Longitudinal cohort studies of the prognosis of epilepsy: Contribution of the National General Practice Study of Epilepsy and other studies

Brain

Volumn 136, Issue 11, 2013, Pages 3497-3510

  Shorvon, Simon D ^a   Goodridge, David M G ^b  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b Warders Medical Centre   (United Kingdom)

Author keywords

Cohort studies; Epidemiology; Epilepsy prognosis; NGPSE

Indexed keywords

ANTICONVULSIVE AGENT;

ARTICLE; CENTRAL NERVOUS SYSTEM TUMOR; CEREBROVASCULAR DISEASE; COHORT ANALYSIS; COMPLEX PARTIAL SEIZURE; ENERGY; EPILEPSY; FEBRILE CONVULSION; FOLLOW UP; GENERALIZED EPILEPSY; HUMAN; LEISURE; LIFE EXPECTANCY; LONGITUDINAL STUDY; MORTALITY; MULTICENTER STUDY (TOPIC); NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; QUESTIONNAIRE; RECURRENCE RISK; RECURRENT DISEASE; REMISSION; SEIZURE; SIMPLE PARTIAL SEIZURE; STIGMA; STRUCTURED INTERVIEW; SUDDEN DEATH; SYMPTOMATIC EPILEPSY; TONIC CLONIC SEIZURE; TREATMENT RESPONSE;

EID: 84890539360     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt223     Document Type: Article

References (132)

1. Annegers JF, Hauser WA, Elveback LR. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979; 20: 729-37.
2. Anon. Basic Statistics on the epilepsies. Washington: Epilepsy Foundation of America; 1975.
3. Beghi E, Tognoni G. Prognosis of epilepsy in newly referred patients: a multicenter prospective study. Collaborative Group for the Study of Epilepsy. Epilepsia 1988; 29: 236-43.
4. Bell GS, Gaitatzis A, Johnson AL, Sander JW. Predictive value of death certification in the case ascertainment of epilepsy. J Neurol Neurosurg Psychiatry 2004; 75: 1756-8.
5. Berg AT, Shinnar S. Unprovoked seizures in children with febrile seizures: shortterm outcome. Neurology 1996; 47: 562-8.
6. Berg AT, Shinnar S, Levy SR, Testa FM, Smith-Rapaport S, Beckerman B, et al. Two-year remission and subsequent relapse in children with newly diagnosed epilepsy. Epilepsia 2001; 42: 1553-62.
7. Berg AT, Shinnar S, Testa FM, Levy SR, Smith SN, Beckerman B. Mortality in childhood-onset epilepsy. Arch Pediatr Adolesc Med 2004; 158: 1147-52.
8. Birca A, Guy N, Fortier I, Cossette P, Lortie A, Carmant L. Genetic influence on the clinical characteristics and outcome of febrile seizure-A retrospective study. Eur J Paediatr Neurol 2005; 9: 339-45.
9. Borusiak P, Herbold S. Serum neuron-specific enolase in children with febrile seizures: time profile and prognostic implications. Brain Dev 2003; 25: 272-4.
10. Britten N, Morgan K, Fenwick PB, Britten H. Epilepsy and handicap from birth to age 36. Dev Med Child Neurol 1986; 28: 719-28.
11. Brodie MJ, Barry SJ, Bamagous GA, Norrie JD, Kwan P. Patterns of treatment response in newly diagnosed epilepsy. Neurology 2012; 78: 1548-54.
12. Bronson LO, Wranne L. Long-Term prognosis in childhood epilepsy: survival and seizure prognosis. Epilepsia 1987; 28: 324-30.
13. Callaghan N, Kenny RA, O'Neill B, Crowley M, Goggin T. A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy. J Neurol Neurosurg Psychiatry 1985; 48: 639-44.
14. Callaghan N, O'Callaghan M, Duggan B, Feely M. Carbamazepine as a single drug in the treatment of epilepsy. A prospective study of serum levels and seizure control. J Neurol Neurosurg Psychiatr 1978; 41: 907-12.
15. Callenbach PM, Westendorp RG, Geerts AT, Arts WF, Peeters EA, van Donselaar CA, et al. Mortality risk in children with epilepsy: the Dutch study of epilepsy in childhood. Pediatrics 2001; 107: 1259-63.
16. Camfield CS, Camfield PR, Veugelers PJ. Death in children with epilepsy: a population-based study. Lancet 2002; 359: 1891-5.
17. Chang YC, Guo NW, Huang CC, Wang ST, Tsai JJ. Neurocognitive attention and behavior outcome of school-Age children with a history of febrile convulsions: a population study. Epilepsia 2000; 41: 412-20.
18. Chaplin JE, Yepez Lasso R, Shorvon SD, Floyd M. National general practice study of epilepsy: the social and psychological effects of a recent diagnosis of epilepsy. BMJ 1992; 304: 1416-8.
19. Chaplin JE, Floyd M, Lasso RY. Early psychosocial adjustment and the experience of epilepsy: findings from a general practice survey. Int J Rehabil Res 1993; 16: 316-18.
20. Charlton RA, Weil JG, Cunnington MC, de Vries CS. Identifying major congenital malformations in the UK General Practice Research Database (GPRD): a study reporting on the sensitivity and added value of photocopied medical records and free text in the GPRD. Drug Saf 2010; 33: 741-50.
21. Charlton RA, Weil JG, Cunnington MC, Ray S, de Vries CS. Comparing the general practice research database and the UK Epilepsy and pregnancy register as tools for postmarketing teratogen surveillance: anticonvulsants and the risk of major congenital malformations. Drug Saf 2011; 34: 157-71.
22. Chungath M, Shorvon S. The mortality and morbidity of febrile seizures. Nat Clin Pract Neurol 2008; 4: 610-21.
23. Cleary P, Shorvon S, Tallis R. Late-onset seizures as a predictor of subsequent stroke. Lancet 2004; 363: 1184-6.
24. Cockerell OC, Hart YM, Sander JW, Shorvon SD. The cost of epilepsy in the United Kingdom: an estimation based on the results of two population-based studies. Epilepsy Res 1994b; 18: 249-60.
25. Cockerell OC, Johnson AL, Sander JW, Hart YM, Goodridge DM, Shorvon SD. Mortality from epilepsy: results from a prospective population-based study. Lancet 1994a; 344: 918-21.
26. Cockerell OC, Johnson AL, Sander JW, Hart YM, Shorvon SD. Remission of epilepsy: results from the National General Practice Study of Epilepsy. Lancet 1995; 346: 140-4.
27. Cockerell OC, Johnson AL, Sander JW, Shorvon SD. Prognosis of epilepsy: a review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective populationbased study. Epilepsia 1997; 38: 31-46.
28. Collaborative Group for the Study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-Term course of epilepsy. Epilepsia 1992; 33: 45-51.
29. Derby LE, Tennis P, Jick H. Sudden unexplained death among subjects with refractory epilepsy. Epilepsia 1996; 37: 931-5.
30. de Silva M, MacArdle B, McGowan M, Hughes E, Stewart J, Neville B, et al. Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy. Lancet 1996; 347: 709-13.
31. Ding D, Wang W, Wu J, Yang H, Li S, Dai X, et al. Premature mortality risk in people with convulsive epilepsy: Long follow-up of a cohort in rural China. Epilepsia 2013; 54: 512-7.
32. El-Radhi AS. Lower degree of fever at the initial febrile convulsion is associated with increased risk of subsequent convulsions. Eur Paediatr Neurol 1998; 2: 91-6.
33. Elwes RD, Johnson AL, Shorvon SD, Reynolds EH. The prognosis for seizure control in newly diagnosed epilepsy. N Engl J Med 1984; 311: 944-7.
34. Feksi AT, Kaamugisha J, Sander JW, Gatiti S, Shorvon SD. Comprehensive primary healthcare antiepileptic drug treatment programme in rural and semi-urban Kenya. Lancet 1991; 337: 406-9.
35. Ficker DM, So EL, Annegers JF, O'Brien PC, Cascino GD, Belau PG. Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology 1998; 51: 1270-4.
36. Forsgren L. Prospective incidence study and clinical characterization of seizures in newly referred adults. Epilepsia 1990; 31: 292-301.
37. Forsgren L, Heijbel J, Nyström L, Sidenvall R. A follow-up of an incident case-referent study of febrile convulsions seven years after the onset. Seizure 1997; 6: 21-6.
38. Gaitatzis A, Johnson AL, Chadwick DW, Shorvon SD, Sander JW. Life expectancy in people with newly diagnosed epilepsy. Brain 2004; 127 (Pt 11): 2427-32.
39. Geerts A, Arts WF, Stroink H, Peeters E, Brouwer O, Peters B, et al. Course and outcome of childhood epilepsy: a 15-year follow-up of the Dutch study of epilepsy in childhood. Epilepsia 2010; 51: 1189-97.
40. Goodridge DM, Shorvon SD. Epileptic seizures in a population of 6000. II: treatment and prognosis. BMJ 1983a; 287: 645-7.
41. Goodridge DM, Shorvon SD. Epileptic seizures in a population of 6000. I: demography, diagnosis and classification, and role of the hospital services. BMJ 1983b; 287: 641-4.
42. Hackett R, Hackett L, Bhakta P. Febrile seizures in a South Indian district: incidence and associations. Dev Med Child Neurol 1997; 39: 380-4.
43. Hart YM, Sander JW, Johnson AL, Shorvon SD. National General Practice Study of epilepsy: recurrence after a first seizure. Lancet 1990; 336: 1271-4.
44. Hart Y, Sander J, Shorvon S. The National General-Practice Study of Epilepsy and Epileptic Seizures -objective and study methodology of the largest reported prospective cohort study of epilepsy. Neuroepidemiology 1989; 8: 221-7.
45. Hauser WA, Annegers JF, Elveback LR. Mortality in patients with epilepsy. Epilepsia 1980; 21: 399-412.
46. Hauser WA, Kurland LT. The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia 1975; 16: 1-66.
47. Heller AJ, Chesterman P, Elwes RD, Crawford P, Chadwick D, Johnson AL, et al. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. J Neurol Neurosurg Psychiatry 1995; 58: 44-50.
48. Hussain N, Appleton R, Thorburn K. Aetiology, course and outcome of children admitted to paediatric intensive care with convulsive status epilepticus: a retrospective 5-year review. Seizure 2007; 16: 305-12.
49. Jick SS, Cole TB, Mesher RA, Tennis P, Jick H. Sudden unexpected death in young persons with primary epilepsy. Pharmacoepidemiol Drug Saf 1992; 1: 59-64.
50. Keranen T, Riekkinen PJ. Remission of seizures in untreated epilepsy. BMJ 1993; 307: 483.
51. Kjeldsen MJ, Kyvik KO, Friis ML, Christensen K. Genetic and environmental factors in febrile seizures: a Danish population-based twin study. Epilepsy Res 2002; 51: 167-77.
52. Kim LG, Johnson TL, Marson AG, Chadwick DW; MRC MESS Study group. Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial. Lancet Neurol 2006; 5: 317-22.
53. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342: 314-9.
54. Kwan P, Wang W, Wu J, Li S, Yang H, Ding D, et al. Long-Term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study. Epilepsia 2013; 54: 537-42.
55. Laditan AA. Seizure recurrence after a first febrile convulsion. Ann Tropical Paediatr 1994; 14: 303-8.
56. Langan Y. The incidence of sudden unexpected deaths in epilepsy in South Dublin and Wicklow. Seizure 1998; 7: 355-8.
57. Lee WL, Ong HT. Afebrile seizures associated with minor infections: comparison with febrile seizures and unprovoked seizures. Pediatr Neurol 2004; 31: 157-64.
58. Leestma JE, Kalelkar MB, Teas SS, Jay GW, Hughes Jr. Sudden unexpected death associated with seizures: analysis of 66 cases. Epilepsia 1984; 25: 84-8.
59. Leestma JE, Walczak T, Hughes JR, Kalelkar MB, Teas SS. A prospective study on sudden unexpected death in epilepsy. Ann Neurol 1989; 26: 195-203.
60. Lhatoo SD, Johnson AL, Goodridge DM, MacDonald BK, Sander JW, Shorvon SD. Mortality in epilepsy in the first 11 to 14 years after diagnosis: multivariate analysis of a long-Term, prospective, population-based cohort. Ann Neurol 2001a; 49: 336-44.
61. Lhatoo SD, Langan Y, MacDonald BK, Zeidan S, Sander JW. Sudden unexpected death: a rare event in a large community based prospective cohort with newly diagnosed epilepsy and high remission rates. J Neurol Neurosurg Psychiatry 1999; 66: 692-3.
62. Lhatoo SD, Sander JW, Shorvon SD. The dynamics of drug treatment in epilepsy: an observational study in an unselected population based cohort with newly diagnosed epilepsy followed up prospectively over 11-14 years. J Neurol Neurosurg Psychiatry 2001b; 71: 632-7.
63. Lindsten H, Nyström L, Forsgren L. Mortality in an adult cohort with newly diagnosed unprovoked epileptic seizure. A population-based study. Epilepsia 2000; 41: 1469-73.
64. Lindsten H, Stenlund H, Forsgren L. Remission of seizures in a population-based adult cohort with a newly diagnosed unprovoked epileptic seizure. Epilepsia 2001; 42: 1025-30.
65. Loiseau J, Picot MC, Loiseau P. Short-Term mortality after a first epileptic seizure: a population-based study. Epilepsia 1999; 40: 1388-93.
66. Luciano A, Shorvon S. Results of treatment changes in patients with apparently drug-resistant chronic epilepsy. Ann Neurol 2007; 62: 375-81.
67. Manford M, Hart YM, Sander JW, Shorvon SD. National General Practice Study of Epilepsy (NGPSE): partial seizure patterns in a general population. Neurology 1992a; 42: 1911-7.
68. Manford M, Hart YM, Sander JW, Shorvon SD. The National General Practice Study of Epilepsy. The syndromic classification of the international league against epilepsy applied to epilepsy in a general population. Arch Neurol 1992b; 49: 801-8.
69. MacDonald BK, Johnson AL, Goodridge DM, Cockerell OC, Sander JW, Shorvon SD. Factors predicting prognosis of epilepsy after presentation with seizures. Ann Neurol 2000; 48: 833-41.
70. MacDonald BK, Johnson AL, Sander JW, Shorvon SD. Febrile convulsions in 220 children -neurological sequelae at 12 years follow-up. Eur Neurol 1999; 41: 179-86.
71. Marson A, Jacoby A, Johnson A, Kim L, Gamble C, Chadwick D. Medical Research Council MESS Study Group. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005; 365: 2007-13.
72. Marson AG, Williamson PR, Taylor S, Maguire M, Chadwick DW. Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures. Neurology 2006; 67: 1872-5.
73. Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partialepilepsy: an unblinded randomised controlled trial. Lancet 2007a; 369: 1000-15.
74. Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 2007b; 369: 1016-26.
75. Mauceri L, Pavone L. Febrile seizures: neurological findings after a 30-year follow-up. Ital J Pediatr 2002; 28: 295-300.
76. Metsäranta P, Koivikko M, Peltola J, Eriksson K. Outcome after prolonged convulsive seizures in 186 children: low morbidity, no mortality. Dev Med Child Neurol 2004; 46: 4-8.
77. Miyake S, Fujita F, Kitamura T, Ueda T, Murao S, Takahashi R. Followup study of children with a history of a febrile convulsion. Epilepsia 1996; 37 (Suppl 3): 72-3.
78. Musicco M, Beghi E, Solari A, Viani F. Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy: first seizure trial group (First Group). Neurology 1997; 49: 991-8.
79. Neligan A, Bell GS, Giavasi C, Johnson AL, Goodridge DM, Shorvon SD, et al. Long-Term risk of developing epilepsy after febrile seizures: a prospective cohort study. Neurology 2012; 78: 1166-70.
80. Neligan A, Bell GS, Johnson AL, Goodridge DM, Shorvon SD, Sander JW. The long-Term risk of premature mortality in people with epilepsy. Brain 2011; 134 (Pt 2): 388-95.
81. Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976; 295: 1029-33.
82. Nevo Y, Shinnar S, Samuel E, Kramer U, Leitner Y, Fatal A, et al. Unprovoked seizures and developmental disabilities: clinical characteristics of children referred to a child development center. Pediatr Neurol 1995; 13: 235-41.
83. Nicholas JM, Ridsdale L, Richardson MP, Grieve AP, Gulliford MC. Fracture risk with use of liver enzyme inducing antiepileptic drugs in people with active epilepsy: cohort study using the General Practice Research Database. Seizure 2013; 22: 37-42.
84. Nicoletti A, Sofia V, Vitale G, Bonelli SI, Bejarano V, Bartalesi F, et al. Natural history and mortality of chronic epilepsy in an untreated population of rural Bolivia: a follow-up after 10 years. Epilepsia 2009; 50: 2199-2206.
85. Oka E, Yamatogi Y, Ohtsuka Y, Ohtahara S. Clinical course and prognosis of childhood epilepsy. Acta Paediatr Jpn 1989; 31: 259-66.
86. Okuma T, Kumashiro H. The group for the study of prognosis of epilepsy in Japan: natural history and prognosis of epilepsy: report of a multiinstitutional study in Japan. Epilepsia 1981; 22: 35-53.
87. Okumara A, Ishiguro Y, Sofue A, Suzuki Y, Maruyama K, Kubota T, et al. Treatment and outcome in patients with febrile convulsion associated with epileptiform discharges on electroencephalography. Brain Dev 2004; 26: 241-4.
88. Olafsson E, Hauser WA, Gudmundsson G. Long-Term survival of people with unprovoked seizures. A population-based study. Epilepsia 1998; 39: 89-92.
89. Opeskin K, Berkovic SF. Risk factors for sudden unexpected death in epilepsy: a controlled prospective study based on coroners cases. Seizure 2003; 12: 456-64.
90. Pavlovic MV, Jarebinski MS, Pekmezovic TD, Marjanovic BD, Levic ZM. Febrile convulsions in a Serbian region: a 10-year epidemiological study. Eur J Neurol 1999; 6: 39-42.
91. Pavone L, Galli V, Rizzo R, Cice V, Cocuzza M, Cavazzuti GB, et al. Febrile and afebrile convulsions: a clinical follow-up. Childs Nerv Syst 1993; 9: 154-6.
92. Piperidou HN, Heliopoulos IN, Maltezos ES, Stathopoulos GA, Milonas IA. Retrospective study of febrile seizures: subsequent electroencephalogram findings, unprovoked seizures and epilepsy in adolescents. J Int Med Res 2002; 30: 560-5.
93. Placencia M, Sander JW, Shorvon SD, Roman M, Alarcon F, Bimos C, et al. Antiepileptic drug treatment in a community health care setting in northern Ecuador: a prospective 12-month assessment. Epilepsy Res 1993; 14: 237-44.
94. Placencia M, Sander JW, Roman M, Madera A, Crespo F, Cascante S, et al. The characteristics of epilepsy in a largely untreated population in rural Ecuador. J Neurol Neurosurg Psychiatry 1994; 57: 320-5.
95. Reynolds EH. Early treatment and prognosis of epilepsy. Epilepsia 1987; 28: 97-106.
96. Reynolds EH. Changing view of prognosis of epilepsy. BMJ 1990; 301: 1112-4.
97. Reynolds EH, Chadwick D, Galbraith AW. One drug (phenytoin) in the treatment of epilepsy. Lancet 1976; 1: 923-6.
98. Ridsdale L, Charlton J, Ashworth M, Richardson MP, Gulliford MC. Epilepsy mortality and risk factors for death in epilepsy: a population-based study. Br J Gen Pract 2011; 61: e271-8.
99. Rodin EA. The prognosis of patients with epilepsy. Illinois: Charles C Thomas; 1968.
100. Rosman NP, Colton T, Labazzo J, Gilbert PL, Gardella NB, Kaye EM, et al. A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. N Engl J Med 1993; 329: 79-84.
101. Ross EM, Peckham C, Butler NR. Epilepsy in childhood: findings from National Child Development Study. BMJ 1980; 1: 207-11.
102. Sander JW, Hart YM, Johnson AL, Shorvon SD. National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population. Lancet 1990; 336: 1267-71.
103. Sapir D, Leitner Y, Harel S, Kramer U. Unprovoked seizures after complex febrile convulsions. Brain Dev 2000; 22: 484-6.
104. Shorvon SD. The temporal aspects of prognosis in epilepsy. J Neurol Neurosurg Psychiatry 1984; 47: 1157-65.
105. Shorvon SD, Chadwick D, Galbraith AW, Reynolds EH. One drug for epilepsy. BMJ 1978; 1: 474-6.
106. Shorvon S, Luciano AL. Prognosis of chronic and newly diagnosed epilepsy: revisiting temporal aspects. Curr Opin Neurol 2007; 20: 208-12.
107. Shorvon SD, Reynolds EH. Early prognosis of epilepsy. BMJ 1982; 285: 1699-701.
108. Shorvon SD, Tallis RC, Wallace HK. Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice. J Neurol Neurosurg Psychiatry 2002; 72: 114-5.
109. Shorvon S, Tomson T. Sudden unexpected death in epilepsy. Lancet 2011; 378: 2028-38.
110. SillanpääM. Medico-social prpognosis of children with epilepsy. Epidemiological study and analysis of 245 patients. Acta Paetiatr Scand Suppl 1973; 237: 3-104.
111. SillanpääM, Jalava M, Kaleva O, Shinnar S. Long-Term prognosis of seizures with onset in childhood. N Engl J Med 1998; 338: 1715-22.
112. SillanpääM, Saarinen M, Schmidt D. Long-Term risks following first remission in childhood-onset epilepsy. A population-based study. Epilepsy Behav 2012; 25: 145-9.
113. SillanpääM, Schmidt D. Natural history of treated childhood-onset epilepsy: prospective, long-Term population-based study. Brain 2006; 129: 617-24.
114. SillanpääM, Schmidt D. Is incident drug resistant childhood-onset epilepsy reversible? A long-Term follow-up study. Brain 2012; 135 (Pt 7): 2256-62.
115. SillanpääM, Shinnar S. Long-Term mortality in childhood-onset epilepsy. N Engl J Med 2010; 362: 2522-9.
116. Souverein PC, Webb DJ, Weil JG, Van Staa TP, Egberts AC. Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy. Neurology 2006; 66: 1318-24.
117. Souverein PC, Webb DJ, Petri H, Weil J, Van Staa TP, Egberts T. Incidence of fractures among epilepsy patients: a population-based retrospective cohort study in the General Practice Research Database. Epilepsia 2005; 46: 304-10.
118. Tarkka R, PääkköE, Phytinen J, Uhari M, Rantala H. Febrile seizures and mesial temporal sclerosis, no association in a long-Term follow-up study. Neurology 2003; 60: 215-18.
119. Tarkka R, Uhari M, Rantala H, Pokka T. Risk of recurrence and outcome after the first febrile seizure. Neurology 1998; 18: 218-20.
120. Tennis P, Cole TB, Annegers JF, Leestma JE, McNutt M, Rajput A. Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada. Epilepsia 1995; 36: 29-36.
121. Terrence CF Jr, Wisotzkey HM, Perper JA. Unexpected, unexplained death in epileptic patients. Neurology 1975; 25: 594-8.
122. Tsai ML, Hung KL. Risk factors for subsequent epilepsy after febrile convulsions. J Formos Med Assoc 1995; 94: 327-31.
123. Verity CM, Ross EM, Golding G. Outcome of childhood status epilepticus and lengthy febrile convulsions: findings of national cohort study. BMJ 1993; 307: 225-8.
124. Verity C, Ross EM, Golding J. Epilepsy in the first 10 years of life: findings of the child health and education study. BMJ 1992; 305: 857-61.
125. van Esch A, Ramlal IR, van Steensel-Moll HA, Steyerberg EW, Derjseb-Lubsen G. Outcome after febrile status epilepticus. Dev Med Child Neurol 1996; 38: 19-24.
126. Vestergaard M, Hviid A, Madsen KM, Wohlfahrt J, Thorsen P, Schendel D, et al. MMR vaccination and febrile seizures. Evaluation of susceptible subgroups and long-Term prognosis. JAMA 2004; 292: 351-7.
127. Vestergaard M, Pedersen CB, Sidenius P, Olsen J, Christensen J. The long-Term risk of Epilepsy after febrile seizure in susceptible subgroups. Am J Epidemiol 2007; 165: 911-18.
128. Wakamoto H, Nagao H, Hayashi M, Morimoto T. Long-Term medical, educational, and social prognoses of childhood-onset epilepsy: a population-based study in a rural district of Japan. Brain Dev 2000; 22: 246-55.
129. Wallace H, Shorvon S, Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 1998; 352: 1970-3.
130. Watts AE. The natural history of untreated epilepsy in a rural community in Africa. Epilepsia 1992; 33: 464-8.
131. Yu ZL, Jiang JM, Wu DH, Xie HJ, Jiang JJ, Zhou L, et al. Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific gene. J Neurosci Res 2007; 85: 166-72.
132. Yucel O, Aka S, Yazicioglu L, Ceran O. Role of early EEG and neuroimaging in determination of prognosis in children with complex febrile seizures. Pediatr Int 2004; 46: 463-7.