How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response

Archives of Toxicology

Volumn 87, Issue 12, 2013, Pages 2063-2081

  Calabrese, Edward J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Dose response; History of science; Linearity; Muller; Mutation; Risk assessment

Indexed keywords

ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; DOSE RESPONSE; HISTORY; HUMAN; IONIZING RADIATION; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RISK ASSESSMENT;

DECEPTION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; NATIONAL ACADEMY OF SCIENCES (U.S.); NEOPLASMS; RADIATION, IONIZING; RISK ASSESSMENT; SCIENTIFIC MISCONDUCT; UNITED STATES;

EID: 84890568102     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1105-6     Document Type: Article

References (94)

1. American Philosophical Society (1946) Muller letter to Stern. Stern Papers, Muller File - Box 16, 12 Nov
2. American Philosophical Society (1947a) Stern letter to Muller, 22 Jan 1947
3. American Philosophical Society (1947b) Stern letter to Muller, 23 July 1947
4. American Philosophical Society (1947c) Stern letter to Muller (cable), 7 Aug 1947
5. American Philosophical Society (1947d) Muller letter to Stern, 8 Aug 1947
6. American Philosophical Society (1947e) Stern letter to Muller, 9 Sept 1947
7. American Philosophical Society (1947f) Caspari letter to Stern. Stern Papers, 25 Sept 1947
8. American Philosophical Society (1947g) Caspari letter to Stern. Stern Papers, Box 21, 7 Oct
9. American Philosophical Society (Undated) Stern letter to Caspari, July-Aug 1947
10. American Philosophical Society (1949) Stern letter to Caspari. Stern Papers, 9 Feb 1949
11. American Philosophical Society (1973) A geneticists' journey, pp 1-19, Stern Nov 1973
12. Barron ESG (1954) The effect of x rays on systems of biological importance. In: Hollaender A (ed) Radiation biology, volume I: high energy radiation, chapter 5. McGraw-Hill Book Company, New York, pp 283-314
13. Beadle GW (1959) Ionizing radiation and the citizen. Sci Am 201:219-232
14. BEAR I (1956) Genetic effects of atomic radiation. Science 124:1157-1164
15. Bonnier G, Lüning HG (1949) Studies of X-ray mutations in the white and forked loci of Drosophila melanogaster. I. A Statistical analysis of mutation frequencies. Hereditas 35:116-189
16. Bonnier G, Lüning HG, Perje AM (1949) Studies of X-ray mutations on the white and forked loci of Drosophila melanogaster. II. A study of the formation of Gynandromphs and other kinds of mosaics. Hereditas 35:301-336
17. Byers L (1954) Thermal effects on the spontaneous mutation rate in mature spermatozoa of Drosophila melanogaster. Caryologia Suppl 1(6):694-696
18. Byers L, Muller HJ (1952) Influence of ageing at two different temperatures on the spontaneous mutation rate in mature spermatozoa of Drosophila melanogaster. Genetics 37(5):570-571
19. Calabrese EJ (2009) The road to linearity: why linearity at low doses became the basis for carcinogen risk assessment. Arch Toxicol 83:203-225
20. Calabrese EJ (2011a) Toxicology rewrites its history and rethinks its future: giving equal focus to both harmful and beneficial effects. Environ Toxicol Chem 30(12):2658-2673
21. Calabrese EJ (2011b) Key studies to support cancer risk assessment questioned. Environ Mol Mutagen 52(8):595-606
22. Calabrese EJ (2011c) Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science? Arch Toxicol 85(12):1495-1498
23. Calabrese EJ (2012) Muller's Nobel Prize lecture: when ideology prevailed over science. Toxicol Sci 126(1):1-4
24. Caspari E, Stern C (1948) The influence of chronic irradiation with gamma rays at low dosages on the mutation rate in Drosophila melanogaster. Genetics 33:75-95
25. Catcheside DG (1950) Radiations and genetics. Practitioner 165(990):590-593
26. Crow JF (1957a) Testimony - Statement of Dr. James F. Crow, Professor of Genetics and Zoology, University of Wisconsin. Hearings before the Special Subcommittee on Radiation of the Joint Committee on Atomic Energy, Congress of the United States. 85th Congress, 1st session, part 1. United States Government Printing Office, Washington DC
27. Crow JF (1957b) Genetic considerations in establishing maximum radiation doses. Radiology 69(1):18-22
28. Crow JF (1995) Quarreling geneticists and a diplomat. Genetics 140:421-426
29. Demerec M, Fano U (1944) Frequency of dominant lethal induced by radiation in sperms of Drosophila melanogaster. Genetics 29:348-360
30. Erk FC (2009) Biographical memoirs. H. Bentley Glass. Proc Am Philos Soc 153(3):327-339
31. Evans RD (1949) Quantitative inferences concerning the genetic effects of radiation on human beings. Science 109:299-304
32. Giles N (1940) Spontaneous chromosome aberrations in Tradescantia. Genetics 25:69-87
33. Glass B (1957a) Testimony - Statement of Dr. Bentley Glass, Professor of Biology, the Johns Hopkins University. Hearings before the Special Subcommittee on Radiation of the Joint Committee on Atomic Energy, Congress of the United States. 85th Congress, 1st session, part 1. United States Government Printing Office, Washington DC
34. Glass B (1957b) The genetic basis for the limitation of radiation exposure. Am J Roentgen Radium Ther Nucl Med 78(6):955-960
35. Glucksmann A (1950) Cytological aspects of protection from ionizing radiations. Br J Radiol 23(265):41-45
36. Graf U (1972) Spontaneous mutations in Drosophila melanogaster. Humangen Hum Genet 16(1):27-32
37. Haas Fl, Clark JB, Wyss O, Stone WS (1950) Mutations and mutagenic agents in bacteria. Am Nat 84(817):261-274
38. Hamblin JD (2007) A dispassionate and objective effort: negotiating the first study on the biological effects of atomic radiation. J Hist Biol 40(1):147-177
39. Hanson FB, Heys F (1929) An analysis of the effects of the different rays of radium in producing lethal mutations in Drosophila. Am Nat 63:201-213
40. Higgins E (1951) Atomic radiation hazards for fish. J Wildl Manag 15(1):1-12
41. Hollaender A, Stapleton GE (1959) Ionizing radiation and the living cell. Sci Am 201(3):94-100
42. Joint Committee on Atomic Energy (1957) 85th Congress, 1st session. Summary-analysis of hearings 27-29 May, and 3-7 June, 1957 on the nature of radioactive fallout and its effect on man. United States Government Printing Office, Washington DC, Aug 1957
43. Jolly JC (2004) Thresholds of uncertainty: radiation and responsibility in the fallout controversy. Ph.D. Dissertation. Oregon State University, Corvallis
44. Kaufmann BP (1947) Spontaneous mutation rate in Drosophila. Am Nat 81:77-80
45. Kelner A, Bellamy WD, Stapleton GE, Zelle MR (1955) Symposium on radiation effects on cells and bacteria. Bacteriol Rev 19:22-44
46. Lefevre G Jr (1950) X-ray induced genetic effects in germinal and somatic tissue of Drosophila Melanogaster. Am Nat 84(818):341-365
47. Lewis EB (1957) Leukemia and ionizing radiation. Science 125(3255):965-972
48. Lilly Library (1938a) Indiana University, Bloomington, IN. Stern letter to Demerec, 21 Jan 1938
49. Lilly Library (1938b) Indiana University, Bloomington, IN. Demerec letter to Stern, 16 Mar 1938
50. Lilly Library (1938c) Indiana University, Bloomington, IN. Stern letter to Demerec, 31 Mar 1938
51. Lilly Library (1946) Indiana University, Bloomington, IN. Muller letter to Stern, 13 Sept 1946
52. Lilly Library (1947a) Indiana University, Bloomington, IN. Muller letter to Stern, 14 Jan 1947
53. Lilly Library (1947b) Indiana University, Bloomington, IN. Muller letter to Stern, 3 Feb 1947
54. Lilly Library (1947c) Indiana University, Bloomington, IN. Muller letter to Stern, 4 Aug 1947
55. Lilly Library (1949) Indiana University, Bloomington, IN. Muller letter to Stern, 5 Feb 1949
56. Lipshitz HD (2005) From fruit flies to fallout: Ed Lewis and his science. Dev Dyn 232:529-546
57. Lüning KG (1954) Effect of oxygen on irradiated males and females of Drosophila. Hereditas 40(3-4):295-312
58. MacKey J (1951) Neutron and x-ray experiments in barley. Hereditas 37(3):421-464
59. Muller HJ (1945) Age in relation to the frequency of spontaneous mutations in Drosophila. Yearb Am Philos Soc 150-153
60. Muller HJ (1946a) The production of mutations. Nobel Lecture, 1946. Nobleprize.org. http: www.nobelprize.org/nobel-prizes/medicine/laureates/1946
61. Muller HJ (1946b) Age in relation to the frequency of spontaneous mutations in Drosophila. In: Year book 1 Jan 1945, 31 Dec 1945. The American Philosophical Society, Philadelphia, PA, pp 150-153
62. Muller J (1947) The production of mutations. J Hered 38(9):259-270
63. Muller HJ (1948) Mutational prophylaxis. Bull N Y Acad Med 24(7):447-469
64. Muller HJ (1950a) Some present problems in the genetic effects of radiation. J Cell Comp Physiol 35(suppl 2):9-70
65. Muller HJ (1950b) Radiation damage to the genetic material. Am Sci 38(1):32-59, 126
66. Muller HJ (1952) Genetic effects of cosmic radiation. Chapter XVII. (Reprinted from Physics and Medicine of the Upper Atmosphere)
67. Muller HJ (1954a) The nature of the genetic effects produced by radiation. In: Hollaender A (ed) Radiation biology. Volume I: high energy radiation, chapter 7. McGraw-Hill Book Company, New York, pp 351-473
68. Muller HJ (1954b) The manner of production of mutations by radiation. In: Hollaender A (ed) Radiation biology. Volume I: high energy radiation, chapter 8. McGraw-Hill Book Company, New York, pp 475-626
69. Muller HJ (1956) How radiation changes the genetic constitution. In: Proceedings of the international conference on the peaceful uses of atomic energy. Volume 11, biological effects of radiation, held in Geneva Aug 1955. United Nations, New York, NY, pp 387-399
70. Muller HJ (1957a) How radiation changes the genetic constitution: congressional testimony [reprinted from the Bulletin of the Atomic Scientists, Nov 1955]
71. Muller HJ (1957b) Potential hazards of radiation - congressional testimony. Hearings before the Special Subcommittee on Radiation of the Joint Committee on Atomic Energy, Congress of the United States. 85th Congress, 1st session, part 1. United States Government Printing Office, Washington DC
72. Muller HJ, Carlson E, Schalet A (1961) Mutation by alteration of the already existing gene. Genetics 46:213-226
73. Newcombe B (1960) Genetic effects of ionizing radiation. Can J Biochem Physiol 38(3):330-337
74. Norwood WD (1958) Common sense approach to the problem of genetic hazard due to diagnostic radiology. JAMA 167(16):1928-1935
75. Nybom N, Gustafsson A, Granhall I, Ehrenberg L (1956) The genetic effects of chronic-gamma irradiation in barley. Hereditas 42(1-2):74-84
76. Oliver CP (1930) The effect of varying the duration of x-ray treatment upon the frequency of mutation. Science 71:44-46
77. Oliver CP (1931) An analysis of the effect of varying the duration of x-ray treatment upon the frequency of mutations. Doctor of Philosophy Thesis, University of Texas. Austin, Texas
78. Rajewski BN, Timofeeff-Ressovsky NW (1939) Höhen-Strahlung und die Mutationsrate von Drosophila melanogaster. ZIAV 77:488-500
79. Ray-Chaudhuri SP (1944) The validity of the Bunsen-Roscoe law in the production of mutations by radiation of extremely low intensity. Proc R Soc Edinb 62:66-72
80. Rinehart RR (1969) Spontaneous sex-linked recessive lethal frequencies from aged and non-aged spermatozoa of Drosophila melanogaster. Mutat Res 7:417-423
81. Sankaranarayanan K, Wassom JS (2008) Reflections on the impact of advances in the assessment of genetic risks of exposure to ionizing radiation on international radiation protection recommendations between the mid-1950s and the present. Mutat Res 658:1-27
82. Sax K (1950) The cytological effects of low-intensity radiation. Science 112(2908):332-333
83. Singleton WR (1954a) The effect of chronic gamma radiation on endosperm mutations in maize. Genetics 39:587-603
84. Singleton WR (1954b) Radiation effect on living systems. J Hered 45:58-64
85. Sparrow AH, Singleton WR (1953) The use of radiocobalt as a source of gamma rays and some effects of chronic irradiation on growing plants. Am Nat 87(832):29-48
86. Spear FG (1958) Some biological aspects of experimental radiology. A historical review. Intern Rev Cytol 7:1-77
87. Spencer WP, Stern C (1948) Experiments to test the validity of the linear R-dose/mutation at low dosage. Genetics 33:43-74
88. Stern C (1950) Principles of human genetics. WH Freeman and Company, San Francisco
89. Stern C (1960) Principles of human genetics, 2nd edn. WH Freeman and Company, San Francisco
90. Stone RS (1952) The concept of a maximum permissible exposure. Radiology 58(5):639-661
91. Strömnaes O (1951) X-ray induced lethal mutations in several strains of Drosophila melanogaster. Hereditas 37:533-559
92. Timoféeff-Ressovsky NW, Zimmer KG, Delbruck M (1935) Uber die Natur der Genmutation und der Genstruktur. Nachrichten von der Gesellschaft der Wissenschaften zu Gottingen:Mathematische-Physikalische Klass, Fachgruppe VI, Biologie 1(13):189-245
93. Uphoff DE, Stern C (1947) Influence of 24-hour gamma-ray irradiation at low dosage on the mutation rate in Drosophila. MDDC-1492, US Atomic Energy Commission, pp 1-6. Hathi Trust Digital Library. Available at http://www.hathitrust.org
94. Uphoff DE, Stern C (1949) The genetic effects of low intensity in irradiation. Science 109:609-610