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Volumn 7, Issue 4, 2013, Pages 959-968

Angiogenesis in liver regeneration and fibrosis: "A double-edged sword"

Author keywords

Angiogenesis; Endothelial progenitor cells; Fibrosis; Liver regeneration

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GELATINASE A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMATINIB; MACROPHAGE MIGRATION INHIBITION FACTOR; PLACENTAL GROWTH FACTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR; SORAFENIB; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

EID: 84890571870     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-013-9483-7     Document Type: Review
Times cited : (28)

References (74)
  • 1
    • 34848864570 scopus 로고    scopus 로고
    • Liver regeneration
    • 17559071 10.1002/jcp.21172 1:CAS:528:DC%2BD2sXhtFKnu73L
    • Michalopoulos GK. Liver regeneration. J Cell Physiol 2007;213:286-300
    • (2007) J Cell Physiol , vol.213 , pp. 286-300
    • Michalopoulos, G.K.1
  • 2
    • 78651447817 scopus 로고    scopus 로고
    • Liver regeneration: Alternative epithelial pathways
    • 19788929 10.1016/j.biocel.2009.09.014 1:CAS:528:DC%2BC3MXmsVKluw%3D%3D
    • Michalopoulos GK. Liver regeneration: alternative epithelial pathways. Int J Biochem Cell Biol 2011;43:173-179
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 173-179
    • Michalopoulos, G.K.1
  • 4
    • 55649121341 scopus 로고    scopus 로고
    • An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: Relationship between fibrosis and angiogenesis
    • 19134051 10.1111/j.1365-2613.2008.00608.x
    • Vanheule E, Geerts AM, Van Huysse J, Schelfhout D, Praet M, Van Vlierberghe H, et al. An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis. Int J Exp Pathol 2008;89:419-432
    • (2008) Int J Exp Pathol , vol.89 , pp. 419-432
    • Vanheule, E.1    Geerts, A.M.2    Van Huysse, J.3    Schelfhout, D.4    Praet, M.5    Van Vlierberghe, H.6
  • 5
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • 10742145 10.1038/74651 1:CAS:528:DC%2BD3cXisVOrur4%3D
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000;6:389-395
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 6
    • 77952092300 scopus 로고    scopus 로고
    • Endothelial precursors in vascular repair
    • 20184904 10.1016/j.mvr.2010.02.009 1:CAS:528:DC%2BC3cXkvFKruro%3D
    • Kirton JP, Xu Q. Endothelial precursors in vascular repair. Microvasc Res 2010;79:193-199
    • (2010) Microvasc Res , vol.79 , pp. 193-199
    • Kirton, J.P.1    Xu, Q.2
  • 7
    • 56449088260 scopus 로고    scopus 로고
    • The potential of circulating endothelial progenitor cells to form colonies is inversely proportional to total vascular risk score in patients with coronary artery disease
    • 19151462
    • Kaur S, Jayakumar K, Kartha CC. The potential of circulating endothelial progenitor cells to form colonies is inversely proportional to total vascular risk score in patients with coronary artery disease. Indian Heart J 2007;59:475-481
    • (2007) Indian Heart J , vol.59 , pp. 475-481
    • Kaur, S.1    Jayakumar, K.2    Kartha, C.C.3
  • 8
    • 84869203453 scopus 로고    scopus 로고
    • Increased number and function of endothelial progenitor cells stimulate angiogenesis by resident liver sinusoidal endothelial cells (SECs) in cirrhosis through paracrine factors
    • 22824816 10.1016/j.jhep.2012.07.016 1:CAS:528:DC%2BC38XhslWqsb7E
    • Kaur S, Tripathi D, Dongre K, Garg V, Rooge S, Mukopadhyay A, et al. Increased number and function of endothelial progenitor cells stimulate angiogenesis by resident liver sinusoidal endothelial cells (SECs) in cirrhosis through paracrine factors. J Hepatol 2012;57:1193-1198
    • (2012) J Hepatol , vol.57 , pp. 1193-1198
    • Kaur, S.1    Tripathi, D.2    Dongre, K.3    Garg, V.4    Rooge, S.5    Mukopadhyay, A.6
  • 9
    • 0035232487 scopus 로고    scopus 로고
    • Cooperation of liver cells in health and disease
    • Kmieć Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol 2001;61:1-151
    • (2001) Adv Anat Embryol Cell Biol , vol.61 , pp. 1-151
    • Kmieć, Z.1
  • 10
    • 0032985306 scopus 로고    scopus 로고
    • Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    • 9918916 10.1002/hep.510290244 1:CAS:528:DyaK1MXhtFOksbY%3D
    • Sakamoto T, Liu Z, Murase N, Ezure T, Yokomuro S, Poli V, et al. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 1999;29:403-411
    • (1999) Hepatology , vol.29 , pp. 403-411
    • Sakamoto, T.1    Liu, Z.2    Murase, N.3    Ezure, T.4    Yokomuro, S.5    Poli, V.6
  • 11
    • 0017730940 scopus 로고
    • Kinetics of hepatocellular proliferation as a function of the microvascular structure and functional state of the liver
    • 248005
    • Rabes HM. Kinetics of hepatocellular proliferation as a function of the microvascular structure and functional state of the liver. Ciba Found Symp 1977;55:31-53
    • (1977) Ciba Found Symp , vol.55 , pp. 31-53
    • Rabes, H.M.1
  • 12
    • 0031787394 scopus 로고    scopus 로고
    • Tumor necrosis factor primes hepatocytes for DNA replication in the rat
    • 9794905 10.1002/hep.510280509 1:CAS:528:DyaK1cXntlSjs70%3D
    • Webber EM, Bruix J, Pierce RH, Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 1998;28:1226-1234
    • (1998) Hepatology , vol.28 , pp. 1226-1234
    • Webber, E.M.1    Bruix, J.2    Pierce, R.H.3    Fausto, N.4
  • 14
    • 0021858187 scopus 로고
    • The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
    • 3926620 10.1002/hep.1840050427 1:STN:280:DyaL2M3lvFCmsg%3D%3D
    • Wisse E, De Zanger RB, Charels K, Van Der Smissen P, McCuskey RS. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 1985;5:683-692
    • (1985) Hepatology , vol.5 , pp. 683-692
    • Wisse, E.1    De Zanger, R.B.2    Charels, K.3    Van Der Smissen, P.4    McCuskey, R.S.5
  • 15
    • 0028789311 scopus 로고
    • The extracellular matrix in hepatic regeneration
    • 7589981 1:CAS:528:DyaK2MXpsFOgtbc%3D
    • Martinez-Hernandez A, Amenta PS. The extracellular matrix in hepatic regeneration. FASEB J 1995;9:1401-410
    • (1995) FASEB J , vol.9 , pp. 1401-1410
    • Martinez-Hernandez, A.1    Amenta, P.S.2
  • 16
    • 0035144232 scopus 로고    scopus 로고
    • Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver
    • 11172338 10.1053/jhep.2001.21998 1:STN:280:DC%2BD3M7kvVOrtA%3D%3D
    • Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC, Stolz DB. Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology 2001;33:363-378
    • (2001) Hepatology , vol.33 , pp. 363-378
    • Wack, K.E.1    Ross, M.A.2    Zegarra, V.3    Sysko, L.R.4    Watkins, S.C.5    Stolz, D.B.6
  • 17
    • 0035190838 scopus 로고    scopus 로고
    • Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver
    • 11732003 10.1053/jhep.2001.29624 1:CAS:528:DC%2BD38XhslWisg%3D%3D
    • Ross MA, Sander CM, Kleeb TB, Watkins SC, Stolz DB. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Hepatology 2001;34:1135-1148
    • (2001) Hepatology , vol.34 , pp. 1135-1148
    • Ross, M.A.1    Sander, C.M.2    Kleeb, T.B.3    Watkins, S.C.4    Stolz, D.B.5
  • 18
    • 26044436859 scopus 로고    scopus 로고
    • Expression of hypoxia inducible factor-1alpha during liver regeneration induced by partial hepatectomy in rats
    • 16162160 10.1111/j.1478-3231.2005.01144.x 1:CAS:528:DC%2BD2MXhtFGiu73P
    • Maeno H, Ono T, Dhar DK, Sato T, Yamanoi A, Nagasue N. Expression of hypoxia inducible factor-1alpha during liver regeneration induced by partial hepatectomy in rats. Liver Int 2005;25:1002-1009
    • (2005) Liver Int , vol.25 , pp. 1002-1009
    • Maeno, H.1    Ono, T.2    Dhar, D.K.3    Sato, T.4    Yamanoi, A.5    Nagasue, N.6
  • 19
    • 1642450652 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice
    • 14739103 10.1016/j.jhep.2003.10.027 1:CAS:528:DC%2BD2cXltVChsA%3D%3D
    • Redaelli CA, Semela D, Carrick FE, Ledermann M, Candinas D, Sauter B, et al. Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice. J Hepatol 2004;40:305-312
    • (2004) J Hepatol , vol.40 , pp. 305-312
    • Redaelli, C.A.1    Semela, D.2    Carrick, F.E.3    Ledermann, M.4    Candinas, D.5    Sauter, B.6
  • 20
    • 0035189114 scopus 로고    scopus 로고
    • Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats
    • 11118484 10.1177/002215540104900112 1:CAS:528:DC%2BD3MXhtFChtQ%3D%3D
    • Taniguchi E, Sakisaka S, Matsuo K, Tanikawa K, Sata M. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats. J Histochem Cytochem 2001;49:121-130
    • (2001) J Histochem Cytochem , vol.49 , pp. 121-130
    • Taniguchi, E.1    Sakisaka, S.2    Matsuo, K.3    Tanikawa, K.4    Sata, M.5
  • 21
    • 0035013447 scopus 로고    scopus 로고
    • Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats
    • 11434614 10.1016/S0168-8278(00)00055-6 1:CAS:528:DC%2BD3MXkvVKrsr4%3D
    • Shimizu H, Miyazaki M, Wakabayashi Y, Mitsuhashi N, Kato A, Ito H, et al. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol 2001;34:683-689
    • (2001) J Hepatol , vol.34 , pp. 683-689
    • Shimizu, H.1    Miyazaki, M.2    Wakabayashi, Y.3    Mitsuhashi, N.4    Kato, A.5    Ito, H.6
  • 22
    • 0348013133 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases fenestral permeability in hepatic sinusoidal endothelial cells
    • 14986821 10.1111/j.1478-3231.2003.00880.x 1:CAS:528: DC%2BD2cXjt1SqtA%3D%3D
    • Yokomori H, Oda M, Yoshimura K, Nagai T, Ogi M, Nomura M, et al. Vascular endothelial growth factor increases fenestral permeability in hepatic sinusoidal endothelial cells. Liver Int 2003;23:467-475
    • (2003) Liver Int , vol.23 , pp. 467-475
    • Yokomori, H.1    Oda, M.2    Yoshimura, K.3    Nagai, T.4    Ogi, M.5    Nomura, M.6
  • 23
    • 78149285919 scopus 로고    scopus 로고
    • Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    • 21068842 10.1038/nature09493 1:CAS:528:DC%2BC3cXhsVWjsbzP
    • Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 2010;468:310-315
    • (2010) Nature , vol.468 , pp. 310-315
    • Ding, B.S.1    Nolan, D.J.2    Butler, J.M.3    James, D.4    Babazadeh, A.O.5    Rosenwaks, Z.6
  • 24
    • 0037423321 scopus 로고    scopus 로고
    • Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1
    • 12574630 10.1126/science.1079562 1:CAS:528:DC%2BD3sXpt1Shuw%3D%3D
    • LeCouter J, Moritz DR, Li B, Phillips GL, Liang XH, Gerber HP, et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 2003;299:890-893
    • (2003) Science , vol.299 , pp. 890-893
    • Lecouter, J.1    Moritz, D.R.2    Li, B.3    Phillips, G.L.4    Liang, X.H.5    Gerber, H.P.6
  • 25
    • 2442719965 scopus 로고    scopus 로고
    • The role of hepatic stellate cells in liver regeneration
    • 15158345 10.1016/j.jhep.2004.04.003 1:CAS:528:DC%2BD2cXkt1SntLk%3D
    • Balabaud C, Bioulac-Sage P, Desmouliere A. The role of hepatic stellate cells in liver regeneration. J Hepatol 2004;40:1023-1026
    • (2004) J Hepatol , vol.40 , pp. 1023-1026
    • Balabaud, C.1    Bioulac-Sage, P.2    Desmouliere, A.3
  • 26
    • 34848914316 scopus 로고    scopus 로고
    • Morphologic features in the regenerating liver - A comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells
    • 17674035 10.1007/s00428-007-0472-x
    • Budny T, Palmes D, Stratmann U, Minin E, Herbst H, Spiegel HU. Morphologic features in the regenerating liver - a comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells. Virchows Arch 2007;451:781-791
    • (2007) Virchows Arch , vol.451 , pp. 781-791
    • Budny, T.1    Palmes, D.2    Stratmann, U.3    Minin, E.4    Herbst, H.5    Spiegel, H.U.6
  • 27
    • 0036941610 scopus 로고    scopus 로고
    • The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF
    • 12613545 1:CAS:528:DC%2BD3sXisl2jsLg%3D
    • Neufeld G, Kessler O, Herzog Y. The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF. Adv Exp Med Biol 2002;515:81-90
    • (2002) Adv Exp Med Biol , vol.515 , pp. 81-90
    • Neufeld, G.1    Kessler, O.2    Herzog, Y.3
  • 28
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • 1447317 10.1002/jcp.1041530317 1:CAS:528:DyaK3sXhs12msA%3D%3D
    • Unemori EN, Ferrara N, Bauer EA, Amento EP. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 1992;153:557-562
    • (1992) J Cell Physiol , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3    Amento, E.P.4
  • 29
    • 0032473560 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation
    • 9495249 10.1002/(SICI)1097-0215(19980302)75:5<780: AID-IJC19>3.0.CO;2-A 1:CAS:528:DyaK1cXhsVylsL8%3D
    • Zucker S, Mirza H, Conner CE, Lorenz AF, Drews MH, Bahou WF, et al. Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation. Int J Cancer 1998;75:780-786
    • (1998) Int J Cancer , vol.75 , pp. 780-786
    • Zucker, S.1    Mirza, H.2    Conner, C.E.3    Lorenz, A.F.4    Drews, M.H.5    Bahou, W.F.6
  • 30
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • 1755866 10.1016/0006-291X(91)91276-I 1:CAS:528:DyaK38XhtVSjt7w%3D
    • Pepper MS, Ferrara N, Orci L, Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 1991;181:902-906
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 31
    • 0035024760 scopus 로고    scopus 로고
    • Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver
    • 11434615 10.1016/S0168-8278(00)00109-4 1:CAS:528:DC%2BD3MXkvVKrsr8%3D
    • Sato T, El-Assal ON, Ono T, Yamanoi A, Dhar DK, Nagasue N. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol 2001;34:690-698
    • (2001) J Hepatol , vol.34 , pp. 690-698
    • Sato, T.1    El-Assal, O.N.2    Ono, T.3    Yamanoi, A.4    Dhar, D.K.5    Nagasue, N.6
  • 32
    • 0029001244 scopus 로고
    • Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
    • 7596437 10.1038/376070a0 1:CAS:528:DyaK2MXmvVKjsrg%3D
    • Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995;376:70-74
    • (1995) Nature , vol.376 , pp. 70-74
    • Sato, T.N.1    Tozawa, Y.2    Deutsch, U.3    Wolburg-Buchholz, K.4    Fujiwara, Y.5    Gendron-Maguire, M.6
  • 33
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • 9204896 10.1126/science.277.5322.55 1:CAS:528:DyaK2sXksVyhu78%3D
    • Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997;277:55-60
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3    Bartunkova, S.4    Wiegand, S.J.5    Radziejewski, C.6
  • 34
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • 10498889 10.1038/sj.onc.1203035 1:CAS:528:DyaK1MXms1Ontr0%3D
    • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999;18:5356-5362
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 36
    • 0030955880 scopus 로고    scopus 로고
    • Nonparenchymal cells from regenerating rat liver generates interleukin-1alpha and -1beta: A mechanism of negative regulation of hepatocyte proliferation
    • 9214451 1:CAS:528:DyaK2sXkslagtL4%3D
    • Boulton R, Woodman A, Calnan D, Selden C, Tam F, Hodgson H. Nonparenchymal cells from regenerating rat liver generates interleukin-1alpha and -1beta: a mechanism of negative regulation of hepatocyte proliferation. Hepatology 1997;26:49-58
    • (1997) Hepatology , vol.26 , pp. 49-58
    • Boulton, R.1    Woodman, A.2    Calnan, D.3    Selden, C.4    Tam, F.5    Hodgson, H.6
  • 37
    • 7044228192 scopus 로고    scopus 로고
    • Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice
    • 15389868 10.1002/hep.20426 1:CAS:528:DC%2BD2cXhtVCgt7rN
    • Oe S, Lemmer ER, Conner EA, Factor VM, Levéen P, Larsson J, et al. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004;40:1098-1105
    • (2004) Hepatology , vol.40 , pp. 1098-1105
    • Oe, S.1    Lemmer, E.R.2    Conner, E.A.3    Factor, V.M.4    Levéen, P.5    Larsson, J.6
  • 39
    • 0032857478 scopus 로고    scopus 로고
    • Hepatocellular hypoxia induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis
    • 10514389 10.1016/S0002-9440(10)65209-1 1:CAS:528:DyaK1MXntFWmsbY%3D
    • Rosmorduc O, Wendum D, Corpechot C, Galy B, Sebbagh N, Raleigh J, et al. Hepatocellular hypoxia induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol 1999;155:1065-1073
    • (1999) Am J Pathol , vol.155 , pp. 1065-1073
    • Rosmorduc, O.1    Wendum, D.2    Corpechot, C.3    Galy, B.4    Sebbagh, N.5    Raleigh, J.6
  • 40
    • 0036234428 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF and collagen i expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
    • 11981751 10.1053/jhep.2002.32524 1:CAS:528:DC%2BD38XktF2htbY%3D
    • Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 2002;35:1010-1021
    • (2002) Hepatology , vol.35 , pp. 1010-1021
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Kinnman, N.4    Rey, C.5    Poupon, R.6
  • 41
    • 55249125669 scopus 로고    scopus 로고
    • Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis
    • 18823985 10.1053/j.gastro.2008.07.065 1:CAS:528:DC%2BD1cXhsVOhtbvL
    • Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, et al. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology 2008;135:1729-1738
    • (2008) Gastroenterology , vol.135 , pp. 1729-1738
    • Taura, K.1    De Minicis, S.2    Seki, E.3    Hatano, E.4    Iwaisako, K.5    Osterreicher, C.H.6
  • 42
    • 77957328518 scopus 로고    scopus 로고
    • Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?
    • 20800926 10.1016/j.jhep.2010.07.004
    • Thabut D, Shah V. Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension? J Hepatol 2010;53:976-980
    • (2010) J Hepatol , vol.53 , pp. 976-980
    • Thabut, D.1    Shah, V.2
  • 43
    • 0033980284 scopus 로고    scopus 로고
    • Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells
    • 10613739 10.1002/hep.510310122 1:CAS:528:DC%2BD3cXks1Oiuw%3D%3D
    • Ankoma-Sey V, Wang Y, Dai Z. Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells. Hepatology 2000;31:141-148
    • (2000) Hepatology , vol.31 , pp. 141-148
    • Ankoma-Sey, V.1    Wang, Y.2    Dai, Z.3
  • 44
    • 34447317835 scopus 로고    scopus 로고
    • Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells
    • 17525262 10.2353/ajpath.2007.060887 1:CAS:528:DC%2BD2sXntlOhtL4%3D
    • Novo E, Cannito S, Zamara E, Valfrè di Bonzo L, Caligiuri A, Cravanzola C, et al. Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. Am J Pathol 2007;170:1942-1953
    • (2007) Am J Pathol , vol.170 , pp. 1942-1953
    • Novo, E.1    Cannito, S.2    Zamara, E.3    Valfrè Di Bonzo, L.4    Caligiuri, A.5    Cravanzola, C.6
  • 45
    • 65349175992 scopus 로고    scopus 로고
    • Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice
    • 19136383 10.1152/ajpgi.90368.2008 1:CAS:528:DC%2BD1MXjtFGrtbk%3D
    • Moon JO, Welch TP, Gonzalez FJ, Copple BL. Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice. Am J Physiol Gastrointest Liver Physiol 2009;296:G582-G592
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Moon, J.O.1    Welch, T.P.2    Gonzalez, F.J.3    Copple, B.L.4
  • 46
    • 84859946390 scopus 로고    scopus 로고
    • Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice
    • 22271822 10.1124/jpet.111.189340 1:CAS:528:DC%2BC38Xmt1Knt7Y%3D
    • Copple BL, Kaska S, Wentling C. Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice. J Pharmacol Exp Ther 2012;341:307-316
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 307-316
    • Copple, B.L.1    Kaska, S.2    Wentling, C.3
  • 47
    • 0037222762 scopus 로고    scopus 로고
    • Vascular mediators in the injured liver
    • 12500181 10.1053/jhep.2003.50044 1:CAS:528:DC%2BD3sXovVWisQ%3D%3D
    • Rockey DC. Vascular mediators in the injured liver. Hepatology 2003;37:4-12
    • (2003) Hepatology , vol.37 , pp. 4-12
    • Rockey, D.C.1
  • 48
    • 20444367984 scopus 로고    scopus 로고
    • Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats
    • 15893841 10.1016/j.jhep.2005.02.022 1:CAS:528:DC%2BD2MXlt1Ghsb8%3D
    • Fernandez M, Mejias M, Angermayr B, Garcia-Pagan JC, Rodes J, Bosch J. Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. J Hepatol 2005;43:98-103
    • (2005) J Hepatol , vol.43 , pp. 98-103
    • Fernandez, M.1    Mejias, M.2    Angermayr, B.3    Garcia-Pagan, J.C.4    Rodes, J.5    Bosch, J.6
  • 49
    • 0034872638 scopus 로고    scopus 로고
    • Increased production of vascular endothelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis
    • 11526533 10.1053/jhep.2001.27093 1:CAS:528:DC%2BD3MXmvV2ktrY%3D
    • Cejudo-Martin P, Ros J, Navasa M, Fernandez J, Fernandez-Varo G, Ruiz-del-Arbol L, et al. Increased production of vascular endothelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis. Hepatology 2001;34:487-493
    • (2001) Hepatology , vol.34 , pp. 487-493
    • Cejudo-Martin, P.1    Ros, J.2    Navasa, M.3    Fernandez, J.4    Fernandez-Varo, G.5    Ruiz-Del-Arbol, L.6
  • 50
    • 0035029963 scopus 로고    scopus 로고
    • Immunohistochemical localization of vascular endothelial growth factor in the rat portal hypertensive gastropathy
    • 11354282 10.1046/j.1440-1746.2001.02452.x 1:CAS:528:DC%2BD3MXktVOhsr0%3D
    • Tsugawa K, Hashizume M, Tomikawa M, Migou S, Kawanaka H, Shiraishi S, et al. Immunohistochemical localization of vascular endothelial growth factor in the rat portal hypertensive gastropathy. J Gastroenterol Hepatol 2001;16:429-437
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 429-437
    • Tsugawa, K.1    Hashizume, M.2    Tomikawa, M.3    Migou, S.4    Kawanaka, H.5    Shiraishi, S.6
  • 51
    • 14744291990 scopus 로고    scopus 로고
    • Molecular mechanisms in hepatocellular carcinoma development
    • 15757803 10.1016/j.bpg.2004.11.005 1:CAS:528:DC%2BD2MXitFCjtLo%3D
    • Cha C, Dematteo RP. Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol 2005;19:25-37
    • (2005) Best Pract Res Clin Gastroenterol , vol.19 , pp. 25-37
    • Cha, C.1    Dematteo, R.P.2
  • 52
    • 33749261599 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma
    • 16564617 10.1016/j.canlet.2006.01.008 1:CAS:528:DC%2BD28XhtVGit7rM
    • Pang R, Poon RT. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma. Cancer Lett 2006;242:151-167
    • (2006) Cancer Lett , vol.242 , pp. 151-167
    • Pang, R.1    Poon, R.T.2
  • 53
    • 37749049919 scopus 로고    scopus 로고
    • Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats
    • 17935226 10.1002/hep.21921 1:CAS:528:DC%2BD2sXhsVGiurzO
    • Tugues S, Fernandez-Varo G, Muñoz-Luque J, Ros J, Arroyo V, Rodés J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007;46:1919-1926
    • (2007) Hepatology , vol.46 , pp. 1919-1926
    • Tugues, S.1    Fernandez-Varo, G.2    Muñoz-Luque, J.3    Ros, J.4    Arroyo, V.5    Rodés, J.6
  • 54
    • 77957021043 scopus 로고    scopus 로고
    • Antiangiogenic therapies in portal hypertension: A breakthrough in hepatology
    • 20630674 10.1016/j.gcb.2010.05.007 1:CAS:528:DC%2BC3cXht1WhtrnP
    • Rosmorduc O. Antiangiogenic therapies in portal hypertension: a breakthrough in hepatology. Gastroenterol Clin Biol 2010;34:446-449
    • (2010) Gastroenterol Clin Biol , vol.34 , pp. 446-449
    • Rosmorduc, O.1
  • 55
    • 72949093354 scopus 로고    scopus 로고
    • Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
    • 19725105 10.1002/hep.23144 1:CAS:528:DC%2BD1MXhsV2js73M
    • Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H, et al. Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology 2009;50:1501-1511
    • (2009) Hepatology , vol.50 , pp. 1501-1511
    • Patsenker, E.1    Popov, Y.2    Stickel, F.3    Schneider, V.4    Ledermann, M.5    Sägesser, H.6
  • 56
    • 84870655974 scopus 로고    scopus 로고
    • Two drugs with paradoxical effects on liver regeneration through antiangiogenesis and antifibrosis: Losartan and Spironolactone: A pharmacologic dilemma on hepatocyte proliferation
    • 22989552 10.1016/j.jss.2012.08.046 1:CAS:528:DC%2BC38XhtlKjsrjO
    • Parlakgumus A, Colakoglu T, Kayaselcuk F, Colakoglu S, Ezer A, CalIskan K, et al. Two drugs with paradoxical effects on liver regeneration through antiangiogenesis and antifibrosis: Losartan and Spironolactone: a pharmacologic dilemma on hepatocyte proliferation. J Surg Res 2013;179:60-65
    • (2013) J Surg Res , vol.179 , pp. 60-65
    • Parlakgumus, A.1    Colakoglu, T.2    Kayaselcuk, F.3    Colakoglu, S.4    Ezer, A.5    Caliskan, K.6
  • 57
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • 9020076 10.1126/science.275.5302.964 1:CAS:528:DyaK2sXht1Clu7k%3D
    • Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3    Silver, M.4    Van Der Zee, R.5    Li, T.6
  • 58
    • 0032528555 scopus 로고    scopus 로고
    • Evidence for circulating bone marrow-derived endothelial cells
    • 9657732 1:CAS:528:DyaK1cXksFarur4%3D
    • Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998;92:362-367
    • (1998) Blood , vol.92 , pp. 362-367
    • Shi, Q.1    Rafii, S.2    Wu, M.H.3    Wijelath, E.S.4    Yu, C.5    Ishida, A.6
  • 59
    • 0032945433 scopus 로고    scopus 로고
    • Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
    • 10202935 10.1038/8462 1:CAS:528:DyaK1MXisFOksbs%3D
    • Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999;5:434-438
    • (1999) Nat Med , vol.5 , pp. 434-438
    • Takahashi, T.1    Kalka, C.2    Masuda, H.3    Chen, D.4    Silver, M.5    Kearney, M.6
  • 60
    • 0035814766 scopus 로고    scopus 로고
    • Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia
    • 11156872 10.1161/01.CIR.103.5.634 1:STN:280:DC%2BD3M3msFWlsQ%3D%3D
    • Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, Masuda H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001;103:634-637
    • (2001) Circulation , vol.103 , pp. 634-637
    • Kawamoto, A.1    Gwon, H.C.2    Iwaguro, H.3    Yamaguchi, J.I.4    Uchida, S.5    Masuda, H.6
  • 61
    • 0034724335 scopus 로고    scopus 로고
    • Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
    • 10725398 10.1073/pnas.97.7.3422 1:CAS:528:DC%2BD3cXitlWqt7w%3D
    • Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000;97:3422-3427
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3422-3427
    • Kalka, C.1    Masuda, H.2    Takahashi, T.3    Kalka-Moll, W.M.4    Silver, M.5    Kearney, M.6
  • 62
    • 24744447016 scopus 로고    scopus 로고
    • Therapeutic neovascularization by autologous transplantation with expanded endothelial progenitor cells from peripheral blood into ischemic hind limbs
    • 16115373 10.1111/j.1745-7254.2005.00168.x 1:CAS:528:DC%2BD2MXhtVWktbvJ
    • Fan CL, Gao PJ, Che ZQ, Liu JJ, Wei J, Zhu DL. Therapeutic neovascularization by autologous transplantation with expanded endothelial progenitor cells from peripheral blood into ischemic hind limbs. Acta Pharmacol Sin 2005;26:1069-1075
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1069-1075
    • Fan, C.L.1    Gao, P.J.2    Che, Z.Q.3    Liu, J.J.4    Wei, J.5    Zhu, D.L.6
  • 63
    • 34447092409 scopus 로고    scopus 로고
    • Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model
    • 17631135 10.1053/j.gastro.2007.03.110 1:CAS:528:DC%2BD2sXptFKit7Y%3D
    • Nakamura T, Torimura T, Sakamoto M, Hashimoto O, Taniguchi E, Inoue K, et al. Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model. Gastroenterology 2007;133:91-107
    • (2007) Gastroenterology , vol.133 , pp. 91-107
    • Nakamura, T.1    Torimura, T.2    Sakamoto, M.3    Hashimoto, O.4    Taniguchi, E.5    Inoue, K.6
  • 64
    • 84862635505 scopus 로고    scopus 로고
    • Prevention of liver fibrosis and liver reconstitution of DMN-treated rat liver by transplanted EPCs
    • 22224757 10.1111/j.1365-2362.2011.02637.x 1:CAS:528:DC%2BC38Xht1Kkt7rJ
    • Nakamura T, Torimura T, Iwamoto H, Masuda H, Naitou M, Koga H, et al. Prevention of liver fibrosis and liver reconstitution of DMN-treated rat liver by transplanted EPCs. Eur J Clin Invest 2012;42:717-728
    • (2012) Eur J Clin Invest , vol.42 , pp. 717-728
    • Nakamura, T.1    Torimura, T.2    Iwamoto, H.3    Masuda, H.4    Naitou, M.5    Koga, H.6
  • 65
    • 84871655442 scopus 로고    scopus 로고
    • Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model
    • 22849788 10.1111/j.1440-1746.2012.07238.x 1:CAS:528:DC%2BC3sXit1On
    • Sakamoto M, Nakamura T, Torimura T, Iwamoto H, Masuda H, Koga H, et al. Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model. J Gastroenterol Hepatol 2013;28:168-178
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 168-178
    • Sakamoto, M.1    Nakamura, T.2    Torimura, T.3    Iwamoto, H.4    Masuda, H.5    Koga, H.6
  • 66
    • 84859723288 scopus 로고    scopus 로고
    • Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
    • 22406533 10.1172/JCI58789 1:CAS:528:DC%2BC38Xlt1egu7g%3D
    • Wang L, Wang X, Xie G, Wang L, Hill CK, DeLeve LD. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest 2012;122:1567-1573
    • (2012) J Clin Invest , vol.122 , pp. 1567-1573
    • Wang, L.1    Wang, X.2    Xie, G.3    Wang, L.4    Hill, C.K.5    Deleve, L.D.6
  • 67
    • 33750621103 scopus 로고    scopus 로고
    • Significance of circulating endothelial progenitor cells in hepatocellular carcinoma
    • 17006919 10.1002/hep.21353 1:CAS:528:DC%2BD28XhtFyqsr%2FL
    • Ho JW, Pang RW, Lau C, Sun CK, Yu WC, Fan ST, et al. Significance of circulating endothelial progenitor cells in hepatocellular carcinoma. Hepatology 2006;44:836-843
    • (2006) Hepatology , vol.44 , pp. 836-843
    • Ho, J.W.1    Pang, R.W.2    Lau, C.3    Sun, C.K.4    Yu, W.C.5    Fan, S.T.6
  • 68
    • 34447114446 scopus 로고    scopus 로고
    • Identification and clinical significance of mobilized endothelial progenitor cells in tumor vasculogenesis of hepatocellular carcinoma
    • 17606712 10.1158/1078-0432.CCR-06-2594 1:CAS:528:DC%2BD2sXntFymsbk%3D
    • Yu D, Sun X, Qiu Y, Zhou J, Wu Y, Zhuang L, et al. Identification and clinical significance of mobilized endothelial progenitor cells in tumor vasculogenesis of hepatocellular carcinoma. Clin Cancer Res 2007;13:3814-3824
    • (2007) Clin Cancer Res , vol.13 , pp. 3814-3824
    • Yu, D.1    Sun, X.2    Qiu, Y.3    Zhou, J.4    Wu, Y.5    Zhuang, L.6
  • 69
    • 77955538262 scopus 로고    scopus 로고
    • Mechanism of endothelial progenitor cell recruitment into neo-vessels in adjacent non-tumor tissues in hepatocellular carcinoma
    • 20716344 10.1186/1471-2407-10-435
    • Yu DC, Chen J, Sun XT, Zhuang LY, Jiang CP, Ding YT. Mechanism of endothelial progenitor cell recruitment into neo-vessels in adjacent non-tumor tissues in hepatocellular carcinoma. BMC Cancer 2010;10:435
    • (2010) BMC Cancer , vol.10 , pp. 435
    • Yu, D.C.1    Chen, J.2    Sun, X.T.3    Zhuang, L.Y.4    Jiang, C.P.5    Ding, Y.T.6
  • 70
    • 77957892417 scopus 로고    scopus 로고
    • Hypoxic and highly angiogenic non-tumor tissues surrounding hepatocellular carcinoma: The 'niche' of endothelial progenitor cells
    • 21152281 10.3390/ijms11082901 1:CAS:528:DC%2BC3cXhtVCitbfJ
    • Yu DC, Chen J, Ding YT. Hypoxic and highly angiogenic non-tumor tissues surrounding hepatocellular carcinoma: the 'niche' of endothelial progenitor cells. Int J Mol Sci 2010;11:2901-2909
    • (2010) Int J Mol Sci , vol.11 , pp. 2901-2909
    • Yu, D.C.1    Chen, J.2    Ding, Y.T.3
  • 71
    • 77950622924 scopus 로고    scopus 로고
    • A prospective pilot study of circulating endothelial cells as a potential new biomarker in portal hypertension
    • 19840257 10.1111/j.1478-3231.2009.02132.x 1:CAS:528:DC%2BC3cXhslWhtb0%3D
    • Abdelmoneim SS, Talwalkar J, Sethi S, Kamath P, Fathalla MM, Kipp BR, et al. A prospective pilot study of circulating endothelial cells as a potential new biomarker in portal hypertension. Liver Int 2010;30:191-197
    • (2010) Liver Int , vol.30 , pp. 191-197
    • Abdelmoneim, S.S.1    Talwalkar, J.2    Sethi, S.3    Kamath, P.4    Fathalla, M.M.5    Kipp, B.R.6
  • 72
    • 84869206410 scopus 로고    scopus 로고
    • Endothelial progenitor cells in cirrhosis: The more, the merrier?
    • 22989564 10.1016/j.jhep.2012.09.001
    • Rautou PE. Endothelial progenitor cells in cirrhosis: The more, the merrier? J Hepatol 2012;57:1163-1165
    • (2012) J Hepatol , vol.57 , pp. 1163-1165
    • Rautou, P.E.1
  • 73
    • 70349652498 scopus 로고    scopus 로고
    • Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: An in vitro study
    • 19479297 10.1007/s00395-009-0039-x
    • Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K, Kartha CC. Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study. Basic Res Cardiol 2009;104:739-749
    • (2009) Basic Res Cardiol , vol.104 , pp. 739-749
    • Kaur, S.1    Kumar, T.R.2    Uruno, A.3    Sugawara, A.4    Jayakumar, K.5    Kartha, C.C.6
  • 74
    • 84890548906 scopus 로고    scopus 로고
    • Transfection of endothelial nitric oxide synthase gene improves angiogenic efficacy of endothelial progenitor cells in rabbits with hindlimb ischemia
    • 1:CAS:528:DC%2BC3MXhsVyqurfE
    • Kaur S, Harikrishnan VS, Shenoy SJ, Radhakrishnan NS, Uruno A, Sugawara A, et al. Transfection of endothelial nitric oxide synthase gene improves angiogenic efficacy of endothelial progenitor cells in rabbits with hindlimb ischemia. J Clin Exp Cardiol 2011;2:140
    • (2011) J Clin Exp Cardiol , vol.2 , pp. 140
    • Kaur, S.1    Harikrishnan, V.S.2    Shenoy, S.J.3    Radhakrishnan, N.S.4    Uruno, A.5    Sugawara, A.6


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