Sequential antibiotic and growth factor releasing chitosan-PAAm semi-IPN hydrogel as a novel wound dressing

Journal of Biomaterials Science, Polymer Edition

Volumn 24, Issue 7, 2013, Pages 807-819

  Pulat, Mehlika ^a   Kahraman, Anil Sera ^b   Tan, Nur ^a   Gümüşderelioglu, Menemse ^b  

^a GAZI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

cell culture; chitosan; EGF; piperacillin tazobactam; semi IPN hydrogels; sequential release

Indexed keywords

ANTIBIOTICS; CELL CULTURE; CELL GROWTH; CHITOSAN; FREE RADICAL POLYMERIZATION; INTERPENETRATING POLYMER NETWORKS;

EGF; EPIDERMAL GROWTH FACTORS; ETHYLENE GLYCOL DIMETHACRYLATE; PIPERACILLIN-TAZOBACTAM; SEMI-INTERPENETRATING NETWORKS (SEMI-IPN); SEMI-IPN HYDROGELS; SEQUENTIAL RELEASE; WOUND DRESSING MATERIALS;

HYDROGELS;

CHITOSAN; EPIDERMAL GROWTH FACTOR; ETHYLENE GLYCOL DIMETHACRYLATE; PIPERACILLIN PLUS TAZOBACTAM; POLYACRYLAMIDE; ACRYLIC ACID RESIN; ANTIINFECTIVE AGENT; BIOMATERIAL; HYDROGEL; PENICILLANIC ACID; PIPERACILLIN; TAZOBACTAM; WATER; DRUG DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CROSS LINKING; FIBROBLAST; HYDROGEL; IN VITRO STUDY; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; WATER CONTENT; WOUND DRESSING; WOUND HEALING; ANALOGS AND DERIVATIVES; ANIMAL; BANDAGE; CELL LINE; CHEMISTRY; KINETICS; WOUNDS AND INJURIES; INJURY;

ACRYLIC RESINS; ANIMALS; ANTI-BACTERIAL AGENTS; BANDAGES; BIOCOMPATIBLE MATERIALS; CELL LINE; CHITOSAN; EPIDERMAL GROWTH FACTOR; HYDROGELS; KINETICS; MICE; PENICILLANIC ACID; PIPERACILLIN; WATER; WOUNDS AND INJURIES;

EID: 84890495155     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2012.718613     Document Type: Article

References (30)

1. Kurita K. Chemical modifications of chitin and chitosan. In: Muzzarelli RAA, Jeuniaux C, Gooday GW, editors. Chitin in nature and technology. New York, NY: Plenum; 1986. p. 287-93.
2. Hirano S, Seino H, Akiyama Y, Nonako I. Chitosan: a biocompatible material for oral and intravenous administrations. In: Gebelein CG, Dunn RL, editors. Progress in biomedical polymers. New York, NY: Plenum; 1990. p. 283-9.
3. Dash M, Chiellini F, Ottenbrite R, Chiellini E. Chitosan-a versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science. 2011;36:981-1014.
4. Ueno H, Mori T, Fujinaga T. Topical formulations and wound healing applications of chitosan. Advanced Drug Delivery Reviews. 2001;52:105-15.
5. Ti{dotless}ǧli{dotless} RS, Karakeçili A, Gümüşderelioǧlu M. In-vitro characterization of chitosan scaffolds: influence of composition and deacetylation degree. Journal of Materials Science: Materials in Medicine. 2007;18:1665-74.
6. Karakeçili A, Satriano C, Gümüşderelioǧlu M, Marletta G. Enhancement of the fibroblastic proliferation by immobilized EGF on chitosan surfaces. Acta Biomaterialia. 2008;4:989-96.
7. Gümüşderelioǧlu M, Agi P. Adsorption of concanavalin A on the well-characterized macroporous chitosan and chitin membranes. Reactive and Functional Polymers. 2004;61:211-20.
8. Krishna RKSV, Vijaya KNB, Subha MCS, Sairam M, Aminabhavi TM. Novel chitosan-based pHsensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohydrate Polymers. 2006;66:333-44.
9. El-Sherbiny IM, Lins RJ, Abdel-Bary EM, Harding DRK. Preparation, characterization, swelling and in vitro drug release behaviour of poly[N-acryloylglycine-chitosan] interpolymeric pH and thermally-responsive hydrogels. European Polymer Journal. 2005;41:2584-91.
10. Çetin D, Kahraman AS, Gümüşderelioǧlu M. Novel scaffolds based on poly(2-hydroxyethyl methacrylate) superporous hydrogels for bone tissue engineering. Journal of Biomaterials Science: Polymer Edition. 2011;22:1157-78.
11. Bae YH, Kim SW. Hydrogel delivery systems based on polymer blends, block co-polymers or interpenetrating networks. Advanced Drug Delivery Reviews. 1993;11:109-35.
12. Shin SR, Park SJ, Yoon SG, Spinks GM, Kim SI, Kim SJ. Synthesis of conducting polyaniline in semi-IPN based on chitosan. Synthetic Metals. 2005;154:213-6.
13. Pulat M, Ekşi H. Determination of swelling behaviour and morphological properties of poly(acrylamide-co-itaconic acid) and poly(acrylic acid-co-itaconic acid) copolymeric hydrogels. Journal of Applied Polymer Science. 2006;102:5994-9.
14. Rokhade AP, Patil SA, Aminabhavi TM. Synthesis and characterization of semi-interpenetrating polymer network microspheres of acrylamide grafted dextran and chitosan for controlled release of acyclovir. Carbohydrate Polymers. 2007;67:605-13.
15. Kokab M, Sirousazar M, Hassan ZM. PVA-clay nanocomposite hydrogels for wound dressing. European Polymer Journal. 2007;43:773-81.
16. Higa OZ, Rogero SO, Machado LDB, Mathor MB, Lugao AB. Biocompatibility study for PVP wound dressing obtained in different conditions. Radiation Physics Chemistry. 1999;55:705-7.
17. Ulubayram K, Cakar AN, Korkusuz P, Ertan C, Hasirci N. EGF containing gelatin-based wound dressings. Biomaterials. 2001;22:1345-56.
18. Britton HTK, Robinson RA. Universal buffer solutions and the dissociation constant of veronal. Journal of the Chemical Society. 1931;458:1456-62.
19. Pulat M, Asi{dotless}l D. Fluconazole release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylic acid, and citraconic acid. Journal of Applied Polymer Science. 2009;113:2613-9.
20. Pulat M, Tan N, Onurdaǧ FK. Swelling dynamics of IPN hydrogels including acrylamide-acrylic acid-chitosan and evaluation of their potential for controlled release of piperacillin-tazobactam. Journal of Applied Polymer Science. 2011;120:441-50.
21. Bourget P, Sertin A, Lesne-Hulin A, Fernandez H, Ville Y, Van Peborgh P. Influence of pregnancy on the pharmacokinetic behaviour and the transplacental transfer of the piperacillin-tazobactam combination. European Journal of Obstetrics & Gynecology and Reproductive Biology. 1998;76:21-7.
22. Erbil C, Yi{dotless}ldi{dotless}z Y, Uyani{dotless}k N. Effect of synthesis-solvent composition and initiator concentration on the swelling behaviour of poly(N-isopropylacrylamide) P(NIPAAM), poly(NIPAAM-co-dimethyl itaconate), and poly(NIPAAM-co itaconic acid) gels. Polymer International. 2000;49:795-800.
23. Ravi Kumar MNV. A review of chitin and chitosan applications. Reactive and Functional Polymers. 2000;46:1-27.
24. Merlin DL, Sivasankar B. Synthesis and characterization of semi-interpenetrating polymer networks using biocompatible polyurethane and acrylamide monomer. European Polymer Journal. 2009;45:165-70.
25. Rodriguez E, Katime I. Behaviour of acrylic acid-itaconic acid hydrogels in swelling, shrinking, and uptakes of some metal ions from aqueous solution. Journal of Applied Polymer Science. 2003;90:530-6.
26. Jang C-H, Park H, Cho YB, Choi C-H. Evaluating the ototoxicity of topical piperacillin-tazobactam. International Journal of Pediatric Otolaryngology Rhinol Layrngol. 2008;72:1815-21.
27. Shukla VK, Shukla D, Tiwary SK, Agrawal S, Rastogi A. Evaluation of pH measurement as a method of wound assessment. Journal of Wound Care. 2007;16:291-4.
28. Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Advanced Drug Delivery Reviews. 2006;58:1655-70.
29. Christoffer WT, Tworzyanski JJ, Imoisili MA, Alexander JJ, Korth-Bradley JM, Gobburu JVS. Optimising piperacillin/tazobactam dosing in pediatrics. International Journal of Antimicrobial Agents. 2007;30:320-4.
30. Gümüşderelioǧlu M, Kesgin D. Release kinetics of bovine serum albumin from pH-sensitive poly (vinyl ether) based hydrogels. International Journal of Pharmaceutics. 2005;288:273-9.