Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 51, 2013, Pages 20681-20686

  Nguyen, Le Xuan Truong ^a   Mitchell, Beverly S ^a  

^a STANFORD CANCER INSTITUTE   (United States)

Author keywords

Acute myelogenous leukemia; PKB Akt

Indexed keywords

AZD 8055; CASEIN KINASE II; DNA DIRECTED RNA POLYMERASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; RIBOSOME RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION INITIATION FACTOR I; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA TRANSCRIPTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA SYNTHESIS; UBIQUITINATION;

EID: 84890810992     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313097110     Document Type: Article

References (40)

1. Montanaro L, Treré D, Derenzini M (2008) Nucleolus, ribosomes, and cancer. Am J Pathol 173(2):301-310.
2. White RJ (2008) RNA polymerases I and III, non-Coding RNAs and cancer. Trends Genet 24(12):622-629.
3. Chan JC, et al. (2011) AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. Sci Signal 4(188):ra56.
4. Miller G, et al. (2001) hRRN3 is essential in the SL1-Mediated recruitment of RNA Polymerase I to rRNA gene promoters. EMBO J 20(6):1373-1382.
5. Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002) Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep 3(11):1082-1087.
6. Zhao J, Yuan X, Frödin M, Grummt I (2003) ERK-Dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell 11(2):405-413.
7. Hoppe S, et al. (2009) AMP-Activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci USA 106(42):17781-17786.
8. Mayer C, Bierhoff H, Grummt I (2005) The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-Regulates rRNA synthesis. Genes Dev 19(8):933-941.
9. Fátyol K, Grummt I (2008) Proteasomal ATPases are associated with rDNA: The ubiquitin proteasome system plays a direct role in RNA polymerase I transcription. Biochim Biophys Acta 1779(12):850-859.
10. Yuan X, et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-Mediated apoptosis. Mol Cell 19(1): 77-87.
11. Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG (2002) Direct identification of PTEN phosphorylation sites. FEBS Lett 528(1-3):145-153.
12. Guerra B (2006) Protein kinase CK2 subunits are positive regulators of AKT kinase. Int J Oncol 28(3):685-693.
13. Di Maira G, et al. (2005) Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ 12(6):668-677.
14. Di Maira G, Brustolon F, Pinna LA, Ruzzene M (2009) Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells. Cell Mol Life Sci 66(20):3363-3373.
15. Ponce DP, et al. (2011) CK2 functionally interacts with AKT/PKB to promote the â-Catenin-Dependent expression of survivin and enhance cell survival. Mol Cell Biochem 356(1-2):127-132.
16. Geyer RK, Yu ZK, Maki CG (2000) The MDM2 RING-Finger domain is required to promote p53 nuclear export. Nat Cell Biol 2(9):569-573.
17. Vassilev LT, et al. (2004) In vivo activation of the p53 pathway by small-Molecule antagonists of MDM2. Science 303(5659):844-848.
18. Bierhoff H, Dundr M, Michels AA, Grummt I (2008) Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol 28(16):4988-4998.
19. Chresta CM, et al. (2010) AZD8055 is a potent, selective, and orally bioavailable ATPcompetitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res 70(1):288-298.
20. Sini P, James D, Chresta C, Guichard S (2010) Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells. Autophagy 6(4):553-554.
21. Honda R, Tanaka H, Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420(1):25-27.
22. Grewal SS, Evans JR, Edgar BA (2007) Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. J Cell Biol 179(6): 1105-1113.
23. James MJ, Zomerdijk JC (2004) Phosphatidylinositol 3-Kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J Biol Chem 279(10):8911-8918.
24. Li H, Tsang CK, Watkins M, Bertram PG, Zheng XF (2006) Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature 442(7106):1058-1061.
25. Meggio F, Pinna LA (2003) One-Thousand-And-One substrates of protein kinase CK2 FASEB J 17(3):349-368.
26. Louvet E, Junéra HR, Berthuy I, Hernandez-Verdun D (2006) Compartmentation of the nucleolar processing proteins in the granular component is a CK2-Driven process. Mol Biol Cell 17(6):2537-2546.
27. Johnston IM, et al. (2002) CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells. Mol Cell Biol 22(11):3757-3768.
28. Hu P, Samudre K, Wu S, Sun Y, Hernandez N (2004) CK2 phosphorylation of Bdp1 executes cell cycle-Specific RNA polymerase III transcription repression. Mol Cell 16(1): 81-92.
29. Lin CY, Navarro S, Reddy S, Comai L (2006) CK2-Mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res 34(17):4752-4766.
30. Panova TB, Panov KI, Russell J, Zomerdijk JC (2006) Casein kinase 2 associates with initiation-Competent RNA polymerase I and has multiple roles in ribosomal DNA transcription. Mol Cell Biol 26(16):5957-5968.
31. Sarno S, Marin O, Ghisellini P, Meggio F, Pinna LA (1998) Biochemical evidence that the N-Terminal segments of the alpha subunit and the beta subunit play interchangeable roles in the activation of protein kinase CK2. FEBS Lett 441(1):29-33.
32. Guerra B, Siemer S, Boldyreff B, Issinger OG (1999) Protein kinase CK2: Evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett 462(3):353-357.
33. Martelli AM, et al. (2007) Targeting the phosphatidylinositol 3-Kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: From bench to bedside. Curr Med Chem 14(19):2009-2023.
34. Polak R, Buitenhuis M (2012) The PI3K/PKB signaling module as key regulator of hematopoiesis: Implications for therapeutic strategies in leukemia. Blood 119(4): 911-923.
35. Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441(7092):424-430.
36. Memmott RM, Dennis PA (2009) Akt-Dependent and-Independent mechanisms of mTOR regulation in cancer. Cell Signal 21(5):656-664.
37. Ruggero D, Sonenberg N (2005) The Akt of translational control. Oncogene 24(50): 7426-7434.
38. Drygin D, Rice WG, Grummt I (2010) The RNA polymerase I transcription machinery: An emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol 50: 131-156.
39. Min YH, et al. (2003) Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: Its significance as a prognostic variable. Leukemia 17(5):995-997.
40. Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M (2003) Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 102(3):972-980.