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Volumn 19, Issue 24, 2013, Pages 6863-6872

Comparative efficacy of bisphosphonates in metastatic breast and prostate cancer and multiple myeloma: A mixed-treatment meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; IBANDRONIC ACID; PAMIDRONIC ACID; PLACEBO; ZOLEDRONIC ACID;

EID: 84890708496     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-2275     Document Type: Article
Times cited : (28)

References (53)
  • 1
    • 0030749321 scopus 로고    scopus 로고
    • Skeletal complications of malignancy
    • Coleman RE. Skeletal complications of malignancy. Cancer 1997;80 Suppl 8:1588-94. (Pubitemid 27444031)
    • (1997) Cancer , vol.80 , Issue.8 SUPPL. , pp. 1588-1594
    • Coleman, R.E.1
  • 2
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
    • DOI 10.1053/ctrv.2000.0210
    • Coleman RE. Metastatic bone disease: clinical features, pathophys-iology and treatment strategies. Cancer Treat Rev 2001;27:165-76. (Pubitemid 32452017)
    • (2001) Cancer Treatment Reviews , vol.27 , Issue.3 , pp. 165-176
    • Coleman, R.E.1
  • 4
    • 11144336663 scopus 로고    scopus 로고
    • Proven efficacy of zoledronic acid in the treatment of bone metastases in patients with breast cancer and other malignancies
    • Cameron D. Proven efficacy of zoledronic acid in the treatment of bone metastases in patients with breast cancer and other malignancies. Breast 2003;12:S22-9. (Pubitemid 40023560)
    • (2003) Breast , vol.12 , Issue.SUPPL. 2
    • Cameron, D.1
  • 5
    • 35048875471 scopus 로고    scopus 로고
    • Pathologic fractures correlate with reduced survival in patients with malignant bone disease
    • DOI 10.1002/cncr.22991
    • Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R. Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Cancer 2007;110:1860-7. (Pubitemid 47557312)
    • (2007) Cancer , vol.110 , Issue.8 , pp. 1860-1867
    • Saad, F.1    Lipton, A.2    Cook, R.3    Chen, Y.-M.4    Smith, M.5    Coleman, R.6
  • 6
    • 79951770973 scopus 로고    scopus 로고
    • The hospital burden of disease associated with bone metastases and skeletal-related events in patients with breast cancer, lung cancer, or prostate cancer in Spain
    • Pockett RD, Castellano D, McEwan P, Oglesby A, Barber BL, Chung K. The hospital burden of disease associated with bone metastases and skeletal-related events in patients with breast cancer, lung cancer, or prostate cancer in Spain. Eur J Cancer Care 2010;19:755-60.
    • (2010) Eur J Cancer Care , vol.19 , pp. 755-760
    • Pockett, R.D.1    Castellano, D.2    McEwan, P.3    Oglesby, A.4    Barber, B.L.5    Chung, K.6
  • 7
    • 0242669907 scopus 로고    scopus 로고
    • Costs of prostate cancer, metastatic to the bone, in The Netherlands
    • DOI 10.1016/S0302-2838(03)00007-1
    • Groot MT, Boeken Kruger CG, Pelger RCM, Uyl-de Groot CA. Costs of prostate cancer, metastatic to the bone, in the Netherlands. Eur Urol 2003;43:226-32. (Pubitemid 36314233)
    • (2003) European Urology , vol.43 , Issue.3 , pp. 226-232
    • Groot, M.T.1    Kruger, C.G.G.B.2    Pelger, R.C.M.3    Uyl-de Groot, C.A.4
  • 8
    • 40149083563 scopus 로고    scopus 로고
    • Guidance on the use of bisphosphonates in solid tumours: Recommendations of an international expert panel
    • Aapro M, Abrahamsson PA, Body JJ, Coleman RE, Colomer R, Costa L, et al. Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel. Ann Oncol 2008; 19:420-32.
    • (2008) Ann Oncol , vol.19 , pp. 420-432
    • Aapro, M.1    Abrahamsson, P.A.2    Body, J.J.3    Coleman, R.E.4    Colomer, R.5    Costa, L.6
  • 9
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma: Recommendations of an expert panel on behalf of the European Myeloma Network
    • Terpos E, Sezer O, Croucher PI, García-Sanz R, Boccadoro M, San Miguel J, et al. The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009;20:1303-17.
    • (2009) Ann Oncol , vol.20 , pp. 1303-1317
    • Terpos, E.1    Sezer, O.2    Croucher, P.I.3    García-Sanz, R.4    Boccadoro, M.5    San Miguel, J.6
  • 10
    • 20044389681 scopus 로고    scopus 로고
    • Bisphosphonates in breast cancer
    • DOI 10.1093/annonc/mdi162
    • Coleman RE. Bisphosphonates in breast cancer. Ann Oncol 2005;16: 687-95. (Pubitemid 40767087)
    • (2005) Annals of Oncology , vol.16 , Issue.5 , pp. 687-695
    • Coleman, R.E.1
  • 15
    • 10744233021 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: A randomized, double-blind, multicenter, comparative trial
    • DOI 10.1002/cncr.11701
    • Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J, et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer 2003;98:1735-44. (Pubitemid 37238631)
    • (2003) Cancer , vol.98 , Issue.8 , pp. 1735-1744
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3    Howell, A.4    Belch, A.5    Mackey, J.6    Apffelstaedt, J.7    Hussein, M.A.8    Coleman, R.E.9    Reitsma, D.J.10    Chen, B.-L.11    Seaman, J.J.12
  • 16
    • 84890655451 scopus 로고    scopus 로고
    • Zoledronate versus ibandronate comparative evaluation (ZICE) trial-first results of a UK NCRI 1, 404 patient phase III trial comparing oral ibandronate versus intravenous zoledronate in the treatment of breast cancer patients with bone metastases [abstract]
    • Dec 4-8; San Antonio, TX
    • Barrett-Lee PJ, Casbard A, Abraham J, Grieve R, Wheatley D, Simmons P, et al. Zoledronate versus ibandronate comparative evaluation (ZICE) trial-first results of a UK NCRI 1, 404 patient phase III trial comparing oral ibandronate versus intravenous zoledronate in the treatment of breast cancer patients with bone metastases [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium; 2012 Dec 4-8; San Antonio, TX.
    • (2012) Proceedings of the San Antonio Breast Cancer Symposium
    • Barrett-Lee, P.J.1    Casbard, A.2    Abraham, J.3    Grieve, R.4    Wheatley, D.5    Simmons, P.6
  • 17
    • 79960891058 scopus 로고    scopus 로고
    • Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): Secondary outcomes from a randomised controlled trial
    • Morgan GJ, Child JA, Gregory WM, Szubert AJ, Cocks K, Bell SE, et al. Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial. Lancet Oncol 2011;12:743-52.
    • (2011) Lancet Oncol , vol.12 , pp. 743-752
    • Morgan, G.J.1    Child, J.A.2    Gregory, W.M.3    Szubert, A.J.4    Cocks, K.5    Bell, S.E.6
  • 18
    • 34547840272 scopus 로고    scopus 로고
    • Oral ibandronate is as active as intravenous zoledronic acid for reducing bone turnover markers in women with breast cancer and bone metastases
    • DOI 10.1093/annonc/mdm119
    • Body JJ, Lichinitser M, Tjulandin S, Garnero P, Bergstro€m B. Oral ibandronate is as active as intravenous zoledronic acid for reducing bone turnover markers in women with breast cancer and bone metas-tases. Ann Oncol 2007;18:1165-71. (Pubitemid 47244361)
    • (2007) Annals of Oncology , vol.18 , Issue.7 , pp. 1165-1171
    • Body, J.-J.1    Lichinitser, M.2    Tjulandin, S.3    Garnero, P.4    Bergstrom, B.5
  • 19
    • 80052720817 scopus 로고    scopus 로고
    • Effects of intravenous zoledronic acid and oral ibandronate on early changes in markers of bone turnover in patients with bone metastases from non-small cell lung cancer
    • Francini F, Pascucci A, Bargagli G, Francini E, Conca R, Miano ST, et al. Effects of intravenous zoledronic acid and oral ibandronate on early changes in markers of bone turnover in patients with bone metastases from non-small cell lung cancer. Int J Clin Oncol 2011;16:264-9.
    • (2011) Int J Clin Oncol , vol.16 , pp. 264-269
    • Francini, F.1    Pascucci, A.2    Bargagli, G.3    Francini, E.4    Conca, R.5    Miano, S.T.6
  • 20
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound
    • Green JR, M€uller K, Jaeggi KA. Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 1994;9:745-51. (Pubitemid 24130477)
    • (1994) Journal of Bone and Mineral Research , vol.9 , Issue.5 , pp. 745-751
    • Green, J.R.1    Muller, K.2    Jaeggi, K.A.3
  • 21
    • 62549164935 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence Publication, February
    • National Institute for Health and Clinical Excellence Publication. CG81 Advanced breast cancer: NICE guideline. February 2009.
    • (2009) CG81 Advanced Breast Cancer: NICE Guideline
  • 22
    • 51149095603 scopus 로고    scopus 로고
    • Use of indirect and mixed treatment comparisons for technology assessment
    • Sutton A, Ades AE, Cooper N, Abrams K. Use of indirect and mixed treatment comparisons for technology assessment. Pharmacoeco-nomics 2008;26:753-67.
    • (2008) Pharmacoeco-nomics , vol.26 , pp. 753-767
    • Sutton, A.1    Ades, A.E.2    Cooper, N.3    Abrams, K.4
  • 23
    • 26944454062 scopus 로고    scopus 로고
    • Simultaneous comparison of multiple treatments: Combining direct and indirect evidence
    • Caldwell DM, Ades AE, Higgins JP. Simultaneous comparison of multiple treatments: combining direct and indirect evidence. BMJ 2005;331:897-900. (Pubitemid 41502718)
    • (2005) British Medical Journal , vol.331 , Issue.7521 , pp. 897-900
    • Caldwell, D.M.1    Ades, A.E.2    Higgins, J.P.T.3
  • 24
    • 80755180389 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence, June
    • National Institute for Health and Clinical Excellence. Guide to the methods of technology appraisal. June 2008.
    • (2008) Guide to the Methods of Technology Appraisal
  • 27
    • 79551568488 scopus 로고    scopus 로고
    • Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study
    • Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010;28:5132-9.
    • (2010) J Clin Oncol , vol.28 , pp. 5132-5139
    • Stopeck, A.T.1    Lipton, A.2    Body, J.J.3    Steger, G.G.4    Tonkin, K.5    De Boer, R.H.6
  • 28
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • Fizazi K, Carducci M, Smith M, Damiao R, Brown J, Karsh L, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet 2011;377:813-22.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3    Damiao, R.4    Brown, J.5    Karsh, L.6
  • 29
    • 79952761418 scopus 로고    scopus 로고
    • Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • Henry DH, Costa L, Goldwasser F, Hirsh V, Hungria V, Prausova J, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011;29:1125-32.
    • (2011) J Clin Oncol , vol.29 , pp. 1125-1132
    • Henry, D.H.1    Costa, L.2    Goldwasser, F.3    Hirsh, V.4    Hungria, V.5    Prausova, J.6
  • 30
    • 77952118055 scopus 로고    scopus 로고
    • Amgen Limited, Available at, [Accessed November 2013]
    • Amgen Limited. Xgeva summary of product characteristics. Available at: https://www.medicines.org.uk/EMC/medicine/24755/SPC/XGEVA/[Accessed November 2013].
    • Xgeva Summary of Product Characteristics
  • 31
    • 0006407254 scopus 로고    scopus 로고
    • WinBUGS-a Bayesian modelling framework: Concepts, structure and extensibility
    • Lunn DJ, Thomas A, Best N, Spiegelhalter D. WinBUGS-a Bayesian modelling framework: concepts, structure and extensibility. Stat Com-put 2000;26:325-37.
    • (2000) Stat Com-put , vol.26 , pp. 325-337
    • Lunn, D.J.1    Thomas, A.2    Best, N.3    Spiegelhalter, D.4
  • 32
    • 84873409248 scopus 로고    scopus 로고
    • MRC Biostatistics Unit, Cambridge UK, [cited 2012 Dec], Available from
    • MRC Biostatistics Unit, Cambridge, UK. The BUGS project. [cited 2012 Dec]. Available from: http://www.mrc-bsu.cam.ac.uk/bugs/.
    • The BUGS Project
  • 34
    • 36248938315 scopus 로고    scopus 로고
    • Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma
    • DOI 10.1007/BF02698044
    • Aviles A, Nambo MJ, Neri N, Castaneda C, Cleto S, Huerta-Guzman J. Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma. Med Oncol 2007;24:227-30. (Pubitemid 350135975)
    • (2007) Medical Oncology , vol.24 , Issue.2 , pp. 227-230
    • Aviles, A.1    Nambo, M.J.2    Neri, N.3    Castaneda, C.4    Cleto, S.5    Huerta-Guzman, J.6
  • 35
    • 54049124120 scopus 로고    scopus 로고
    • A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma
    • Musto P, Petrucci MT, Bringhen S, Guglielmelli T, Caravita T, Bon-garzoni V, et al. A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 2008;113:1588-95.
    • (2008) Cancer , vol.113 , pp. 1588-1595
    • Musto, P.1    Petrucci, M.T.2    Bringhen, S.3    Guglielmelli, T.4    Caravita, T.5    Bon-Garzoni, V.6
  • 36
    • 20644449488 scopus 로고    scopus 로고
    • Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial
    • Kohno N, Aogi K, Minami H, Nakamura S, Asaga T, Lino Y, et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J Clin Oncol 2005;23:3314-21.
    • (2005) J Clin Oncol , vol.23 , pp. 3314-3321
    • Kohno, N.1    Aogi, K.2    Minami, H.3    Nakamura, S.4    Asaga, T.5    Lino, Y.6
  • 37
    • 0034162528 scopus 로고    scopus 로고
    • Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: Long term follow-up of two randomized, placebo-controlled trials
    • DOI 10.1002 /(SICI) 1097-0142 (20000301) 88:5<1082::AID-CNCR20>3.0. CO;2-Z
    • Lipton A, Theriault RL, Hortobagyi GN, Simeone J, Knight RD, Mellars K, et al. Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials. Cancer 2000;88:1082-90. (Pubitemid 30127670)
    • (2000) Cancer , vol.88 , Issue.5 , pp. 1082-1090
    • Lipton, A.1    Theriault, R.L.2    Hortobagyi, G.N.3    Simeone, J.4    Knight, R.D.5    Mellars, K.6    Reitsma, D.J.7    Heffernan, M.8    Seaman, J.J.9
  • 38
    • 0642337996 scopus 로고    scopus 로고
    • Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer
    • DOI 10.1200/JCO.2003.05.147
    • Small EJ, Smith MR, Seaman JJ, Ptrone S, Kowalski MO. Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer. J Clin Oncol 2003;21:4277-84. (Pubitemid 46621802)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.23 , pp. 4277-4284
    • Small, E.J.1    Smith, M.R.2    Seaman, J.J.3    Petrone, S.4    Kowalski, M.O.5
  • 43
    • 0026646339 scopus 로고
    • Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma
    • Finnish Leukaemia Group
    • Lahtinen R, Laakso M, Palva I, Virkkunen P, Elomaa I. Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group. Lancet 1992;340:1049-52.
    • (1992) Lancet , vol.340 , pp. 1049-1052
    • Lahtinen, R.1    Laakso, M.2    Palva, I.3    Virkkunen, P.4    Elomaa, I.5
  • 46
    • 1942501727 scopus 로고    scopus 로고
    • Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: Results from two randomised, placebo-controlled phase III studies
    • DOI 10.1038/sj.bjc.6601663
    • Body JJ, Diel IJ, Lichinitzer M, Lazarev A, Pecherstorfer M, Bell R, et al. Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies. Br J Cancer 2004;90: 1133-7. (Pubitemid 38496803)
    • (2004) British Journal of Cancer , vol.90 , Issue.6 , pp. 1133-1137
    • Body, J.J.1    Diel, I.J.2    Liehinitzer, M.3    Lazarev, A.4    Pecherstorfer, M.5    Bell, R.6    Tripathy, D.7    Bergstrom, B.8
  • 47
    • 0031911183 scopus 로고    scopus 로고
    • A randomized trial of the effect of clodronate on skeletal morbidity in multiple myeloma
    • DOI 10.1046/j.1365-2141.1998.00567.x
    • McCloskey EV, MacLennan IC, Drayson MT, Chapman C, Dunn J, Kanis JA. A randomized trial of the effect of clodronate on skeletal morbidity in multiple myeloma. MRC Working Party on Leukaemia in Adults. Br J Haematol 1998;100:317-25. (Pubitemid 28131063)
    • (1998) British Journal of Haematology , vol.100 , Issue.2 , pp. 317-325
    • McCloskey, E.V.1    Maclennan, I.C.M.2    Drayson, M.T.3    Chapman, C.4    Dunn, J.5    Kanis, J.A.6
  • 48
    • 0034937438 scopus 로고    scopus 로고
    • Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma
    • DOI 10.1046/j.1365-2141.2001.02851.x
    • McCloskey EV, Dunn JA, Kanis JA, MacLennan IC, Drayson MT. Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma. Br J Haematol 2001;113:1035-43. (Pubitemid 32634773)
    • (2001) British Journal of Haematology , vol.113 , Issue.4 , pp. 1035-1043
    • McCloskey, E.V.1    Dunn, J.A.2    Kanis, J.A.3    MacLennan, I.C.M.4    Drayson, M.T.5
  • 49
    • 36549012194 scopus 로고    scopus 로고
    • Higher persistency with i. V. Bisphosphonates in patients with bone metastases
    • (suppl; abstr 18623)
    • Mangiapane S, Hoer A, Gothe H, Barghout V, Haeussler B. Higher persistency with i. v. bisphosphonates in patients with bone metastases. J Clin Oncol 24, 2006(suppl; abstr 18623).
    • (2006) J Clin Oncol , vol.24
    • Mangiapane, S.1    Hoer, A.2    Gothe, H.3    Barghout, V.4    Haeussler, B.5
  • 50
    • 84859895325 scopus 로고    scopus 로고
    • Persistency with zoledronic acid is associated with clinical benefit in patients with multiple myeloma
    • Henk HJ, Teitelbaum A, Perez JR, Kaura S. Persistency with zoledronic acid is associated with clinical benefit in patients with multiple myeloma. Am J Hematol 2012;87:490-5.
    • (2012) Am J Hematol , vol.87 , pp. 490-495
    • Henk, H.J.1    Teitelbaum, A.2    Perez, J.R.3    Kaura, S.4
  • 51
    • 79952609241 scopus 로고    scopus 로고
    • Improving progression-free and overall survival in patients with cancer: A potential role for bisphosphonates
    • Lipton A. Improving progression-free and overall survival in patients with cancer: a potential role for bisphosphonates. Expert Opin Phar-macother 2011;12:749-62.
    • (2011) Expert Opin Phar-macother , vol.12 , pp. 749-762
    • Lipton, A.1
  • 52
    • 84867582660 scopus 로고    scopus 로고
    • Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials
    • Lipton A, Fizazi K, Stopeck AT, Henry DH, Brown JE, Yardley DA, et al. Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer 2012;48:3082-92.
    • (2012) Eur J Cancer , vol.48 , pp. 3082-3092
    • Lipton, A.1    Fizazi, K.2    Stopeck, A.T.3    Henry, D.H.4    Brown, J.E.5    Yardley, D.A.6
  • 53
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate cancer
    • Saad F, Gleason DM, Murray R, Tchekmedyian S, Venner P, Lacombe L, et al. A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate cancer. J Natl Cancer Inst 2002;94:1458-68.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3    Tchekmedyian, S.4    Venner, P.5    Lacombe, L.6


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