A modeling approach for compounds affecting body composition

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 40, Issue 6, 2013, Pages 651-667

  Gennemark, Peter ^a   Jansson Löfmark, Rasmus ^a   Hyberg, Gina ^a   Wigstrand, Maria ^a   Kakol Palm, Dorota ^a   Håkansson, Pernilla ^a   Hovdal, Daniel ^a   Brodin, Peter ^a   Fritsch Fredin, Maria ^a   Antonsson, Madeleine ^a   Ploj, Karolina ^a   Gabrielsson, Johan ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Body composition; Forbes relationship; Mathematical modeling; Model based drug discovery; Obesity; Turnover model

Indexed keywords

APPETITE REGULATING COMPOUND; CHEMICAL COMPOUND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY MASS; C57BL 6 MOUSE; CALORIC INTAKE; CONTROLLED STUDY; DRUG MECHANISM; ENERGY CONSERVATION; ENERGY EXPENDITURE; FAT FREE MASS; FAT MASS; FEMALE; MALE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PHARMACODYNAMICS; PHARMACOKINETICS; PREDICTION; PRIORITY JOURNAL; SIMULATION;

ANIMALS; APPETITE DEPRESSANTS; BODY COMPOSITION; BODY WEIGHT; DIET, HIGH-FAT; DRUG DISCOVERY; ENERGY INTAKE; ENERGY METABOLISM; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; OBESITY;

EID: 84890553826     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-013-9337-x     Document Type: Article

References (28)

1. Torgerson JS, Hauptman J, Boldrin MN, Sjöström L (2004) XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 27(1):155-61
2. Kang JG, Park CY (2012) Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J 36(1):13-25
3. Jusko WJ, Ko HC, Ebling WF (1995) Convergence of direct and indirect pharmacodynamic response models. J Pharmacokinet Biopharm 23:5-8
4. Danhof M, Alvan G, Dahl SG, Kuhlmann J, Paintaud G (2005) Mechanism-based pharmacokinetic-pharmacodynamic modeling: a new classification of biomarkers. Pharm Res 22(9):1432-7
5. Guo J, Hall KD (2009) Estimating the continuous-time dynamics of energy and fat metabolism in mice. PLoS Comput Biol 5(9):e1000511
6. Guo J, Hall KD (2011) Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice. PLoS One 6(1):e15961
7. Ellacott KL, Morton GJ, Woods SC, Tso P, Schwartz MW (2010) Assessment of feeding behavior in laboratory mice. Cell Metab 12(1):10-7
8. Gabrielsson J, Weiner D (2010) Pharmacokinetic & pharmacodynamic, data analysis, concepts and applications, 4th edn. 2nd print, Swedish Pharmaceutical Press, Stockholm. ISBN-139789197651004
9. Westertep K, Donkers J, Fredrix E, Boekhoudt P (1995) Energy intake, physical activity and body weight: a simulation model. Br J Nutr 73:337-347
10. Christiansen E, Garby L (2002) Prediction of body weight changes caused by changes in energybalance. Eur J Clin Invest 32:826-30
11. Christiansen E, Garby L, Sørensen TIA (2005) Quantitative analysis of the energy requirements for development of obesity. J Theor Biol 234:99-106
12. Hall KD (2006) Computational model of in vivo human energy metabolism during semi starvation and refeeding. Am J Physiol Endocrinol Metab 291:E23-27
13. Chow CC, Hall KD (2008) The dynamics of human body weight change. PLoS Comput Biol 4(3):e1000045
14. Hall KD, Jordan PN (2008) Modeling weight-loss maintenance to help prevent body weight regain. Am J Clin Nutr 88(6):1495-503
15. Hou C, Zuo W, Moses ME, Woodruff WH, Brown JH, West GB (2008) Energy uptake and allocation during ontogeny. Sci Agric 322(5902):736-9
16. Thomas DM, Ciesla A, Levine JA, Stevens JG, Martin CK (2009) A mathematical model of weight change with adaptation. Math Biosci Eng 6(4):873-887
17. Landersdorfer CB, DuBois DC, Almon RR, Jusko WJ (2009) Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats. J Pharmacol Exp Ther 328(2):644-51
18. Hall KD (2010) Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrinol Metab 298(3):E449-66
19. Navarro-Barrientos JE, Rivera DE, Collins LM (2011) A dynamical model for describing behavioural interventions for weight loss and body composition change. Math Comput Model Dyn Syst 17(2):183-203
20. Hall KD (2011) Quantification of the effect of energy imbalance on bodyweight. Lancet 378:826-37
21. Hall KD (2008) What is the required energy deficit per unit weight loss?. Int J Obes (Lond) 32:573-576
22. Forbes GB (1987) Lean body mass-body fat interrelationships in humans. Nutr Rev 45:225-231
23. Forbes GB (2000) Body fat content influences the body composition response to nutrition and exercise. Ann N Y Acad Sci 904:359-365
24. Hall KD (2010) Mathematical modelling of energy expenditure during tissue deposition. Br J Nutr 104:4-7
25. Kleiber M (1975) The fire of life: an introduction to animal energetics. Robert E Krieger Publishing Company, Malabar
26. Guo J, Jou W, Gavrilova O, Hall KD (2009) Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One 4:e5370
27. Johansson CC, Gennemark P, Artursson P, Äbelö A, Ashton M, Jansson-Löfmark R (2013) Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat. J Pharmacokinet Pharmacodyn 40(1):117-28
28. Vickers SP, Jackson HC, Cheetham SC (2011) The utility of animal models to evaluate novel anti-obesity agents. Br J Pharmacol 164(4):1248-62