Toll-like receptor 4 is required for the cytotoxicity of cytokine-induced killer cells

Acta Haematologica

Volumn 132, Issue 1, 2014, Pages 5-9

  Cai, Chunyuan ^a   Chen, Weibo ^a   Miao, Daoyi ^a   Cheng, Li ^a   Yang, Guojing ^a   Zhang, Linzhou ^a   Li, Yongjiang ^a   Zhang, Lei ^a  

^a THE THIRD AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cytokine induced killer cells; Cytotoxicity; Toll like receptor 4

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4;

ARTICLE; CYTOKINE INDUCED KILLER CELL; CYTOKINE PRODUCTION; CYTOTOXICITY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL; UPREGULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLYSIS; GENE SILENCING; LEUKEMIA CELL LINE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL LINE; CYTOKINE-INDUCED KILLER CELLS; CYTOTOXICITY, IMMUNOLOGIC; GENE KNOCKDOWN TECHNIQUES; HEMATOLOGIC NEOPLASMS; HUMANS; IMMUNITY, INNATE; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-15; INTERLEUKIN-6; K562 CELLS; LEUKEMIA; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84890528855     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000355190     Document Type: Article

References (21)

1. Linn YC, Hui KM: Cytokine-induced NK-like T cells: from bench to bedside. J Biomed Biotechnol 2010; 2010: 435745.
2. Jiang J, Wu C, Lu B: Cytokine-induced killer cells promote antitumor immunity. J Transl Med 2013; 11: 83.
3. Guo L, Junttila IS, Paul WE: Cytokine-induced cytokine production by conventional and innate lymphoid cells. Trends Immunol 2012; 33: 598-606.
4. Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL: Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 1991; 174: 139-149.
5. Introna M, Borleri G, Conti E, Franceschetti M, Barbui AM, Broady R, Dander E, Gaipa G, D'Amico G, Biagi E, Parma M, Pogliani EM, Spinelli O, Baronciani D, Grassi A, Golay J, Barbui T, Biondi A, Rambaldi A: Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study. Haematologica 2007; 92: 952-959.
6. Alajez NM, Schmielau J, Alter MD, Cascio M, Finn OJ: Therapeutic potential of a tumorspecific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution. Blood 2005; 105: 4583-4589.
7. Xu Y, Jagannath C, Liu X-D, Sharafkhaneh A, Kolodziejska KE, Eissa NT: Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27: 135-144.
8. Xu C, Liu J, Hsu L-C, Luo Y, Xiang R, Chuang T-H: Functional interaction of heat shock protein 90 and beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J 2011; 25: 2700-2710.
9. Blasius AL, Beutler B: Intracellular Toll-like receptors. Immunity 2010; 32: 305-315.
10. Kawai T, Akira S: Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011; 34: 637-650.
11. Rettinger E, Kuci S, Naumann I, Becker P, Kreyenberg H, Anzaghe M, Willasch A, Koehl U, Bug G, Ruthardt M, Klingebiel T, Fulda S, Bader P: The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. Cytotherapy 2012; 14: 91-103.
12. Kuci S, Rettinger E, Voss B, Weber G, Stais M, Kreyenberg H, Willasch A, Kuci Z, Koscielniak E, Kloss S, von Laer D, Klingebiel T, Bader P: Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation. Haematologica 2010; 95: 1579-1586.
13. Niam M, Linn YC, Fook Chong S, Lim TJ, Chu S, Choong A, Yong HX, Suck G, Chan M, Koh M: Clinical scale expansion of cytokineinduced killer cells is feasible from healthy donors and patients with acute and chronic myeloid leukemia at various stages of therapy. Exp Hematol 2011; 39: 897-903.e891.
14. Marin V, Pizzitola I, Agostoni V, Attianese GM, Finney H, Lawson A, Pule M, Rousseau R, Biondi A, Biagi E: Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica 2010; 95: 2144-2152.
15. Greaves P, Gribben JG: The role of B7 family molecules in hematologic malignancy. Blood 2013; 121: 734-744.
16. Jenq RR, van den Brink MR: Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer. Nat Rev Cancer 2010; 10: 213-221.
17. Huang XJ, Chang YJ: Unmanipulated HLAmismatched/haploidentical blood and marrow hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17: 197-204.
18. Koh LP, Rizzieri DA, Chao NJ: Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors. Biol Blood Marrow Transplant 2007; 13: 1249-1267.
19. Penack O, Holler E, van den Brink MRM: Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood 2010; 115: 1865-1872.
20. Stenger EO, Turnquist HR, Mapara MY, Thomson AW: Dendritic cells and regulation of graft-versus-host disease and graft-versusleukemia activity. Blood 2012; 119: 5088-5103.
21. Lin G, Wang J, Lao X, Wang J, Li L, Li S, Zhang J, Dong Y, Chang AE, Li Q, Li S: Interleukin-6 inhibits regulatory T cells and improves the proliferation and cytotoxic activity of cytokine-induced killer cells. J Immunother 2012; 35: 337-343.