Jacobson IM, Gordon SC, Kowdley KV, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med 2013; 368: 1867-77.
    • (2013) N Engl J Med , vol.368 , pp. 1867-1877
    • Jacobson, I.M.1    Gordon, S.C.2    Kowdley, K.V.3
  • 31
    • 84881311874 scopus 로고    scopus 로고
    • Phase 3 randomized controlled trial of all oral treatment with Sofosbuvir + ribavirin for 12 weeks compared to 24 weeks of Peg + ribavirin in treatment-naïve GT 2/3 HCV-infected patients (FISSION)
    • Gane E, Lawitz E, Rodriguez-Torres M, et al. Phase 3 randomized controlled trial of all oral treatment with Sofosbuvir + ribavirin for 12 weeks compared to 24 weeks of Peg + ribavirin in treatment-naïve GT 2/3 HCV-infected patients (FISSION). J Hepatol 2013; 58(Suppl. 1): S3.
    • (2013) J Hepatol , vol.58 , Issue.SUPPL. 1
    • Gane, E.1    Lawitz, E.2    Rodriguez-Torres, M.3
  • 32
    • 84888860697 scopus 로고    scopus 로고
    • All oral therapy with Sofosbuvir + ribavirin for 12 or 16 weeks in treatment experienced GT 2/3 HCV-infected patients: results of the phase 3 FUSION trial
    • Nelson DR, Feld J, Kowdley KV, et al. All oral therapy with Sofosbuvir + ribavirin for 12 or 16 weeks in treatment experienced GT 2/3 HCV-infected patients: results of the phase 3 FUSION trial. J Hepatol 2013; 58(Suppl. 1): S3-4.
    • (2013) J Hepatol , vol.58 , Issue.SUPPL. 1
    • Nelson, D.R.1    Feld, J.2    Kowdley, K.V.3
  • 33
    • 84890872872 scopus 로고    scopus 로고
    • th Conference on Retroviruses and Opportunistic Infections (CROI 2013). Atlanta, March 3-6 2013. Abstract 155LB.
    • th Conference on Retroviruses and Opportunistic Infections (CROI 2013). Atlanta, March 3-6 2013. Abstract 155LB.
    • Lawitz, E.1    Ghalib, R.2    Rodriguez-Torres, M.3
  • 34
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial
    • doi: 10.1016/S0140-6736(13)62121-2 [Epub ahead of print].
    • Lawitz E, Poordad F, Pang P, et al. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial. Lancet 2013; doi: 10.1016/S0140-6736(13)62121-2 [Epub ahead of print].
    • (2013) Lancet
    • Lawitz, E.1    Poordad, F.2    Pang, P.3
  • 35
    • 84880292800 scopus 로고    scopus 로고
    • Sustained virologic response with Daclatasvir plus Sofosbuvir +/- ribavirin (RBV) in chronic HCV genotype (GT) 1 -infected patients who previously failed Telaprevir (TVR) or Boceprevir (BOC)
    • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. Sustained virologic response with Daclatasvir plus Sofosbuvir +/- ribavirin (RBV) in chronic HCV genotype (GT) 1 -infected patients who previously failed Telaprevir (TVR) or Boceprevir (BOC). J Hepatol 2013; 58(Suppl. 1): S570.
    • (2013) J Hepatol , vol.58 , Issue.SUPPL. 1
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 36
    • 84890876607 scopus 로고    scopus 로고
    • High rate of sustained virologic response with the all-oral Combination of Daclatasvir (NS5A inhibitor) plus Sofosbuvir (nucleotide NS5B inhibitor), with or without ribavirin, in treatment-naïve patients chronically infected with HCV genotype 1, 2, or 3. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-02.
    • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. High rate of sustained virologic response with the all-oral Combination of Daclatasvir (NS5A inhibitor) plus Sofosbuvir (nucleotide NS5B inhibitor), with or without ribavirin, in treatment-naïve patients chronically infected with HCV genotype 1, 2, or 3. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-02.
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 37
    • 84890884875 scopus 로고    scopus 로고
    • A 12-week interferon-free treatment regimen with ABT 450/r, ABT-267, ABT-333, and ribavirin achieves SVR12 rates (observed data) of 99% in treatment naïve patients and 93% in prior null responders in HCV genotype 1 infection. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-01.
    • Kowdley KV, Lawitz E, Poordad F, et al. A 12-week interferon-free treatment regimen with ABT 450/r, ABT-267, ABT-333, and ribavirin achieves SVR12 rates (observed data) of 99% in treatment naïve patients and 93% in prior null responders in HCV genotype 1 infection. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-01.
    • Kowdley, K.V.1    Lawitz, E.2    Poordad, F.3
  • 38
    • 84890869828 scopus 로고    scopus 로고
    • An Interferon-free, Ribavirin-free 12-Week Regimen of Daclatasvir (DCV), Asunaprevir (ASV), and BMS-791325 Yielded SVR4 of 94% in Treatment-Naive Patients with Genotype (GT) 1 Chronic Hepatitis C Virus (HCV) Infection. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-3.
    • Everson GT, Sims KD, Rodriguez-Torres M, et al. An Interferon-free, Ribavirin-free 12-Week Regimen of Daclatasvir (DCV), Asunaprevir (ASV), and BMS-791325 Yielded SVR4 of 94% in Treatment-Naive Patients with Genotype (GT) 1 Chronic Hepatitis C Virus (HCV) Infection. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2012). Boston, November 9-13, 2012. Abstract LB-3.
    • Everson, G.T.1    Sims, K.D.2    Rodriguez-Torres, M.3
  • 39
    • 84863704212 scopus 로고    scopus 로고
    • Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or GT3 patients: SVR12 results from VITAL-1 phase 2b study
    • Pawlotsky JM, Sarin SK, Foster G, et al. Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or GT3 patients: SVR12 results from VITAL-1 phase 2b study. J Hepatol 2012; 56(Suppl. 2): S553.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • Pawlotsky, J.M.1    Sarin, S.K.2    Foster, G.3


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