메뉴 건너뛰기




Volumn 16, Issue 9, 2007, Pages 1345-1354

Cyclophilin inhibitors in hepatitis C viral infection

Author keywords

Anti HCV treatment; Cyclophilin; Cyclophilin inhibitor; Debio 025; Hepatitis C; NIM 811

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; ANTIVIRUS AGENT; BETA INTERFERON; BIL 2061; CONSENSUS INTERFERON; CYCLOPHILIN; CYCLOPHILIN INHIBITOR; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; DEBIO 025; INTERFERON; ISOMERASE; NIM 811; PEGINTERFERON; PEGINTERFERON ALPHA; PLACEBO; PREDNISONE; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; RIBAVIRIN; RNA POLYMERASE; SCH 503034; SCY 635; TACROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALOPICITABINE; VIRUS RNA; VX 950; ENZYME INHIBITOR;

EID: 34548567684     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.16.9.1345     Document Type: Review
Times cited : (49)

References (62)
  • 1
    • 0034695289 scopus 로고    scopus 로고
    • Hepatitis C - global prevalence (update)
    • Hepatitis C - global prevalence (update). Wkly Epidemiol. Rec. (2000) 75(3):18-19.
    • (2000) Wkly Epidemiol. Rec , vol.75 , Issue.3 , pp. 18-19
  • 2
    • 24344503816 scopus 로고    scopus 로고
    • HCV natural history: The retrospective and prospective in perspective
    • ALTER HJ: HCV natural history: the retrospective and prospective in perspective. J. Hepatol. (2005) 43(4):550-552.
    • (2005) J. Hepatol , vol.43 , Issue.4 , pp. 550-552
    • ALTER, H.J.1
  • 3
    • 0037242882 scopus 로고    scopus 로고
    • Clinical consequences of hepatitis C virus infection
    • ZOULIM F, CHEVALLIER M, MAYNARD M, TREPO C: Clinical consequences of hepatitis C virus infection. Rev. Med. Virol. (2003) 13(1):57-68.
    • (2003) Rev. Med. Virol , vol.13 , Issue.1 , pp. 57-68
    • ZOULIM, F.1    CHEVALLIER, M.2    MAYNARD, M.3    TREPO, C.4
  • 4
    • 32344431567 scopus 로고    scopus 로고
    • Chronic hepatitis C virus management: 2000 - 2005 update
    • HUGHES CA, SHAFRAN SD: Chronic hepatitis C virus management: 2000 - 2005 update. Ann. Pharmacother. (2006) 40(1):74-82.
    • (2006) Ann. Pharmacother , vol.40 , Issue.1 , pp. 74-82
    • HUGHES, C.A.1    SHAFRAN, S.D.2
  • 5
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection
    • FRIED MW, SHIFFMAN ML, REDDY KR et al.: Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. (2002) 347(13):975-982.
    • (2002) N. Engl. J. Med , vol.347 , Issue.13 , pp. 975-982
    • FRIED, M.W.1    SHIFFMAN, M.L.2    REDDY, K.R.3
  • 6
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • MANNS MP, MCHUTCHISON JG, GORDON SC et al.: Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet (2001) 358(9286):958-965.
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • MANNS, M.P.1    MCHUTCHISON, J.G.2    GORDON, S.C.3
  • 7
    • 23944476834 scopus 로고    scopus 로고
    • Unravelling hepatitis C virus replication from genome to function
    • LINDENBACH BD, RICE CM: Unravelling hepatitis C virus replication from genome to function. Nature (2005) 436(7053):933-938.
    • (2005) Nature , vol.436 , Issue.7053 , pp. 933-938
    • LINDENBACH, B.D.1    RICE, C.M.2
  • 9
    • 33749360242 scopus 로고    scopus 로고
    • Rapid decline of viral RNA in hepatitis C patients treated with VX-950: A Phase Ib, placebo-controlled, randomized study
    • REESINK HW, ZEUZEM S, WEEGINK CJ et al.: Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a Phase Ib, placebo-controlled, randomized study. Gastroenterology (2006) 131(4):997-1002.
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 997-1002
    • REESINK, H.W.1    ZEUZEM, S.2    WEEGINK, C.J.3
  • 10
    • 33847676669 scopus 로고    scopus 로고
    • Combination of telaprevir (VX-950) and PEG-IFN-α suppressed both wild-type virus and resistance variants in HCV genotype 1-infected patients in a 14-day Phase IB study
    • Abstract 92
    • KIEFER T, SARRAZIN C, MILLER J et al.: Combination of telaprevir (VX-950) and PEG-IFN-α suppressed both wild-type virus and resistance variants in HCV genotype 1-infected patients in a 14-day Phase IB study. Hepatology (2006) 44:A222 (Abstract 92).
    • (2006) Hepatology , vol.44
    • KIEFER, T.1    SARRAZIN, C.2    MILLER, J.3
  • 11
    • 33644758023 scopus 로고    scopus 로고
    • Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype 1 peg-intron non-responders: Phase Ib results
    • Abstract 201
    • ZEUZEM S, SARRAZIN C, WAGNER F: Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype 1 peg-intron non-responders: Phase Ib results. Hepatology (2005) 42:A276 (Abstract 201).
    • (2005) Hepatology , vol.42
    • ZEUZEM, S.1    SARRAZIN, C.2    WAGNER, F.3
  • 12
    • 30344466537 scopus 로고    scopus 로고
    • Randomized trial of valopicitabine (NM283) alone or with peg-interferon vs retreatment with peg-interferon plus ribavirin in hepatitis C patients with previous non-response PEGIFN/RBV: First interim results
    • Abstract 95
    • O'BRIEN C, GODOFSKY E, RODRIQUEZ-TORRES M: Randomized trial of valopicitabine (NM283) alone or with peg-interferon vs retreatment with peg-interferon plus ribavirin in hepatitis C patients with previous non-response PEGIFN/RBV: first interim results. Hepatology (2005) 42:A234 (Abstract 95).
    • (2005) Hepatology , vol.42
    • O'BRIEN, C.1    GODOFSKY, E.2    RODRIQUEZ-TORRES, M.3
  • 13
    • 33847680350 scopus 로고    scopus 로고
    • Valopicitabine (NM283) plus PEG-interferon in treatment-naive hepatitis C patients with HCV genotype-1 infection: HCV RNA clearance during 24 weeks of treatment
    • Abstract 93
    • LAWITZ E, NGUYEN T, YOUNES Z et al.: Valopicitabine (NM283) plus PEG-interferon in treatment-naive hepatitis C patients with HCV genotype-1 infection: HCV RNA clearance during 24 weeks of treatment. Hepatalogy (2006) 44:A223 (Abstract 93).
    • (2006) Hepatalogy , vol.44
    • LAWITZ, E.1    NGUYEN, T.2    YOUNES, Z.3
  • 14
    • 33947656594 scopus 로고    scopus 로고
    • Analysis of HCV NS5B genetic variants following monotherapy with HCV-796, a non-nucleoside polymerase inhibitor, in treatment-naive HCV-infected patients
    • Abstract 1127
    • VILLANO S, HOWE A, RAIBLE D et al.: Analysis of HCV NS5B genetic variants following monotherapy with HCV-796, a non-nucleoside polymerase inhibitor, in treatment-naive HCV-infected patients. Hepatology (2006) 44:A607 (Abstract 1127).
    • (2006) Hepatology , vol.44
    • VILLANO, S.1    HOWE, A.2    RAIBLE, D.3
  • 15
    • 33847656463 scopus 로고    scopus 로고
    • Results of a Phase IB multiple dose study of R1626 a novel nucleoside analog targetting HCV polymerase in chronic HCV genotype 1 patients
    • Abstract LB2
    • ROBERTS S, COOKSLEY G, DORE G et al.: Results of a Phase IB multiple dose study of R1626 a novel nucleoside analog targetting HCV polymerase in chronic HCV genotype 1 patients. Hepatology (2006) 44:A692 (Abstract LB2).
    • (2006) Hepatology , vol.44
    • ROBERTS, S.1    COOKSLEY, G.2    DORE, G.3
  • 16
    • 0022507035 scopus 로고
    • Cyclophilin: Distribution and variant properties in normal and neoplastic tissues
    • KOLETSKY AJ, HARDING MW, HANDSCHUMACHER RE: Cyclophilin: distribution and variant properties in normal and neoplastic tissues. J. Immunol. (1986) 137(3):1054-1059.
    • (1986) J. Immunol , vol.137 , Issue.3 , pp. 1054-1059
    • KOLETSKY, A.J.1    HARDING, M.W.2    HANDSCHUMACHER, R.E.3
  • 17
    • 33645994497 scopus 로고    scopus 로고
    • Pharmacological targeting of catalyzed protein folding: The example of peptide bond cis/trans isomerases
    • EDLICH F, FISCHER G: Pharmacological targeting of catalyzed protein folding: the example of peptide bond cis/trans isomerases. Handb. Exp. Pharmacol. (2006) (172):359-404.
    • (2006) Handb. Exp. Pharmacol , vol.172 , pp. 359-404
    • EDLICH, F.1    FISCHER, G.2
  • 18
    • 0025733035 scopus 로고
    • Distribution of the cyclosporine binding protein cyclophilin in human tissues
    • RYFFEL B, WOERLY G, GREINER B et al.: Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology (1991) 72(3):399-404.
    • (1991) Immunology , vol.72 , Issue.3 , pp. 399-404
    • RYFFEL, B.1    WOERLY, G.2    GREINER, B.3
  • 19
    • 24144468662 scopus 로고    scopus 로고
    • Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins
    • NAKAGAWA M, SAKAMOTO N, TANABE Y et al.: Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology (2005) 129(3):1031-1041.
    • (2005) Gastroenterology , vol.129 , Issue.3 , pp. 1031-1041
    • NAKAGAWA, M.1    SAKAMOTO, N.2    TANABE, Y.3
  • 20
    • 21244433445 scopus 로고    scopus 로고
    • Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase
    • WATASHI K, ISHII N, HIJIKATA M et al.: Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol. Cell (2005) 19(1):111-122.
    • (2005) Mol. Cell , vol.19 , Issue.1 , pp. 111-122
    • WATASHI, K.1    ISHII, N.2    HIJIKATA, M.3
  • 21
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • WATASHI K, HIJIKATA M, HOSAKA M, YAMAJI M, SHIMOTOHNO K: Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology (2003) 38(5):1282-1288.
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1282-1288
    • WATASHI, K.1    HIJIKATA, M.2    HOSAKA, M.3    YAMAJI, M.4    SHIMOTOHNO, K.5
  • 22
    • 33645106470 scopus 로고    scopus 로고
    • Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
    • FIRPI RJ, ZHU H, MORELLI G et al.: Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation. Liver Transplant. (2006) 12(1):51-57.
    • (2006) Liver Transplant , vol.12 , Issue.1 , pp. 51-57
    • FIRPI, R.J.1    ZHU, H.2    MORELLI, G.3
  • 23
    • 0038102952 scopus 로고    scopus 로고
    • Combined interferon α2b and cyclosporin A in the treatment of chronic hepatitis C: Controlled trial
    • INOUE K, SEKIYAMA K, YAMADA M et al.: Combined interferon α2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial. J. Gastroenterol. (2003) 38(6):567-572.
    • (2003) J. Gastroenterol , vol.38 , Issue.6 , pp. 567-572
    • INOUE, K.1    SEKIYAMA, K.2    YAMADA, M.3
  • 24
    • 33748687426 scopus 로고    scopus 로고
    • NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with α interferon
    • MA S, BOERNER JE, TIONGYIP C et al.: NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with α interferon. Antimicrob. Agents. Chemother. (2006) 50(9):2976-2982.
    • (2006) Antimicrob. Agents. Chemother , vol.50 , Issue.9 , pp. 2976-2982
    • MA, S.1    BOERNER, J.E.2    TIONGYIP, C.3
  • 25
    • 33646015668 scopus 로고    scopus 로고
    • The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    • PAESHUYSE J, KAUL A, DE CLERCQ E et al.: The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology (2006) 43(4):761-770.
    • (2006) Hepatology , vol.43 , Issue.4 , pp. 761-770
    • PAESHUYSE, J.1    KAUL, A.2    DE CLERCQ, E.3
  • 26
    • 34848911201 scopus 로고    scopus 로고
    • The cyclophilin inhibitor DEBIO-025 has a potent dual anti-HIV and anti-HCV activity in treatment-naive HIV/HCV co-infected subjects
    • Boston, MA, USA 27-31 October
    • FLISIAK R, HORBAN A, KIERKUS J et al.: The cyclophilin inhibitor DEBIO-025 has a potent dual anti-HIV and anti-HCV activity in treatment-naive HIV/HCV co-infected subjects. 57th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, USA (27-31 October 2006).
    • (2006) 57th Annual Meeting of the American Association for the Study of Liver Diseases
    • FLISIAK, R.1    HORBAN, A.2    KIERKUS, J.3
  • 27
    • 0032926319 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts
    • GOTHEL SF, MARAHIEL MA: Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol. Life Sci. (1999) 55(3):423-436.
    • (1999) Cell Mol. Life Sci , vol.55 , Issue.3 , pp. 423-436
    • GOTHEL, S.F.1    MARAHIEL, M.A.2
  • 28
    • 85012553495 scopus 로고    scopus 로고
    • Molecular targets for existing and novel immunosuppressive drugs
    • STEPKOWSKI SM: Molecular targets for existing and novel immunosuppressive drugs. Expert Rev. Mol. Med. (2000) 2000:1-23.
    • (2000) Expert Rev. Mol. Med , vol.2000 , pp. 1-23
    • STEPKOWSKI, S.M.1
  • 29
    • 0042208090 scopus 로고    scopus 로고
    • Redistribution of cyclophilin A to viral factories during vaccinia virus infection and its incorporation into mature particles
    • CASTRO AP, CARVALHO TM, MOUSSATCHE N, DAMASO CR: Redistribution of cyclophilin A to viral factories during vaccinia virus infection and its incorporation into mature particles. J. Virol. (2003) 77(16):9052-9068.
    • (2003) J. Virol , vol.77 , Issue.16 , pp. 9052-9068
    • CASTRO, A.P.1    CARVALHO, T.M.2    MOUSSATCHE, N.3    DAMASO, C.R.4
  • 30
    • 0027940713 scopus 로고
    • Specific incorporation of cyclophilin A into HIV-1 virions
    • FRANKE EK, YUAN HE, LUBAN J: Specific incorporation of cyclophilin A into HIV-1 virions. Nature (1994) 372(6504):359-362.
    • (1994) Nature , vol.372 , Issue.6504 , pp. 359-362
    • FRANKE, E.K.1    YUAN, H.E.2    LUBAN, J.3
  • 31
    • 33846610519 scopus 로고    scopus 로고
    • Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection
    • LUBAN J: Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J. Virol. (2007) 81(3):1054-1061.
    • (2007) J. Virol , vol.81 , Issue.3 , pp. 1054-1061
    • LUBAN, J.1
  • 32
    • 0141796317 scopus 로고    scopus 로고
    • Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    • TOWERS GJ, HATZIIOANNOU T, COWAN S et al.: Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. (2003) 9(9):1138-1143.
    • (2003) Nat. Med , vol.9 , Issue.9 , pp. 1138-1143
    • TOWERS, G.J.1    HATZIIOANNOU, T.2    COWAN, S.3
  • 33
    • 33645064275 scopus 로고    scopus 로고
    • Dealing with the family: CD147 interactions with cyclophilins
    • YURCHENKO V, CONSTANT S, BUKRINSKY M: Dealing with the family: CD147 interactions with cyclophilins. Immunology (2006) 117(3):301-309.
    • (2006) Immunology , vol.117 , Issue.3 , pp. 301-309
    • YURCHENKO, V.1    CONSTANT, S.2    BUKRINSKY, M.3
  • 34
    • 20044396197 scopus 로고    scopus 로고
    • Roles of cyclophilins in cancers and other organ systems
    • YAO Q, LI M, YANG H et al.: Roles of cyclophilins in cancers and other organ systems. World J. Surg. (2005) 29(3):276-280.
    • (2005) World J. Surg , vol.29 , Issue.3 , pp. 276-280
    • YAO, Q.1    LI, M.2    YANG, H.3
  • 35
    • 0033179326 scopus 로고    scopus 로고
    • Cyclophilin B binding to platelets supports calcium-dependent adhesion to collagen
    • ALLAIN F, DURIEUX S, DENYS A, CARPENTIER M, SPIK G: Cyclophilin B binding to platelets supports calcium-dependent adhesion to collagen. Blood (1999) 94(3):976-983.
    • (1999) Blood , vol.94 , Issue.3 , pp. 976-983
    • ALLAIN, F.1    DURIEUX, S.2    DENYS, A.3    CARPENTIER, M.4    SPIK, G.5
  • 36
    • 0028888570 scopus 로고
    • Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies
    • ALLAIN F, BOUTILLON C, MARILLER C, SPIK G: Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies. J. Immunol. Methods (1995) 178(1):113-120.
    • (1995) J. Immunol. Methods , vol.178 , Issue.1 , pp. 113-120
    • ALLAIN, F.1    BOUTILLON, C.2    MARILLER, C.3    SPIK, G.4
  • 37
    • 33845384844 scopus 로고    scopus 로고
    • Cyclophilin C-associated protein is up-regulated during wound healing
    • KONG W, LI S, LONGAKER MT, LORENZ HP: Cyclophilin C-associated protein is up-regulated during wound healing. J. Cell Physiol. (2007) 210(1):153-160.
    • (2007) J. Cell Physiol , vol.210 , Issue.1 , pp. 153-160
    • KONG, W.1    LI, S.2    LONGAKER, M.T.3    LORENZ, H.P.4
  • 39
    • 32944481736 scopus 로고    scopus 로고
    • Treating hepatitis C: Can you teach old dogs new tricks?
    • RICE CM, YOU S: Treating hepatitis C: can you teach old dogs new tricks? Hepatology (2005) 42(6):1455-1458.
    • (2005) Hepatology , vol.42 , Issue.6 , pp. 1455-1458
    • RICE, C.M.1    YOU, S.2
  • 40
    • 34447514070 scopus 로고    scopus 로고
    • Chemical genetics approach to hepatitis C virus replication: Cyclophilin as a target for anti-hepatitis C virus strategy
    • WATASHI K, SHIMOTOHNO K: Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy. Rev. Med. Virol. (2007) 17(4):245-52.
    • (2007) Rev. Med. Virol , vol.17 , Issue.4 , pp. 245-252
    • WATASHI, K.1    SHIMOTOHNO, K.2
  • 41
    • 34848863213 scopus 로고    scopus 로고
    • Cyclophilin and viruses: Cyclophilin as a cofactor for viral infection and possible anti-viral target
    • WATASHI K, SHIMOTOHNO K: Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target. J. Drug Target Insights (2007) 1:9-18.
    • (2007) J. Drug Target Insights , vol.1 , pp. 9-18
    • WATASHI, K.1    SHIMOTOHNO, K.2
  • 42
    • 33646194456 scopus 로고    scopus 로고
    • Diverse effects of cyclosporine on hepatitis C virus strain replication
    • ISHII N, WATASHI K, HISHIKI T et al.: Diverse effects of cyclosporine on hepatitis C virus strain replication. J. Virol. (2006) 80(9):4510-4520.
    • (2006) J. Virol , vol.80 , Issue.9 , pp. 4510-4520
    • ISHII, N.1    WATASHI, K.2    HISHIKI, T.3
  • 43
    • 24944519305 scopus 로고    scopus 로고
    • Comparison between subgenomic replicons of hepatitis C virus genotypes 2a (JFH-1) and 1b (Con1 NK5.1)
    • MIYAMOTO M, KATO T, DATE T, MIZOKAMI M, WAKITA T: Comparison between subgenomic replicons of hepatitis C virus genotypes 2a (JFH-1) and 1b (Con1 NK5.1). Intervirology (2006) 49(1-2):37-43.
    • (2006) Intervirology , vol.49 , Issue.1-2 , pp. 37-43
    • MIYAMOTO, M.1    KATO, T.2    DATE, T.3    MIZOKAMI, M.4    WAKITA, T.5
  • 44
    • 34249817897 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro
    • ROBIDA JM, NELSON HB, LIU Z, TANG H: Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J. Virol. (2007) 81(11):5829-5840.
    • (2007) J. Virol , vol.81 , Issue.11 , pp. 5829-5840
    • ROBIDA, J.M.1    NELSON, H.B.2    LIU, Z.3    TANG, H.4
  • 45
    • 0023927002 scopus 로고
    • Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus
    • TERAOKA S, MISHIRO S, EBIHARA K et al.: Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus. Transplant. Proc. (1988) 20(3 Suppl. 3):868-876.
    • (1988) Transplant. Proc , vol.20 , Issue.3 SUPPL. 3 , pp. 868-876
    • TERAOKA, S.1    MISHIRO, S.2    EBIHARA, K.3
  • 46
    • 0028109343 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog
    • ROSENWIRTH B, BILLICH A, DATEMA R et al.: Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. Antimicrob. Agents Chemother. (1994) 38(8):1763-1772.
    • (1994) Antimicrob. Agents Chemother , vol.38 , Issue.8 , pp. 1763-1772
    • ROSENWIRTH, B.1    BILLICH, A.2    DATEMA, R.3
  • 47
    • 33645911783 scopus 로고    scopus 로고
    • Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811
    • GOTO K, WATASHI K, MURATA T et al.: Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811. Biochem. Biophys. Res. Commun. (2006) 343(3):879-884.
    • (2006) Biochem. Biophys. Res. Commun , vol.343 , Issue.3 , pp. 879-884
    • GOTO, K.1    WATASHI, K.2    MURATA, T.3
  • 48
    • 34848905487 scopus 로고    scopus 로고
    • LIN K, BOERNER J, COOREMAN M: NIM811, a cyclophilin inhibitor targetting host-viral interaction, significantly enhances the antiviral activity of HCV polymerase inhibitors and reduces the emergence of resistance in vitro. First International Workshop on Hepatitis C Resistance and New Compounds, Boston, MA, USA (25-26 October 2006).
    • LIN K, BOERNER J, COOREMAN M: NIM811, a cyclophilin inhibitor targetting host-viral interaction, significantly enhances the antiviral activity of HCV polymerase inhibitors and reduces the emergence of resistance in vitro. First International Workshop on Hepatitis C Resistance and New Compounds, Boston, MA, USA (25-26 October 2006).
  • 49
    • 10244236553 scopus 로고    scopus 로고
    • The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria
    • HANSSON MJ, MATTIASSON G, MANSSON R et al.: The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria. J. Bioenerg. Biomembr. (2004) 36(4):407-413.
    • (2004) J. Bioenerg. Biomembr , vol.36 , Issue.4 , pp. 407-413
    • HANSSON, M.J.1    MATTIASSON, G.2    MANSSON, R.3
  • 50
    • 28844479566 scopus 로고    scopus 로고
    • Naturally occuring capsid substitutions render HIV-1 cyclophilin a independent in human cells and trim-cyclophilin resistant in owl monkey cells
    • CHATTERJI U, BOBARDT MD, STANFIELD R et al.: Naturally occuring capsid substitutions render HIV-1 cyclophilin a independent in human cells and trim-cyclophilin resistant in owl monkey cells. J. Biol. Chem. (2005) 280(48):40293-40300.
    • (2005) J. Biol. Chem , vol.280 , Issue.48 , pp. 40293-40300
    • CHATTERJI, U.1    BOBARDT, M.D.2    STANFIELD, R.3
  • 52
    • 34848831001 scopus 로고    scopus 로고
    • The cyclophilin Debio-025, a potent inhibitor of hepatitis C virus replication in vitro has a unique resistance profile
    • Boston, MA, USA October 25-26
    • COELMONT L, PAESHUYSE J, KAPTEIN S et al.: The cyclophilin Debio-025, a potent inhibitor of hepatitis C virus replication in vitro has a unique resistance profile. 1st International Workshop on Hepatitis C Resistance and New Compounds. Boston, MA, USA (October 25-26 2006).
    • (2006) 1st International Workshop on Hepatitis C Resistance and New Compounds
    • COELMONT, L.1    PAESHUYSE, J.2    KAPTEIN, S.3
  • 53
    • 34247383488 scopus 로고    scopus 로고
    • Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo
    • INOUE K, UMEHARA T, RUEGG UT et al.: Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo. Hepatology (2007) 45(4):921-928.
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 921-928
    • INOUE, K.1    UMEHARA, T.2    RUEGG, U.T.3
  • 54
    • 34848912104 scopus 로고    scopus 로고
    • Preclinical evaluation of SCY-635, a cyclophilin inhibitor with potent anti-HCV activity
    • Abstract 934
    • HOUCK D, HOPKINS S: Preclinical evaluation of SCY-635, a cyclophilin inhibitor with potent anti-HCV activity. Hepatology (2006) 44:A534 (Abstract 934).
    • (2006) Hepatology , vol.44
    • HOUCK, D.1    HOPKINS, S.2
  • 55
    • 33747131043 scopus 로고    scopus 로고
    • Selective inhibitors of hepatitis C virus replication
    • NEYTS J: Selective inhibitors of hepatitis C virus replication. Antiviral. Res. (2006) 71(1-2):363-371.
    • (2006) Antiviral. Res , vol.71 , Issue.1-2 , pp. 363-371
    • NEYTS, J.1
  • 56
    • 0037376084 scopus 로고    scopus 로고
    • A pilot study of the combination of cyclosporin A and interferon alfacon-1 for the treatment of hepatitis C in previous nonresponder patients
    • COTLER SJ, MORRISSEY MJ, WILEY TE, LAYDEN TJ, JENSEN DM: A pilot study of the combination of cyclosporin A and interferon alfacon-1 for the treatment of hepatitis C in previous nonresponder patients. J. Clin. Gastroenterol. (2003) 36(4):352-355.
    • (2003) J. Clin. Gastroenterol , vol.36 , Issue.4 , pp. 352-355
    • COTLER, S.J.1    MORRISSEY, M.J.2    WILEY, T.E.3    LAYDEN, T.J.4    JENSEN, D.M.5
  • 57
    • 17844375433 scopus 로고    scopus 로고
    • Interferon combined with cyclosporine treatment as an effective countermeasure against hepatitis C virus recurrence in liver transplant patients with end-stage hepatitis C virus related disease
    • INOUE K, YOSHIBA M: Interferon combined with cyclosporine treatment as an effective countermeasure against hepatitis C virus recurrence in liver transplant patients with end-stage hepatitis C virus related disease. Transplant. Proc. (2005) 37(2):1233-1234.
    • (2005) Transplant. Proc , vol.37 , Issue.2 , pp. 1233-1234
    • INOUE, K.1    YOSHIBA, M.2
  • 58
    • 33646454268 scopus 로고    scopus 로고
    • Effect of calcineurin inhibitors on survival and histologic disease severity in HCV-infected liver transplant recipients
    • BERENGUER M, AGUILERA V, PRIETO M et al.: Effect of calcineurin inhibitors on survival and histologic disease severity in HCV-infected liver transplant recipients. Liver Transplant. (2006) 12(5):762-767.
    • (2006) Liver Transplant , vol.12 , Issue.5 , pp. 762-767
    • BERENGUER, M.1    AGUILERA, V.2    PRIETO, M.3
  • 59
    • 33644897319 scopus 로고    scopus 로고
    • Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: Effects on virus replication and recurrent hepatitis
    • HILGARD P, KAHRAMAN A, LEHMANN N et al.: Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: effects on virus replication and recurrent hepatitis. World J. Gastroenterol. (2006) 12(5):697-702.
    • (2006) World J. Gastroenterol , vol.12 , Issue.5 , pp. 697-702
    • HILGARD, P.1    KAHRAMAN, A.2    LEHMANN, N.3
  • 60
    • 33750952074 scopus 로고    scopus 로고
    • Long-term outcomes in liver transplant patients with hepatic C infection receiving tacrolimus or cyclosporine
    • VILLAMIL F, LEVY G, GRAZI GL et al.: Long-term outcomes in liver transplant patients with hepatic C infection receiving tacrolimus or cyclosporine. Transplant. Proc. (2006) 38(9):2964-2967.
    • (2006) Transplant. Proc , vol.38 , Issue.9 , pp. 2964-2967
    • VILLAMIL, F.1    LEVY, G.2    GRAZI, G.L.3
  • 61
    • 34848824845 scopus 로고    scopus 로고
    • Interim antiviral and safety data with albumin interferon α-2B combined with ribavirin in a Phase IIB study conducted in a genotype 1, IFN-naive, chronic hepatitis C population
    • Abstract 1141
    • MCHUTCHISON JG, ZEUZEM S, BENHAMOU Y et al.: Interim antiviral and safety data with albumin interferon α-2B combined with ribavirin in a Phase IIB study conducted in a genotype 1, IFN-naive, chronic hepatitis C population. Hepatology (2006) 44:A614 (Abstract 1141).
    • (2006) Hepatology , vol.44
    • MCHUTCHISON, J.G.1    ZEUZEM, S.2    BENHAMOU, Y.3
  • 62
    • 34848813024 scopus 로고    scopus 로고
    • Impact of taribavirin and ribavirin exposure on efficacy and anemia rates when combined with pegylated interferon α-2B in the treatment of chronic HCV
    • Abstract 1133
    • JACOBSON I, POCKROS P, BENHAMOU Y et al.: Impact of taribavirin and ribavirin exposure on efficacy and anemia rates when combined with pegylated interferon α-2B in the treatment of chronic HCV. Hepatology (2006) 44:A610 (Abstract 1133).
    • (2006) Hepatology , vol.44
    • JACOBSON, I.1    POCKROS, P.2    BENHAMOU, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.