Evaluation of the anti-atherogenic potential of chrysin in Wistar rats

Molecular and Cellular Biochemistry

Volumn 385, Issue 1-2, 2014, Pages 103-113

  Anandhi, Ramalingam ^a   Thomas, Philip A ^b   Geraldine, Pitchairaj ^a  

^a BHARATHIDASAN UNIVERSITY   (India)

^b JOSEPH EYE HOSPITAL   (India)

Author keywords

Antioxidant; Atherogenic diet; Atherosclerosis; Chrysin; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; CHRYSIN; FLAVONOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LACTATE DEHYDROGENASE; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER; MALE; NONHUMAN; RAT; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; FLAVONOIDS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPIDS; LIPOPROTEIN LIPASE; LIVER; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR;

EID: 84890502277     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1819-z     Document Type: Article

References (64)

1. Mensink RP, Aro A, Den Hond E, German JB, Griffin BA, ten Meer HU, Mutanen M, Pannemans D, Stahl W (2003) PASSCLAIM - Diet-related cardiovascular disease. Eur J Nutr 42:16-27
2. Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425-430
3. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915-924
4. Halliwell B (1996) Mechanisms involved in the generation of free radicals. Pathol Biol (Paris) 44:6-13
5. Shi W, Haberland ME, Jien ML, Shih DM, Lusis AJ (2000) Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation 102:75-81
6. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O (2000) Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic Res 33:197-215
7. Carew TE, Schwenke DC, Steinberg D (1987) Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 84:7725-7729
8. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P (1995) The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 332:488-493
9. Diaz MN, Frei B, Vita JA, Keaney JF Jr (1997) Antioxidants and atherosclerotic heart disease. N Engl J Med 337:408-416
10. Chrysselis MC, Rekka EA, Kourounakis PN (2000) Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity. J Med Chem 43:609-612
11. Wolfman C, Viola H, Paladini A, Dajas F, Medina JH (1994) Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 47:1-4
12. Rapta P, Misík V, Stasko A, Vrábel I (1995) Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study. Free Radic Biol Med 18:901-908
13. Williams CA, Harborne JB, Newman M, Greenham J, Eagles J (1997) Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry 46:1349-1353
14. Habtemariam S (1997) Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells. J Nat Prod 60:775-778
15. Dhawan K, Kumar S, Sharma A (2002) Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food 5:43-48
16. Cho H, Yun CW, Park WK, Kong JY, Kim KS, Park Y, Lee S, Kim BK (2004) Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. Pharmacol Res 49:37-43
17. Bradford M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
18. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
19. Baginsky ML (1981) Measurement of lipoprotein lipase and hepatic triglyceride lipase in human postheparin plasma. Methods Enzymol 72:325-338
20. Rao AV, Ramakrishnan S (1975) Indirect assessment of hydroxymethylglutaryl-CoA reductase (NADPH) activity in liver tissue. Clin Chem 21:1523-1525
21. King J (1965) The transferases-alanine and aspartate transaminases. In: Van D (ed) Practical clinical enzymology. Nostrand Company Limited, London, pp 121-138
22. King J (1965) The hydrolases - acid and alkaline phosphatases. In: Van D (ed) Practical clinical enzymology. Nostrand Company Limited, London, pp 191-208
23. King J (1965) The dehydrogenases or oxidoreductases - lactate dehydrogenase. In: Van D (ed) Practical clinical enzymology. Nostrand Company Limited, London, pp 83-93
24. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47:389-394
25. Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474
26. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588-590
27. Moron MS, Depierre JW, Mannervik B (1979) Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 582:67-78
28. Omaye ST, Turnbull JD, Sauberlich HE (1979) Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3-11
29. Desai ID (1984) Vitamin E analysis methods for animal tissues. Methods Enzymol 105:138-147
30. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
31. Drury RAD, Wallington EA (1980) Carleton's histological technique. Oxford University Press, New York
32. Eisenberg DA (1998) Cholesterol lowering in the management of coronary artery disease: the clinical implications of recent trials. Am J Med 104:2S-5S
33. Sudhahar V, Kumar SA, Varalakshmi P (2006) Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia. Life Sci 78:1329-1335
34. Thiruchenduran M, Vijayan NA, Sawaminathan JK, Devaraj SN (2011) Protective effect of grape seed proanthocyanidins against cholesterol cholic acid diet-induced hypercholesterolemia in rats. Cardiovasc Pathol 20:361-368. doi: 10.1016/j.carpath.2010.09.002
35. Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, Suthisisang C (2006) Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol 103:252-260
36. Wang L, Geng C, Jiang L, Gong D, Liu D, Yoshimura H, Zhong L (2008) The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr 47:235-243. doi: 10.1007/s00394-008-0717-8
37. Raja B, Saravanakumar M, Sathya G (2012) Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet. Mol Cell Biochem 366:21-30. doi: 10.1007/s11010-012-1278-y
38. Balasinska B (1998) Hypocholesterolemic effect of dietary evening primrose (Oenothera paradoxa) cake extract in rats. Food Chem 63:453-459
39. Chanet A, Milenkovic D, Deval C, Potier M, Constans J, Mazur A, Bennetau-Pelissero C, Morand C, Bérard AM (2012) Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. J Nutr Biochem 23:469-477. doi: 10.1016/j.jnutbio.2011.02.001
40. Kim HK, Jeong TS, Lee MK, Park YB, Choi MS (2003) Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clin Chim Acta 327:129-137
41. Bensadoun A (1991) Lipoprotein lipase. Annu Rev Nutr 11:217-237
42. Reymer PW, Groenemeyer BE, Gagné E, Miao L, Appelman EE, Seidel JC, Kromhout D, Bijvoet SM, van de Oever K, Bruin T et al (1995) A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia. Hum Mol Genet 4:1543-1549
43. Kavitha R, Nalini N (2001) Hypolipidemic effect of green and red chilli extract in rats fed high fat diet. Med Sci Res 28:17-21
44. Sudhahar V, Ashokkumar S, Varalakshmi P (2006) Effect of lupeol and lupeol linoleate on lipemic-hepatocellular aberrations in rats fed a high cholesterol diet. Mol Nutr Food Res 50:1212-1219
45. Kita T, Brown MS, Goldstein JL (1980) Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 66:1094-1100
46. Vijayakumar RS, Nalini N (2006) Lipid-lowering efficacy of piperine from Piper nigrum L. in high-fat diet and antithyroid drug-induced hypercholesterolemic rats. J Food Biochem 30:405-421
47. Napoli C, de Nigris F, Palinski W (2001) Multiple role of reactive oxygen species in the arterial wall. J Cell Biochem 82:674-682
48. Keaney JF Jr, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA (1994) Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest 93:844-851
49. Gupta PP, Tandon HD, Ramalingaswami V (1976) Cirrhosis of the liver in rabbits induced by a high cholesterol diet - an experimental model. Indian J Med Res 64:1516-1526
50. Molander DW, Wroblewski F, Ladue JS (1955) Serum glutamic oxalacetic transaminase as an index of hepatocellular integrity. J Lab Clin Med 46:831-839
51. Prasad K, Kalra J (1993) Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J 125:958-973
52. Sheela CG, Augusti KT (1995) Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats. Indian J Exp Biol 33:337-341
53. Sathiavelu J, Senapathy GJ, Devaraj R, Namasivayam N (2009) Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. J Pharm Pharmacol 61:809-817
54. Recknagel RO, Glende EA Jr, Britton RS (1991) Free radical damage and lipid peroxidation. In: Meeks RG (ed) Hepatotoxicology. CRC Press, Boca Raton, pp 401-436
55. Deepa PR, Varalakshmi P (2004) Protective effects of certoparin sodium, a low molecular weight heparin derivative, in experimental atherosclerosis. Clin Chim Acta 339:105-115
56. Traber MG, Sies H (1996) Vitamin E in humans: demand and delivery. Annu Rev Nutr 16:321-347
57. Freeman BA, Crapo JD (1982) Biology of disease: free radicals and tissue injury. Lab Invest 47:412-426
58. Halliwell B (2000) Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res 47:410-418
59. Gutteridge JM, Halliwell B (1990) The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 15:129-135
60. Geetha RK, Vasudevan DM (2004) Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies. Life Sci 76:21-28
61. Wissler RW (1992) Theories and new horizons in the pathogenesis of atherosclerosis and the mechanisms of clinical effects. Arch Pathol Lab Med 116:1281-1291
62. Gökkusu C, Ademoǧlu E, Türkoǧlu UM, Oz H, Oz F (1996) Thymosin alpha 1 protects liver and aorta from oxidative damage in atherosclerotic rabbits. Life Sci 59:1059-1067
63. Sankhari JM, Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV (2012) Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet. J Sci Food Agric 92:1688-1693
64. Mitani H, Egashira K, Kimura M (2003) HMG-CoA reductase inhibitor, fluvastatin, has cholesterol-lowering independent "direct" effects on atherosclerotic vessels in high cholesterol diet-fed rabbits. Pharmacol Res 48:417-427