IL-17A induces pro-inflammatory cytokines production in macrophages via MAPKinases, NF-κB and AP-1

Cellular Physiology and Biochemistry

Volumn 32, Issue 5, 2013, Pages 1265-1274

  Chen, Jian ^a   Liao, Meng Yang ^a   Gao, Xing Li ^a   Zhong, Qi ^b   Tang, Ting Ting ^a   Yu, Xian ^a   Liao, Yu Hua ^a   Cheng, Xiang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Inflammatory cytokines; Interleukin 17A; Macrophages

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CURCUMIN; CYTOKINE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17RA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; INTERLEUKIN 1; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; ATTENUATION; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; MACROPHAGE; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; WESTERN BLOTTING; ATHEROSCLEROTIC PLAQUE;

ANIMALS; CELL LINE; CYTOKINES; ENZYME INHIBITORS; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTORS, INTERLEUKIN-17; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84890742361     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354525     Document Type: Article

References (37)

1. Libby P: Inflammation in atherosclerosis. Nature 2002;420:868-874.
2. Weber C, Zernecke A, Libby P: The multifaceted contributions of leukocyte subsets to atherosclerosis: Lessons from mouse models. Nat Rev Immunol 2008;8:802-815.
3. Halvorsen B, Otterdal K, Dahl TB, Skjelland M, Gullestad L, Oie E, Aukrust P: Atherosclerotic plaque stability-what determines the fate of a plaque? Prog Cardiovasc Dis 2008;51:183-194.
4. van den Berg WB, Miossec P: Il-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol 2009;5:549-553.
5. Abraham C, Cho J: Interleukin-23/th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis 2009;15:1090-1100.
6. Yuan J, Yu M, Lin QW, Cao AL, Yu X, Dong JH, Wang JP, Zhang JH, Wang M, Guo HP, Cheng X, Liao YH: Th17 cells contribute to viral replication in coxsackievirus b3-induced acute viral myocarditis. J Immunol 2010;185:4004-4010.
7. Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X: Interleukin-17a contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol 2012;59:420-429.
8. Chen Z, O'Shea JJ: Th17 cells: A new fate for differentiating helper t cells. Immunol Res 2008;41:87-102.
9. Iwakura Y, Ishigame H, Saijo S, Nakae S: Functional specialization of interleukin-17 family members. Immunity 2011;34:149-162.
10. Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, Yao R, Chen Y, Liao YH: The th17/treg imbalance in patients with acute coronary syndrome. Clin Immunol 2008;127:89-97.
11. Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G: Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating t cells and act synergistically on vascular smooth muscle cells. Circulation 2009;119:1424-1432.
12. Madhur MS, Funt SA, Li L, Vinh A, Chen W, Lob HE, Iwakura Y, Blinder Y, Rahman A, Quyyumi AA, Harrison DG: Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol 2011;31:1565-1572.
13. Boyle JJ: Macrophage activation in atherosclerosis: Pathogenesis and pharmacology of plaque rupture. Curr Vasc Pharmacol 2005;3:63-68.
14. Kitami S, Tanaka H, Kawato T, Tanabe N, Katono-Tani T, Zhang F, Suzuki N, Yonehara Y, Maeno M: Il-17a suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via il-17ra or il-17rc receptors in raw264.7 cells. Biochimie 2010;92:398-404.
15. Shahrara S, Pickens SR, Dorfleutner A, Pope RM: Il-17 induces monocyte migration in rheumatoid arthritis. J Immunol 2009;182:3884-3891.
16. Galkina E, Ley K: Immune and inflammatory mechanisms of atherosclerosis (#). Annu Rev Immunol 2009;27:165-197.
17. Taleb S, Tedgui A, Mallat Z: Adaptive t cell immune responses and atherogenesis. Curr Opin Pharmacol 2010;10:197-202.
18. Zhou X, Nicoletti A, Elhage R, Hansson GK: Transfer of cd4(+) t cells aggravates atherosclerosis in immunodeficient apolipoprotein e knockout mice. Circulation 2000;102:2919-2922.
19. Zhou X, Robertson AK, Hjerpe C, Hansson GK: Adoptive transfer of cd4+ t cells reactive to modified low-density lipoprotein aggravates atherosclerosis. Arterioscler Thromb Vasc Biol 2006;26:864-870.
20. Lahoute C, Herbin O, Mallat Z, Tedgui A: Adaptive immunity in atherosclerosis: Mechanisms and future therapeutic targets. Nat Rev Cardiol 2011;8:348-358.
21. Xie JJ, Wang J, Tang TT, Chen J, Gao XL, Yuan J, Zhou ZH, Liao MY, Yao R, Yu X, Wang D, Cheng Y, Liao YH, Cheng X: The th17/treg functional imbalance during atherogenesis in apoe(-/-) mice. Cytokine 2010;49:185-193.
22. Pejnovic N, Vratimos A, Lee SH, Popadic D, Takeda K, Akira S, Chan WL: Increased atherosclerotic lesions and th17 in interleukin-18 deficient apolipoprotein e-knockout mice fed high-fat diet. Mol Immunol 2009;47:37-45.
23. Smith E, Prasad KM, Butcher M, Dobrian A, Kolls JK, Ley K, Galkina E: Blockade of interleukin-17a results in reduced atherosclerosis in apolipoprotein e-deficient mice. Circulation 2010;121:1746-1755.
24. van Es T, van Puijvelde GH, Ramos OH, Segers FM, Joosten LA, van den Berg WB, Michon IM, de Vos P, van Berkel TJ, Kuiper J: Attenuated atherosclerosis upon il-17r signaling disruption in ldlr deficient mice. Biochem Biophys Res Commun 2009;388:261-265.
25. Erbel C, Chen L, Bea F, Wangler S, Celik S, Lasitschka F, Wang Y, Bockler D, Katus HA, Dengler TJ: Inhibition of il-17a attenuates atherosclerotic lesion development in apoe-deficient mice. J Immunol 2009;183:8167-8175.
26. Cheng X, Taleb S, Wang J, Tang TT, Chen J, Gao XL, Yao R, Xie JJ, Yu X, Xia N, Yan XX, Nie SF, Liao MY, Cheng Y, Mallat Z, Liao YH: Inhibition of il-17a in atherosclerosis. Atherosclerosis 2011;215:471-474.
27. Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z: Loss of socs3 expression in t cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med 2009;206:2067-2077.
28. Swirski FK, Weissleder R, Pittet MJ: Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arterioscler Thromb Vasc Biol 2009;29:1424-1432.
29. Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP: Il-17 stimulates the production and expression of proinflammatory cytokines, il-beta and tnf-alpha, by human macrophages. J Immunol 1998;160:3513-3521.
30. Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D: Macrophages participate in il-17-mediated inflammation. Eur J Immunol 2012;42:726-736.
31. Kaminska B: Mapk signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 2005;1754:253-262.
32. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM: Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998;273:18623-18632.
33. Patel DN, King CA, Bailey SR, Holt JW, Venkatachalam K, Agrawal A, Valente AJ, Chandrasekar B: Interleukin-17 stimulates c-reactive protein expression in hepatocytes and smooth muscle cells via p38 mapk and erk1/2-dependent nf-kappab and c/ebpbeta activation. J Biol Chem 2007;282:27229-27238.
34. Shen F, Hu Z, Goswami J, Gaffen SL: Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 2006;281:24138-24148.
35. Xanthoulea S, Curfs DM, Hofker MH, de Winther MP: Nuclear factor kappa b signaling in macrophage function and atherogenesis. Curr Opin Lipidol 2005;16:536-542.
36. Schonthaler HB, Guinea-Viniegra J, Wagner EF: Targeting inflammation by modulating the jun/ap-1 pathway. Ann Rheum Dis 2011;70:i109-112.
37. Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y: Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with helicobacter pylori. Mol Biol Cell 2005;16:4954-4966.