In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [18F]-CP18 for PET imaging of apoptosis in tumors

Molecular Imaging and Biology

Volumn 15, Issue 6, 2013, Pages 748-757

  Xia, Chun Fang ^a   Chen, Gang ^a   Gangadharmath, Umesh ^a   Gomez, Luis F ^a   Liang, Qianwa ^a   Mu, Fanrong ^a   Mocharla, Vani P ^a   Su, Helen ^a   Szardenings, A Katrin ^a   Walsh, Joseph C ^a   Zhao, Tieming ^a   Kolb, Hartmuth C ^a  

^a SIEMENS CORPORATE RESEARCH   (United States)

Author keywords

18F CP18; Apoptosis; Caspase imaging; Caspase 3; PET imaging

Indexed keywords

CASPASE 3; CASPASE 7; FLUORODEOXYGLUCOSE F 18;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BIOLOGICAL MONITORING; CELL ASSAY; CELL LYSATE; CONTROLLED STUDY; DRUG DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LUNG CARCINOMA; MALE; MOUSE; NICK END LABELING; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN CLEAVAGE; TISSUE HOMOGENATE; TISSUE SECTION; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; GLYCOPEPTIDES; HUMANS; LINEAR MODELS; MICE; MOLECULAR IMAGING; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84890478418     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-013-0646-7     Document Type: Article

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