Cardiac fibroblasts recruit Th17 cells infiltration into myocardium by secreting CcL20 in CVB3-induced acute viral myocarditis

Cellular Physiology and Biochemistry

Volumn 32, Issue 5, 2013, Pages 1437-1450

  Yu, Miao ^a   Hu, Jun ^a   Zhu, Ming Xin ^a   Zhao, Tong ^a   Liang, Wei ^a   Wen, Shuang ^a   Li, Huan Huan ^a   Long, Qi ^a   Wang, Min ^a   Guo, He Ping ^a   Cheng, Xiang ^a   Liao, Yu Hua ^a   Yuan, Jing ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acute viral myocarditis; Cardiac fibroblasts; CCL20; Th17 cells

Indexed keywords

CCL20 MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE VIRAL MYOCARDITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDIAC FIBROBLAST; CELL DIFFERENTIATION; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENDOTHELIUM; FEMALE; FIBROBLAST; HEART; HEART MUSCLE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATORY CELL; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; TH17 CELL; VIRUS MYOCARDITIS; ANIMAL MODEL; ANIMAL TISSUE; CELL CYCLE ARREST; CYTOKINE RELEASE; ENDOTHELIUM CELL; INFLAMMATORY INFILTRATE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC INFILTRATION; NEWBORN; PERIPHERAL LYMPHOCYTE;

MUS;

ACUTE DISEASE; ANIMALS; CELL DIFFERENTIATION; CHEMOKINE CCL20; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS B, HUMAN; FIBROBLASTS; HEART; HUMANS; MALE; MICE; MICE, INBRED BALB C; MYOCARDITIS; MYOCARDIUM; MYOCYTES, CARDIAC; TH17 CELLS;

EID: 84890745471     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356581     Document Type: Article

References (33)

1. Dennert R, Crijns HJ, Heymans S: Acute viral myocarditis: Eur Hear J 2008;29:2073-2082.
2. Deonarain R, Cerullo D, Fuse K, Liu PP, Fish EN: Protective role for interferon-beta in coxsackievirus B3 infection. Circulation 2004;110:3540-3543.
3. Liu PP, Mason JW: Advances in the understanding of myocarditis. Circulation 2001;104:1076-1082.
4. Cooper LT Jr: Myocarditis. N Engl J Med 2009;360:1526-1538.
5. Yuan J, Cao AL, Yu M, Lin QW, Yu X, Zhang JH, Wang M, Guo HP, Liao YH: Thl7 cells facilitate the humoral immune response in patients with acute viral myocarditis. J Clin Immunol 2010;30:226-234.
6. Yuan J, Yu M, Lin QW, Cao AL, Yu X, Dong JH, Wang JP, Zhang JH, Wang M, Guo HP, Liao YH: Neutralization of IL-17 inhibits the production of anti-ANT autoantibodies in CVB3-induced acute viral myocarditis. Int Immunopharmacol 2010;10:272-276.
7. Yuan J, Yu M, Lin QW, Cao AL, Yu X, Dong JH, Wang JP, Zhang JH, Wang M, Guo HP, Cheng X, Liao YH: Thl7 cells contribute to viral replication in coxsackievirus B3-induced acute viral myocarditis. J Immunol 2010;185:4004-4010.
8. Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X: Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol 2012;59:420-429.
9. Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D: Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 2010;106:1646-1655.
10. Bromley SK, Mempel TR, Luster AD: Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 2008;9:970-980.
11. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, Sallusto F, Napolitani G: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007;8:639-646.
12. Metzler B, Mair J, Lercher A, Schaber C, Hintringer F, Pachinger O, Xu Q: Mouse model of myocardial remodelling after role of intercellular adhesion molecule-1. Cardiovasc Res 2001;49:399-407.
13. Nishio R, Matsumori A, Shioi T, Ishida H, Sasayama S: Treatment of experimental viral myocarditis with interleukin-10. Circulation 1999;100:1102-1108.
14. Rui T, Cepinskas G, Feng Q, Ho YS, Kvietys PR: Cardiac myocytes exposed to anoxiareoxygenation promote neutrophil transendothelial migration. Am J Physiol Heart Circ Physiol 2001;281:H440-447.
15. Yu Q, Watson RR, Marchalonis JJ, Larson DF: A role for T lymphocytes in mediating cardiac diastolic function. Am J Physiol Heart Circ Physiol 2005;289:H643-651.
16. Bowden RA, Ding ZM, Donnachie EM, Petersen TK, Michael LH, Ballantyne CM, Burns AR: Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ Res 2002;90:562-569.
17. Lim YC, Luscinskas FW: Isolation and culture of murine heart and lung endothelial cells for in vitro model systems. Methods Mol Biol 2006;341:141-154.
18. Kokura S, Wolf RE, Yoshikawa T, Granger DN, Aw TY: T-lymphocyte-derived tumor necrosis factor exacerbates anoxia-reoxygenation-induced neutrophil-endothelial cell adhesion. Circ Res 2000;86:205-213.
19. Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithauser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N: PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013;123:1310-1322.
20. Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrucker HW, Tiegs G, Stahl RA, Panzer U: CCR6 recruits regulatory T cells and Thl7 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 2010;21:974-985.
21. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F: C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009;10:514-523.
22. Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S: Preferential recruitment of CCR6-expressing Thl7 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 2007;204:2803-2812.
23. Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, Wang H, Chen J, Wang H: Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice. PLoS One 2011;6:el9495.
24. Kao CY, Huang F, Chen Y, Thai P, Wachi S, Kim C, Tarn L, Wu R: Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-κB-dependent signaling pathway. J Immunol 2005;175:6676-6685.
25. Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano X Taketani Y: Recruitment of CCR6-expressing Thl7 cells by CCL20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells. Endocrinology 2010;151:5468-5476.
26. Kanda N, Shibata S, Tada Y, Nashiro K, Tamaki K, Watanabe S: Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. Eur J Immunol 2009; 39:996-1006.
27. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-314.
28. Luster AD, Alon R, von Andrian UH: Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 2005;6:1182-1190.
29. Ley K, Laudanna C, Cybulsky MI, Nourshargh S: Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007;7:678-689.
30. Ley K, Kansas GS: Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol 2004;4:325-335.
31. Xie Y, Liao J, Li M, Wang X, Yang Y, Ge J, Chen R, Chen H: Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potential role in cardiac fibrosis. Virus Res 2012;169:188-194.
32. Sutton CE, Mielke LA, Mills KH: IL-17-producing γ8 T cells and innate lymphoid cells. Eur J Immunol 2012;42:2221-2231.
33. Brodlie M, Lordan J, Ward C: Can cells other than Thl7 lymphocytes be important sources of IL-17 in the lungs? Thorax 2011;66:1096-1097.