Impact of bone morphogenetic proteins on frequency of revision surgery, use of autograft bone, and total hospital charges in surgery for lumbar degenerative disease: Review of the Nationwide Inpatient Sample from 2002 to 2008

Spine Journal

Volumn 14, Issue 1, 2014, Pages 20-30

  Dagostino, Phillip R ^a   Whitmore, Robert G ^b   Smith, Gabriel A ^c   Maltenfort, Mitchell G ^a   Ratliff, John K ^d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Arthrodesis; Bone morphogenetic protein; Hospital charges; Lumbar spine surgery; Nationwide Inpatient Sample

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

ARTHRODESIS; ARTICLE; BONE GRAFT; HOSPITAL CHARGE; HUMAN; JOINT DEGENERATION; LENGTH OF STAY; LUMBAR DEGENERATIVE DISEASE; LUMBAR PSEUDOARTHROSIS; LUMBAR SPINE; LUMBOSACRAL SPINE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PSEUDARTHROSIS; SPINE FUSION; THORACOLUMBAR SPINE;

ARTHRODESIS; BONE MORPHOGENETIC PROTEIN; HOSPITAL CHARGES; LUMBAR SPINE SURGERY; NATIONWIDE INPATIENT SAMPLE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEINS; BONE TRANSPLANTATION; FEMALE; HOSPITAL CHARGES; HUMANS; INCIDENCE; LUMBAR VERTEBRAE; LUMBOSACRAL REGION; MALE; MIDDLE AGED; REOPERATION; SPINAL DISEASES; SPINAL FUSION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84890558171     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2012.10.035     Document Type: Article

References (38)

1. W. Abdu, J. Lurie, and K. Spratt Degenerative spondylolisthesis: does fusion method influence outcome? Four-year results of the spine patient outcomes research trial Spine 34 2010 2351 2360
2. J. Brox, O. Reikerås, and O. Nygaard Lumbar instrumented fusion compared with cognitive intervention and exercises in patients with chronic back pain after previous surgery for disc herniation: a prospective randomized controlled study Pain 122 2006 145 155
3. J. Brox, R. Sorensen, and A. Friis Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration Spine 28 2003 1913 1921
4. P. Fritzell, O. Hagg, P. Wessberg, and A. Nordwall Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group Spine 26 2001 2521 2532
5. J. Gibson, and G. Waddell Surgical interventions for lumbar disc prolapse: updated Cochrane review Spine 32 2007 1735 1747
6. J. Weinstein, J. Lurie, and T. Tosteson Surgical versus nonoperative treatment for lumbard disc herniation: four-year results for the Spine Patient Outcomes Research Trial (SPORT) Spine 33 2008 2789 2800
7. J. Weinstein, T. Tosteson, and J. Lurie Surgical vs. nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial JAMA 296 2006 2441 2450
8. S. Glassman, L. Carreon, and J. Dimar Outcome of lumbar arthrodesis in patients sixty-five years of age or older J Bone Joint Surg Am 92 2010 S77 S84
9. J. Cowan, J. Dimick, and R. Wainess Change in utilization of spinal fusion in the United States Neurosurgery 58 2006 15 20
10. R. Deyo, D. Gray, and W. Kreuter United States trends in lumbar fusion surgery for degenerative conditions Spine 30 2005 1441 1445
11. US Food and Drug Administration. InFUSE bone graft-P050053. Washington, D.C. Available at: http://www.fda.gov/MedicalDevices/ ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently- ApprovedDevices/ucm077024.htm. Accessed March 16, 2011.
12. K. Cahill, J. Chi, A. Day, and E. Claus Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures JAMA 302 2009 58 66
13. Blue Cross of Idaho MP 7.01.100: Bone morphogenetic protein. 2010; Available at: www.bcidaho.com/providers/medical-policies/sur/mp-701100.asp. Accessed March 9, 2011.
14. S. Lad, J. Nathan, and M. Boakye Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States Spine 36 2011 E274 E281
15. K. Ong, M. Villarraga, and E. Lau Off-label use of bone morphogenetic proteins in the United States using administrative data Spine 35 2010 1794 1800
16. K. Yaremchuk, M. Toma, M. Somers, and E. Peterson Acute airway obstruction in cervical spinal procedures with bone morphogenetic proteins Laryngoscope 120 2010 1954 1957
17. E. Fisher, J. Bynum, and J. Skinner Slowing the growth of health care costs: lessons from regional variation N Engl J Med 260 2009 849 852
18. R. Deyo, A. Nachemson, and S. Mirza Spinal fusion surgery: the case for restraint N Engl J Med 350 2004 722 726
19. B. Lebude, D. Wang, and J. Harrop Clinical survey: patterns of utilization of lumbar epidural steroid injections by a cohort of spinal surgeons PM R 1 2009 329 334
20. B. Martin, R. Deyo, and S. Mirza Expenditures and health status among adults with back and neck problems JAMA 299 2008 656 664
21. S. Glassman, L. Carreon, and M. Campbell The perioperative cost of infuse bone graft in posterolateral lumbar spine fusion Spine J 8 2008 443 448
22. R. Sasso, J. LeHuec, C. Shaffrey Group SIR Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment J Spinal Disord Tech 18 2005 S77 S81
23. K. Garrison, S. Donell, and J. Ryder Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review Health Technol Assess 11 2007 1 150
24. A. Baaj, J. Uribe, and T. Nichols Health care burden of cervical spine fractures in the United States: analysis of a nationwide database over a 10-year period J Neurosurg Spine 13 2010 61 66
25. D. Gray, R. Deyo, and W. Kreuter Population-based trends in volumes and rates of ambulatory lumbar spine surgery Spine 31 2006 1957 1963
26. M. Shamji, S. Parker, and C. Cook Impact of body habitus on perioperative morbidity associated with fusion of the thoracolumbar and lumbar spine Neurosurgery 65 2009 290 298
27. G. Smith, P. Dagostino, and M. Maltenfort Geographic variation and regional trends in adoption of endovascular techniques for cerebral aneurysms J Neurosurg 114 2011 1768 1777
28. S. Yadla, J. Malone, and P. Campbell Early complications in spine surgery and relation to preoperative diagnosis: a single-center prospective study J Neurosurg Spine 13 2010 360 366
29. S. Boden, J. Kang, H. Sandhu, and J. Heller Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies Spine 27 2002 2662 2673
30. K. Cahill, J. Chi, and M. Groff Outcomes for single-level lumbar fusion: the role of bone morphogenetic protein Spine 36 2011 2354 2362
31. L. Shields, G. Raque, and S. Glassman Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion Spine 31 2006 542 547
32. J. Silber, D. Anderson, and S. Daffner Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion Spine 28 2003 134 139
33. S. Glassman, L. Carreon, and M. Djurasovic RhBMP-2 versus iliac crest bone graft for lumbar spine fusion: a randomized, controlled trial in patients over sixty years of age Spine 33 2008 2843 2849
34. S. Ackerman, M. Mafilios, and D. Polly Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: an evidence-based modeling approach Spine 27 2002 S94 S99
35. US Department of Health and Human Services Centers of Medicare and Medicaid Services National Physician Fee Schedule and Relative Value Scales. Washington, DC 2011; Available at: http://www.cms.gov/apps/physician-fee- schedule/documentation.aspx. Accessed March 25, 2011.
36. W. Elias, N. Simmons, and G. Kaptain Complications of posterior lumbar interbody fusion when using a titanium threaded cage device J Neurosurg 93 2000 45 52
37. B. Martin, S. Mirza, and B. Comstock Are lumbar spine reoperation rates falling with greater use of fusion surgery and new technology? Spine 32 2007 2119 2126
38. P. Whang, B. O'Hara, and J. Ratliff Pseudarthrosis following lumbar interbody fusion using bone morphogenetic protein-2: intraoperative and histopathologic findings Orthopedics 31 2008 1031 1034