A comparative high-throughput screening protocol to identify entry inhibitors of enveloped viruses

Journal of Biomolecular Screening

Volumn 19, Issue 1, 2014, Pages 100-107

  Wang, Juan ^a,b   Cheng, Han ^a   Ratia, Kiira ^c   Varhegyi, Elizabeth ^a   Hendrickson, William G ^a   Li, Juan ^b   Rong, Lijun ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

antiviral drugs; cell based assays; comparative HTS; high throughput screening; phenotypic drug discovery

Indexed keywords

ARTICLE; DATA ANALYSIS; FILOVIRUS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INFLUENZA VIRUS A H5N1; LASSA VIRUS; MARBURG VIRUS; PRIORITY JOURNAL; PSEUDOTYPING; QUALITY CONTROL; SCREENING; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS INFECTIVITY;

ANTIVIRAL DRUGS; CELL-BASED ASSAYS; COMPARATIVE HTS; HIGH-THROUGHPUT SCREENING; PHENOTYPIC DRUG DISCOVERY;

ANTIVIRAL AGENTS; CELL LINE; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROBIAL SENSITIVITY TESTS; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; VIRUS INTERNALIZATION; VIRUSES;

EID: 84890821001     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113494405     Document Type: Article

References (34)

1. Wright P. F., Newumann G., Kawaoka Y. Fields Virology. Knipe D. M. Howley P. M., ed. Philadelphia, PA: Wolters Kluwer, Lippincott Williams & Wilkins ; 2007: 1691-1740.
2. Sanchez A., Geiger T. W., Feldmann H. Fields Virology. Knipe D. M. Howley P. M., ed. Philadelphia, PA: Wolters Kluwer, Lippincott Williams & Wilkins ; 2007: 1409-1448.
3. White J. M.. Viral and Cellular Membrane Fusion Proteins. Annu. Rev. Physiol. 1990 ; 52: 675-697
4. Doms R. W., Moore J. P.. HIV-1 Membrane Fusion: Targets of Opportunity. J. Cell. Biol. 2000 ; 151: F9 - F14
5. Eckert D. M., Kim P. S.. Mechanisms of Viral Membrane Fusion and Its Inhibition. Annu. Rev. Biochem. 2001 ; 70: 777-810
6. Skehel J. J., Wiley D. C.. Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin. Annu. Rev. Biochem. 2000 ; 69: 531-569
7. Rojek J. M., Kunz S.. Cell Entry by Human Pathogenic Arenaviruses. Cell Microbiol. 2008 ; 10: 828-835
8. Abel S., Back D. J., Vourvahis M.. Maraviroc: Pharmacokinetics and Drug Interactions. Antivir. Ther. 2009 ; 14: 607-618
9. Levy J. A.. HIV Pathogenesis: 25 Years of Progress and Persistent Challenges. AIDS. 2009 ; 23: 147-160
10. Lalezari J. P., Henry K., O'Hearn M., et al. Enfuvirtide, an HIV-1 Fusion Inhibitor, for Drug-Resistant HIV Infection in North and South America. N. Engl. J. Med. 2003 ; 348: 2175-2185
11. Kilby J. M., Hopkins S., Venetta T. M., et al. Potent Suppression of HIV-1 Replication in Humans by T-20, a Peptide Inhibitor of gp41-Mediated Virus Entry. Nat. Med. 1998 ; 4: 1302-1307
12. Hunter E., Swanstrom R.. Retrovirus Envelope GPs. Cur. Topic Microbiol. Immun. 1990 ; 157: 187-253
13. Chan S. Y., Speck R. F., Ma M. C., et al. Distinct Mechanisms of Entry by Envelope GPs of Marburg and Ebola (Zaire) Viruses. J. Virol. 2000 ; 74: 4933-4937
14. Wool-Lewis R., Bates P.. Characterization of Ebola Virus Entry by Using Pseudotyped Viruses: Identification of Receptor Deficient Cell Lines. J. Virol. 1998 ; 72: 3155-3160
15. Jeffers S. A., Sanders D. A., Sanchez A.. Covalent Modifications of the Ebola Virus GP. J. Virol. 2002 ; 76: 12463-12472
16. Takada A., Robison C., Goto H., et al. A System for Functional Analysis of Ebola Virus GP. Proc. Natl. Acad. Sci. U. S. A. 1997 ; 94: 14764-14769
17. Manicassamy B., Wang J., Jiang H., et al. Comprehensive Analysis of Ebola Virus GP1 in Viral Entry. J. Virol. 2005 ; 79: 4793-4805
18. Guo Y., Rumschlag-Booms E., Wang J., et al. Analysis of Hemagglutinin-Mediated Entry Tropism of H5N1 Avian Influenza. Virol. J. 2009 ; 6: 39
19. Guo Y., Tisoncik J., McReynolds S., et al. Identification of a New Region of SARS-CoV S Protein Critical for Viral Entry. J. Mol. Biol. 2009 ; 394: 600-605
20. Basu A., Li B., Mills D. M., et al. Identification of a Small-Molecule Entry Inhibitor for Filoviruses. J. Virol. 2011 ; 85: 3106-3119
21. Yermolina M. V., Wang J., Caffrey M., et al. Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry. J. Med. Chem. 2011 ; 54: 765-781
22. Martinez O., Johnson J., Manicassamy B., et al. Zaire Ebola Virus Entry into Human Dendritic Cells Is Insensitive to Cathepsin L Inhibition. Cell Microbiol. 2010 ; 12: 148-157
23. Zhang H., Rothwangl K., Mesecar A. D., et al. Lamiridosins, Hepatitis C Virus Entry Inhibitors from Lamium album. J. Nat. Prod. 2009 ; 72: 2158-2162
24. Manicassamy B., Wang J., Rumschlag E., et al. Characterization of Marburg Virus GP in Viral Entry. Virology. 2007 ; 358: 79-88
25. Radoshitzky S. R., Abraham J., Spiropoulou C. F., et al. Transferrin Receptor 1 Is a Cellular Receptor for New World Hemorrhagic Fever Arenaviruses. Nature. 2007 ; 446: 92-96
26. He J., Choe S., Walker R., et al. Human Immunodeficiency Virus Type 1 Viral Protein R (Vpr) Arrests Cells in the G2 Phase of the Cell Cycle by Inhibiting p34cdc2 Activity. J. Virol. 1995 ; 69: 6705-6711
27. Connor R. I., Chen B. K., Choe S., et al. Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes. Virology. 1995 ; 206: 935-944
28. Tisoncik J. R., Guo Y., Cordero K. S., et al. Identification of Critical Residues of Influenza Neuraminidase in Viral Particle Release. Virol. J. 2011 ; 8: 14
29. R Development Core Team. R: A Language and Environment for Statistical Computing;R Foundation for Statistical Computing: Vienna, Austria, 2011. http://www.R-project.org/
30. White J. M.. Membrane Fusion. Science. 1992 ; 258: 917-924
31. Zhang J. H., Chung T. D., Oldenburg K. R.. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen. 1999 ; 4: 67-73
32. Manicassamy B., Rong L.. Expression of Ebolavirus GP on the Target Cells Enhances Viral Entry. Virol. J. 2009 ; 6: 75
33. Tscherne D. M., Manicassamy B., Garcia-Sastre A.. An Enzymatic Virus-Like Particle Assay for Sensitive Detection of Virus Entry. J. Virol. Methods. 2010 ; 163: 336-343
34. Rumschlag-Booms E., Zhang H., Soejarto D. D., et al. Development of an Antiviral Screening Protocol: One-Stone-Two-Birds. J. Antivir. Antiretrovir. 2011 ; 3: 1