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Volumn 2017, Issue 12, 2012, Pages

Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CD20 ANTIBODY; FLUDARABINE; MONOCLONAL ANTIBODY; OBINUTUZUMAB; OFATUMUMAB; RITUXIMAB; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; VIDARABINE;

EID: 84873193703     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD008079.pub2     Document Type: Review
Times cited : (26)

References (149)
  • 1
    • 33644847307 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy
    • Byrd JC, Gribben JG, Peterson BL, Grever MR, Lozanski G, Lucas DM, et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy. Journal of Clinical Oncology 2006;24:437-43.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 437-443
    • Byrd, J.C.1    Gribben, J.G.2    Peterson, B.L.3    Grever, M.R.4    Lozanski, G.5    Lucas, D.M.6
  • 2
    • 0003273905 scopus 로고    scopus 로고
    • Rituximab added to fludarabine improves response in previously untreated chronic lymphocytic leukemia: preliminary results from CALGB 9712
    • Byrd JC, Peterson B, Park K, Morrison V, Vardiman JW, Jacobson RJ, et al. Rituximab added to fludarabine improves response in previously untreated chronic lymphocytic leukemia: preliminary results from CALGB 9712. Journal of Clinical Oncology 2001;20 (Pt 1):280a.
    • (2001) Journal of Clinical Oncology , vol.20 , pp. 280a
    • Byrd, J.C.1    Peterson, B.2    Park, K.3    Morrison, V.4    Vardiman, J.W.5    Jacobson, R.J.6
  • 3
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, Park K, Jacobson R, Hoke E, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 2003;101(1):6-14.
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6
  • 4
    • 79960971528 scopus 로고    scopus 로고
    • Concurrent rituximab and fludarabine has a higher complete response rate than sequential treatment in untreated chronic lymphocytic leukemia (CLL) patients: results from CALGB 9712
    • Byrd JC, Peterson BL, Park K. Concurrent rituximab and fludarabine has a higher complete response rate than sequential treatment in untreated chronic lymphocytic leukemia (CLL) patients: results from CALGB 9712. Blood 2001;98(1):A-3212.
    • (2001) Blood , vol.98 , Issue.1 , pp. A3212
    • Byrd, J.C.1    Peterson, B.L.2    Park, K.3
  • 5
    • 19944429446 scopus 로고    scopus 로고
    • The addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, Appelbaum FR, Morrison VA, Kolitz JE, et al. The addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005;105:49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6
  • 6
    • 25944457857 scopus 로고    scopus 로고
    • Adding rituximab to fludarabine therapy for patients with untreated chronic lymphocytic leukemia (CLL) does not increase the risk of infection: Cancer and Leukemia Group B (CALGB) Study 9712
    • Morrison VA, Byrd JC, Peterson BL, Rai KR, Larson RA. Adding rituximab to fludarabine therapy for patients with untreated chronic lymphocytic leukemia (CLL) does not increase the risk of infection: Cancer and Leukemia Group B (CALGB) Study 9712. Blood 2003;102:440a.
    • (2003) Blood , vol.102 , pp. 440a
    • Morrison, V.A.1    Byrd, J.C.2    Peterson, B.L.3    Rai, K.R.4    Larson, R.A.5
  • 7
    • 55249095945 scopus 로고    scopus 로고
    • Alemtuzumab increases serious infections in patients with previously untreated chronic lymphocytic leukemia (CLL) receiving fludarabine-based therapy: a comparative analysis of 3 Cancer and Leukemia Group B studies (CALGB 9011, 9712, 19901)
    • Morrison VA, Peterson BL, Rai KR, Byrd JC, Larson JC. Alemtuzumab increases serious infections in patients with previously untreated chronic lymphocytic leukemia (CLL) receiving fludarabine-based therapy: a comparative analysis of 3 Cancer and Leukemia Group B studies (CALGB 9011, 9712, 19901). Blood 2007;110(11):A-756.
    • (2007) Blood , vol.110 , Issue.11 , pp. A756
    • Morrison, V.A.1    Peterson, B.L.2    Rai, K.R.3    Byrd, J.C.4    Larson, J.C.5
  • 8
    • 77950314844 scopus 로고    scopus 로고
    • Treatment with fludarabine and rituximab produces extended overall survival (OS) and progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) without increased risk of second malignancy: long-term follow up of CALGB Study 9712
    • Woyach JA, Ruppert AS, Heerema NA, Peterson B, Gribben JG, Morrison VA, et al. Treatment with fludarabine and rituximab produces extended overall survival (OS) and progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) without increased risk of second malignancy: long-term follow up of CALGB Study 9712. Blood 2009;114:539.
    • (2009) Blood , vol.114 , pp. 539
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3    Peterson, B.4    Gribben, J.G.5    Morrison, V.A.6
  • 9
    • 79954435811 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term follow-up of CALGB study 9712
    • Woyach JA, Ruppert AS, Heerema NA, Peterson BL, Gribben JG, Morrison VA. Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term follow-up of CALGB study 9712. Journal of Clinical Oncology 2011;29:1349-55.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 1349-1355
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3    Peterson, B.L.4    Gribben, J.G.5    Morrison, V.A.6
  • 10
    • 77950308297 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine (F), cyclophosphamide (C) and MabCampath (Cam) (FCCam) in previously untreated patients (pts) with advanced B-chronic lymphocytic leukemia (B-CLL): experience on safety and efficacy within a randomised multicenter phase III trial of the French Cooperative Group on CLL and WM (FCGCLL/MW)
    • Lepretre S, Aurran T, Mahe B, Cazin B, Tournihlac O, Maisonneuve H, et al. Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine (F), cyclophosphamide (C) and MabCampath (Cam) (FCCam) in previously untreated patients (pts) with advanced B-chronic lymphocytic leukemia (B-CLL): experience on safety and efficacy within a randomised multicenter phase III trial of the French Cooperative Group on CLL and WM (FCGCLL/MW) and the "Groupe Ouest-Est d'Etudes Des Leucemies Aigues Et Autres Maladies Du Sang" (GOELAMS): CLL2007FMP (for fit medically patients). Blood 2009;114:538.
    • (2009) Blood , vol.114 , pp. 538
    • Lepretre, S.1    Aurran, T.2    Mahe, B.3    Cazin, B.4    Tournihlac, O.5    Maisonneuve, H.6
  • 11
    • 85036503543 scopus 로고    scopus 로고
    • Interest of early determination of bone marrow MRD by a sensitive 6-color flow cytometry in the evaluation of response: the experience of the CLL2007FMP, an intergroup phase III randomized multicentric trial comparing fludarabine cyclophosphamide (FC) and rituximab (FCR) versus FC and MabCampath (FCCam) in previously untreated B-chronic lymphocytic leukemia patients
    • Letestu R, Leprêtre S, Arnoulet C, Baseggio L, Campos L, Chatelain B, et al. Interest of early determination of bone marrow MRD by a sensitive 6-color flow cytometry in the evaluation of response: the experience of the CLL2007FMP, an intergroup phase III randomized multicentric trial comparing fludarabine cyclophosphamide (FC) and rituximab (FCR) versus FC and MabCampath (FCCam) in previously untreated B-chronic lymphocytic leukemia patients. Blood 2011;118:1797.
    • (2011) Blood , vol.118 , pp. 1797
    • Letestu, R.1    Leprêtre, S.2    Arnoulet, C.3    Baseggio, L.4    Campos, L.5    Chatelain, B.6
  • 12
    • 84930330664 scopus 로고    scopus 로고
    • CLL2007FMP, a phase III randomized multicentric trial of the French Cooperative Group on CLL and WM (FCGCLL/MW) and the "Groupe Ouest-Est D'etudes Des Leucemies Aigues Et Autres Maladies Du Sang" (GOELAMS): immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) yields a significantly better response than fludarabine (F), cyclophosphamide (C)
    • Remi L, Leprêtre S, Arnoulet C, Baseggio L, Campos L, Chatelain B, et al. CLL2007FMP, a phase III randomized multicentric trial of the French Cooperative Group on CLL and WM (FCGCLL/MW) and the "Groupe Ouest-Est D'etudes Des Leucemies Aigues Et Autres Maladies Du Sang" (GOELAMS): immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) yields a significantly better response than fludarabine (F), cyclophosphamide (C) and MabCampath (Cam) (FCCam) in previously untreated B-chronic lymphocytic leukemia patients as evaluated by a sensitive 6 color flow cytometry MRD. Blood 2010;116:698.
    • (2010) Blood , vol.116 , pp. 698
    • Remi, L.1    Leprêtre, S.2    Arnoulet, C.3    Baseggio, L.4    Campos, L.5    Chatelain, B.6
  • 13
    • 70350259810 scopus 로고    scopus 로고
    • Quantitative MRD assessments predict progression free survival in CLL patients treated with fludarabine and cyclophosphamide with or without rituximab - a prospective analysis in 471 patients from the randomized GCLLSG CLL8 trial
    • Boettcher S, Fischer K, Stilgenbauer S, Busch R, Fingerle-Rowson G, Fink AM, et al. Quantitative MRD assessments predict progression free survival in CLL patients treated with fludarabine and cyclophosphamide with or without rituximab - a prospective analysis in 471 patients from the randomized GCLLSG CLL8 trial. Blood 2008;112:326.
    • (2008) Blood , vol.112 , pp. 326
    • Boettcher, S.1    Fischer, K.2    Stilgenbauer, S.3    Busch, R.4    Fingerle-Rowson, G.5    Fink, A.M.6
  • 14
    • 70450233582 scopus 로고    scopus 로고
    • Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis
    • Bottcher S, Stilgenbauer S, Busch R, Bruggemann M, Raff T, Pott C, et al. Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis. Leukemia 2009;23(11):2007-17.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2007-2017
    • Bottcher, S.1    Stilgenbauer, S.2    Busch, R.3    Bruggemann, M.4    Raff, T.5    Pott, C.6
  • 15
    • 84871427640 scopus 로고    scopus 로고
    • Second-line therapies after treatment with fludarabine, cyclophosphamide, and rituximab (FCR) or fludarabine and cyclophosphamid alone (FC) for chronic lymphocytic leukemia (CLL) within the CLL8-protocol of the German CLL Study Group (GCLLSG)
    • Cramer P, Fink A, Busch R, Eichhorst B, Wendtner CM, Pflug N, et al. Second-line therapies after treatment with fludarabine, cyclophosphamide, and rituximab (FCR) or fludarabine and cyclophosphamid alone (FC) for chronic lymphocytic leukemia (CLL) within the CLL8-protocol of the German CLL Study Group (GCLLSG). Blood 2011;118:2863.
    • (2011) Blood , vol.118 , pp. 2863
    • Cramer, P.1    Fink, A.2    Busch, R.3    Eichhorst, B.4    Wendtner, C.M.5    Pflug, N.6
  • 17
    • 79952654677 scopus 로고    scopus 로고
    • Health related quality of life (HRQOL) in patients receiving chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) or fludarabine and cyclophosphamide (FC) for first line therapy with advanced chronic lymphocytic leukemia (CLL)
    • Eichhorst B, Fischer K, Fink A, Fingerle-Rowson G, Westermann A, Wendtner C-M, et al. Health related quality of life (HRQOL) in patients receiving chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) or fludarabine and cyclophosphamide (FC) for first line therapy with advanced chronic lymphocytic leukemia (CLL). Blood 2009;114(22):3438.
    • (2009) Blood , vol.114 , Issue.22 , pp. 3438
    • Eichhorst, B.1    Fischer, K.2    Fink, A.3    Fingerle-Rowson, G.4    Westermann, A.5    Wendtner, C.-M.6
  • 18
    • 79951504881 scopus 로고    scopus 로고
    • Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis
    • Eichhorst BF, Fischer K, Fink AM, Elter T, Wendtner CM, Goede V, et al. Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis. Blood 2011;117(6):1817-21.
    • (2011) Blood , vol.117 , Issue.6 , pp. 1817-1821
    • Eichhorst, B.F.1    Fischer, K.2    Fink, A.M.3    Elter, T.4    Wendtner, C.M.5    Goede, V.6
  • 19
    • 84875779946 scopus 로고    scopus 로고
    • Prediction of poor outcome in CLL patients treated with FCR (fludarabine, cyclophosphamide, rituximab) in the CLL8 trial of the German CLL Study Group (GCLLSG)
    • Fink A, Busch R, Pflug N, Boettcher S, Winkler D, Buehler A, et al. Prediction of poor outcome in CLL patients treated with FCR (fludarabine, cyclophosphamide, rituximab) in the CLL8 trial of the German CLL Study Group (GCLLSG). Blood 2011;118:977.
    • (2011) Blood , vol.118 , pp. 977
    • Fink, A.1    Busch, R.2    Pflug, N.3    Boettcher, S.4    Winkler, D.5    Buehler, A.6
  • 20
    • 84880303108 scopus 로고    scopus 로고
    • Serum factors predict therapeutic outcome in patients with chronic lymphocytic leukemia treated in the CLL8 trial of the German CLL Study Group (GCLLSG)
    • Fink A, Pflug N, Busch R, Fingerle-Rowson GR, Eichhorst B, Wendtner CM, et al. Serum factors predict therapeutic outcome in patients with chronic lymphocytic leukemia treated in the CLL8 trial of the German CLL Study Group (GCLLSG). Blood 2010;116:918.
    • (2010) Blood , vol.116 , pp. 918
    • Fink, A.1    Pflug, N.2    Busch, R.3    Fingerle-Rowson, G.R.4    Eichhorst, B.5    Wendtner, C.M.6
  • 21
    • 85036562092 scopus 로고    scopus 로고
    • Phase III trial of combined immunochemotherapy with fludarabine, cyclophosphamide and rituximab (FCR) versus chemotherapy with fludarabine and cyclophosphamide (FC) alone in patients with previously untreated chronic lymphocytic leukaemia CLL-8 / ML17102 Protocol of the German CLL Study Group (GCLLSG)
    • (accessed 17 August 2012), (only public data used), Cologne, D
    • Hallek M, Fingerle-Rowson G. Phase III trial of combined immunochemotherapy with fludarabine, cyclophosphamide and rituximab (FCR) versus chemotherapy with fludarabine and cyclophosphamide (FC) alone in patients with previously untreated chronic lymphocytic leukaemia CLL-8 / ML17102 Protocol of the German CLL Study Group (GCLLSG). www.dcllsg.de/en/trial/cll8/index.php (only public data used). 2004. (accessed 17 August 2012). Cologne, D.
    • (2004)
    • Hallek, M.1    Fingerle-Rowson, G.2
  • 22
    • 76949091824 scopus 로고    scopus 로고
    • First-line treatment with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) improves overall survival (OS) in previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a randomized phase III trial on behalf of an International Group of Investigators and the German CLL Study Group
    • Hallek M, Fingerle-Rowson G, Fink A-M, Busch R, Mayer J, Hensel M, et al. First-line treatment with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) improves overall survival (OS) in previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a randomized phase III trial on behalf of an International Group of Investigators and the German CLL Study Group. Blood 2009;114(22):535.
    • (2009) Blood , vol.114 , Issue.22 , pp. 535
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.-M.3    Busch, R.4    Mayer, J.5    Hensel, M.6
  • 23
    • 61849091076 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL)
    • Hallek M, Fingerle-Rowson G, Fink AM, Busch R, Mayer J, Hensel M, et al. Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL). Blood 2009;112(11):325.
    • (2009) Blood , vol.112 , Issue.11 , pp. 325
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3    Busch, R.4    Mayer, J.5    Hensel, M.6
  • 24
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, Fink A M, Busch R, Mayer J, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164-74.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 25
    • 70449497016 scopus 로고    scopus 로고
    • Genomic aberrations, VH mutation status and outcome after fludarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial
    • Stilgenbauer S, Zenz T, Winkler D, Buhler A, Busch R, Fingerle-Rowson G, et al. Genomic aberrations, VH mutation status and outcome after fludarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial. Blood 2008;112:781.
    • (2008) Blood , vol.112 , pp. 781
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3    Buhler, A.4    Busch, R.5    Fingerle-Rowson, G.6
  • 26
    • 79957520824 scopus 로고    scopus 로고
    • Genetics of patients with F-refractory CLL or early relapse after FC or FCR: results from the CLL8 trial of the GCLLSG
    • Zenz T, Busch R, Fink A, Winkler D, Fischer K, Buhler A, et al. Genetics of patients with F-refractory CLL or early relapse after FC or FCR: results from the CLL8 trial of the GCLLSG. Blood 2010;116:2427.
    • (2010) Blood , vol.116 , pp. 2427
    • Zenz, T.1    Busch, R.2    Fink, A.3    Winkler, D.4    Fischer, K.5    Buhler, A.6
  • 27
    • 79951869041 scopus 로고    scopus 로고
    • TP53 mutations and outcome after fludarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial of the GCLLSG
    • Zenz T, Hoth P, Busch R, Helfrich H, Winkler D, Buhler A, et al. TP53 mutations and outcome after fludarabine and cyclophosphamide (FC) or FC plus rituximab (FCR) in the CLL8 trial of the GCLLSG. Blood 2009;114(22):1267.
    • (2009) Blood , vol.114 , Issue.22 , pp. 1267
    • Zenz, T.1    Hoth, P.2    Busch, R.3    Helfrich, H.4    Winkler, D.5    Buhler, A.6
  • 28
    • 33750025381 scopus 로고    scopus 로고
    • Fludarabine and alemtuzumab versus fludarabine and rituximab in the treatment of relapsed B-cell chronic lymphocytic leukemia: results from a phase II study
    • Gribben J, Stephans K, Marshal B. Fludarabine and alemtuzumab versus fludarabine and rituximab in the treatment of relapsed B-cell chronic lymphocytic leukemia: results from a phase II study. Blood 2005;106:343.
    • (2005) Blood , vol.106 , pp. 343
    • Gribben, J.1    Stephans, K.2    Marshal, B.3
  • 29
    • 79951521940 scopus 로고    scopus 로고
    • A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia
    • Hillmen P, Cohen DR, Cocks K, Pettitt A, Sayala HA, Rawstron AC, et al. A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia. British Journal of Haematology 2011;152:570-8.
    • (2011) British Journal of Haematology , vol.152 , pp. 570-578
    • Hillmen, P.1    Cohen, D.R.2    Cocks, K.3    Pettitt, A.4    Sayala, H.A.5    Rawstron, A.C.6
  • 30
    • 77950546050 scopus 로고    scopus 로고
    • NCRI CLL201 trial: a randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated CLL
    • Hillmen P, Pocock C, Cohen D, Cocks K, Sayala HA, Rawstron A, et al. NCRI CLL201 trial: a randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated CLL. Blood 2007;110(11):752.
    • (2007) Blood , vol.110 , Issue.11 , pp. 752
    • Hillmen, P.1    Pocock, C.2    Cohen, D.3    Cocks, K.4    Sayala, H.A.5    Rawstron, A.6
  • 31
    • 71049139152 scopus 로고    scopus 로고
    • NCRI CLL201 Trial: a randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated CLL
    • Hillmen P, Pocock C, Cohen D, Gregory W, Cocks K, Rawstron AC, et al. NCRI CLL201 Trial: a randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated CLL. British Journal of Haematology 2008;141(Suppl 1):119.
    • (2008) British Journal of Haematology , vol.141 , pp. 119
    • Hillmen, P.1    Pocock, C.2    Cohen, D.3    Gregory, W.4    Cocks, K.5    Rawstron, A.C.6
  • 32
    • 76949094333 scopus 로고    scopus 로고
    • FC-gamma receptor (FCGR) 2A and 3A polymorphisms do not influence the outcome of relapsed or refractory CLL patients treated with rituximab, fludarabine, and cyclophosphamide (R-FC) or fludarabine, and cyclophosphamide (FC) alone
    • Dornan D, Spleiss O, Yeh RF, Duchateau-Nguyen G, Robak T, Moiseev SI, et al. FC-gamma receptor (FCGR) 2A and 3A polymorphisms do not influence the outcome of relapsed or refractory CLL patients treated with rituximab, fludarabine, and cyclophosphamide (R-FC) or fludarabine, and cyclophosphamide (FC) alone. Blood 2009;114(22):2338.
    • (2009) Blood , vol.114 , Issue.22 , pp. 2338
    • Dornan, D.1    Spleiss, O.2    Yeh, R.F.3    Duchateau-Nguyen, G.4    Robak, T.5    Moiseev, S.I.6
  • 33
    • 84857581413 scopus 로고    scopus 로고
    • Higher doses of rituximab may be required for patients with CLL as compared to NHL based on population pharmacokinetic (PK) modeling
    • Li J, Zhi J, Wenger MK, Valente N, Visich J. Higher doses of rituximab may be required for patients with CLL as compared to NHL based on population pharmacokinetic (PK) modeling. Blood 2009;114(22):1742.
    • (2009) Blood , vol.114 , Issue.22 , pp. 1742
    • Li, J.1    Zhi, J.2    Wenger, M.K.3    Valente, N.4    Visich, J.5
  • 34
    • 77958050280 scopus 로고    scopus 로고
    • Quality-adjusted survival (Q-TWiST) analysis of patients with relapsed or refractory chronic lymphocytic leukaemia treated with rituximab plus fludarabine and cyclophosphamide (R-FC) versus FC alone
    • Robak T, Aultman R, Oertel SHK, Carr ESC. Quality-adjusted survival (Q-TWiST) analysis of patients with relapsed or refractory chronic lymphocytic leukaemia treated with rituximab plus fludarabine and cyclophosphamide (R-FC) versus FC alone. Blood 2009;114(22):1368.
    • (2009) Blood , vol.114 , Issue.22 , pp. 1368
    • Robak, T.1    Aultman, R.2    Oertel, S.H.K.3    Carr, E.S.C.4
  • 35
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P, Warzocha K, Loscertales J, Catalano J, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. Journal of Clinical Oncology 2010;28(10):1756-65.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.10 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3    Warzocha, K.4    Loscertales, J.5    Catalano, J.6
  • 36
    • 65749114275 scopus 로고    scopus 로고
    • Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia (CLL) compared with FC alone: final results from the international randomized phase III REACH trial
    • lba-lb1
    • Robak T, Moiseev SI, Dmoszynska A, Solal-Celigny P, Warzocha K, Loscertales J, et al. Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia (CLL) compared with FC alone: final results from the international randomized phase III REACH trial. Blood 2008;112:lba-1.
    • (2008) Blood , vol.112
    • Robak, T.1    Moiseev, S.I.2    Dmoszynska, A.3    Solal-Celigny, P.4    Warzocha, K.5    Loscertales, J.6
  • 37
    • 85036559266 scopus 로고    scopus 로고
    • Long-term health outcomes and costs associated with the use of rituximab in combination with fludarabine and cyclophosphamide (R-FC) in the treatment of relapsed or refractory chronic lymphocytic leukaemia (CLL) in Poland
    • Robak T, Szkultecka-Debek M, Aultman R, Carr ES, Kawalec P. Long-term health outcomes and costs associated with the use of rituximab in combination with fludarabine and cyclophosphamide (R-FC) in the treatment of relapsed or refractory chronic lymphocytic leukaemia (CLL) in Poland. Blood 2009;114(22):4528.
    • (2009) Blood , vol.114 , Issue.22 , pp. 4528
    • Robak, T.1    Szkultecka-Debek, M.2    Aultman, R.3    Carr, E.S.4    Kawalec, P.5
  • 38
    • 85036585950 scopus 로고    scopus 로고
    • Correlations between ofatumumab exposure and treatment outcomes for patients with chronic lymphocytic leukemia (CLL) treated with frontline ofatumumab, fludarabine, and cyclophosphamide chemoimmunotherapy (Abstract 1793)
    • Wierda W, Jewell RC, Kipps TJ, Dürig J, Griskevicius L, Stilgenbauer S, et al. Correlations between ofatumumab exposure and treatment outcomes for patients with chronic lymphocytic leukemia (CLL) treated with frontline ofatumumab, fludarabine, and cyclophosphamide chemoimmunotherapy (Abstract 1793). Blood. 2011.
    • (2011) Blood.
    • Wierda, W.1    Jewell, R.C.2    Kipps, T.J.3    Dürig, J.4    Griskevicius, L.5    Stilgenbauer, S.6
  • 39
    • 76149128849 scopus 로고    scopus 로고
    • Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): results from a randomized, multicenter, international, two-dose, parallel group, phase II trial
    • Wierda WG, Kipps TJ, Durig J, Griskevicius L, Stilgenbauer S, Mayer J, et al. Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): results from a randomized, multicenter, international, two-dose, parallel group, phase II trial. Blood 2009;114(22):207.
    • (2009) Blood , vol.114 , Issue.22 , pp. 207
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3    Griskevicius, L.4    Stilgenbauer, S.5    Mayer, J.6
  • 40
    • 79959190996 scopus 로고    scopus 로고
    • Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Dürig J, Griskevicius L, Stilgenbauer S, Mayer J. Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia. Blood 2011;117(24):6450-8.
    • (2011) Blood , vol.117 , Issue.24 , pp. 6450-6458
    • Wierda, W.G.1    Kipps, T.J.2    Dürig, J.3    Griskevicius, L.4    Stilgenbauer, S.5    Mayer, J.6
  • 41
    • 59149089558 scopus 로고    scopus 로고
    • Variations on the fludarabine, cyclophosphamide, and rituximab combination in chronic lymphocytic leukemia therapy: what have we learned?
    • Ahmadi T, Schuster SJ. Variations on the fludarabine, cyclophosphamide, and rituximab combination in chronic lymphocytic leukemia therapy: what have we learned?. Journal of Clinical Oncology 2009;27:479-80.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 479-480
    • Ahmadi, T.1    Schuster, S.J.2
  • 42
    • 74949092446 scopus 로고    scopus 로고
    • New agents for the treatment of genetically high-risk chronic lymphocytic leukemia
    • Bazargan A, Tam CS. New agents for the treatment of genetically high-risk chronic lymphocytic leukemia. Leukemia & Lymphoma 2010;51:3-4.
    • (2010) Leukemia & Lymphoma , vol.51 , pp. 3-4
    • Bazargan, A.1    Tam, C.S.2
  • 43
    • 2942569721 scopus 로고    scopus 로고
    • Interim results from a phase I study of lumiliximab (IDEC-152, anti-CD23 antibody) therapy for relapsed refractory CLL
    • Byrd JC, O'Brien S, Flinn I, Kipps TJ, Weiss MA, Reid J, et al. Interim results from a phase I study of lumiliximab (IDEC-152, anti-CD23 antibody) therapy for relapsed refractory CLL. Blood 2003;102:74a.
    • (2003) Blood , vol.102 , pp. 74a
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.3    Kipps, T.J.4    Weiss, M.A.5    Reid, J.6
  • 44
    • 2942541474 scopus 로고    scopus 로고
    • The addition of rituximab to fludarabine significantly improves progression-free and overall survival in previously untreated chronic lymphocytic leukemia (CLL) patients
    • Byrd JC, Rai KR, Peterson BL, Appelbaum FR, Morrison VA, Kolitz JE, et al. The addition of rituximab to fludarabine significantly improves progression-free and overall survival in previously untreated chronic lymphocytic leukemia (CLL) patients. Blood 2003;102:73a.
    • (2003) Blood , vol.102 , pp. 73a
    • Byrd, J.C.1    Rai, K.R.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6
  • 45
    • 0141567516 scopus 로고    scopus 로고
    • Fludarabine plus rituximab for untreated B-cell chronic lymphocytic leukemia
    • Castagna L, Sarina B, Santoro A. Fludarabine plus rituximab for untreated B-cell chronic lymphocytic leukemia. Blood 2003;102:2309-10.
    • (2003) Blood , vol.102 , pp. 2309-2310
    • Castagna, L.1    Sarina, B.2    Santoro, A.3
  • 46
    • 67649368710 scopus 로고    scopus 로고
    • Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
    • Castillo J, Milani C, Mendez-Allwood D. Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders. Expert Opinion on Investigational Drugs 2009;18:491-500.
    • (2009) Expert Opinion on Investigational Drugs , vol.18 , pp. 491-500
    • Castillo, J.1    Milani, C.2    Mendez-Allwood, D.3
  • 47
    • 59049091983 scopus 로고    scopus 로고
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
    • Decker T, Sandherr M, Goetze K, Oelsner M, Ringshausen I, Peschel C. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Annals of Hematology 2009;88:221-7.
    • (2009) Annals of Hematology , vol.88 , pp. 221-227
    • Decker, T.1    Sandherr, M.2    Goetze, K.3    Oelsner, M.4    Ringshausen, I.5    Peschel, C.6
  • 48
    • 0034198736 scopus 로고    scopus 로고
    • Pentostatin and rituximab in the treatment of patients with B-cell malignancies
    • Drapkin R. Pentostatin and rituximab in the treatment of patients with B-cell malignancies. Oncology 2000;14:25-9.
    • (2000) Oncology , vol.14 , pp. 25-29
    • Drapkin, R.1
  • 49
  • 52
    • 79952668019 scopus 로고    scopus 로고
    • Comparative efficacy of first line therapies for chronic lymphocytic leukemia: a systematic review and meta-analyses
    • Janssens A, Foa R, Keating M, Ouwens M, Tatt I, Carr ESC. Comparative efficacy of first line therapies for chronic lymphocytic leukemia: a systematic review and meta-analyses. Blood 2009;114:3432.
    • (2009) Blood , vol.114 , pp. 3432
    • Janssens, A.1    Foa, R.2    Keating, M.3    Ouwens, M.4    Tatt, I.5    Carr, E.S.C.6
  • 53
    • 77956263666 scopus 로고    scopus 로고
    • Long term outcome following treatment failure of FCR chemoimmunotherapy as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, Wierda WG, Tam CS, Lynn A, O'Brien S, Lerner S, et al. Long term outcome following treatment failure of FCR chemoimmunotherapy as initial therapy for chronic lymphocytic leukemia. Drug Discovery 2009;114:2381.
    • (2009) Drug Discovery , vol.114 , pp. 2381
    • Keating, M.J.1    Wierda, W.G.2    Tam, C.S.3    Lynn, A.4    O'Brien, S.5    Lerner, S.6
  • 55
    • 84855230182 scopus 로고    scopus 로고
    • The safety and tolerability of oral fludarabine, (+/-)oral cyclophosphamide and iv rituximab therapy in previously untreated patients with chronic lymphocytic leukaemia (CLL) aged >=65 years - interim analysis from the Australasian Leukaemia and Lymphoma Group (ALLG) and CLL Australian Research Consortium (CLLARC) CLL5 study
    • Mulligan SP, Gill DS, Renwick WEP, Sulda ML, Best OG, Kuss BJ, et al. The safety and tolerability of oral fludarabine, (+/-)oral cyclophosphamide and iv rituximab therapy in previously untreated patients with chronic lymphocytic leukaemia (CLL) aged >=65 years - interim analysis from the Australasian Leukaemia and Lymphoma Group (ALLG) and CLL Australian Research Consortium (CLLARC) CLL5 study. Blood 2010;116:699.
    • (2010) Blood , vol.116 , pp. 699
    • Mulligan, S.P.1    Gill, D.S.2    Renwick, W.E.P.3    Sulda, M.L.4    Best, O.G.5    Kuss, B.J.6
  • 56
    • 76149115709 scopus 로고    scopus 로고
    • Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab for treatment of indolent B-cell malignancies
    • Negrea OG, Allen SL, Rai KR, Elstrom R, Abassi R, Farber CM, et al. Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab for treatment of indolent B-cell malignancies. Blood 2009;114:3757.
    • (2009) Blood , vol.114 , pp. 3757
    • Negrea, O.G.1    Allen, S.L.2    Rai, K.R.3    Elstrom, R.4    Abassi, R.5    Farber, C.M.6
  • 57
    • 58849162358 scopus 로고    scopus 로고
    • Dasatinib induces a response in chronic lymphocytic leukemia
    • Pitini V, Arrigo C, Altavilla G. Dasatinib induces a response in chronic lymphocytic leukemia. Blood 2009;113:498.
    • (2009) Blood , vol.113 , pp. 498
    • Pitini, V.1    Arrigo, C.2    Altavilla, G.3
  • 59
    • 67749097105 scopus 로고    scopus 로고
    • Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia
    • Reynolds C, Di Bella N, Lyons RM, Hyman WJ, Lee GL, Richards DA, et al. Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia. Blood 2008;112:327.
    • (2008) Blood , vol.112 , pp. 327
    • Reynolds, C.1    Di Bella, N.2    Lyons, R.M.3    Hyman, W.J.4    Lee, G.L.5    Richards, D.A.6
  • 60
    • 77956115972 scopus 로고    scopus 로고
    • Safety and efficacy of bendamustine with or without rituximab for the treatment of heavily pretreated CLL and lymphoma patients. A multicenter retrospective study
    • Rigacci L, Puccini B, Orciuolo E, D'Arco A, Storti S, Gaidano G, et al. Safety and efficacy of bendamustine with or without rituximab for the treatment of heavily pretreated CLL and lymphoma patients. A multicenter retrospective study. Blood 2009;114:1662.
    • (2009) Blood , vol.114 , pp. 1662
    • Rigacci, L.1    Puccini, B.2    Orciuolo, E.3    D'Arco, A.4    Storti, S.5    Gaidano, G.6
  • 61
    • 0032693012 scopus 로고    scopus 로고
    • Recent advances and future directions using monoclonal antibodies for B-cell malignancies
    • Rosen ST. Recent advances and future directions using monoclonal antibodies for B-cell malignancies. Seminars in Oncology 1999;26:1-122.
    • (1999) Seminars in Oncology , vol.26 , pp. 1-122
    • Rosen, S.T.1
  • 62
    • 57649088296 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG)
    • Schweighofer CD, Ritgen M, Eichhorst BF, Busch R, Abenhardt W, Kneba M, et al. Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG). British Journal of Haematology 2009;144:95-8.
    • (2009) British Journal of Haematology , vol.144 , pp. 95-98
    • Schweighofer, C.D.1    Ritgen, M.2    Eichhorst, B.F.3    Busch, R.4    Abenhardt, W.5    Kneba, M.6
  • 64
    • 85036528299 scopus 로고    scopus 로고
    • Alemtuzumab and rituximab for consolidation in CLL (NCT00771602)
    • Alemtuzumab and rituximab for consolidation in CLL (NCT00771602). Ongoing study August 2008.
    • (2008) Ongoing study
  • 65
    • 85036510836 scopus 로고    scopus 로고
    • A study to compare subcutaneous versus intravenous MabThera (rituximab) in combination with chemotherapy in patients with CLL (NCT01292603)
    • A study to compare subcutaneous versus intravenous MabThera (rituximab) in combination with chemotherapy in patients with CLL (NCT01292603). Ongoing study February 2011.
    • (2011) Ongoing study
  • 66
    • 85036497572 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and rituximab followed by rituximab or observation in treating older patients with previously untreated CLL (NCT00645606)
    • Fludarabine, cyclophosphamide, and rituximab followed by rituximab or observation in treating older patients with previously untreated CLL (NCT00645606). Ongoing study November 2007.
    • (2007) Ongoing study
  • 67
    • 85036503358 scopus 로고    scopus 로고
    • Intensified rituximab pre-phase before FluC-R in untreated CLL (NCT01370772)
    • Intensified rituximab pre-phase before FluC-R in untreated CLL (NCT01370772). Ongoing study May 2011.
    • (2011) Ongoing study
  • 68
    • 85036582312 scopus 로고    scopus 로고
    • Rituximab and alemtuzumab in treating older patients with progressive CLL (NCT01013961)
    • Rituximab and alemtuzumab in treating older patients with progressive CLL (NCT01013961). Ongoing study October 2010.
    • (2010) Ongoing study
  • 69
    • 84871437669 scopus 로고    scopus 로고
    • A phase II study of chlorambucil + rituximab (Clb-R) followed by R maintenance vs observation in elderly patients with previously untreated chronic lymphocytic leukemia (CLL): induction phase results
    • Foa R, Alietti A, Guarini A, Ciolli S, Di Raimondo F, Del Poeta G, et al. A phase II study of chlorambucil + rituximab (Clb-R) followed by R maintenance vs observation in elderly patients with previously untreated chronic lymphocytic leukemia (CLL): induction phase results. Haematologica 2011;96:226.
    • (2011) Haematologica , vol.96 , pp. 226
    • Foa, R.1    Alietti, A.2    Guarini, A.3    Ciolli, S.4    Di Raimondo, F.5    Del Poeta, G.6
  • 70
    • 84861342267 scopus 로고    scopus 로고
    • Rituximab plus chlorambucil as initial treatment for elderly patients with chronic lymphocytic leukemia (CLL): effect of pre-treatment biological characteristics and gene expression patterns on response to treatment
    • Foa R, Ciolli S, Di Raimondo F, Del Poeta G, Lauria F, Forconi F, et al. Rituximab plus chlorambucil as initial treatment for elderly patients with chronic lymphocytic leukemia (CLL): effect of pre-treatment biological characteristics and gene expression patterns on response to treatment. Blood 2011;118:294.
    • (2011) Blood , vol.118 , pp. 294
    • Foa, R.1    Ciolli, S.2    Di Raimondo, F.3    Del Poeta, G.4    Lauria, F.5    Forconi, F.6
  • 71
    • 79960389370 scopus 로고    scopus 로고
    • A phase II study of chlorambucil plus rituximab followed by maintenance versus observation in elderly patients with previously untreated chronic lymphocytic leukemia: results of the first interim analysis
    • Foa R, Ciolli S, Di Raimondo F, Del'Poeta G, Lauria F, Forconi F, et al. A phase II study of chlorambucil plus rituximab followed by maintenance versus observation in elderly patients with previously untreated chronic lymphocytic leukemia: results of the first interim analysis. Blood 2010;116:2462.
    • (2010) Blood , vol.116 , pp. 2462
    • Foa, R.1    Ciolli, S.2    Di Raimondo, F.3    Del'Poeta, G.4    Lauria, F.5    Forconi, F.6
  • 72
    • 85036516599 scopus 로고    scopus 로고
    • A phase II study of chlorambucil plus rituximab followed by maintenance versus observation in elderly patients with previously untreated chronic lymphocytic leukemia: results of the induction phase
    • Mauro FR, Ciolli S, Di Raimondo F, Del Poeta G, Forconi F, Cuneo A, et al. A phase II study of chlorambucil plus rituximab followed by maintenance versus observation in elderly patients with previously untreated chronic lymphocytic leukemia: results of the induction phase. Journal of Clinical Oncology 2011;29:6629.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 6629
    • Mauro, F.R.1    Ciolli, S.2    Di Raimondo, F.3    Del Poeta, G.4    Forconi, F.5    Cuneo, A.6
  • 73
    • 85036576669 scopus 로고    scopus 로고
    • A study comparing RO5072759 (GA101) 1000 mg versus 2000 mg in patients with previously untreated chronic lymphocytic leukaemia (NCT01414205)
    • A study comparing RO5072759 (GA101) 1000 mg versus 2000 mg in patients with previously untreated chronic lymphocytic leukaemia (NCT01414205). Ongoing study September 2011.
    • (2011) Ongoing study
  • 74
    • 85036532824 scopus 로고    scopus 로고
    • A study of RO5072759 with chlorambucil in patients with previously untreated CLL (NCT01010061)
    • A study of RO5072759 with chlorambucil in patients with previously untreated CLL (NCT01010061). Ongoing study November 2009.
    • (2009) Ongoing study
  • 75
    • 85036586237 scopus 로고    scopus 로고
    • Rituximab, fludarabine, and cyclophosphamide or observation alone in treating patients with stage 0, I, or II CLL (NCT00275054)
    • Rituximab, fludarabine, and cyclophosphamide or observation alone in treating patients with stage 0, I, or II CLL (NCT00275054). Ongoing study October 2005.
    • (2005) Ongoing study
  • 76
    • 85036512903 scopus 로고    scopus 로고
    • Ofatumumab added to FC versus FC in relapsed subjects with CLL (NCT00824265)
    • Ofatumumab added to FC versus FC in relapsed subjects with CLL (NCT00824265). Ongoing study March 2009.
    • (2009) Ongoing study
  • 77
    • 85036531179 scopus 로고    scopus 로고
    • Ofatumumab maintenance treatment versus no further treatment in relapsed CLL responding to induction therapy (PROLONG) (NCT01039376)
    • Ofatumumab maintenance treatment versus no further treatment in relapsed CLL responding to induction therapy (PROLONG) (NCT01039376). Ongoing study May 2010.
    • (2010) Ongoing study
  • 78
    • 85036533889 scopus 로고    scopus 로고
    • Ofatumumab versus physicians' choice in subjects with bulky fludarabine-refractory chronic lymphocytic leukaemia
    • Ofatumumab versus physicians' choice in subjects with bulky fludarabine-refractory chronic lymphocytic leukaemia. Ongoing study April 2011.
    • (2011) Ongoing study
  • 79
    • 85036581295 scopus 로고    scopus 로고
    • Rituximab versus observation as maintenance therapy in CLL (NCT01118234)
    • Rituximab versus observation as maintenance therapy in CLL (NCT01118234). Ongoing study December 2009.
    • (2009) Ongoing study
  • 80
    • 85036598050 scopus 로고    scopus 로고
    • A study of maintenance treatment with rituximab in patients with progressive CLL (NCT00718549)
    • A study of maintenance treatment with rituximab in patients with progressive CLL (NCT00718549). Ongoing study July 2009.
    • (2009) Ongoing study
  • 81
    • 85036570931 scopus 로고    scopus 로고
    • Ofatumumab + chlorambucil versus chlorambucil monotherapy in previously untreated patients with CLL (NCT00748189)
    • Ofatumumab + chlorambucil versus chlorambucil monotherapy in previously untreated patients with CLL (NCT00748189). Ongoing study December 2008.
    • (2008) Ongoing study
  • 82
    • 85036497149 scopus 로고    scopus 로고
    • Rituximab therapy of chronic lymphocytic leukemia patients in remission
    • Zagoskina P, Demyanova V, Zotina E, Grishina I. Rituximab therapy of chronic lymphocytic leukemia patients in remission. Haematologica 2011;96:225.
    • (2011) Haematologica , vol.96 , pp. 225
    • Zagoskina, P.1    Demyanova, V.2    Zotina, E.3    Grishina, I.4
  • 83
    • 81855205479 scopus 로고    scopus 로고
    • Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: initial results of a phase II trial
    • Badoux X, O'Brien S, Wierda WG, Faderl S, Estrov Z, Yerrow K, et al. Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: initial results of a phase II trial. Blood 2010;116:2464.
    • (2010) Blood , vol.116 , pp. 2464
    • Badoux, X.1    O'Brien, S.2    Wierda, W.G.3    Faderl, S.4    Estrov, Z.5    Yerrow, K.6
  • 84
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981;48:198-206.
    • (1981) Cancer , vol.48 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3    Chastang, C.4    Piguet, H.5    Goasguen, J.6
  • 85
    • 77949472413 scopus 로고    scopus 로고
    • Rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) is a highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia (Abstract 2097)
    • Bosch F, Abrisqueta P, Villamor N, Terol M, Ribera JM, Gonzalez-Barca E, et al. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) is a highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia (Abstract 2097). Blood. 2008.
    • (2008) Blood.
    • Bosch, F.1    Abrisqueta, P.2    Villamor, N.3    Terol, M.4    Ribera, J.M.5    Gonzalez-Barca, E.6
  • 86
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, Park K, Jacobson R, Hoke E, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 2003;101(1):6-14.
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6
  • 87
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, Appelbaum FR, Morrison VA, Kolitz JE, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005;105(1):49-53.
    • (2005) Blood , vol.105 , Issue.1 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6
  • 88
    • 70350749633 scopus 로고    scopus 로고
    • Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901
    • Byrd JC, Peterson BL, Rai KR, Hurd D, Hohl R, Perry MC, et al. Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901. Leukemia and Lymphoma 2009;50:1589-96.
    • (2009) Leukemia and Lymphoma , vol.50 , pp. 1589-1596
    • Byrd, J.C.1    Peterson, B.L.2    Rai, K.R.3    Hurd, D.4    Hohl, R.5    Perry, M.C.6
  • 89
    • 70350132633 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
    • Castro JE, James DF, Sandoval-Sus JD, Jain S, Bole J, Rassenti L, et al. Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. Leukemia 2009;23:1779-89.
    • (2009) Leukemia , vol.23 , pp. 1779-1789
    • Castro, J.E.1    James, D.F.2    Sandoval-Sus, J.D.3    Jain, S.4    Bole, J.5    Rassenti, L.6
  • 90
    • 83255170348 scopus 로고    scopus 로고
    • Ofatumumab and high-dose methylprednisolone is an effective salvage treatment for heavily pretreated, unfit or refractory patients with chronic lymphocytic leukemia: single institution experience
    • Castro JE, Barajas-Gamboa JS, Melo-Cardenas J, Paz RN, Bernal-Corzo C, Ale-Ali A, et al. Ofatumumab and high-dose methylprednisolone is an effective salvage treatment for heavily pretreated, unfit or refractory patients with chronic lymphocytic leukemia: single institution experience. Blood 2010;116:4638.
    • (2010) Blood , vol.116 , pp. 4638
    • Castro, J.E.1    Barajas-Gamboa, J.S.2    Melo-Cardenas, J.3    Paz, R.N.4    Bernal-Corzo, C.5    Ale-Ali, A.6
  • 91
    • 85036508905 scopus 로고    scopus 로고
    • Rituximab in chronic lymphocytic leukemia
    • Program in Evidence-based Care. NGC:007886, (accessed 17 August 2012)
    • Cheung M, Tey R, Haynes A. Rituximab in chronic lymphocytic leukemia. Program in Evidence-based Care. NGC:007886. 2009. ngc.gov/content.aspx?id=16388&search=Chronic+lymphocytic+leukemia. (accessed 17 August 2012).
    • , vol.2009
    • Cheung, M.1    Tey, R.2    Haynes, A.3
  • 93
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, Gadeberg O, Fredriksen H, van Oers MHJ, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood 2008;111(3):1094-100.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3    Gadeberg, O.4    Fredriksen, H.5    van Oers, M.H.J.6
  • 94
    • 78650542873 scopus 로고    scopus 로고
    • Impact of different chemotherapy regimen in comorbid patients with advanced chronic lymphocytic leukemia: metaanalysis of two phase-III-trials of the German CLL Study Group
    • Cramer P, Goede V, Jenke P, Busch R, Hallek M, Eichhorst B. Impact of different chemotherapy regimen in comorbid patients with advanced chronic lymphocytic leukemia: metaanalysis of two phase-III-trials of the German CLL Study Group. Blood 2006;108:2840.
    • (2006) Blood , vol.108 , pp. 2840
    • Cramer, P.1    Goede, V.2    Jenke, P.3    Busch, R.4    Hallek, M.5    Eichhorst, B.6
  • 95
    • 77953507105 scopus 로고    scopus 로고
    • The future of CD20 monoclonal antibody therapy in B-cell malignancies
    • Czuczman MS, Gregory SA. The future of CD20 monoclonal antibody therapy in B-cell malignancies. Leukemia and Lymphoma 2010;51:983-94.
    • (2010) Leukemia and Lymphoma , vol.51 , pp. 983-994
    • Czuczman, M.S.1    Gregory, S.A.2
  • 98
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, Pasold R, Hensel M, Steinbrecher C, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood 2006;107(3):885-91.
    • (2006) Blood , vol.107 , Issue.3 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3    Pasold, R.4    Hensel, M.5    Steinbrecher, C.6
  • 100
    • 79551543248 scopus 로고    scopus 로고
    • Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports
    • Evens AM, Jovanovic BD, Su YC, Raisch DW, Ganger D, Belknap SM, et al. Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports. Annals of Oncology 2011;22:1170-80.
    • (2011) Annals of Oncology , vol.22 , pp. 1170-1180
    • Evens, A.M.1    Jovanovic, B.D.2    Su, Y.C.3    Raisch, D.W.4    Ganger, D.5    Belknap, S.M.6
  • 101
    • 65749110753 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): a multicentre phase II trial of the German CLL Study Group (GCLLSG)
    • Fischer K, Stilgenbauer S, Schweighofer CD, Busch R, Renschler J, Kiehl M, et al. Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): a multicentre phase II trial of the German CLL Study Group (GCLLSG). Blood 2008;112:330.
    • (2008) Blood , vol.112 , pp. 330
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.D.3    Busch, R.4    Renschler, J.5    Kiehl, M.6
  • 102
    • 77950321929 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL Study Group (GCLLSG)
    • Fischer K, Cramer P, Stilgenbauer S, Busch R, Balleisen L, Kilp J, et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL Study Group (GCLLSG). Blood 2009;114:205.
    • (2009) Blood , vol.114 , pp. 205
    • Fischer, K.1    Cramer, P.2    Stilgenbauer, S.3    Busch, R.4    Balleisen, L.5    Kilp, J.6
  • 103
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • Flinn IW, Neuberg DS, Grever MR, Dewald GW, Bennett JM, Paietta EM, et al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. Journal of Clinical Oncology 2007;25(7):793-8.
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.7 , pp. 793-798
    • Flinn, I.W.1    Neuberg, D.S.2    Grever, M.R.3    Dewald, G.W.4    Bennett, J.M.5    Paietta, E.M.6
  • 104
    • 80053055044 scopus 로고    scopus 로고
    • Chemoimmunotherapy with chlorambucil and the type II CD20-antibody GA101 in patients with chronic lymphocytic leukemia and comorbidity: results of the run-in phase of the CLL11 (BO21004) trial
    • Goede V, Fischer K, Busch R, Jaeger U, Dilhuydy MS, Wickham N, et al. Chemoimmunotherapy with chlorambucil and the type II CD20-antibody GA101 in patients with chronic lymphocytic leukemia and comorbidity: results of the run-in phase of the CLL11 (BO21004) trial. Blood 2010;116:1387.
    • (2010) Blood , vol.116 , pp. 1387
    • Goede, V.1    Fischer, K.2    Busch, R.3    Jaeger, U.4    Dilhuydy, M.S.5    Wickham, N.6
  • 105
    • 41149101075 scopus 로고    scopus 로고
    • Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Vazquez ER, Spigel DR, Raefsky E, Bearden JD, Saez RA, et al. Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network. Cancer 2008;112:1288-95.
    • (2008) Cancer , vol.112 , pp. 1288-1295
    • Hainsworth, J.D.1    Vazquez, E.R.2    Spigel, D.R.3    Raefsky, E.4    Bearden, J.D.5    Saez, R.A.6
  • 106
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111(12):5446-56.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Dohner, H.6
  • 107
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, Fink AM, Busch R, Mayer J, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376(9747):1164-74.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 111
  • 112
    • 77956198078 scopus 로고    scopus 로고
    • An open-label phase II study to investigate the safety and efficacy of rituximab plus chlorambucil in previously untreated patients with CD20-positive B-Cell chronic lymphocytic leukaemia (CLL)
    • Hillmen P, Gribben JG, Follows GA, Milligan DW, Sayala HA, Moreton P, et al. An open-label phase II study to investigate the safety and efficacy of rituximab plus chlorambucil in previously untreated patients with CD20-positive B-Cell chronic lymphocytic leukaemia (CLL). Blood 2009;114:3428.
    • (2009) Blood , vol.114 , pp. 3428
    • Hillmen, P.1    Gribben, J.G.2    Follows, G.A.3    Milligan, D.W.4    Sayala, H.A.5    Moreton, P.6
  • 113
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, Ho AD, Hallek M, Kuse R, et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 2001;98(5):1326-31.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1326-1331
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3    Ho, A.D.4    Hallek, M.5    Kuse, R.6
  • 114
    • 79954424213 scopus 로고    scopus 로고
    • Bendamustine with or without rituximab in the treatment of relapsed chronic lymphocytic leukaemia: an Italian retrospective study
    • Iannitto E, Morabito F, Mancuso S, Gentile M, Montanini A, Augello A, et al. Bendamustine with or without rituximab in the treatment of relapsed chronic lymphocytic leukaemia: an Italian retrospective study. British Journal of Haematology 2011;153(3):351-7.
    • (2011) British Journal of Haematology , vol.153 , Issue.3 , pp. 351-357
    • Iannitto, E.1    Morabito, F.2    Mancuso, S.3    Gentile, M.4    Montanini, A.5    Augello, A.6
  • 115
    • 24344497929 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of leukaemias and lymphomas
    • Jacobs SA, Foon KA. Monoclonal antibody therapy of leukaemias and lymphomas. Expert Opinion on Biological Therapy 2005;5(9):1225-43.
    • (2005) Expert Opinion on Biological Therapy , vol.5 , Issue.9 , pp. 1225-1243
    • Jacobs, S.A.1    Foon, K.A.2
  • 116
    • 77951456080 scopus 로고    scopus 로고
    • Pentostatin and rituximab therapy for previously untreated patients with B-cell chronic lymphocytic leukemia
    • Kay NE, Wu W, Kabat B, LaPlant B, Lin TS, Byrd JC, et al. Pentostatin and rituximab therapy for previously untreated patients with B-cell chronic lymphocytic leukemia. Cancer 2010;116:2180-7.
    • (2010) Cancer , vol.116 , pp. 2180-2187
    • Kay, N.E.1    Wu, W.2    Kabat, B.3    LaPlant, B.4    Lin, T.S.5    Byrd, J.C.6
  • 117
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, Lerner S, Plunkett W, Giles F, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. Journal of Clinical Oncology 2005;23(18):4079-88.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.18 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3    Lerner, S.4    Plunkett, W.5    Giles, F.6
  • 118
    • 33645732715 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia
    • Lamanna N, Kalaycio M, Maslak P, Jurcic JG, Heaney M, Brentjens R, et al. Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia. Journal of Clinical Oncology 2006;24:1575-81.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 1575-1581
    • Lamanna, N.1    Kalaycio, M.2    Maslak, P.3    Jurcic, J.G.4    Heaney, M.5    Brentjens, R.6
  • 119
    • 79951884063 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab show significant clinical activity in patients with previously untreated chronic lymphocytic leukemia
    • Lamanna N, Weiss MA. Pentostatin, cyclophosphamide, and rituximab show significant clinical activity in patients with previously untreated chronic lymphocytic leukemia. Current Oncology Reports 2007;9:335-6.
    • (2007) Current Oncology Reports , vol.9 , pp. 335-336
    • Lamanna, N.1    Weiss, M.A.2
  • 120
    • 70349547000 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, rituximab, and mitoxantrone (PCRM): a new highly active regimen for patients with chronic lymphocytic leukemia (CLL) previously treated with PCR or FCR
    • Lamanna N, Heaney ML, Brentjens RJ, Jurcic JG, Weiss MA. Pentostatin, cyclophosphamide, rituximab, and mitoxantrone (PCRM): a new highly active regimen for patients with chronic lymphocytic leukemia (CLL) previously treated with PCR or FCR. Blood 2007;110:3115.
    • (2007) Blood , vol.110 , pp. 3115
    • Lamanna, N.1    Heaney, M.L.2    Brentjens, R.J.3    Jurcic, J.G.4    Weiss, M.A.5
  • 121
    • 79953905710 scopus 로고    scopus 로고
    • Risk of infection in patients with lymphoma receiving rituximab: systematic review and meta-analysis
    • Lanini S, Molloy AC, Fine PE, Prentice AG, Ippolito G, Kibbler CC. Risk of infection in patients with lymphoma receiving rituximab: systematic review and meta-analysis. BMC Medicine 2011;9:36.
    • (2011) BMC Medicine , vol.9 , pp. 36
    • Lanini, S.1    Molloy, A.C.2    Fine, P.E.3    Prentice, A.G.4    Ippolito, G.5    Kibbler, C.C.6
  • 123
    • 42049085694 scopus 로고    scopus 로고
    • Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity
    • Li B, Shi S, Qian W, Zhao L, Zhang D, Hou S, et al. Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity. Cancer Research 2008;68:2400-8.
    • (2008) Cancer Research , vol.68 , pp. 2400-2408
    • Li, B.1    Shi, S.2    Qian, W.3    Zhao, L.4    Zhang, D.5    Hou, S.6
  • 124
    • 73949084380 scopus 로고    scopus 로고
    • Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
    • Li B, Zhao L, Guo H, Wang C, Zhang X, Wu L, et al. Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma. Blood 2009;114:5007-15.
    • (2009) Blood , vol.114 , pp. 5007-5015
    • Li, B.1    Zhao, L.2    Guo, H.3    Wang, C.4    Zhang, X.5    Wu, L.6
  • 125
  • 126
    • 76949107685 scopus 로고    scopus 로고
    • Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia
    • Morschhauser F, Cartron G, Lamy T, Milpied NJ, Thieblemont C, Tilly H, et al. Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia. Blood 2009;114:884.
    • (2009) Blood , vol.114 , pp. 884
    • Morschhauser, F.1    Cartron, G.2    Lamy, T.3    Milpied, N.J.4    Thieblemont, C.5    Tilly, H.6
  • 127
    • 85036593132 scopus 로고    scopus 로고
    • Rituximab for the first-line treatment of chronic lymphocytic leukaemia
    • (accessed 17 August 2012)
    • National Institute for Health and Clinical Excellence. Rituximab for the first-line treatment of chronic lymphocytic leukaemia. 2009. www.nice.org.uk/nicemedia/live/11907/44906/44906.pdf. (accessed 17 August 2012).
    • , vol.2009
  • 128
    • 85036543351 scopus 로고    scopus 로고
    • Ofatumumab for the treatment of chronic lymphocytic leukaemia refractory to fludarabine and alemtuzumab. NGC:008297
    • (accessed 17 August 2012)
    • National Institute for Health and Clinical Excellence. Ofatumumab for the treatment of chronic lymphocytic leukaemia refractory to fludarabine and alemtuzumab. NGC:008297. 2010. www.nice.org.uk/nicemedia/live/13240/51314/51314.pdf. (accessed 17 August 2012).
    • (2010)
  • 129
    • 85036509322 scopus 로고    scopus 로고
    • Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia
    • (accessed 17 August 2012)
    • National Institute for Health and Clinical Excellence. Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia. 2010. www.nice.org.uk/nicemedia/live/13045/49855/49855.pdf. (accessed 17 August 2012).
    • (2010)
  • 130
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34.
    • (1998) Statistics in Medicine , vol.17 , Issue.24 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 132
    • 79960705415 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
    • (2011)
  • 133
    • 65749114275 scopus 로고    scopus 로고
    • Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory Chronic lymphocytic leukemia (CLL) compared with FC alone: final results from the international randomized phase III REACH trial
    • LBA-LB1
    • Robak T, Moiseev SI, Dmoszynska A, Solal-Céligny P, Warzocha K, Loscertales J. Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory Chronic lymphocytic leukemia (CLL) compared with FC alone: final results from the international randomized phase III REACH trial. Blood 2008;112:LBA-1.
    • (2008) Blood , vol.112
    • Robak, T.1    Moiseev, S.I.2    Dmoszynska, A.3    Solal-Céligny, P.4    Warzocha, K.5    Loscertales, J.6
  • 134
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH, Cohen P, Herst JA, Tulpule A, et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. Journal of Clinical Oncology 2008;26(27):4473-9.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.27 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    van der Jagt, R.H.3    Cohen, P.4    Herst, J.A.5    Tulpule, A.6
  • 135
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • Schulz H, Klein SK, Rehwald U, Reiser M, Hinke A, Knauf WU, et al. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood 2002;100(9):3115-20.
    • (2002) Blood , vol.100 , Issue.9 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3    Reiser, M.4    Hinke, A.5    Knauf, W.U.6
  • 136
    • 34249042684 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia
    • Shanafelt TD, Lin T, Geyer SM, Zent CS, Leung N, Kabat B, et al. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer 2007;109:2291-8.
    • (2007) Cancer , vol.109 , pp. 2291-2298
    • Shanafelt, T.D.1    Lin, T.2    Geyer, S.M.3    Zent, C.S.4    Leung, N.5    Kabat, B.6
  • 141
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, Kantarjian H, Wen S, Do KA, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 2008;112(4):975-80.
    • (2008) Blood , vol.112 , Issue.4 , pp. 975-980
    • Tam, C.S.1    O'Brien, S.2    Wierda, W.3    Kantarjian, H.4    Wen, S.5    Do, K.A.6
  • 142
    • 0028108050 scopus 로고
    • CD20: a regulator of cell-cycle progression of B lymphocytes
    • Tedder TF, Engel P. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunology Today 1994;15:450-4.
    • (1994) Immunology Today , vol.15 , pp. 450-454
    • Tedder, T.F.1    Engel, P.2
  • 143
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • Teeling JL, French RR, Cragg MS, van den BJ, Pluyter M, Huang H, et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 2004;104(6):1793-800.
    • (2004) Blood , vol.104 , Issue.6 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3    van den, B.J.4    Pluyter, M.5    Huang, H.6
  • 145
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 146
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, Faderl S, Garcia-Manero G, Thomas D, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. Journal of Clinical Oncology 2005;23(18):4070-8.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.18 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3    Faderl, S.4    Garcia-Manero, G.5    Thomas, D.6
  • 147
    • 30744448409 scopus 로고    scopus 로고
    • A retrospective comparison of three sequential groups of patients with Recurrent/Refractory chronic lymphocytic leukemia treated with fludarabine-based regimens
    • Wierda W, O'Brien S, Faderl S, Ferrajoli A, Wang X, Do KA, et al. A retrospective comparison of three sequential groups of patients with Recurrent/Refractory chronic lymphocytic leukemia treated with fludarabine-based regimens. Cancer 2006;106(2):337-45.
    • (2006) Cancer , vol.106 , Issue.2 , pp. 337-345
    • Wierda, W.1    O'Brien, S.2    Faderl, S.3    Ferrajoli, A.4    Wang, X.5    Do, K.A.6
  • 149
    • 81055148076 scopus 로고    scopus 로고
    • Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase II international study
    • Wierda WG, Padmanabhan S, Chan GW, Gupta IV, Lisby S, Österborg A. Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase II international study. Blood 2011; Vol. 118:5126-9.
    • (2011) Blood , vol.118 , pp. 5126-5129
    • Wierda, W.G.1    Padmanabhan, S.2    Chan, G.W.3    Gupta, I.V.4    Lisby, S.5    Österborg, A.6


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