Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: An experimental study on nude mice

Neurology India

Volumn 61, Issue 5, 2013, Pages 491-496

  Wenke, Liu ^a   Peng, Li ^a   Xing, Wang ^a   Yujun, Shi ^a   Qi, Zhong ^a   Haibo, Ren ^a   Wei, Wang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Gamma knife; gene therapy; glioblastoma multiforme; recombinant plasmid pcDNA3.1 Egr. 1p p16

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DNA; COMPLEMENTARY DNA; DRUG CARRIER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPOSOME; MESSENGER RNA; PCDNA3.1 EGR. 1P P16; PROTEIN P16; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER GENE THERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURGERY; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL STUDY; GAMMA KNIFE; GAMMA KNIFE RADIOSURGERY; GENE CONTROL; GENE EXPRESSION; GLIOBLASTOMA; HISTOLOGY; HUMAN; HUMAN CELL; LIPOSOMAL GENE DELIVERY SYSTEM; MOUSE; MULTIMODALITY CANCER THERAPY; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; RADIATION DOSE; RECOMBINANT PLASMID; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERAPY EFFECT; TREATMENT OUTCOME; TUMOR CELL DESTRUCTION; TUMOR GROWTH;

ANIMALS; APOPTOSIS; COMBINED MODALITY THERAPY; EARLY GROWTH RESPONSE PROTEIN 1; GENETIC THERAPY; GLIOBLASTOMA; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RADIOSURGERY; TRANSFECTION; TREATMENT OUTCOME;

EID: 84890474095     PISSN: 00283886     EISSN: 19984022     Source Type: Journal    
DOI: 10.4103/0028-3886.121917     Document Type: Article

References (11)

1. Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors. Neurol Clin 2007; 25: 867-90, vii.
2. Kawamura K, Tasaki K, Hamada H, Takenaga K, Sakiyama S, Tagawa M. Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity. Cancer Gene Ther 2000; 7: 637-43.
3. Clavier JB, Voirin J, Kehrli P, Noël G. Systematic review of stereotactic radiotherapy for high-grade gliomas. Cancer Radiother 2010; 14: 739-54.
4. Cuneo KC, Vredenburgh JJ, Sampson JH, Reardon DA, Desjardins A, Peters KB, et al. Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 2012; 82: 2018-24.
5. Larson DA, Gutin PH, McDermott M, Lamborn K, Sneed PK, Wara WM, et al. Gamma knife for glioma: Selection factors and survival. Int J Radiat Oncol Biol Phys 1996; 36: 1045-53.
6. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 1994; 180: 525-35.
7. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7: 683-94.
8. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727-30.
9. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-7.
10. Zhivotovsky B, Joseph B, Orrenius S. Tumor radiosensitivity and apoptosis. Exp Cell Res 1999; 248: 10-7.
11. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436-40.