Disseminated toxoplasmosis in non-allografted patients with hematologic malignancies: Report of two cases and literature review

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 32, Issue 10, 2013, Pages 1259-1268

  Scerra, S ^a   Coignard Biehler, H ^a   Lanternier, F ^a,b   Suarez, F ^a   Charlier Woerther, C ^a   Bougnoux, M E ^a   Gilquin, J ^a   Lecuit, M ^a,b,c   Hermine, O ^a   Lortholary, O ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CLINDAMYCIN; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; IMMUNOGLOBULIN G; MELPHALAN; PENTAMIDINE; PREDNISONE; PROTOZOON ANTIBODY; PYRIMETHAMINE; RITUXIMAB; TOXOPLASMA GONDII ANTIBODY; UNCLASSIFIED DRUG; VINCRISTINE;

ADULT; CASE REPORT; CHRONIC DISEASE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LYMPHOPROLIFERATIVE DISEASE; MANTLE CELL LYMPHOMA; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; TOXOPLASMOSIS; WHOLE BODY RADIATION;

AGED; FEMALE; HEMATOLOGIC NEOPLASMS; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; TOXOPLASMA; TOXOPLASMOSIS;

EID: 84890557760     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-013-1879-8     Document Type: Review

References (65)

1. Denkers EY, Gazzinelli RT (1998) Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 11(4):569-588
2. Abgrall S, Rabaud C, Costagliola D; Clinical Epidemiology Group of the French Hospital Database on HIV (2001) Incidence and risk factors for toxoplasmic encephalitis in human immunodeficiency virus-infected patients before and during the highly active antiretroviral therapy era. Clin Infect Dis 33(10):1747-1755
3. Derouin F, Pelloux H; ESCMID Study Group on Clinical Parasitology (2008) Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect 14(12):1089-1101
4. Baden LR, Katz JT, Franck L, Tsang S, Hall M, Rubin RH, Jarcho J (2003) Successful toxoplasmosis prophylaxis after orthotopic cardiac transplantation with trimethoprim-sulfamethoxazole. Transplantation 75(3):339-343
5. Martino R, Bretagne S, Rovira M, Ullmann AJ, Maertens J, Held T, Deconinck E, Cordonnier C (2000) Toxoplasmosis after hematopoietic stem transplantation. Report of a 5-year survey from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 25(10):1111-1114
6. Desmond R, Lynch K, Gleeson M, Farrell M, Murphy P (2010) Progressive multifocal leukencephalopathy and cerebral toxoplasmosis in a patient with CLL. Am J Hematol 85(8):607
7. Abedalthagafi M, Rushing EJ, Garvin D, Cheson B, Ozdemirli M (2009) Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature. Int J Clin Exp Pathol 3(1):106-109
8. Bacchu S, Fegan C, Neal J (2007) Cerebral toxoplasmosis in a patient with chronic lymphocytic leukaemia treated with fludarabine. Br J Haematol 139(3):349
9. Grosu I, Ghekiere O, Layios N, Hantson P, Cosnard G (2007) Toxoplasma encephalitis after autologous stem cell transplantation. Leuk Lymphoma 48(1):201-203
10. López-Duarte M, Insunza A, Conde E, Iriondo A, Mazorra F, Zubizarreta A (2003) Cerebral toxoplasmosis after autologous peripheral blood stem cell transplantation. Eur J Clin Microbiol Infect Dis 22(9):548-550
11. Touahri T, Pulik M, Fezoui H, Genet P, Lionnet F, Louvel D (2002) Toxoplasmic encephalitis in a non-HIV patient with follicular lymphoma. Int J Hematol 75(1):111-112
12. García-Bujalance S, Ocampo Sánchez A, Ladrón De Guevara García C (2002) Toxoplasmosis after antineoplastic therapy in non-Hodgkin lymphoma. Demand of preventive measures. Rev Clin Esp 202(3):148-151
13. Re D, Reiser M, Bamborschke S, Schröder R, Lehrke R, Tesch H, Salzberger B, Diehl V, Fätkenheuer G (1999) Two cases of toxoplasmic encephalitis in patients with acute T-cell leukaemia and lymphoma. J Infect 38(1):26-29
14. Herold MA, Kühne R, Vosberg M, Ostheeren-Michaelis S, Vogt P, Karrer U (2009) Disseminated toxoplasmosis in a patient with non-Hodgkin lymphoma. Infection 37(6):551-554
15. King RS (2000) Toxoplasmosis in a patient with non-Hodgkin's lymphoma: the need for a good differential diagnosis. Clin Eye Vis Care 12(1-2):61-69
16. Mashaly R, Gray F, Poisson M, Rancurel G, Escourolle R, Buge A (1983) Acquired cerebral toxoplasmosis in adults. Clinical and neuropathologic study. Rev Neurol (Paris) 139(10):561-568
17. Peacock JE Jr, Greven CM, Cruz JM, Hurd DD (1995) Reactivation toxoplasmic retinochoroiditis in patients undergoing bone marrow transplantation: is there a role for chemoprophylaxis? Bone Marrow Transplant 15(6):983-987
18. Geissmann F, Derouin F, Marolleau JP, Gisselbrecht C, Brice P (1994) Disseminated toxoplasmosis following autologous bone marrow transplantation. Clin Infect Dis 19(4):800-801
19. Arnold SJ, Kinney MC, McCormick MS, Dummer S, Scott MA (1997) Disseminated toxoplasmosis. Unusual presentations in the immunocompromised host. Arch Pathol Lab Med 121(8):869-873
20. Edvinsson B, Lappalainen M, Anttila VJ, Paetau A, Evengård B (2009) Toxoplasmosis in immunocompromized patients. Scand J Infect Dis 41(5):368-371
21. Pagano L, Trapè G, Putzulu R, Caramatti C, Picardi M, Nosari A, Cinieri S, Caira M, Del Favero A; GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto)-Infection Program (2004) Toxoplasma gondii infection in patients with hematological malignancies. Ann Hematol 83(9):592-595
22. Yeo JH, Jakobiec FA, Iwamoto T, Richard G, Kreissig I (1983) Opportunistic toxoplasmic retinochoroiditis following chemotherapy for systemic lymphoma. A light and electron microscopic study. Ophthalmology 90(8):885-898
23. Barquero Jiménez MS, Guerrero Sola A, Villarroel P, Roca V, Gracìa Ruiz P, García Urra D (1990) Toxoplasmosis of the central nervous system in immunodepressed patients. Our experience. Rev Clin Esp 186(3):112-115
24. Smith GM, Leyland MJ, Crocker J, Geddes AM (1987) Cerebral toxoplasmosis in a patient with Hodgkin's disease. J Infect 14(3):243-245
25. Prosmanne O, Chalaoui J, Sylvestre J, Lefebvre R (1984) Small nodular pattern in the lungs due to opportunistic toxoplasmosis. J Can Assoc Radiol 35(2):186-188
26. Graveleau P, Henin D, Masson M, Daumas-Duport C, Graveleau J, Cambier J (1984) Acquired cerebral toxoplasmosis: 3 anatomoclinical cases. Rev Neurol (Paris) 140(5):330-342
27. Mazer S, Araujo JC, Ribeiro RC, Kasting G (1983) Unusual computed tomographic presentation of cerebral toxoplasmosis. AJNR Am J Neuroradiol 4(3):458-460
28. Andres TL, Dorman SA, Winn W Jr, Trainer TD, Perl DP (1981) Immunohistochemical demonstration of Toxoplasma gondii. Am J Clin Pathol 75(3):431-434
29. Straathof CS, Kortbeek LM, Roerdink H, Sillevis Smitt PA, van den Bent MJ (2001) A solitary spinal cord toxoplasma lesion after peripheral stem-cell transplantation. J Neurol 248(9):814-815
30. Basu S, Das T, Biswas G (2010) Bilateral toxoplasma retinochoroiditis in a patient with chronic myeloid leukemia treated with imatinib mesylate. Ocul Immunol Inflamm 18(1):64-65
31. Karkouche B, Gremain J, Godeau P, Chomette G (1985) Toxoplasmosis in the immunosuppressed patient. Apropos of 3 anatomoclinical cases. Arch Anat Cytol Pathol 33(5-6):281-284
32. Jamet D, Quinio D, Moalic E, Ianotto JC, Dalbies F, Guillerm G, Marion V, Berthou C, Nevez G (2009) Systemic microsporidiosis and toxoplasmosis in a patient with T prolymphocytic leukemia. Med Mal Infect 39(6):406-408
33. Maciel E, Siqueira I, Queiroz AC, Melo A (2000) Toxoplasma gondii myelitis in a patient with adult T-cell leukemia-lymphoma. Arq Neuropsiquiatr 58(4):1107-1109
34. Nakane M, Ohashi K, Tominaga J, Akiyama H, Hiruma K, Sakamaki H (2000) Disseminated toxoplasmosis after CD34+-selected autologous peripheral blood stem cell transplantation. Haematologica 85(3):334-335
35. Yoshimura K, Hara T, Tsurumi H, Goto H, Tajika M, Fukutomi Y, Murakami N, Moriwaki H (1999) Non-Hodgkin's lymphoma with Toxoplasma encephalitis. Rinsho Ketsueki 40(7):563-567
36. Foss FM, Ihde DC, Linnoila IR, Fischmann AB, Schechter GP, Cotelingam JD, Steinberg SM, Ghosh BC, Stocker JL, Bastian A, Phares JC, Sausville EA (1994) Phase II trial of fludarabine phosphate and interferon alfa-2a in advanced mycosis fungoides/Sézary syndrome. J Clin Oncol 12(10):2051-2059
37. Bendelac A, Laporte JP, Marteau M, Mougeot G, Najman A, Poirot JL, Roux P (1984) Detection of a pulmonary localization of Toxoplasma gondii in an immunosuppressed patient. Presse Med 13(19):1213-1214
38. Launais B, Laurent G, Benchekroun S, Moulin JJ, Pris J, Bec P, Monnier J (1983) Meningoencephalic and chorioretinal manifestations of toxoplasmosis in an immunodeficient patient. Sem Hop 59(1):40-42
39. Brown NJ, McKenzie S, Decker MD (1991) Case report: fatal pulmonary toxoplasmosis following chemotherapy. Am J Med Sci 302(3):152-154
40. Bertrand Y, Fegueux N, Rodière M, Jean R (1988) Fatal cerebral toxoplasmosis in a leukemia child in remission. Arch Fr Pediatr 45(5):347-348
41. Connor E, Menegus M, Cecalupo A, Gigliotti F (1984) Central nervous system toxoplasmosis mimicking a brain abscess in a compromised pediatric patient. Pediatr Infect Dis 3(6):552-555
42. Adurthi S, Sahoo T, Chakka K, Radhika B, Appaji L, Bapsy P, Ramesh C, Jayshree R (2008) Acute toxoplasmosis in nonstem cell transplant patients with haematological malignancies: a study from a regional cancer institute in South India. Hematol Oncol 26(4):229-233
43. Martino R, Bretagne S, Einsele H, Maertens J, Ullmann AJ, Parody R, Schumacher U, Pautas C, Theunissen K, Schindel C, Muñoz C, Margall N, Cordonnier C; Infectious Disease Working Party of the European Group for Blood and Marrow Transplantation (2005) Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation. Clin Infect Dis 40(1):67-78
44. Slavin MA, Meyers JD, Remington JS, Hackman RC (1994) Toxoplasma gondii infection in marrow transplant recipients: a 20 year experience. Bone Marrow Transplant 13(5):549-557
45. Derouin F, Devergie A, Auber P, Gluckman E, Beauvais B, Garin YJ, Lariviere M (1992) Toxoplasmosis in bone marrow-transplant recipients: report of seven cases and review. Clin Infect Dis 15(2):267-270
46. Hakes TB, Armstrong D (1983) Toxoplasmosis. Problems in diagnosis and treatment. Cancer 52(8):1535-1540
47. Israelski DM, Remington JS (1993) Toxoplasmosis in patients with cancer. Clin Infect Dis 17(Suppl 2):S423-S435
48. Osterborg A, Karlsson C, Lundin J, Kimby E, Mellstedt H (2006) Strategies in the management of alemtuzumab-related side effects. Semin Oncol 33(2 Suppl 5):S29-S35
49. Bauer K, Rancea M, Roloff V, Elter T, Hallek M, Engert A, Skoetz N (2012) Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia. Cochrane Database Syst Rev 11:CD008079
50. Lanini S, Molloy AC, Fine PE, Prentice AG, Ippolito G, Kibbler CC (2011) Risk of infection in patients with lymphoma receiving rituximab: systematic review and meta-analysis. BMC Med 9:36
51. Robak T, Lech-Maranda E, Korycka A, Robak E (2006) Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Curr Med Chem 13(26):3165-3189
52. Laszlo D, Bassi S, Andreola G, Agazzi A, Antoniotti P, Balzano R, Mancuso P, Bertolini F, Martinelli G (2006) Peripheral T-lymphocyte subsets in patients treated with Rituximab-Chlorambucil combination therapy for indolent NHL. Ann Hematol 85(11):813-814
53. Guillaume T, Rubinstein DB, Symann M (1998) Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation. Blood 92(5):1471-1490
54. Robert-Gangneux F, Dardé ML (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25(2):264-296
55. Nascimento FS, Suzuki LA, Rossi CL (2008) Assessment of the value of detecting specific IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection. Prenat Diagn 28(8):749-752
56. Cibickova L, Horacek J, Prasil P, Slovacek L, Kohout A, Cerovsky V, Hobza V (2007) Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature. Transpl Infect Dis 9(4):332-335
57. Martino R, Maertens J, Bretagne S, Rovira M, Deconinck E, Ullmann AJ, Held T, Cordonnier C (2000) Toxoplasmosis after hematopoietic stem cell transplantation. Clin Infect Dis 31(5):1188-1195
58. Dedicoat M, Livesley N (2006) Management of toxoplasmic encephalitis in HIV-infected adults (with an emphasis on resource-poor settings). Cochrane Database Syst Rev (3):CD005420
59. Leport C, Meulemans A, Robine D, Dameron G, Vildé JL (1992) Levels of pyrimethamine in serum and penetration into brain tissue in humans. AIDS 6(9):1040-1041
60. Gatti G, Malena M, Casazza R, Borin M, Bassetti M, Cruciani M (1998) Penetration of clindamycin and its metabolite N-demethylclindamycin into cerebrospinal fluid following intravenous infusion of clindamycin phosphate in patients with AIDS. Antimicrob Agents Chemother 42(11):3014-3017
61. Torres RA, Weinberg W, Stansell J, Leoung G, Kovacs J, Rogers M, Scott J (1997) Atovaquone for salvage treatment and suppression of toxoplasmic encephalitis in patients with AIDS. Atovaquone/Toxoplasmic Encephalitis Study Group. Clin Infect Dis 24(3):422-429
62. Shubar HM, Lachenmaier S, Heimesaat MM, Lohman U, Mauludin R, Mueller RH, Fitzner R, Borner K, Liesenfeld O (2011) SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriers. J Drug Target 19(2):114-124
63. Osthoff M, Chew E, Bajel A, Kelsey G, Panek-Hudson Y, Mason K, Szer J, Ritchie D, Slavin M (2013) Disseminated toxoplasmosis after allogeneic stem cell transplantation in a seronegative recipient. Transpl Infect Dis 15(1):E14-E19
64. Katlama C, Mouthon B, Gourdon D, Lapierre D, Rousseau F (1996) Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. AIDS 10(10):1107-1112
65. Megged O, Shalit I, Yaniv I, Stein J, Fisher S, Levy I (2008) Breakthrough cerebral toxoplasmosis in a patient receiving atovaquone prophylaxis after a hematopoietic stem cell transplantation. Pediatr Transplant 12(8):902-905