SERCA mutant E309Q binds two Ca 2+ ions but adopts a catalytically incompetent conformation

EMBO Journal

Volumn 32, Issue 24, 2013, Pages 3231-3243

  Clausen, Johannes D ^a   Bublitz, Maike ^a   Arnou, Bertrand ^a   Montigny, Cédric ^b   Jaxel, Christine ^b   Møller, Jesper Vuust ^a   Nissen, Poul ^a   Andersen, Jens Peter ^a   Le Maire, Marc ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

Ca2 + ATPase; Ca2+ binding; Intramolecular signalling; Membrane protein crystallography; Phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; RECOMBINANT ENZYME; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ARTICLE; BINDING SITE; CATALYSIS; COMPETITIVE INHIBITION; CONSENSUS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON; ENERGY TRANSFER; ENZYME CONFORMATION; ENZYME ISOLATION; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; HYDROGEN BOND; HYDROLYSIS; MUTANT; NONHUMAN; PHOSPHORYLATION AND DEPHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STEADY STATE; WILD TYPE;

ADENOSINE TRIPHOSPHATE; CALCIUM; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN CONFORMATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84890548938     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.250     Document Type: Article

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