Cerebral blood flow in the neonate

Paediatric Anaesthesia

Volumn 24, Issue 1, 2014, Pages 22-29

  Vutskits, Laszlo ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

autoregulation; brain; cerebral blood flow; development; hypotension; neonate

Indexed keywords

AUTOREGULATION; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN FUNCTION; BRAIN PERFUSION; CLINICAL RESEARCH; DELIVERY; ETHICS; HUMAN; HYPOTENSION; NEWBORN INTENSIVE CARE; OXYGENATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SYSTOLIC BLOOD PRESSURE;

AUTOREGULATION; BRAIN; CEREBRAL BLOOD FLOW; DEVELOPMENT; HYPOTENSION; NEONATE;

BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; HOMEOSTASIS; HUMANS; HYPOTENSION; INFANT, NEWBORN; REFERENCE VALUES;

EID: 84890803061     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12307     Document Type: Review

References (96)

1. Jevtovic-Todorovic V, Absalom AR, Blomgren K, et al,. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth 2013; 111: 143-151.
2. DiMaggio C, Sun LS, Ing C, et al,. Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis. J Neurosurg Anesthesiol 2012; 24: 376-381.
3. Vutskits L,. General anesthesia: a gateway to modulate synapse formation and neural plasticity? Anesth Analg 2012; 115: 1174-1182.
4. Short BL, Van Meurs K, Evans JR,. Summary proceedings from the cardiology group on cardiovascular instability in preterm infants. Pediatrics 2006; 117: S34-S39.
5. Tan KL,. Blood pressure in full-term healthy neonates. Clin Pediatr (Phila) 1987; 26: 21-24.
6. Tan KL,. Blood pressure in very low birth weight infants in the first 70 days of life. J Pediatr 1988; 112: 266-270.
7. Park MK, Lee DH,. Normative arm and calf blood pressure values in the newborn. Pediatrics 1989; 83: 240-243.
8. Shortland DB, Evans DH, Levene MI,. Blood pressure measurements in very low birth weight infants over the first week of life. J Perinat Med 1988; 16: 93-97.
9. Bada HS, Korones SB, Perry EH, et al,. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. J Pediatr 1990; 117: 607-614.
10. Zubrow AB, Hulman S, Kushner H, et al,. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia Neonatal Blood Pressure Study Group. J Perinatol 1995; 15: 470-479.
11. Cayabyab R, McLean CW, Seri I,. Definition of hypotension and assessment of hemodynamics in the preterm neonate. J Perinatol 2009; 29: S58-S62.
12. Dannevig I, Dale HC, Liestol K, et al,. Blood pressure in the neonate: three non-invasive oscillometric pressure monitors compared with invasively measured blood pressure. Acta Paediatr 2005; 94: 191-196.
13. Gevers M, van Genderingen HR, Lafeber HN, et al,. Accuracy of oscillometric blood pressure measurement in critically ill neonates with reference to the arterial pressure wave shape. Intensive Care Med 1996; 22: 242-248.
14. Crossland DS, Furness JC, Abu-Harb M, et al,. Variability of four limb blood pressure in normal neonates. Arch Dis Child Fetal Neonatal Ed 2004; 89: F325-F327.
15. Short JA,. Noninvasive blood pressure measurement in the upper and lower limbs of anaesthetized children. Paediatr Anaesth 2000; 10: 591-593.
16. Kluckow M, Evans N,. Relationship between blood pressure and cardiac output in preterm infants requiring mechanical ventilation. J Pediatr 1996; 129: 506-512.
17. Kluckow M, Evans N,. Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Arch Dis Child Fetal Neonatal Ed 2000; 82: F182-F187.
18. Evans N, Iyer P,. Assessment of ductus arteriosus shunt in preterm infants supported by mechanical ventilation: effect of interatrial shunting. J Pediatr 1994; 125: 778-785.
19. Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit of the Royal College of Physicians. Arch Dis Child 1992; 67: 1221-1227.
20. Osborn DA, Evans N,. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database Syst Rev 2004; 2: CD002055.
21. Osborn DA, Paradisis M, Evans N,. The effect of inotropes on morbidity and mortality in preterm infants with low systemic or organ blood flow. Cochrane Database Syst Rev 2007; 1: CD005090.
22. Miall-Allen VM, de Vries LS, Whitelaw AG,. Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child 1987; 62: 1068-1069.
23. Watkins AM, West CR, Cooke RW,. Blood pressure and cerebral haemorrhage and ischaemia in very low birthweight infants. Early Hum Dev 1989; 19: 103-110.
24. Goldstein RF, Thompson RJJ, Oehler JM, et al,. Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. Pediatrics 1995; 95: 238-243.
25. Miall-Allen VM, de Vries LS, Dubowitz LM, et al,. Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation. Pediatrics 1989; 83: 657-661.
26. Perry EH, Bada HS, Ray JD, et al,. Blood pressure increases, birth weight-dependent stability boundary, and intraventricular hemorrhage. Pediatrics 1990; 85: 727-732.
27. D'Souza SW, Janakova H, Minors D, et al,. Blood pressure, heart rate, and skin temperature in preterm infants: associations with periventricular haemorrhage. Arch Dis Child Fetal Neonatal Ed 1995; 72: F162-F167.
28. Haque IU, Zaritsky AL,. Analysis of the evidence for the lower limit of systolic and mean arterial pressure in children. Pediatr Crit Care Med 2007; 8: 138-144.
29. Nafiu OO, Voepel-Lewis T, Morris M, et al,. How do pediatric anesthesiologists define intraoperative hypotension? Pediatr Anesth 2009; 19: 1048-1053.
30. Nafiu OO, Kheterpal S, Morris M, et al,. Incidence and risk factors for preincision hypotension in a noncardiac pediatric surgical population. Pediatr Anesth 2009; 19: 232-239.
31. Schmidt CF, Kety SS,. Recent studies of cerebral blood flow and cerebral metabolism in man. Trans Assoc Am Physicians 1947; 60: 52-58.
32. Lassen NA, Ingvar DH,. The blood flow of the cerebral cortex determined by radioactive krypton. Experientia 1961; 17: 42-43.
33. Zauner A, Muizelaar JP,. Measuring cerebral blood flow and metabolism. In:, Reilly P, Bullock R, eds. Head Injury. London: Chapman & Hall, 1997: 217-227.
34. McGehee BE, Pollock JM, Maldjian JA,. Brain perfusion imaging: how does it work and what should I use? J Magn Reson Imaging 2012; 36: 1257-1272.
35. Aaslid R, Markwalder TM, Nornes H,. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982; 57: 769-774.
36. Aaslid R, Lindegaard KF, Sorteberg W, et al,. Cerebral autoregulation dynamics in humans. Stroke 1989; 20: 45-52.
37. Larsen FS, Olsen KS, Hansen BA, et al,. Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation. Stroke 1994; 25: 1985-1988.
38. Jobsis FF,. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 1977; 198: 1264-1267.
39. Ferrari M, Giannini I, Sideri G, et al,. Continuous non invasive monitoring of human brain by near infrared spectroscopy. Adv Exp Med Biol 1985; 191: 873-882.
40. Edwards AD, Richardson C, van der Zee P, et al,. Measurement of hemoglobin flow and blood flow by near-infrared spectroscopy. J Appl Physiol 1993; 75: 1884-1889.
41. Meek JH, Tyszczuk L, Elwell CE, et al,. Cerebral blood flow increases over the first three days of life in extremely preterm neonates. Arch Dis Child Fetal Neonatal Ed 1998; 78: F33-F37.
42. Olsen KS, Svendsen LB, Larsen FS,. Validation of transcranial near-infrared spectroscopy for evaluation of cerebral blood flow autoregulation. J Neurosurg Anesthesiol 1996; 8: 280-285.
43. Ito H, Kanno I, Kato C, et al,. Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging 2004; 31: 635-643.
44. Astrup J, Symon L, Branston NM, et al,. Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 1977; 8: 51-57.
45. Morawetz RB, Crowell RH, DeGirolami U, et al,. Regional cerebral blood flow thresholds during cerebral ischemia. Fed Proc 1979; 38: 2493-2494.
46. Powers WJ, Grubb RLJ, Darriet D, et al,. Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 1985; 5: 600-608.
47. Lou HC, Lassen NA, Friis-Hansen B,. Impaired autoregulation of cerebral blood flow in the distressed newborn infant. J Pediatr 1979; 94: 118-121.
48. Ment LR, Ehrenkranz RA, Lange RC, et al,. Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage. Pediatrics 1981; 68: 763-769.
49. Greisen G,. Cerebral blood flow in preterm infants during the first week of life. Acta Paediatr Scand 1986; 75: 43-51.
50. Fenton AC, Shortland DB, Papathoma E, et al,. Normal range for blood flow velocity in cerebral arteries of newly born term infants. Early Hum Dev 1990; 22: 73-79.
51. Greisen G, Trojaborg W,. Cerebral blood flow, PaCO2 changes, and visual evoked potentials in mechanically ventilated, preterm infants. Acta Paediatr Scand 1987; 76: 394-400.
52. Altman DI, Powers WJ, Perlman JM, et al,. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults. Ann Neurol 1988; 24: 218-226.
53. Greisen G, Pryds O,. Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates. Brain Dev 1989; 11: 164-168.
54. Pryds O, Greisen G,. Preservation of single-flash visual evoked potentials at very low cerebral oxygen delivery in preterm infants. Pediatr Neurol 1990; 6: 151-158.
55. McCall ML,. Cerebral circulation and metabolism in toxemia of pregnancy; observations on the effects of veratrum viride and apresoline (1-hydrazinophthalazine). Am J Obstet Gynecol 1953; 66: 1015-1030.
56. Lassen NA,. Cerebral blood flow and oxygen consumption in man. Physiol Rev 1959; 39: 183-238.
57. Moyer JH, Morris G,. Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide and arfonad). J Clin Invest 1954; 33: 1081-1088.
58. Drummond JC,. The lower limit of autoregulation: time to revise our thinking? Anesthesiology 1997; 86: 1431-1433.
59. Strandgaard S,. Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension. Circulation 1976; 53: 720-727.
60. Waldemar G, Schmidt JF, Andersen AR, et al,. Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. J Hypertens 1989; 7: 229-235.
61. Olsen KS, Svendsen LB, Larsen FS, et al,. Effect of labetalol on cerebral blood flow, oxygen metabolism and autoregulation in healthy humans. Br J Anaesth 1995; 75: 51-54.
62. Purves MJ, James IM,. Observations on the control of cerebral blood flow in the sheep fetus and newborn lamb. Circ Res 1969; 25: 651-667.
63. Papile LA, Rudolph AM, Heymann MA,. Autoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res 1985; 19: 159-161.
64. Lou HC, Lassen NA, Friis-Hansen B,. Low cerebral blood flow in hypotensive perinatal distress. Acta Neurol Scand 1977; 56: 343-352.
65. Tyszczuk L, Meek J, Elwell C, et al,. Cerebral blood flow is independent of mean arterial blood pressure in preterm infants undergoing intensive care. Pediatrics 1998; 102: 337-341.
66. Pryds O, Greisen G, Lou H, et al,. Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation. J Pediatr 1989; 115: 638-645.
67. Boylan GB, Young K, Panerai RB, et al,. Dynamic cerebral autoregulation in sick newborn infants. Pediatr Res 2000; 48: 12-17.
68. Tsuji M, Saul JP, du Plessis A, et al,. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 2000; 106: 625-632.
69. Soul JS, Hammer PE, Tsuji M, et al,. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res 2007; 61: 467-473.
70. Alderliesten T, Lemmers PM, Smarius JJ, et al,. Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage. J Pediatr 2013; 162: 698-704.e2.
71. Wong FY, Leung TS, Austin T, et al,. Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy. Pediatrics 2008; 121: e604-e611.
72. Kety SS, Schmidt CF,. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 1948; 27: 484-492.
73. Aalkjaer C, Poston L,. Effects of pH on vascular tension: which are the important mechanisms? J Vasc Res 1996; 33: 347-359.
74. Persson PB,. Modulation of cardiovascular control mechanisms and their interaction. Physiol Rev 1996; 76: 193-244.
75. Greisen G, Vannucci RC,. Is periventricular leucomalacia a result of hypoxic-ischaemic injury? Hypocapnia and the preterm brain. Biol Neonate 2001; 79: 194-200.
76. Rahilly PM,. Effects of 2% carbon dioxide, 0.5% carbon dioxide, and 100% oxygen on cranial blood flow of the human neonate. Pediatrics 1980; 66: 685-689.
77. Leahy FA, Cates D, MacCallum M, et al,. Effect of CO2 and 100% O2 on cerebral blood flow in preterm infants. J Appl Physiol 1980; 48: 468-472.
78. Levene MI, Shortland D, Gibson N, et al,. Carbon dioxide reactivity of the cerebral circulation in extremely premature infants: effects of postnatal age and indomethacin. Pediatr Res 1988; 24: 175-179.
79. Strebel S, Lam AM, Matta B, et al,. Dynamic and static cerebral autoregulation during isoflurane, desflurane, and propofol anesthesia. Anesthesiology 1995; 83: 66-76.
80. Kaisti KK, Langsjo JW, Aalto S, et al,. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003; 99: 603-613.
81. Strebel S, Kaufmann M, Maitre L, et al,. Effects of ketamine on cerebral blood flow velocity in humans. Influence of pretreatment with midazolam or esmolol. Anaesthesia 1995; 50: 223-228.
82. Gupta S, Heath K, Matta BF,. Effect of incremental doses of sevoflurane on cerebral pressure autoregulation in humans. Br J Anaesth 1997; 79: 469-472.
83. Summors AC, Gupta AK, Matta BF,. Dynamic cerebral autoregulation during sevoflurane anesthesia: a comparison with isoflurane. Anesth Analg 1999; 88: 341-345.
84. Ogawa Y, Iwasaki K, Aoki K, et al,. Dexmedetomidine weakens dynamic cerebral autoregulation as assessed by transfer function analysis and the thigh cuff method. Anesthesiology 2008; 109: 642-650.
85. Hamon I, Hascoet JM, Debbiche A, et al,. Effects of fentanyl administration on general and cerebral haemodynamics in sick newborn infants. Acta Paediatr 1996; 85: 361-365.
86. Azhan A, Wong FY,. Challenges in understanding the impact of blood pressure management on cerebral oxygenation in the preterm brain. Front Physiol 2012; 3: 471.
87. Fanaroff JM, Wilson-Costello DE, Newman NS, et al,. Treated hypotension is associated with neonatal morbidity and hearing loss in extremely low birth weight infants. Pediatrics 2006; 117: 1131-1135.
88. Kuint J, Barak M, Morag I, et al,. Early treated hypotension and outcome in very low birth weight infants. Neonatology 2009; 95: 311-316.
89. Seri I, Rudas G, Bors Z, et al,. Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates. Pediatr Res 1993; 34: 742-749.
90. Munro MJ, Walker AM, Barfield CP,. Hypotensive extremely low birth weight infants have reduced cerebral blood flow. Pediatrics 2004; 114: 1591-1596.
91. Lundstrom K, Pryds O, Greisen G,. The haemodynamic effects of dopamine and volume expansion in sick preterm infants. Early Hum Dev 2000; 57: 157-163.
92. Pellicer A, Valverde E, Elorza MD, et al,. Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial. Pediatrics 2005; 115: 1501-1512.
93. Pellicer A, Bravo MC, Madero R, et al,. Early systemic hypotension and vasopressor support in low birth weight infants: impact on neurodevelopment. Pediatrics 2009; 123: 1369-1376.
94. Bassan H, Gauvreau K, Newburger JW, et al,. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res 2005; 57: 35-41.
95. Chock VY, Ramamoorthy C, Van Meurs KP,. Cerebral autoregulation in neonates with a hemodynamically significant patent ductus arteriosus. J Pediatr 2012; 160: 936-942.
96. Hahn GH,. Testing impact of perinatal inflammation on cerebral autoregulation in preterm neonates: evaluation of a noninvasive method. Dan Med J 2013; 60: B4628.