Statins prevent adverse effects of postnatal glucocorticoid therapy on the developing brain in rats

Pediatric Research

Volumn 74, Issue 6, 2013, Pages 639-645

  Tijsseling, Deodata ^a   Camm, Emily J ^b   Richter, Hans G ^b   Herrera, Emilio A ^b   Kane, Andrew D ^b   Niu, Youguo ^b   Cross, Christine M ^b   De Vries, Willem B ^a   Derks, Jan B ^a   Giussani, Dino A ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLIAL FIBRILLARY ACIDIC PROTEIN; NITRIC OXIDE; NITRITE; PRAVASTATIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOAVAILABILITY; BRAIN ATROPHY; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN PERFUSION; BRAIN SIZE; CELL DENSITY; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DENTATE GYRUS; DRUG SAFETY; GRAY MATTER; MALE; MYELINATION; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; STEREOLOGY; WHITE MATTER;

ANIMALS; BODY WEIGHT; BRAIN; FEMALE; GLUCOCORTICOIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NITRIC OXIDE; ORGAN SIZE; PREGNANCY; RATS; RATS, WISTAR;

EID: 84890716953     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.152     Document Type: Article

References (40)

1. Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. Lancet 2006;367:1421-31.
2. Halliday HL, Ehrenkranz RA, Doyle LW. Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2009;CD001146.
3. Thorp JA, Jones PG, Peabody JL, Knox E, Clark RH. Effect of antenatal and postnatal corticosteroid therapy on weight gain and head circumference growth in the nursery. Obstet Gynecol 2002;99:109-15.
4. Yeh TF, Lin YJ, Lin HC, et al. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N Engl J Med 2004;350:1304-13.
5. Barrington KJ. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr 2001;1:1.
6. Antonow-Schlorke I, Schwab M, Li C, Nathanielsz PW. Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol (Lond) 2003;547(Pt 1):117-23.
7. Weichsel ME Jr. The therapeutic use of glucocorticoid hormones in the perinatal period: potential neurological hazards. Ann Neurol 1977;2:364- 6.
8. Kanagawa T, Tomimatsu T, Hayashi S, et al. The effects of repeated corticosteroid administration on the neurogenesis in the neonatal rat. Am J Obstet Gynecol 2006;194:231-8.
9. Iuchi T, Akaike M, Mitsui T, et al. Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction. Circ Res 2003;92:81-7.
10. Herrera EA, Verkerk MM, Derks JB, Giussani DA. Antioxidant treatment alters peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats. PLoS ONE 2010;5:e9250.
11. Steinberg D. The statins in preventive cardiology. N Engl J Med 2008;359:1426-7.
12. Chen J, Zhang ZG, Li Y, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003;53:743-51.
13. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med 2007;5:20.
14. Tong XK, Lecrux C, Rosa-Neto P, Hamel E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. J Neurosci 2012;32:4705-15.
15. Camm EJ, Tijsseling D, Richter HG, et al. Oxidative stress in the developing brain: effects of postnatal glucocorticoid therapy and antioxidants in the rat. PLoS ONE 2011;6:e21142.
16. de Vries WB, van der Leij FR, Bakker JM, et al. Alterations in adult rat heart after neonatal dexamethasone therapy. Pediatr Res 2002;52:900-6.
17. Monie IW. Comparative development of the nervous, respiratory, and cardiovascular systems. Environ Health Perspect 1976;18:55-60.
18. Watson RE, Desesso JM, Hurtt ME, Cappon GD. Postnatal growth and morphological development of the brain: a species comparison. Birth Defects Res B Dev Reprod Toxicol 2006;77:471-84.
19. Crochemore C, Lu J, Wu Y, et al. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry 2005;10:790-8.
20. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997;17:2492-8.
21. Hellsten J, Wennström M, Mohapel P, Ekdahl CT, Bengzon J, Tingström A. Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment. Eur J Neurosci 2002;16: 283-90.
22. Kreider ML, Tate CA, Cousins MM, Oliver CA, Seidler FJ, Slotkin TA. Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. Neuropsychopharmacology 2006;31:12-35.
23. Eysel UT, Wolfhard U. The effects of partial retinal lesions on activity and size of cells in the dorsal lateral geniculate nucleus. J Comp Neurol 1984;229:301-9.
24. Mountjoy CQ, Roth M, Evans NJ, Evans HM. Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 1983;4:1-11.
25. Kiernan JA, Hudson AJ. Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114 (Pt 2):843-53.
26. Volpe JJ. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 2001;50:553-62.
27. Gelosa P, Cimino M, Pignieri A, Tremoli E, Guerrini U, Sironi L. The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation. Vasc Health Risk Manag 2007;3:567-77.
28. Simmons WW, Ungureanu-Longrois D, Smith GK, Smith TW, Kelly RA. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. J Biol Chem 1996;271:23928-37.
29. Löhle M, Müller T, Wicher C, et al. Betamethasone effects on fetal sheep cerebral blood flow are not dependent on maturation of cerebrovascular system and pituitary-adrenal axis. J Physiol (Lond) 2005;564(Pt 2): 575-88.
30. Ciani E, Virgili M, Contestabile A. Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. J Neurochem 2002;81:218-28.
31. Estrada C, Murillo-Carretero M. Nitric oxide and adult neurogenesis in health and disease. Neuroscientist 2005;11:294-307.
32. Kureishi Y, Luo Z, Shiojima I, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-10.
33. Yamashita T, Kawashima S, Ohashi Y, et al. Mechanisms of reduced nitric oxide/cGMP-mediated vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. Hypertension 2000;36:97-102.
34. Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res 2003;93:280-91.
35. Fowden AL, Forhead AJ. Endocrine mechanisms of intrauterine programming. Reproduction 2004;127:515-26.
36. Mondo CK, Yang WS, Zhang N, Huang TG. Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat. Clin Exp Pharmacol Physiol 2006;33:1029-34.
37. Torrens C, Kelsall CJ, Hopkins LA, Anthony FW, Curzen NP, Hanson MA. Atorvastatin restores endothelial function in offspring of proteinrestricted rats in a cholesterol-independent manner. Hypertension 2009;53:661-7.
38. Gundersen HJ, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147(Pt 3):229-63.
39. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Amsterdam, The Netherlands: Elsevier, 2007.
40. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126:131-8.