FOLFOX versus EOX as a neoadjuvant chemotherapy regimen for patients with advanced gastric cancer

Experimental and Therapeutic Medicine

Volumn 7, Issue 2, 2014, Pages 461-467

  Chen, Wenjun ^a   Shen, Jianguo ^a   Pan, Tao ^a   Hu, Wenxian ^a   Jiang, Zinong ^b   Yuan, Xiaoming ^a   Wang, Linbo ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Capecitabine; Epirubicin; Gastric cancer; Neoadjunvant chemotherapy; Oxaliplatin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CAPECITABINE; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADULT; ANEMIA; ARTICLE; CANCER STAGING; CHINESE; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; DRUG SAFETY; FEMALE; GASTRECTOMY; HAND FOOT SYNDROME; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUTROPENIA; PERIPHERAL NEUROPATHY; QUALITY OF LIFE; STOMACH CANCER; THROMBOCYTOPENIA; TUMOR INVASION; TUMOR REGRESSION;

EID: 84890542734     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1449     Document Type: Article

References (27)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
3. Sasako M: Principles of surgical treatment for curable gastric cancer. J Clin Oncol 21: S274-S275, 2003.
4. Cunningham D, Allum WH, Stenning SP, et al: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 355: 11-20, 2006.
5. Ott K, Lordick F, Herrmann K, Krause BJ, Schuhmacher C and Siewert JR: The new credo: induction chemotherapy in locally advanced gastric cancer: consequences for surgical strategies. Gastric Cancer 11: 1-9, 2008.
6. Wang LB, Shen JG, Xu CY, Chen WJ, Song XY and Yuan XM: Neoadjuvant chemotherapy versus surgery alone for locally advanced gastric cancer: a retrospective comparative study. Hepatogastroenterology 55: 1895-1898, 2008.
7. Zhang J, Chen RX, Zhang J, et al: Efficacy and safety of neoadjuvant chemotherapy with modified FOLFOX7 regimen on the treatment of advanced gastric cancer. Chin Med J (Engl) 125: 2144-2150, 2012.
8. Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45: 228-247, 2009.
9. Japanese Gastric Cancer Association: Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 14: 113-123, 2011.
10. Lowy AM, Mansfield PF, Leach SD, Pazdur R, Dumas P and Ajani JA: Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer. Ann Surg 229: 303-308, 1999.
11. Becker K, Mueller JD, Schulmacher C, et al: Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy. Cancer 98: 1521-1530, 2003.
12. Mansour JC, Tang L, Shah M, et al: Does graded histologic response after neoadjuvant chemotherapy predict survival for completely resected gastric cancer? Ann Surg Oncol 14: 3412-3418, 2007.
13. Mandard AM, Dalibard F, Mandard JC, et al: Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 73: 2680-2686, 1994.
14. Beddy D, Hyland JM, Winter DC, et al: A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. Ann Surg Oncol 15: 3471-3477, 2008.
15. Wang LB, Teng RY, Jiang ZN, et al: Clinicopathologic variables predicting tumor response to neoadjuvant chemotherapy in patients with locally advanced gastric cancer. J Surg Oncol 105: 293-296, 2012.
16. Trotti A, Colevas AD, Setser A, et al: CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 13: 176-181, 2003.
17. Robb WB and Mariette C: Predicting the response to chemotherapy in gastric adenocarcinoma: who benefits from neoadjuvant chemotherapy? Recent Results Cancer Res 196: 241-268, 2012.
18. Hundahl SA, Menck HR, Mansour EG and Winchester DP: The National Cancer Data Base report on gastric carcinoma. Cancer 80: 2333-2341, 1997.
19. Ychou M, Boige V, Pignon JP, et al: Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 29: 1715-1721, 2011.
20. Boige V, Pignon J, Saint-Aubert B, et al: Final results of a randomized trial comparing preoperative 5-fluorouracil/cisplatin to surgery alone in adenocarcinoma of stomach and lower esophagus (ASLE): FNLCC ACCORD07-FFCD 9703 trial (abstract). J Clin Oncol 25: 200s, 2007.
21. Schuhmacher C, Gretschel S, Lordick F, et al: Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer randomized trial 40954. J Clin Oncol 28: 5210-5218, 2010.
22. Persiani R, D'Ugo D, Rausei S, et al: Prognostic indicators in locally advanced gastric cancer (LAGC) treated with preoperative chemotherapy and D2-gastrectomy. J Surg Oncol 89: 227-236, 2005.
23. Moon H, JF J, Wu AW, et al: Oxaliplatin plus 5-fuorouracil/leueovorin (FOLFOX7) as neoadjuvant plus adjuvant treatment versus adjuvant alone in locally advanced resectable gastric cancer: BJSA-01 study design and interim results. Gastro-intestinal Cancers Symposium, Abstract No 39, 2007.
24. Cunningham D, Starling N, Rao S, et al: Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 358: 36-46, 2008.
25. Brown WA, Thomas J, Gotley D, et al: Use of oesophagogastroscopy to assess the response of oesophageal carcinoma to neoadjuvant therapy. Br J Surg 91: 199-204, 2004.
26. Ge L, Wang HJ, Yin D, et al: Effectiveness of 5-flurouracil-based neoadjuvant chemotherapy in locally-advanced gastric/gastroesophageal cancer: a meta-analysis. World J Gastroenterol 18: 7384-7393, 2012.
27. Liao Y, Yang ZL, Peng JS, Xiang J and Wang JP: Neoadjuvant chemotherapy for gastric cancer: a meta-analysis of randomized, controlled trials. J Gastroenterol Hepatol 28: 777-782, 2013