-
1
-
-
8344271026
-
Production of recombinant protein therapeutics in cultivated mammalian cells
-
Wurm, F. (2004). Production of recombinant protein therapeutics in cultivated mammalian cells. Nature Biotechnology 22, 1-6.
-
(2004)
Nature Biotechnology
, vol.22
, pp. 1-6
-
-
Wurm, F.1
-
2
-
-
33744983118
-
The Renaissance of protein purification
-
(June)
-
Gottschalk, U. (2006). The Renaissance of protein purification. BioPharm International 18 (June), 8-9.
-
(2006)
BioPharm International
, vol.18
, pp. 8-9
-
-
Gottschalk, U.1
-
3
-
-
45149110469
-
Bioseparation in antibody manufacturing: The good, the bad and the ugly
-
Gottschalk, U. (2008). Bioseparation in antibody manufacturing: The good, the bad and the ugly. Biotechnology Progress 24, 496-503.
-
(2008)
Biotechnology Progress
, vol.24
, pp. 496-503
-
-
Gottschalk, U.1
-
4
-
-
35348866110
-
Very large scale monoclonal antibody purification: The case for conventional unit operations
-
Kelley, B. (2007). Very large scale monoclonal antibody purification: The case for conventional unit operations. Biotechnology Progress 23, 995-1008.
-
(2007)
Biotechnology Progress
, vol.23
, pp. 995-1008
-
-
Kelley, B.1
-
5
-
-
33847102715
-
Alternatives to chromatographic separations
-
Thommes, J., Etzel, M. (2007). Alternatives to chromatographic separations. Biotechnology Progress 23, 42-45.
-
(2007)
Biotechnology Progress
, vol.23
, pp. 42-45
-
-
Thommes, J.1
Etzel, M.2
-
6
-
-
33847094864
-
Flocculation of antibody-producing mammalian cells with precipitating solutions of soluble cations and anions
-
Presentation at Recovery of Biological Products XII, Litchfield, AZ 2006
-
Coffman, J., Shpritzer, R., Vicik, S. (2006). Flocculation of antibody-producing mammalian cells with precipitating solutions of soluble cations and anions. Presentation at Recovery of Biological Products XII, Litchfield, AZ, 2006.
-
(2006)
-
-
Coffman, J.1
Shpritzer, R.2
Vicik, S.3
-
7
-
-
84949018063
-
Calcium phosphate fl occulation of antibody-producing mammalian cells at pilot scale
-
Presentation at the 232nd ACS National Meeting, San Francisco, CA 2006
-
Shpritzer, R., Vicik, S., Orlando, S., Acharya, H., Coffman, J. (2006). Calcium phosphate fl occulation of antibody-producing mammalian cells at pilot scale. Presentation at the 232nd ACS National Meeting, San Francisco, CA, 2006.
-
(2006)
-
-
Shpritzer, R.1
Vicik, S.2
Orlando, S.3
Acharya, H.4
Coffman, J.5
-
8
-
-
84890676877
-
-
Presentation at the CMC Strategy Forum, Washington, DC 2006
-
Cecchini, D., Thommes, J. (2006). Presentation at the CMC Strategy Forum, Washington, DC, 2006.
-
(2006)
-
-
Cecchini, D.1
Thommes, J.2
-
9
-
-
78649673749
-
Precipitation of proteins: Nonspecific and specific
-
Kumar, A., Galaev, I.Y., Mattiasson, B. (2003). Precipitation of proteins: Nonspecific and specific. Biotechnology and Bioprocessing 27, 225-275.
-
(2003)
Biotechnology and Bioprocessing
, vol.27
, pp. 225-275
-
-
Kumar, A.1
Galaev, I.Y.2
Mattiasson, B.3
-
10
-
-
0038739516
-
Protein purification by affinity precipitation
-
Hilbrig, F., Freitag, R. (2003). Protein purification by affinity precipitation. Journal of Chromatography B 790, 79-90.
-
(2003)
Journal of Chromatography B
, vol.790
, pp. 79-90
-
-
Hilbrig, F.1
Freitag, R.2
-
11
-
-
77953443435
-
Process-scale precipitation of impurities in mammalian cell culture broth
-
Glynn, J. (2008). Process-scale precipitation of impurities in mammalian cell culture broth. BioPharm International 21 (in press).
-
(2008)
BioPharm International
, vol.21
-
-
Glynn, J.1
-
12
-
-
4744342353
-
Alternative bioseparation operations: Life beyond packed-bed chromatography
-
Przybycien, T., Narahari, S., Steele, L. (2004). Alternative bioseparation operations: Life beyond packed-bed chromatography. Current Opinion in Biotechnology 15, 469-478.
-
(2004)
Current Opinion in Biotechnology
, vol.15
, pp. 469-478
-
-
Przybycien, T.1
Narahari, S.2
Steele, L.3
-
13
-
-
0017052074
-
Preparation of human immunoglobulin by ammonium sulfate precipitation
-
Habeeb, A., Francis, R. (1976). Preparation of human immunoglobulin by ammonium sulfate precipitation. Vox Sanguinis 31, 423-434.
-
(1976)
Vox Sanguinis
, vol.31
, pp. 423-434
-
-
Habeeb, A.1
Francis, R.2
-
14
-
-
0032616560
-
Purification of antibodies using ammonium sulfate fractionation or gel fractionation
-
Kent, U. (1999). Purification of antibodies using ammonium sulfate fractionation or gel fractionation. Methods in Molecular Biology 115, 11-18.
-
(1999)
Methods in Molecular Biology
, vol.115
, pp. 11-18
-
-
Kent, U.1
-
15
-
-
84890654144
-
Purification of IgG by precipitation with sodium sulfate or ammonium sulfate
-
Page, M., Thorpe, R. (2002). Purification of IgG by precipitation with sodium sulfate or ammonium sulfate. In Walker, J.M. (ed.) The Protein Protocols Handbook, 2nd ed., Humana Press, Inc., Totowa, NJ, pp. 983, 984.
-
(2002)
n Walker, J.M. (ed.) The Protein Protocols Handbook, 2nd ed., Humana Press, Inc., Totowa, NJ, pp.
, vol.983
, pp. 984
-
-
Page, M.1
Thorpe, R.2
-
18
-
-
84988197550
-
S alt fractionation of immunoglobulins
-
In Herzenberg, L.A., Weir, W.M., Herzenberg, L.A., Blackwell, C. Blackwell Scientific Publishers, Oxford, pp. 6.1-6.11 (eds.)
-
Heide, K., Schwick, H.G. (1973). S alt fractionation of immunoglobulins. In Herzenberg, L.A., Weir, W.M., Herzenberg, L.A., Blackwell, C. (eds.) Weir' s Handbook of Experimental Immunology, Vol. 2, Blackwell Scientific Publishers, Oxford, pp. 6.1-6.11.
-
(1973)
Weir' s Handbook of Experimental Immunology
, vol.2
-
-
Heide, K.1
Schwick, H.G.2
-
19
-
-
33947444499
-
Preparation and properties of serum and plasma proteins
-
Cohn, E.J., Strong, L.E., Hughes, W.L., Mulford, D.J., Asworth, J.N., Melin, M., Taylor, H.L. (1946). Preparation and properties of serum and plasma proteins. IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fl uids. Journal of the American Chemical Society 62, 459-475.
-
(1946)
IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fl uids. Journal of the American Chemical Society
, vol.62
, pp. 459-475
-
-
Cohn, E.J.1
Strong, L.E.2
Hughes, W.L.3
Mulford, D.J.4
Asworth, J.N.5
Melin, M.6
Taylor, H.L.7
-
20
-
-
0017160664
-
Selectivity of protein precipitation with polyethylene glycol fractions of various molecular weights
-
Hönig, W., Kula, M.-R. (1976). Selectivity of protein precipitation with polyethylene glycol fractions of various molecular weights. Analytical Biochemistry 72, 502-512.
-
(1976)
Analytical Biochemistry
, vol.72
, pp. 502-512
-
-
Hönig, W.1
Kula, M.-R.2
-
22
-
-
0242669192
-
Properties of a new intravenous immunoglobulin (IGIV-C, 10%) produced by virus inactivation with caprylate and column chromatography
-
Lebing, W., Remington, K.M., Schreiner, C., Paul, H.-I. (2003). Properties of a new intravenous immunoglobulin (IGIV-C, 10%) produced by virus inactivation with caprylate and column chromatography. Vox Sanguinis 84, 193-201.
-
(2003)
Vox Sanguinis
, vol.84
, pp. 193-201
-
-
Lebing, W.1
Remington, K.M.2
Schreiner, C.3
Paul, H.-I.4
-
23
-
-
33644931642
-
A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance
-
Parkkinen, J., Rahola, A., von Bonsdorff, L., Tölö, H., Törmä, E. (2006). A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance. Vox Sanguinis 90, 97-104.
-
(2006)
Vox Sanguinis
, vol.90
, pp. 97-104
-
-
Parkkinen, J.1
Rahola, A.2
von Bonsdorff, L.3
Tölö, H.4
Törmä, E.5
-
24
-
-
0025975285
-
Inactivation of lipid-enveloped viruses in proteins by caprylate
-
Lundblad, J.L., Seng, R.L. (1991). Inactivation of lipid-enveloped viruses in proteins by caprylate. Vox Sanguinis 60, 75-81.
-
(1991)
Vox Sanguinis
, vol.60
, pp. 75-81
-
-
Lundblad, J.L.1
Seng, R.L.2
-
25
-
-
0028238724
-
Continuous separation of whey proteins with aqueous two-phase systems in a Graesser contactor
-
Dos Reis Coimbra, J., Th ö mmes, J., Kula, M.-R. (1994). Continuous separation of whey proteins with aqueous two-phase systems in a Graesser contactor. Journal of Chromatography A 668, 85-94.
-
(1994)
Journal of Chromatography A
, vol.668
, pp. 85-94
-
-
Dos Reis Coimbra, J.1
Thömmes, J.2
Kula, M.-R.3
-
26
-
-
0028896617
-
Extraction of cholesterol oxidase from Nocardia rhodochrous using a nonionic surfactant-based aqueous two-phase system
-
Minuth, T., Th ö mmes J., Kula, M.-R. (1995). Extraction of cholesterol oxidase from Nocardia rhodochrous using a nonionic surfactant-based aqueous two-phase system. Journal of Biotechnology 38, 151-164.
-
(1995)
Journal of Biotechnology
, vol.38
, pp. 151-164
-
-
Minuth, T.1
Thömmes, J.2
Kula, M.-R.3
-
27
-
-
12144289986
-
Three - phase partitioning as an efficient method for extraction/concentration of immunoreactive excreted-secreted proteins of Corynebacterium pseudotuberculosis
-
Paule, B.J.A., Meyer, R., Moura-Costa, L.F., Bahia, R.C., Carminati, R., Regis, L.F., Vale, V.L.C., Freire, S.M., Nascimento, I., Schaer, R., Azevedo, V. (2004). Three - phase partitioning as an efficient method for extraction/concentration of immunoreactive excreted-secreted proteins of Corynebacterium pseudotuberculosis. Protein Expression and Purification 34, 311-316.
-
(2004)
Protein Expression and Purification
, vol.34
, pp. 311-316
-
-
Paule, B.J.A.1
Meyer, R.2
Moura-Costa, L.F.3
Bahia, R.C.4
Carminati, R.5
Regis, L.F.6
Vale, V.L.C.7
Freire, S.M.8
Nascimento, I.9
Schaer, R.10
Azevedo, V.11
-
28
-
-
0034705762
-
Investigation of mathematical methods for efficient optimisation of aqueous two-phase extraction
-
Selber, K., Nellen, F., Steffen, B., Th ö mmes, J., Kula, M.-R. (2000). Investigation of mathematical methods for efficient optimisation of aqueous two-phase extraction. Journal of Chromatography B 743, 21-30.
-
(2000)
Journal of Chromatography B
, vol.743
, pp. 21-30
-
-
Selber, K.1
Nellen, F.2
Steffen, B.3
Thömmes, J.4
Kula, M.-R.5
-
29
-
-
0036145798
-
Three-phase affinity partitioning of proteins
-
Roy, I., Gupta, M.N. (2002). Three-phase affinity partitioning of proteins. Analytical Biochemistry 300, 11-14.
-
(2002)
Analytical Biochemistry
, vol.300
, pp. 11-14
-
-
Roy, I.1
Gupta, M.N.2
-
30
-
-
0002312293
-
Protein purification, aqueous liquid extraction
-
Flicker, M., Drew, S. (eds.) , Wiley, New York, NY, pp. 2179-2191 Banik, R.M., Santhiagu, A., Kanari, B., Sabarinath, C., Upadhyay, N.J. (2003). Technological aspects of extractive fermentation using aqueous two-phase systems. World Journal of Microbiology and Biotechnology
-
Kula, M.-R., Selber, K. (1999). Protein purification, aqueous liquid extraction. In Flicker, M., Drew, S. (eds.) Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseperation, Wiley, New York, NY, pp. 2179-2191 Banik, R.M., Santhiagu, A., Kanari, B., Sabarinath, C., Upadhyay, N.J. (2003). Technological aspects of extractive fermentation using aqueous two-phase systems. World Journal of Microbiology and Biotechnology 19, 337-348.
-
(1999)
Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseperation
, vol.19
, pp. 337-348
-
-
Kula, M.-R.1
Selber, K.2
-
32
-
-
0037795752
-
Crystalline monoclonal antibodies for subcutaneous delivery
-
Yang, M.X., Shenoy, B., Disttler, M., Patel, R., McGrath, M., Pechenov, S., Margolin, A.L. (2003). Crystalline monoclonal antibodies for subcutaneous delivery. Proceedings of the National Academy of Sciences of the United States of America 100, 6934-6939.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 6934-6939
-
-
Yang, M.X.1
Shenoy, B.2
Disttler, M.3
Patel, R.4
McGrath, M.5
Pechenov, S.6
Margolin, A.L.7
-
33
-
-
84890575338
-
-
Stabilized protein crystals, formulations containing them and methods of making them. US Patent #6541606.
-
Margolin, A.L., Khalaf, N.K. ,St. Clair, N.L., Rakestraw, S.L., Shenoy, B.C. (2003). Stabilized protein crystals, formulations containing them and methods of making them. US Patent #6541606.
-
(2003)
-
-
Margolin, A.L.1
Khalaf St, N.K.2
Clair, N.L.3
Rakestraw, S.L.4
Shenoy, B.C.5
-
34
-
-
84890714724
-
-
Stabilized protein crystals formulations comprising them and methods of making them. US Patent #7351798.
-
Margolin, A.L., Khalaf, N.K., St. Clair, N.L., Rakestraw, S.L., Shenoy, B.C. (2008). Stabilized protein crystals formulations comprising them and methods of making them. US Patent #7351798.
-
(2008)
-
-
Margolin, A.L.1
Khalaf St, N.K.2
Clair, N.L.3
Rakestraw, S.L.4
Shenoy, B.C.5
-
35
-
-
10644257654
-
Implementation of a crystallization step into the purification process of a recombinant protein
-
Peters, J., Minuth, T., Schr ö der, W. (2005). Implementation of a crystallization step into the purification process of a recombinant protein. Protein Expression and Purification 39, 43-53.
-
(2005)
Protein Expression and Purification
, vol.39
, pp. 43-53
-
-
Peters, J.1
Minuth, T.2
Schröder, W.3
-
36
-
-
84890713526
-
-
Apo-2 ligand/trail formulations. US Patent Application #20060009387 A1.
-
Flores, H., Lin, T., Matthews, T., Pai, R., Shahrokh, Z. (2006). Apo-2 ligand/trail formulations. US Patent Application #20060009387 A1.
-
(2006)
-
-
Flores, H.1
Lin, T.2
Matthews, T.3
Pai, R.4
Shahrokh, Z.5
-
38
-
-
33845258911
-
Crystallization of IgG1 by mapping its liquid-liquid phase separation curves
-
Jion, A., Goh, L., Oh, S. (2006). Crystallization of IgG1 by mapping its liquid-liquid phase separation curves. Biotechnology and Bioengineering 95, 911-918.
-
(2006)
Biotechnology and Bioengineering
, vol.95
, pp. 911-918
-
-
Jion, A.1
Goh, L.2
Oh, S.3
-
39
-
-
34447303560
-
Phase behavior of an intact monoclonal antibody
-
Ahamed, T., Esteban, B.N.A., Ottens, M., van Dedem, G.W.K., Van der Wielen, L.A.M., Bisschops, M.A.T., Lee, A., Pham, C., Th ö mmes, J. (2007). Phase behavior of an intact monoclonal antibody. Biophysical Journal 93, 610-619.
-
(2007)
Biophysical Journal
, vol.93
, pp. 610-619
-
-
Ahamed, T.1
Esteban, B.N.A.2
Ottens, M.3
van Dedem, G.W.K.4
Van der Wielen, L.A.M.5
Bisschops, M.A.T.6
Lee, A.7
Pham, C.8
Thömmes, J.9
-
40
-
-
33544464424
-
Large-scale freezing and thawing of biopharmaceutical products
-
Avis, K., Wu, V. (eds.) , Processing and Preservation, Interpharm Press, Denver, CO, pp. 7-59.
-
Wisniewski, R., Wu, V. (1996). Large-scale freezing and thawing of biopharmaceutical products. In Avis, K., Wu, V. (eds.) Biotechnology and Biopharmaceutical Manufacturing, Processing and Preservation, Interpharm Press, Denver, CO, pp. 7-59.
-
(1996)
Biotechnology and Biopharmaceutical Manufacturing
-
-
Wisniewski, R.1
Wu, V.2
-
41
-
-
0031776793
-
Developing large-scale cryopreservation systems for biopharmaceutical products
-
Wisniewski, R. (1999). Developing large-scale cryopreservation systems for biopharmaceutical products. BioPharm International 13, 50-60.
-
(1999)
BioPharm International
, vol.13
, pp. 50-60
-
-
Wisniewski, R.1
-
42
-
-
0022011325
-
Studies on heat transfer from a vertical cylinder, with or without fins, embedded in a solid phase change medium
-
Kalhori, B., Ramadhyani, S. (1985). Studies on heat transfer from a vertical cylinder, with or without fins, embedded in a solid phase change medium. ASME Journal of Heat Transfer 107, 44-51.
-
(1985)
ASME Journal of Heat Transfer
, vol.107
, pp. 44-51
-
-
Kalhori, B.1
Ramadhyani, S.2
-
43
-
-
0037440925
-
Bioprocessing - Controlled freeze/thaw for biopharmaceuticals
-
Wisniewski, R. (2003). Bioprocessing - Controlled freeze/thaw for biopharmaceuticals . Genetic Engineering News 32, 36-38.
-
(2003)
Genetic Engineering News
, vol.32
, pp. 36-38
-
-
Wisniewski, R.1
-
44
-
-
84890727667
-
Freeze-drying
-
Wilson, I.D. (ed.) , Elsevier Science, London
-
Oetjen, G.W. (2000). Freeze-drying. In Wilson, I.D. (ed.) Encyclopedia of Separation Science, Elsevier Science, London, pp. 1023-1034.
-
(2000)
Encyclopedia of Separation Science
, pp. 1023-1034
-
-
Oetjen, G.W.1
-
46
-
-
0008507595
-
Membrane chromatography
-
Flickinger, M., Drew, S. (eds.) , Wiley, New York, NY
-
Th ö mmes, J. (1999). Membrane chromatography. In Flickinger, M., Drew, S. (eds.) Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation, Wiley, New York, NY, pp. 1683-1695.
-
(1999)
Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation
, pp. 1683-1695
-
-
Thömmes, J.1
-
47
-
-
33646041909
-
Basic concepts in Q membrane chromatography for large-scale antibody production
-
Zhou, J., Tressel, T. (2006). Basic concepts in Q membrane chromatography for large-scale antibody production. Biotechnology Progress 22, 341-349.
-
(2006)
Biotechnology Progress
, vol.22
, pp. 341-349
-
-
Zhou, J.1
Tressel, T.2
-
48
-
-
84885548890
-
M embrane chromatography: Analysis of breakthrough curves and viral clearance
-
Shukla, A., Etzel, M., Gadam, S. (eds.) , Taylor & Francis, Boca Raton, FL.
-
Etzel, M., Riordan, W. (2006). M embrane chromatography: Analysis of breakthrough curves and viral clearance. In Shukla, A., Etzel, M., Gadam, S. (eds.) Process Scale Bioseparations for the Biopharmaceutical Industry, Taylor & Francis, Boca Raton, FL.
-
(2006)
Process Scale Bioseparations for the Biopharmaceutical Industry
-
-
Etzel, M.1
Riordan, W.2
-
49
-
-
84955731373
-
-
Processing, Quality and Characterization, Economics, Safety and Hygiene, Wiley-VCH, New York, NY
-
Walter, J.K. (1998). Strategies and considerations for advanced economy in downstream processing of biopharmaceutical proteins. In S ubramanian, G. (ed.) B ioseparation and Bioprocessing. Processing, Quality and Characterization, Economics, Safety and Hygiene, Wiley-VCH, New York, NY, pp. 447-460.
-
(1998)
Strategies and considerations for advanced economy in downstream processing of biopharmaceutical proteins. In S ubramanian, G. (ed.) B ioseparation and Bioprocessing
, pp. 447-460
-
-
Walter, J.K.1
-
50
-
-
15044344530
-
Impact of multiple re-use of anion exchange chromatography media on virus removal
-
Norling, L., Lute, S., Emery, R., Khuu, W., Voisard, M., Xu, Y., Chen, Q., Blank, G., Brorson, K. (2005). Impact of multiple re-use of anion exchange chromatography media on virus removal. Journal of Chromatography A 1069, 79-89.
-
(2005)
Journal of Chromatography A
, vol.1069
, pp. 79-89
-
-
Norling, L.1
Lute, S.2
Emery, R.3
Khuu, W.4
Voisard, M.5
Xu, Y.6
Chen, Q.7
Blank, G.8
Brorson, K.9
-
51
-
-
33750368993
-
New Q membrane scale - down model for process-scale antibody purification
-
Zhou, J.X., Tressel, T., Gottschalk, U., Solamo, F., Pastor, A., Dermawan, S., Hong, T., Reif, O., Mora, J., Hutchinton, F., Murphy, M. (2006). New Q membrane scale - down model for process-scale antibody purification. Journal of Chromatography A 1134, 66-73.
-
(2006)
Journal of Chromatography A
, vol.1134
, pp. 66-73
-
-
Zhou, J.X.1
Tressel, T.2
Gottschalk, U.3
Solamo, F.4
Pastor, A.5
Dermawan, S.6
Hong, T.7
Reif, O.8
Mora, J.9
Hutchinton, F.10
Murphy, M.11
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