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Volumn 39, Issue 1, 2014, Pages 248-249

Functional selectivity at GPCRs: New opportunities in psychiatric drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; LIGAND; RETINA S ANTIGEN; SEROTONIN RECEPTOR;

EID: 84890462032     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.205     Document Type: Short Survey
Times cited : (16)

References (7)
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    • Bruchas MR, Chavkin C (2010). Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) 210: 137-147
    • (2010) Psychopharmacology (Berl , vol.210 , pp. 137-147
    • Bruchas, M.R.1    Chavkin, C.2
  • 2
    • 79961197759 scopus 로고    scopus 로고
    • Selective p38a MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction
    • Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB et al (2011). Selective p38a MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron 71: 498-511
    • (2011) Neuron , vol.71 , pp. 498-511
    • Bruchas, M.R.1    Schindler, A.G.2    Shankar, H.3    Messinger, D.I.4    Miyatake, M.5    Land, B.B.6
  • 3
    • 84875227396 scopus 로고    scopus 로고
    • Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
    • Kenakin T, Christopoulos A (2013). Signalling bias in new drug discovery: Detection, quantification and therapeutic impact. Nat Rev Drug Discov 12: 205-216
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 205-216
    • Kenakin, T.1    Christopoulos, A.2
  • 4
    • 77952415656 scopus 로고    scopus 로고
    • Beyond desensitization: Physiological relevance of arrestin-dependent signaling
    • Luttrell LM, Gesty-Palmer D (2010). Beyond desensitization: Physiological relevance of arrestin-dependent signaling. Pharmacol Rev 62: 305-330
    • (2010) Pharmacol Rev , vol.62 , pp. 305-330
    • Luttrell, L.M.1    Gesty-Palmer, D.2
  • 5
    • 77957742904 scopus 로고    scopus 로고
    • Serotonin, but not N-methyltryptamines, activates the serotonin 2 A receptor via a --Arrestin2/Src/Akt signaling complex in vivo
    • Schmid CL, Bohn LM (2010). Serotonin, but not N-methyltryptamines, activates the serotonin 2 A receptor via a --Arrestin2/Src/Akt signaling complex in vivo. J Neurosci 30: 13513-13524
    • (2010) J Neurosci , vol.30 , pp. 13513-13524
    • Schmid, C.L.1    Bohn, L.M.2
  • 6
    • 84874407555 scopus 로고    scopus 로고
    • Deletion of GSK3b in D2Rexpressing neurons reveals distinct roles for barrestin signaling in antipsychotic and lithium action
    • Urs NM, Snyder JC, Jacobsen JPR, Peterson SM, Caron MG (2012). Deletion of GSK3b in D2Rexpressing neurons reveals distinct roles for barrestin signaling in antipsychotic and lithium action. Proc Natl Acad Sci USA 109: 20732-20737
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 20732-20737
    • Urs, N.M.1    Snyder, J.C.2    Jacobsen, J.P.R.3    Peterson, S.M.4    Caron, M.G.5
  • 7
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    • Structural features for functional selectivity at serotonin receptors
    • Wacker D, Wang C, Katritch V, Han GW, Huang X-P, Vardy E et al (2013). Structural features for functional selectivity at serotonin receptors. Science 340: 615-619
    • (2013) Science , vol.340 , pp. 615-619
    • Wacker, D.1    Wang, C.2    Katritch, V.3    Han, G.W.4    Huang, X.-P.5    Vardy, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.