메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages 325-332

The new landscape of therapy for myelofibrosis

Author keywords

Hematologic malignancy; JAK2 inhibitors; Myelofibrosis; Myeloproliferative neoplasms; Ruxolitinib

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; ANDROGEN; ANTIANEMIC AGENT; BMS 911543; CORTICOSTEROID; EVEROLIMUS; FEDRATINIB; GANDOTINIB; GIVINOSTAT; GRN 163; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; IMMUNOMODULATING AGENT; INCB 39110; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; LENALIDOMIDE; LESTAURTINIB; MOMELOTINIB; NS 018; PACRITINIB; PANOBINOSTAT; PHENYLALANINE; PLACEBO; POMALIDOMIDE; PREDNISONE; PROTEIN TYROSINE KINASE INHIBITOR; RUXOLITINIB; SARIDEGIB; SIMTUZUMAB; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE; XL 019;

EID: 84890501821     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-013-0178-x     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 34248364065 scopus 로고    scopus 로고
    • Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)
    • Mesa RA, Verstovsek S, Cervantes F, Barosi G, Reilly JT, Dupriez B et al. Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). Leuk Res. 2007.
    • (2007) Leuk Res
    • Mesa, R.A.1    Verstovsek, S.2    Cervantes, F.3    Barosi, G.4    Reilly, J.T.5    Dupriez, B.6
  • 2
    • 28244496095 scopus 로고    scopus 로고
    • A JAK2 mutation in myeloproliferative disorders: Pathogenesis and therapeutic and scientific prospects
    • 16271512 10.1016/j.molmed.2005.10.003 1:CAS:528:DC%2BD2MXht1Omsr3I The first description of JAK2-V617F in MPNs, a watershed both in therapeutic targeting and well as pathogenetic insight
    • James C, Ugo V, Casadevall N, Constantinescu SN, Vainchenker W. A JAK2 mutation in myeloproliferative disorders: Pathogenesis and therapeutic and scientific prospects. Trends Mol Med. 2005;11(12):546-54. The first description of JAK2-V617F in MPNs, a watershed both in therapeutic targeting and well as pathogenetic insight.
    • (2005) Trends Mol Med , vol.11 , Issue.12 , pp. 546-554
    • James, C.1    Ugo, V.2    Casadevall, N.3    Constantinescu, S.N.4    Vainchenker, W.5
  • 3
    • 17644424955 scopus 로고    scopus 로고
    • A gain of function mutation in Jak2 is frequently found in patients with myeloproliferative disorders
    • 15858187 10.1056/NEJMoa051113 1:CAS:528:DC%2BD2MXjsFyhsLw%3D
    • Kralovics R, Passamonti F, Buser AS, Soon-Siong T, Tiedt R, Passweg JR, et al. A gain of function mutation in Jak2 is frequently found in patients with myeloproliferative disorders. New Engl J Med. 2005;352:1779-90.
    • (2005) New Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3    Soon-Siong, T.4    Tiedt, R.5    Passweg, J.R.6
  • 4
    • 84866613593 scopus 로고    scopus 로고
    • Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms
    • 10.1016/j.hoc.2012.07.006 23009937 10.1016/j.hoc.2012.07.006
    • Abdel-Wahab O, Tefferi A, Levine RL. Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms. Hematol Oncol Clin North Am. 2012;26(5):1053-64. doi: 10.1016/j.hoc.2012.07.006.
    • (2012) Hematol Oncol Clin North Am , vol.26 , Issue.5 , pp. 1053-1064
    • Abdel-Wahab, O.1    Tefferi, A.2    Levine, R.L.3
  • 5
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • 10.1056/NEJMoa0810069 19474426 10.1056/NEJMoa0810069
    • Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-301. doi: 10.1056/NEJMoa0810069.
    • (2009) N Engl J Med , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della Valle, V.3    James, C.4    Trannoy, S.5    Masse, A.6
  • 6
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • 10.1182/blood-2010-02-270108 20404132 10.1182/blood-2010-02-270108 1:CAS:528:DC%2BC3cXhtFSks7%2FF
    • Oh ST, Simonds EF, Jones C, Hale MB, Goltsev Y, Gibbs Jr KD, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116(6):988-92. doi: 10.1182/blood-2010-02-270108.
    • (2010) Blood , vol.116 , Issue.6 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3    Hale, M.B.4    Goltsev, Y.5    Gibbs Jr., K.D.6
  • 7
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • 16834459 10.1371/journal.pmed.0030270
    • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270.
    • (2006) PLoS Med , vol.3 , Issue.7 , pp. 270
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6
  • 8
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • 10.1038/nrc3343 22898539 10.1038/nrc3343 1:CAS:528:DC%2BC38Xht1Wkt7zF
    • Shih AH, Abdel-Wahab O, Patel JP, Levine RL. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer. 2012;12(9):599-612. doi: 10.1038/nrc3343.
    • (2012) Nat Rev Cancer , vol.12 , Issue.9 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3    Levine, R.L.4
  • 9
    • 77954581139 scopus 로고    scopus 로고
    • Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    • 10.1038/leu.2010.69 20428194 10.1038/leu.2010.69 1:CAS:528: DC%2BC3cXntFShs78%3D
    • Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia. 2010;24(6):1128-38. doi: 10.1038/leu.2010.69.
    • (2010) Leukemia , vol.24 , Issue.6 , pp. 1128-1138
    • Tefferi, A.1
  • 10
    • 80051931772 scopus 로고    scopus 로고
    • New mutations and pathogenesis of myeloproliferative neoplasms
    • 10.1182/blood-2011-02-292102 21653328 10.1182/blood-2011-02-292102 1:CAS:528:DC%2BC3MXhtFeqsLfP
    • Vainchenker W, Delhommeau F, Constantinescu SN, Bernard OA. New mutations and pathogenesis of myeloproliferative neoplasms. Blood. 2011;118(7):1723-35. doi: 10.1182/blood-2011-02-292102.
    • (2011) Blood , vol.118 , Issue.7 , pp. 1723-1735
    • Vainchenker, W.1    Delhommeau, F.2    Constantinescu, S.N.3    Bernard, O.A.4
  • 11
    • 84859226893 scopus 로고    scopus 로고
    • Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms
    • 10.1007/s11899-011-0105-y 22170482 10.1007/s11899-011-0105-y
    • Zhang SJ, Abdel-Wahab O. Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms. Curr Hematol Malig Rep. 2012;7(1):34-42. doi: 10.1007/s11899-011-0105-y.
    • (2012) Curr Hematol Malig Rep , vol.7 , Issue.1 , pp. 34-42
    • Zhang, S.J.1    Abdel-Wahab, O.2
  • 12
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • 10.1182/blood-2009-03-209262 19357394
    • Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009. doi: 10.1182/blood-2009-03-209262.
    • (2009) Blood
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 13
    • 84879781319 scopus 로고    scopus 로고
    • Progressive burden of myelofibrosis in untreated patients: Assessment of patient-reported outcomes in patients randomized to placebo in the COMFORT-I study
    • 10.1016/j.leukres.2013.04.017 23684482
    • Mesa RA, Shields A, Hare T, Erickson-Viitanen S, Sun W, Sarlis NJ, et al. Progressive burden of myelofibrosis in untreated patients: Assessment of patient-reported outcomes in patients randomized to placebo in the COMFORT-I study. Leuk Res. 2013. doi: 10.1016/j.leukres.2013.04.017.
    • (2013) Leuk Res
    • Mesa, R.A.1    Shields, A.2    Hare, T.3    Erickson-Viitanen, S.4    Sun, W.5    Sarlis, N.J.6
  • 14
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • 10.1182/blood-2008-07-170449 18988864 10.1182/blood-2008-07-170449 1:CAS:528:DC%2BD1MXktFWnsLc%3D
    • Cervantes F, Dupriez B, Pereira A, Passamonti F, Reilly JT, Morra E, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113(13):2895-901. doi: 10.1182/blood-2008-07-170449.
    • (2009) Blood , vol.113 , Issue.13 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3    Passamonti, F.4    Reilly, J.T.5    Morra, E.6
  • 15
    • 84869381382 scopus 로고    scopus 로고
    • Myeloproliferative neoplasm (MPN) symptom assessment form total symptom score: Prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs
    • 10.1200/JCO.2012.42.3863 23071245 10.1200/JCO.2012.42.3863
    • Emanuel RM, Dueck AC, Geyer HL, Kiladjian JJ, Slot S, Zweegman S, et al. Myeloproliferative neoplasm (MPN) symptom assessment form total symptom score: Prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs. J Clin Oncol. 2012;30(33):4098-103. doi: 10.1200/JCO.2012.42.3863.
    • (2012) J Clin Oncol , vol.30 , Issue.33 , pp. 4098-4103
    • Emanuel, R.M.1    Dueck, A.C.2    Geyer, H.L.3    Kiladjian, J.J.4    Slot, S.5    Zweegman, S.6
  • 16
    • 77949328094 scopus 로고    scopus 로고
    • Thrombosis in primary myelofibrosis: Incidence and risk factors
    • 10.1182/blood-2009-08-238956 19965680 10.1182/blood-2009-08-238956 1:CAS:528:DC%2BC3cXhs1Giur0%3D
    • Barbui T, Carobbio A, Cervantes F, Vannucchi AM, Guglielmelli P, Antonioli E, et al. Thrombosis in primary myelofibrosis: Incidence and risk factors. Blood. 2010;115(4):778-82. doi: 10.1182/blood-2009-08-238956.
    • (2010) Blood , vol.115 , Issue.4 , pp. 778-782
    • Barbui, T.1    Carobbio, A.2    Cervantes, F.3    Vannucchi, A.M.4    Guglielmelli, P.5    Antonioli, E.6
  • 17
    • 79960437973 scopus 로고    scopus 로고
    • The myeloproliferative neoplasm symptom assessment form (MPN-SAF): International prospective validation and reliability trial in 402 patients
    • 10.1182/blood-2011-01-328955 21536863 10.1182/blood-2011-01-328955 1:CAS:528:DC%2BC3MXpsVWmtbw%3D
    • Scherber R, Dueck AC, Johansson P, Barbui T, Barosi G, Vannucchi AM, et al. The myeloproliferative neoplasm symptom assessment form (MPN-SAF): International prospective validation and reliability trial in 402 patients. Blood. 2011;118(2):401-8. doi: 10.1182/blood-2011-01-328955.
    • (2011) Blood , vol.118 , Issue.2 , pp. 401-408
    • Scherber, R.1    Dueck, A.C.2    Johansson, P.3    Barbui, T.4    Barosi, G.5    Vannucchi, A.M.6
  • 19
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • 10.1182/blood-2009-09-245837 20008785 10.1182/blood-2009-09-245837 1:CAS:528:DC%2BC3cXjtlGisL4%3D
    • Passamonti F, Cervantes F, Vannucchi AM, Morra E, Rumi E, Pereira A, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-8. doi: 10.1182/blood-2009-09-245837.
    • (2010) Blood , vol.115 , Issue.9 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3    Morra, E.4    Rumi, E.5    Pereira, A.6
  • 20
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS plus: A refined dynamic international prognostic scoring system for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • 21149668 10.1200/JCO.2010.32.2446
    • Gangat N, Caramazza D, Vaidya R, George G, Begna K, Schwager S, et al. DIPSS plus: A refined dynamic international prognostic scoring system for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29(4):392-7.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3    George, G.4    Begna, K.5    Schwager, S.6
  • 21
    • 84872049837 scopus 로고    scopus 로고
    • The evolving treatment paradigm in myelofibrosis
    • 10.3109/10428194.2012.710905 22793267 10.3109/10428194.2012.710905 1:CAS:528:DC%2BC3sXktFKgsg%3D%3D
    • Mesa RA. The evolving treatment paradigm in myelofibrosis. Leuk Lymphoma. 2013;54(2):242-51. doi: 10.3109/10428194.2012.710905.
    • (2013) Leuk Lymphoma , vol.54 , Issue.2 , pp. 242-251
    • Mesa, R.A.1
  • 22
    • 73949084969 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: A prospective, multicenter study of the chronic leukemia working party of the European group for blood and marrow transplantation
    • 10.1182/blood-2009-07-234880 19812383 10.1182/blood-2009-07-234880
    • Kroger N, Holler E, Kobbe G, Bornhauser M, Schwerdtfeger R, Baurmann H, et al. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the chronic leukemia working party of the European group for blood and marrow transplantation. Blood. 2009;114(26):5264-70. doi: 10.1182/blood-2009-07-234880.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5264-5270
    • Kroger, N.1    Holler, E.2    Kobbe, G.3    Bornhauser, M.4    Schwerdtfeger, R.5    Baurmann, H.6
  • 23
    • 84890460988 scopus 로고    scopus 로고
    • Allogeneic stem cell transplant for myelofibrosis patients over age 60: Likely impact of the JAK2 inhibitors
    • Fauble V, Leis J, Mesa R. Allogeneic stem cell transplant for myelofibrosis patients over age 60: likely impact of the JAK2 inhibitors. Leukemia. 2012(Supplement 2012):S2-S7
    • (2012) Leukemia , Issue.SUPPL. 2012
    • Fauble, V.1    Leis, J.2    Mesa, R.3
  • 24
    • 21344468831 scopus 로고    scopus 로고
    • Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: Long-term results in 30 patients
    • 15953003 10.1111/j.1365-2141.2005.05524.x 1:CAS:528:DC%2BD2MXms1ehsL8%3D
    • Cervantes F, Alvarez-Larran A, Domingo A, Arellano-Rodrigo E, Montserrat E. Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: Long-term results in 30 patients. Br J Haematol. 2005;129(6):771-5.
    • (2005) Br J Haematol , vol.129 , Issue.6 , pp. 771-775
    • Cervantes, F.1    Alvarez-Larran, A.2    Domingo, A.3    Arellano-Rodrigo, E.4    Montserrat, E.5
  • 25
    • 33947691295 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis
    • 10.1159/000097463 17159338 10.1159/000097463 1:CAS:528: DC%2BD2sXjsV2is78%3D
    • Tsiara SN, Chaidos A, Bourantas LK, Kapsali HD, Bourantas KL. Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis. Acta Haematol. 2007;117(3):156-61. doi: 10.1159/000097463.
    • (2007) Acta Haematol , vol.117 , Issue.3 , pp. 156-161
    • Tsiara, S.N.1    Chaidos, A.2    Bourantas, L.K.3    Kapsali, H.D.4    Bourantas, K.L.5
  • 26
    • 67650766311 scopus 로고    scopus 로고
    • Erythropoiesis stimulating agents have limited therapeutic activity in transfusion-dependent patients with primary myelofibrosis regardless of serum erythropoietin level
    • 10.1111/j.1600-0609.2009.01266.x 19366369 10.1111/j.1600-0609.2009.01266. x 1:CAS:528:DC%2BD1MXpvFehsLo%3D
    • Huang J, Tefferi A. Erythropoiesis stimulating agents have limited therapeutic activity in transfusion-dependent patients with primary myelofibrosis regardless of serum erythropoietin level. Eur J Haematol. 2009;83(2):154-5. doi: 10.1111/j.1600-0609.2009.01266.x.
    • (2009) Eur J Haematol , vol.83 , Issue.2 , pp. 154-155
    • Huang, J.1    Tefferi, A.2
  • 27
    • 78650355146 scopus 로고    scopus 로고
    • International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens
    • 10.1002/ajh.21892 21132732 10.1002/ajh.21892 1:CAS:528: DC%2BC3MXhs1altr0%3D
    • Thapaliya P, Tefferi A, Pardanani A, Steensma DP, Camoriano J, Wu W, et al. International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens. Am J Hematol. 2011;86(1):96-8. doi: 10.1002/ajh.21892.
    • (2011) Am J Hematol , vol.86 , Issue.1 , pp. 96-98
    • Thapaliya, P.1    Tefferi, A.2    Pardanani, A.3    Steensma, D.P.4    Camoriano, J.5    Wu, W.6
  • 28
    • 78549245112 scopus 로고    scopus 로고
    • Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: Results in 40 patients
    • 20567824 10.1007/s00277-010-1019-9 1:CAS:528:DC%2BC3cXhtlyktbfK
    • Martinez-Trillos A, Gaya A, Maffioli M, Arellano-Rodrigo E, Calvo X, Diaz-Beya M, et al. Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: Results in 40 patients. Ann Hematol. 2010;89(12):1233-7.
    • (2010) Ann Hematol , vol.89 , Issue.12 , pp. 1233-1237
    • Martinez-Trillos, A.1    Gaya, A.2    Maffioli, M.3    Arellano-Rodrigo, E.4    Calvo, X.5    Diaz-Beya, M.6
  • 29
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • 10.1056/NEJMoa1110556 22375970 10.1056/NEJMoa1110556 1:CAS:528: DC%2BC38XjsV2qurs%3D First randomized phase III trial of a JAK2 inhibitor vs. best available therapy in myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366(9):787-98. doi: 10.1056/NEJMoa1110556. First randomized phase III trial of a JAK2 inhibitor vs. best available therapy in myelofibrosis.
    • (2012) N Engl J Med , vol.366 , Issue.9 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3    Gisslinger, H.4    Waltzman, R.5    Stalbovskaya, V.6
  • 30
    • 84890465793 scopus 로고    scopus 로고
    • Long-term analysis of the palliative benefit of 2-Chlorodeoxyadenosine (2-CdA) for myelofibrosis with myeloid metaplasia
    • Faoro L, Mesa R, Gertz MA, Tefferi A. Long-term analysis of the palliative benefit of 2-Chlorodeoxyadenosine (2-CdA) for myelofibrosis with myeloid metaplasia. Am J Clin Oncol. 2004.
    • (2004) Am J Clin Oncol
    • Faoro, L.1    Mesa, R.2    Gertz, M.A.3    Tefferi, A.4
  • 31
    • 33745811661 scopus 로고    scopus 로고
    • Palliative goals, patient selection, and perioperative platelet management: Outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
    • 16770787 10.1002/cncr.22021
    • Mesa RA, Nagorney DS, Schwager S, Allred J, Tefferi A. Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic. Cancer. 2006;107(2):361-70.
    • (2006) Cancer , vol.107 , Issue.2 , pp. 361-370
    • Mesa, R.A.1    Nagorney, D.S.2    Schwager, S.3    Allred, J.4    Tefferi, A.5
  • 32
    • 0031784441 scopus 로고    scopus 로고
    • Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia
    • 9827926 10.1046/j.1365-2141.1998.00998.x 1:STN:280:DyaK1M%2FktlKhug%3D%3D
    • Elliott MA, Chen MG, Silverstein MN, Tefferi A. Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia. Br J Haematol. 1998;103(2):505-11.
    • (1998) Br J Haematol , vol.103 , Issue.2 , pp. 505-511
    • Elliott, M.A.1    Chen, M.G.2    Silverstein, M.N.3    Tefferi, A.4
  • 33
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
    • 10.1056/NEJMoa1002028 20843246 10.1056/NEJMoa1002028 1:CAS:528: DC%2BC3cXhtFOltrjJ
    • Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis. New Engl J Med. 2010;363(12):1117-27. doi: 10.1056/NEJMoa1002028.
    • (2010) New Engl J Med , vol.363 , Issue.12 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3    Pardanani, A.D.4    Cortes-Franco, J.5    Thomas, D.A.6
  • 34
    • 84865192181 scopus 로고    scopus 로고
    • Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: Survival advantage in comparison to matched historical controls
    • 10.1182/blood-2012-02-414631 22718840 10.1182/blood-2012-02-414631 1:CAS:528:DC%2BC38Xht1WjsrrJ
    • Verstovsek S, Kantarjian HM, Estrov Z, Cortes JE, Thomas DA, Kadia T, et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: Survival advantage in comparison to matched historical controls. Blood. 2012;120(6):1202-9. doi: 10.1182/blood-2012-02-414631.
    • (2012) Blood , vol.120 , Issue.6 , pp. 1202-1209
    • Verstovsek, S.1    Kantarjian, H.M.2    Estrov, Z.3    Cortes, J.E.4    Thomas, D.A.5    Kadia, T.6
  • 35
    • 84882803340 scopus 로고    scopus 로고
    • Exploratory analysis of the effect of ruxolitinib on bone marrow morphology in patients with myelofibrosis
    • Kvasnicka H-M, Thiele J, Bueso-Ramos CE, Hou K, Cortes JE, Kantarjian HM. Exploratory analysis of the effect of ruxolitinib on bone marrow morphology in patients with myelofibrosis. J Clin Oncol. 2013;31:7030.
    • (2013) J Clin Oncol , vol.31 , pp. 7030
    • Kvasnicka, H.-M.1    Thiele, J.2    Bueso-Ramos, C.E.3    Hou, K.4    Cortes, J.E.5    Kantarjian, H.M.6
  • 36
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • 10.1056/NEJMoa1110557 22375971 10.1056/NEJMoa1110557 1:CAS:528: DC%2BC38XjsV2qurg%3D First randomized trial of JAK2 inhibitor vs. placebo, demonstrating a survival advantage in myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807. doi: 10.1056/NEJMoa1110557. First randomized trial of JAK2 inhibitor vs. placebo, demonstrating a survival advantage in myelofibrosis.
    • (2012) N Engl J Med , vol.366 , Issue.9 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3    Levy, R.S.4    Gupta, V.5    Dipersio, J.F.6
  • 37
    • 84876082159 scopus 로고    scopus 로고
    • Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: A randomized, double-blind, placebo-controlled trial
    • 10.1200/JCO.2012.44.4489 23423753 10.1200/JCO.2012.44.4489 1:CAS:528:DC%2BC3sXnsl2ltrk%3D
    • Mesa RA, Gotlib J, Gupta V, Catalano JV, Deininger MW, Shields AL, et al. Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial. J Clin Oncol. 2013;31(10):1285-92. doi: 10.1200/JCO.2012.44.4489.
    • (2013) J Clin Oncol , vol.31 , Issue.10 , pp. 1285-1292
    • Mesa, R.A.1    Gotlib, J.2    Gupta, V.3    Catalano, J.V.4    Deininger, M.W.5    Shields, A.L.6
  • 38
    • 84879840304 scopus 로고    scopus 로고
    • Health-related quality of life and symptoms in patients with myelofibrosis treated with ruxolitinib versus best available therapy
    • 10.1111/bjh.12375
    • Harrison CN, Mesa RA, Kiladjian JJ, Al-Ali HK, Gisslinger H, Knoops L, et al. Health-related quality of life and symptoms in patients with myelofibrosis treated with ruxolitinib versus best available therapy. Br J Haematol. 2013. doi: 10.1111/bjh.12375.
    • (2013) Br J Haematol
    • Harrison, C.N.1    Mesa, R.A.2    Kiladjian, J.J.3    Al-Ali, H.K.4    Gisslinger, H.5    Knoops, L.6
  • 39
    • 84876790720 scopus 로고    scopus 로고
    • The clinical benefit of ruxolitinib across patient subgroups: Analysis of a placebo-controlled, Phase III study in patients with myelofibrosis
    • 10.1111/bjh.12274 23480528 10.1111/bjh.12274 1:CAS:528: DC%2BC3sXms1Ggu7o%3D
    • Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis. Br J Haematol. 2013;161(4):508-16. doi: 10.1111/bjh.12274.
    • (2013) Br J Haematol , vol.161 , Issue.4 , pp. 508-516
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3    Levy, R.S.4    Gupta, V.5    Dipersio, J.F.6
  • 40
    • 84890476619 scopus 로고    scopus 로고
    • Long-term outcomes from a phase 3 study comparing ruxolitinib with best available therapy (BAT) for the treatment of myelofibrosis (MF): A 3-YEAR update of COMFORT-II
    • Vannucchi A, Cervantes F, Niederwieser D, Sirulnik A, Stalbovskaya V, McQuitty M et al. Long-term outcomes from a phase 3 study comparing ruxolitinib with best available therapy (BAT) for the treatment of myelofibrosis (MF): A 3-YEAR update of COMFORT-II. Haematologica. 2013; Suppl:a5828.
    • (2013) Haematologica , Issue.SUPPL.
    • Vannucchi, A.1    Cervantes, F.2    Niederwieser, D.3    Sirulnik, A.4    Stalbovskaya, V.5    McQuitty, M.6
  • 41
    • 79952333359 scopus 로고    scopus 로고
    • Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
    • 21220608 10.1200/JCO.2010.32.8021 1:CAS:528:DC%2BC3MXktlelsL0%3D
    • Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM, et al. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011;29(7):789-96.
    • (2011) J Clin Oncol , vol.29 , Issue.7 , pp. 789-796
    • Pardanani, A.1    Gotlib, J.R.2    Jamieson, C.3    Cortes, J.E.4    Talpaz, M.5    Stone, R.M.6
  • 42
    • 84887715160 scopus 로고    scopus 로고
    • Updated results from a randomized phase II dose-ranging study of the JAK2-selective inhibitor SAR302503 in patients with myelofibrosis (MF)
    • Animesh Dev Pardanani CHMJ, Gabrail NY, et al. Updated results from a randomized phase II dose-ranging study of the JAK2-selective inhibitor SAR302503 in patients with myelofibrosis (MF). J Clin Oncol. 2013;31:7109.
    • (2013) J Clin Oncol , vol.31 , pp. 7109
    • Animesh Dev Pardanani, C.1    Gabrail, N.Y.2
  • 43
    • 80054098336 scopus 로고    scopus 로고
    • Phase II study of SB1518, an orally available novel Jak2 inhibitor, in patients with myelofibrosis
    • Deeg HJOO, Scott BL, et al. Phase II study of SB1518, an orally available novel Jak2 inhibitor, in patients with myelofibrosis. J Clin Oncol. 2011;29:6515.
    • (2011) J Clin Oncol , vol.29 , pp. 6515
    • Deeg, H.1    Scott, B.L.2
  • 44
    • 84858848013 scopus 로고    scopus 로고
    • Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, in Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis
    • Komrokji RS, Wadleigh M, Seymour JF, Roberts AW, To LB, Zhu HJ, et al. Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis. ASH Ann Meet Abs. 2011;118(21):282.
    • (2011) ASH Ann Meet Abs , vol.118 , Issue.21 , pp. 282
    • Komrokji, R.S.1    Wadleigh, M.2    Seymour, J.F.3    Roberts, A.W.4    To, L.B.5    Zhu, H.J.6
  • 45
    • 84878951826 scopus 로고    scopus 로고
    • Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • 10.1038/leu.2013.71 23459451 10.1038/leu.2013.71 1:CAS:528: DC%2BC3sXptFeksb8%3D
    • Pardanani A, Laborde RR, Lasho TL, Finke C, Begna K, Al-Kali A, et al. Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis. Leukemia. 2013;27(6):1322-7. doi: 10.1038/leu.2013.71.
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1322-1327
    • Pardanani, A.1    Laborde, R.R.2    Lasho, T.L.3    Finke, C.4    Begna, K.5    Al-Kali, A.6
  • 47
    • 75449087842 scopus 로고    scopus 로고
    • Phase1/-2 study of Pomalidomide in myelofibrosis
    • 10.1002/ajh.21598 20052748 1:CAS:528:DC%2BC3cXitlKmsrg%3D
    • Mesa RA, Pardanani AD, Hussein K, Wu W, Schwager S, Litzow MR, et al. Phase1/-2 study of Pomalidomide in myelofibrosis. Am J Hematol. 2010;85(2):129-30. doi: 10.1002/ajh.21598.
    • (2010) Am J Hematol , vol.85 , Issue.2 , pp. 129-130
    • Mesa, R.A.1    Pardanani, A.D.2    Hussein, K.3    Wu, W.4    Schwager, S.5    Litzow, M.R.6
  • 48
    • 84880321219 scopus 로고    scopus 로고
    • Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis
    • 10.1111/bjh.12384 23701016
    • Deangelo DJ, Mesa RA, Fiskus W, Tefferi A, Paley C, Wadleigh M, et al. Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis. Br J Haematol. 2013. doi: 10.1111/bjh.12384.
    • (2013) Br J Haematol
    • Deangelo, D.J.1    Mesa, R.A.2    Fiskus, W.3    Tefferi, A.4    Paley, C.5    Wadleigh, M.6
  • 49
    • 77955168425 scopus 로고    scopus 로고
    • A pilot study of the histone-deacetylase inhibitor givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms
    • 10.1111/j.1365-2141.2010.08266.x 20560970 1:CAS:528:DC%2BC3cXhtFCru77L
    • Rambaldi A, Dellacasa CM, Finazzi G, Carobbio A, Ferrari ML, Guglielmelli P, et al. A pilot study of the histone-deacetylase inhibitor givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms. Br J Haematol. 2010;150(4):446-55. doi: 10.1111/j.1365-2141.2010.08266.x.
    • (2010) Br J Haematol , vol.150 , Issue.4 , pp. 446-455
    • Rambaldi, A.1    Dellacasa, C.M.2    Finazzi, G.3    Carobbio, A.4    Ferrari, M.L.5    Guglielmelli, P.6
  • 50
    • 80052184481 scopus 로고    scopus 로고
    • Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis
    • 10.1182/blood-2011-01-330563 21725052 10.1182/blood-2011-01-330563 1:CAS:528:DC%2BC3MXhtFGisrnO
    • Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, et al. Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis. Blood. 2011;118(8):2069-76. doi: 10.1182/blood-2011-01-330563.
    • (2011) Blood , vol.118 , Issue.8 , pp. 2069-2076
    • Guglielmelli, P.1    Barosi, G.2    Rambaldi, A.3    Marchioli, R.4    Masciulli, A.5    Tozzi, L.6
  • 51
    • 84879342780 scopus 로고    scopus 로고
    • Small-molecule inhibitors in myeloproliferative neoplasms: Are we aiming for the right targets?
    • 10.1182/asheducation-2012.1.553
    • Constantinescu SN, Vainchenker W. Small-molecule inhibitors in myeloproliferative neoplasms: Are we aiming for the right targets? Hematol Am Soc Hematol Educ Program. 2012;2012:553-60. doi: 10.1182/asheducation-2012.1. 553.
    • (2012) Hematol Am Soc Hematol Educ Program , vol.2012 , pp. 553-560
    • Constantinescu, S.N.1    Vainchenker, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.