Oncologic Issues and Kidney Transplantation: A Review of Frequency, Mortality, and Screening

Advances in Chronic Kidney Disease

Volumn 21, Issue 1, 2014, Pages 106-113

  Asch, William S ^a   Bia, Margaret J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer screening; Immunosuppression; Kidney transplant; Malignancy

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ANUS CANCER; BREAST CANCER; CANCER MORTALITY; CANCER PREVENTION; CANCER RISK; CANCER SCREENING; COLORECTAL CANCER; GENITAL TRACT CANCER; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY CARCINOMA; KIDNEY TRANSPLANTATION; NON MELANOMA SKIN CANCER; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; REVIEW; SKIN CANCER;

CANCER SCREENING; IMMUNOSUPPRESSION; KIDNEY TRANSPLANT; MALIGNANCY;

ANUS NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, RENAL CELL; COLORECTAL NEOPLASMS; EARLY DETECTION OF CANCER; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; KIDNEY NEOPLASMS; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; NEOPLASMS; SKIN NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

EID: 84890670657     PISSN: 15485595     EISSN: 15485609     Source Type: Journal    
DOI: 10.1053/j.ackd.2013.07.003     Document Type: Review

References (51)

1. Kasiske B.L., Cangro C.B., Hariharan S., et al. The evaluation of renal transplantation candidates: clinical practice guidelines. Am J Transplant 2001, 1(suppl 2):3-95.
2. Engels E.A., Pfeiffer R.M., Fraumeni J.F., et al. Spectrum of cancer risk among US solid organ transplant recipients. JAMA 2011, 306(17):1891-1901.
3. Vajdic C.M., McDonald S.P., McCredie M.R., et al. Cancer incidence before and after kidney transplantation. JAMA 2006, 296(23):2823-2831.
4. Stewart J.H., Vajdic C.M., van Leeuwen M.T., et al. The pattern of excess cancer in dialysis and transplantation. Nephrol Dial Transplant 2009, 24(10):3225-3231.
5. Joshi K., Jha V. Malignancies following kidney transplantation. JNephrol Ren Transplant 2009, 2(1):94-105.
6. Chapman J, Webster A. Cancer Report: ANZDATA Registry 2004 Report. Adelaide, Australia: Australia and New Zealand Dialysis and Transplant Registry;2004.
7. Grulich A.E., van Leeuwen M.T., Falster M.O., Vajdic C.M. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007, 370(9581):59-67.
8. Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guidelines for the care of kidney transplant recipients. Am J Transplant 2009, 9(suppl 3):S1-S155.
9. Moloney F.J., Comber H., O'Lorcain P., O'Kelly P., Conlon P.J., Murphy G.M. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol 2006, 154(3):498-504.
10. de Fijter J.W. Use of proliferation signal inhibitors in non-melanoma skin cancer following renal transplantation. Nephrol Dial Transplant 2007, 22(suppl 1):i23-i26.
11. Park J.M., Choi M.G., Kim S.W., et al. Increased incidence of colorectal malignancies in renal transplant recipients: a case control study. Am J Transplant 2010, 10(9):2043-2050.
12. Flechner S. Cancer and renal transplantation. Adv Stud Med 2007, 7(13):411-419.
13. Patel H.S., Silver A.R., Northover J.M. Anal cancer in renal transplant patients. Int J Colorectal Dis 2007, 22(1):1-5.
14. Webster A.C., Craig J.C., Simpson J.M., Jones M.P., Chapman J.R. Identifying high risk groups and quantifying absolute risk of cancer after kidney transplantation: a cohort study of 15,183 recipients. Am J Transplant 2007, 7(9):2140-2151.
15. Bugelski P.J., Volk A., Walker M.R., Krayer J.H., Martin P., Descotes J. Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia. Int J Toxicol 2010, 29(5):435-466.
16. Dantal J., Soulillou J.P. Immunosuppressive drugs and the risk of cancer after organ transplantation. N Engl J Med 2005, 352(13):1371-1373.
17. O'Donovan P., Perrett C.M., Zhang X., et al. Azathioprine and UVA lightgenerate mutagenic oxidative DNA damage. Science 2005, 309(5742):1871-1874.
18. Perrett C.M., Walker S.L., O'Donovan P., et al. Azathioprine treatment photosensitizes human skin to ultraviolet A radiation. Br J Dermatol 2008, 159(1):198-204.
19. Yarosh D.B., Pena A.V., Nay S.L., Canning M.T., Brown D.A. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 2005, 125(5):1020-1025.
20. McLaughlin-Drubin M.E., Munger K. Viruses associated with human cancer. Biochim Biophys Acta 2008, 1782(3):127-150.
21. Kiberd B.A., Rose C., Gill J.S. Cancer mortality in kidney transplantation. Am J Transplant 2009, 9(8):1868-1875.
22. Bia M., Adey D.B., Bloom R.D., Chan L., Kulkarni S., Tomlanovich S. KDOQI US commentary on the 2009 KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Kidney Dis 2010, 56(2):189-218.
23. Wisgerhof H.C., Edelbroek J.R., de Fijter J.W., et al. Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010, 89(10):1231-1238.
24. Ramsay H.M., Reece S.M., Fryer A.A., Smith A.G., Harden P.N. Seven-year prospective study of nonmelanoma skin cancer incidence inU.K. renal transplant recipients. Transplantation 2007, 84(3):437-439.
25. Murphy G.M. Ultraviolet radiation and immunosuppression. Br J Dermatol 2009, 161(suppl 3):90-95.
26. Jemal A., Simard E.P., Dorell C., et al. Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 2013, 105(3):175-201.
27. Schiffman M., Castle P.E., Jeronimo J., Rodriguez A.C., Wacholder S. Human papillomavirus and cervical cancer. Lancet 2007, 370(9590):890-907.
28. Watson M., Saraiya M., Ahmed F., et al. Using population-based cancer registry data to assess the burden of human papillomavirus-associated cancers in the United States: overview of methods. Cancer 2008, 113(suppl 10):2841-2854.
29. Sillman F.H., Sentovich S., Shaffer D. Ano-genital neoplasia in renal transplant patients. Ann Transplant 1997, 2(4):59-66.
30. Chen H.C., Schiffman M., Lin C.Y., et al. Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. J Natl Cancer Inst 2011, 103(18):1387-1396.
31. Opelz G., Henderson R. Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 1993, 342(8886-8887):1514-1516.
32. Végso G., Hajdu M., Sebestyén A. Lymphoproliferative disorders after solid organ transplantation-classification, incidence, risk factors, early detection and treatment options. Pathol Oncol Res 2011, 17(3):443-454.
33. Khedmat H., Taheri S. Characteristics and prognosis of post-transplant lymphoproliferative disorders within renal allograft: report from the PTLD.Int. Survey. Ann Transplant 2010, 15(3):80-86.
34. Perrine S.P., Hermine O., Small T., et al. A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. Blood 2007, 109(6):2571-2578.
35. Howlader N., Noone A., Krapcho M., et al. SEER Cancer Statistics Review, 1975-2010 2013, National Cancer Institute, Bethesda, MD.
36. Kiberd B.A., Keough-Ryan T., Clase C.M. Screening for prostate, breast and colorectal cancer in renal transplant recipients. Am J Transplant 2003, 3(5):619-625.
37. Nourbala M.H., Nemati E., Rostami Z., Einollahi B. Impact of cigarette smoking on kidney transplant recipients: a systematic review. Iran J Kidney Dis 2011, 5(3):141-148.
38. Danpanich E., Kasiske B.L. Risk factors for cancer in renal transplant recipients. Transplantation 1999, 68(12):1859-1864.
39. Kasiske B.L., Klinger D. Cigarette smoking in renal transplant recipients. J Am Soc Nephrol 2000, 11(4):753-759.
40. Urwin H.R., Jones P.W., Harden P.N., et al. Predicting risk of nonmelanoma skin cancer and premalignant skin lesions in renal transplant recipients. Transplantation 2009, 87(11):1667-1671.
41. Bangash H.K., Colegio O.R. Management of non-melanoma skin cancer in immunocompromised solid organ transplant recipients. Curr Treat Options Oncol 2012, 13(3):354-376.
42. Euvrard S., Morelon E., Rostaing L., et al. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med 2012, 367(4):329-339.
43. National Library of Medicine. Antibody response to human papillomavirus recombinant vaccine (Gardasil®) in girls and young women with chronic kidney disease. Available at: Accessed May 9,2013. http://clinicaltrials.gov/show/NCT00806676.
44. Rowe D.T., Webber S., Schauer E.M., Reyes J., Green M. Epstein-Barr virus load monitoring: its role in the prevention and management of post-transplant lymphoproliferative disease. Transpl Infect Dis 2001, 3(2):79-87.
45. Martin S.I., Dodson B., Wheeler C., Davis J., Pesavento T., Bumgardner G.L. Monitoring infection with Epstein-Barr virus among seromismatch adult renal transplant recipients. Am J Transplant 2011, 11(5):1058-1063.
46. Preiksaitis J.K., Pang X.L., Fox J.D., et al. Interlaboratory comparison ofEpstein-Barr virus viral load assays. Am J Transplant 2009, 9(2):269-279.
47. Kasiske B.L., Vazquez M.A., Harmon W.E., et al. Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 2000, 11(suppl 15):S1-S86.
48. Wong G., Howard K., Webster A.C., Chapman J.R., Craig J.C. Screening for renal cancer in recipients of kidney transplants. Nephrol Dial Transplant 2011, 26(5):1729-1739.
49. Jørgensen K.J., Gøtzsche P.C. Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends. BMJ 2009, 339:b2587.
50. Kalager M., Zelen M., Langmark F., Adami H.O. Effect of screening mammography on breast-cancer mortality in Norway. N Engl J Med 2010, 363(13):1203-1210.
51. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.6.2. Cancer risk after renal transplantation. Skin cancers: prevention and treatment. Nephrol Dial Transplant 2002, 17(suppl 4):31-36. EBPG Expert Group on Renal Transplantation.