Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer

Protein Engineering, Design and Selection

Volumn 26, Issue 11, 2013, Pages 743-753

  Podust, Vladimir N ^a   Sim, Bee Cheng ^a   Kothari, Dharti ^a   Henthorn, Lana ^a   Gu, Chen ^a   Wang, Chia Wei ^a   McLaughlin, Bryant ^a   Schellenberger, Volker ^a  

^a Amunix Inc   (United States)

Author keywords

Chemical conjugation; GLP2; Half life extension; Protein polymer; XTEN

Indexed keywords

BIODEGRADABLE PROTEINS; BIOLOGICALLY ACTIVE MOLECULES; BIOLOGICALLY ACTIVE PEPTIDES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GLP2; HALF-LIFE EXTENSION; PROTEIN POLYMERS; XTEN;

CONJUGATED POLYMERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULES; PEPTIDES; PLASMA STABILITY; POLYMERS; PURIFICATION;

CHROMATOGRAPHY;

GLUCAGON LIKE PEPTIDE 2; GLUCAGON LIKE PEPTIDE 2 2G; MALEIMIDE; POLYMER; THIOL; UNCLASSIFIED DRUG; XTEN PROTEIN POLYMER;

ARTICLE; COMPARATIVE STUDY; DRUG CONJUGATION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED PHASE LIQUID CHROMATOGRAPHY;

CHEMICAL CONJUGATION; GLP2; HALF-LIFE EXTENSION; PROTEIN POLYMER; XTEN;

AMINO ACID SEQUENCE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FEMALE; GLUCAGON-LIKE PEPTIDE 2; HALF-LIFE; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84890517477     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt048     Document Type: Article

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