The association of low serum alanine aminotransferase activity with mortality in the us population

American Journal of Epidemiology

Volumn 178, Issue 12, 2013, Pages 1702-1711

  Ruhl, Constance E ^a   Everhart, James E ^b  

^a SOCIAL AND SCIENTIFIC SYSTEMS INC   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Alanine aminotransferase; Body composition; Mortality; National Health and Nutrition Examination Survey

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C ANTIBODY; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRANSFERRIN;

BIOMARKER; BODY CONDITION; ENZYME ACTIVITY; HEALTH SURVEY; HEPATITIS; INJURY; MORTALITY RISK; SERUM;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY COMPOSITION; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL EVALUATION; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; ETHNICITY; FAT MASS; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEALTH SURVEY; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHYSICAL ACTIVITY; POPULATION; PROSPECTIVE STUDY; REVIEW; SMOKING; SYSTOLIC BLOOD PRESSURE; UNITED STATES; WAIST HIP RATIO;

ALANINE AMINOTRANSFERASE; BODY COMPOSITION; MORTALITY; NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY;

ABSORPTIOMETRY, PHOTON; ADULT; AGE FACTORS; AGED; ALANINE TRANSAMINASE; APPENDIX; BIOLOGICAL MARKERS; BODY COMPOSITION; CROSS-SECTIONAL STUDIES; FEMALE; HEALTH BEHAVIOR; HEALTH SURVEYS; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; MORTALITY; SOCIOECONOMIC FACTORS; UNITED STATES;

UNITED STATES;

EID: 84890683512     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwt209     Document Type: Review

References (40)

1. Arndt V, Brenner H, Rothenbacher D, et al. Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality. Int Arch Occup Environ Health. 1998;71(6):405-412.
2. Kim HC, Nam CM, Jee SH, et al. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ. 2004; 328(7446):983.
3. Nakamura K, Okamura T, Kanda H, et al. The value of combining serum alanine aminotransferase levels and body mass index to predict mortality and medical costs: a 10-year follow-up study of National Health Insurance in Shiga, Japan. J Epidemiol. 2006;16(1):15-20.
4. Schindhelm RK, Dekker JM, Nijpels G, et al. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis. 2007; 191(2):391-396.
5. Lee TH, Kim WR, Benson JT, et al. Serum aminotransferase activity and mortality risk in a United States community. Hepatology. 2008;47(3):880-887.
6. Ruhl CE, Everhart JE. Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology. 2009;136(2):477-485.
7. National Center for Health Statistics. Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-94. (Vital and health statistics, series 1: programs and collection procedures, no. 32). Hyattsville, MD: National Center for Health Statistics; 1994. (DHHS publication no. (PHS) 94-1308).
8. Gunter EW, Lewis BG, Koncikowski SM. Laboratory Procedures Used for the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Atlanta, GA: National Center for Environmental Health, Centers for Disease Control and Prevention; 1996. (http://www.cdc.gov/nchs/data/nhanes/nhanes3/ cdrom/nchs/manuals/labman.pdf). (Accessed July 29, 2013).
9. American Diabetes Association. Executive summary: standards of medical care in diabetes-2010. Diabetes Care. 2010;33(suppl 1):4S-10S.
10. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2003;124(1):71-79.
11. Ruhl CE, Everhart JE. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology. 2003;124(7):1821-1829.
12. Ruhl CE, Everhart JE. Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2005; 128(1):24-32.
13. Ainsworth BE, Haskell WL, Leon AS, et al. Compendium of Physical Activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25(1):71-80.
14. Michels KB, Willett WC, Fuchs CS, et al. Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. J Natl Cancer Inst. 2005;97(4):282-292.
15. National Center for Health Statistics. National Health and Nutrition Examination Survey III. Body Measurements (Anthropometry). Rockville, MD:Westat, Inc; 1988. (http://www.cdc.gov/nchs/data/nhanes/nhanes3/cdrom/nchs/manuals/ anthro.pdf). (Accessed July 29, 2013).
16. National Center for Health Statistics. National Health and Nutrition Examination Survey III Cycle 2: Pulse and Blood Pressure Procedures for Household Interviewers. Rockville, MD:Westat, Inc; 1989. (http://www.cdc.gov/ nchs/data/nhanes/nhanes3/cdrom/nchs/manuals/pressure.pdf). (Accessed July 29, 2013).
17. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9):604-612.
18. National Center for Health Statistics. National Health and Nutrition Examination Survey III. Physical Function Examination Manual. Rockville, MD:Westat, Inc; 1993. (http://www.cdc.gov/nchs/data/nhanes/nhanes3/cdrom/nchs/ manuals/physical.pdf). (Accessed July 29, 2013).
19. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412-423.
20. Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000;55(4):M221-M231.
21. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85-M94.
22. National Center for Health Statistics. The Third National Health and Nutrition Examination Survey (NHANES III) Linked Mortality File: Mortality Follow-up Through 2006. Matching Methodology. Hyattsville, MD: National Center for Health Statistics; 2009. (http://www.cdc.gov/nchs/data/datalinkage/matching- methodology-nhanes3-final.pdf). (Accessed July 29, 2013).
23. Menke A, Muntner P, Batuman V, et al. Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults. Circulation. 2006;114(13):1388- 1394.
24. Kleinbaum DG. Survival Analysis: A Self-Learning Text. New York, NY: Springer Publishing Company; 1996.
25. Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol 2. The Design and Analysis of Cohort Studies. (IARC Scientific Publication no. 82). Lyon, France: International Agency for Research on Cancer; 1987:48-79.
26. Ruhl CE, Everhart JE. Trunk fat is associated with increased serum levels of alanine aminotransferase in the United States. Gastroenterology. 2010;138(4):1346-1356.
27. National Center for Health Statistics. National Health and Nutrition Examination Survey. Body Composition Procedures Manual. Hyattsville, MD: National Center for Health Statistics; 2000. (http://www.cdc.gov/nchs/data/ nhanes/bc. pdf). (Accessed July 29, 2013).
28. Flegal KM, Shepherd JA, Looker AC, et al. Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr. 2009; 89(2):500-508.
29. Kelly TL, Wilson KE, Heymsfield SB. Dual energy x-ray absorptiometry body composition reference values from NHANES. PLoS One. 2009;4(9):e7038.
30. National Center for Health Statistics. National Health and Nutrition Examination Survey: Technical Documentation for the 1999-2004 Dual Energy X-Ray Absorptiometry (DXA) Multiple Imputation Data Files. Hyattsville, MD: National Center for Health Statistics; 2008. (http://www.cdc.gov/nchs/data/nhanes/dxa/ dxa-techdoc.pdf). (Accessed July 29, 2013).
31. Delmonico MJ, Harris TB, Lee JS, et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55(5):769-774.
32. Dufour AB, Hannan MT, Murabito JM, et al. Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: the Framingham Study. J Gerontol A Biol Sci Med Sci. 2013;68(2):168-174.
33. Yun KE, Shin CY, Yoon YS, et al. Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans. Atherosclerosis. 2009; 205(2):533-537.
34. Elinav E, Ackerman Z, Maaravi Y, et al. Low alanine aminotransferase activity in older people is associated with greater long-term mortality. J Am Geriatr Soc. 2006; 54(11):1719-1724.
35. Le Couteur DG, Blyth FM, Creasey HM, et al. The association of alanine transaminase with aging, frailty, and mortality. J Gerontol A Biol Sci Med Sci. 2010;65(7): 712-717.
36. Ford I, Mooijaart SP, Lloyd S, et al. The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes. Int J Epidemiol. 2011;40(6):1530-1538.
37. Flegal KM, Kit BK, Orpana H, et al. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309(1):71-82.
38. Bigaard J, Frederiksen K, Tjonneland A, et al. Body fat and fat-free mass and all-cause mortality. Obes Res. 2004; 12(7):1042-1049.
39. Fisher AL. Of worms and women: sarcopenia and its role in disability and mortality. J Am Geriatr Soc. 2004;52(7): 1185-1190.
40. Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition Study cohort. J Gerontol A Biol Sci Med Sci. 2006;61(1):72-77. Kidney Diseases